DGIdb - CDC25B Gene Record

CDC25B 994 Druggable Genome

Alternate Names:

994
CELL DIVISION CYCLE 25B
CDC25B
116949
1726
ENSG00000101224
OTTHUMG00000031764
P30305
M-PHASE INDUCER PHOSPHATASE 2
MPIP2_HUMAN
BE0001705
M-PHASE INDUCER PHOSPHATASE 2 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25B). [SOURCE:UNIPROT/SWISSPROT;ACC:P30305]
CDC25HU2
MPIP2
T46365
-

Gene Info:

Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Rhodanese-like_dom
Interpro Acc	IPR001763
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Name	Rhodanese-like domain
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

PROTEIN PHOSPHATASE
KINASE
DRUGGABLE GENOME

Publications:

George Rosenker KM et al., 2015, Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B., Bioorg Med Chem
Lavecchia A et al., 2012, Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening., J Med Chem
Mak LH et al., 2012, Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases., Bioorg Med Chem

CHEMBL357170 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2059068 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2059274 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1333982 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2003658 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2059074 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1600564 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1414990 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1270061 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1331754 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2059067 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL507159 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1408031 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1481453 CDC25B

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL471004 CDC25B

Interaction Score: 2.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2057662 CDC25B

Interaction Score: 2.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22705189

Sources:
DTC
CHEMBL1370674 CDC25B

Interaction Score: 1.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1172911 CDC25B

Interaction Score: 1.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL337173 CDC25B

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25703307

Sources:
DTC
CHEMBL1481974 CDC25B

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC

Ensembl: ENSG00000101224
- Version: 101_38
Alternate Names:

CDC25B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000101224

Version: 26-July-2011

Alternate Names:

ENSG00000101224 Ensembl Gene Id

M-PHASE INDUCER PHOSPHATASE 2 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25B). [SOURCE:UNIPROT/SWISSPROT;ACC:P30305] Description

CDC25B Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P30305
- Version: 11-September-2012
Alternate Names:

994 Entrez Gene Id

MPIP2_HUMAN Uniprot Id

CDC25B Uniprot Gene Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Rhodanese-like_dom

Gene Categories:

DRUGGABLE GENOME

Publications:
DrugBank: BE0001705
- Version: 5.1.7
Alternate Names:

CDC25B DrugBank Gene Name

P30305 UniProt Accession

994 Entrez Gene Id

Gene Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
NCI: CDC25B
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Oguri et al., 2004, Induction of Cdc25B expression by epidermal growth factor and transforming growth factor-alpha., Biochem. Pharmacol.

DTC: CDC25B

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

George Rosenker KM et al., 2015, Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B., Bioorg Med Chem

Lavecchia A et al., 2012, Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening., J Med Chem

Mak LH et al., 2012, Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases., Bioorg Med Chem

HingoraniCasas: ENSG00000101224
- Version: 31-May-2017
Alternate Names:

ENSG00000101224 Gene Symbol

CDC25B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: CDC25B
- Version: 03-September-2020
Alternate Names:

M-phase inducer phosphatase 2 Gene Name

P30305 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: CDC25B
- Version: 05-September-2020
Alternate Names:

CDC25HU2 GO Gene Synonym

Gene Info:

Gene Categories:

PROTEIN PHOSPHATASE

Publications:
dGene: CDC25B
- Version: 27-Jun-2013
Alternate Names:

994 Gene ID

- dGene Synonym

Gene Info:

Gene Categories:

PROTEIN PHOSPHATASE

Publications:
TTD: M-phase inducer phosphatase 2
- Version: 2020.06.01
Alternate Names:

MPIP2 TTD Gene Abbreviation

T46365 TTD Target ID

Gene Info:

Publications:

ENSG00000101224	Ensembl Gene Id
M-PHASE INDUCER PHOSPHATASE 2 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25B). [SOURCE:UNIPROT/SWISSPROT;ACC:P30305]	Description
CDC25B	Display Id

994	Entrez Gene Id
MPIP2_HUMAN	Uniprot Id
CDC25B	Uniprot Gene Name

CDC25B	DrugBank Gene Name
P30305	UniProt Accession
994	Entrez Gene Id

CDC25B Gene Record

CDC25B 994 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22705189

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22705189

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25703307

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Alternate Names:

CDC25B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000101224 Ensembl Gene Id

M-PHASE INDUCER PHOSPHATASE 2 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25B). [SOURCE:UNIPROT/SWISSPROT;ACC:P30305] Description

CDC25B Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

994 Entrez Gene Id

MPIP2_HUMAN Uniprot Id

CDC25B Uniprot Gene Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Rhodanese-like_dom

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CDC25B DrugBank Gene Name

P30305 UniProt Accession

994 Entrez Gene Id

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Publications:

Oguri et al., 2004, Induction of Cdc25B expression by epidermal growth factor and transforming growth factor-alpha., Biochem. Pharmacol.

Alternate Names:

ENSG00000101224 Gene Symbol

CDC25B Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

M-phase inducer phosphatase 2 Gene Name

P30305 UniProt ID

Gene Categories:

KINASE

Alternate Names:

CDC25HU2 GO Gene Synonym

Gene Categories:

PROTEIN PHOSPHATASE

Alternate Names:

994 Gene ID

- dGene Synonym