DGIdb - CDC25B Gene Record

CDC25B 994 Druggable Genome

Alternate Names:

994
CELL DIVISION CYCLE 25B
CDC25B
116949
1726
ENSG00000101224
OTTHUMG00000031764
P30305
M-PHASE INDUCER PHOSPHATASE 2
MPIP2_HUMAN
M-PHASE INDUCER PHOSPHATASE 2 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25B). [SOURCE:UNIPROT/SWISSPROT;ACC:P30305]
MPIP2
T46365
-
CDC25HU2

Gene Info:

Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Rhodanese-like_dom
Interpro Acc	IPR001763
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Name	Rhodanese-like domain
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

PROTEIN PHOSPHATASE
KINASE
DRUGGABLE GENOME

Publications:

George Rosenker KM et al., 2015, Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B., Bioorg Med Chem
Lavecchia A et al., 2012, Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening., J Med Chem
Mak LH et al., 2012, Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases., Bioorg Med Chem

CHEMBL357170 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2059068 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2059274 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1333982 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2003658 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2059074 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1600564 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1414990 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1270061 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1331754 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2059067 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL507159 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1408031 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1481453 CDC25B

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL471004 CDC25B

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL2057662 CDC25B

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22705189

Sources:
DTC
CHEMBL1370674 CDC25B

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL1172911 CDC25B

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC
CHEMBL337173 CDC25B

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25703307

Sources:
DTC
CHEMBL1481974 CDC25B

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22524450

Sources:
DTC

Ensembl: ENSG00000101224
- Version: 101_38
Alternate Names:

CDC25B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000101224

Version: 26-July-2011

Alternate Names:

ENSG00000101224 Ensembl Gene Id

M-PHASE INDUCER PHOSPHATASE 2 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25B). [SOURCE:UNIPROT/SWISSPROT;ACC:P30305] Description

CDC25B Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P30305
- Version: 11-September-2012
Alternate Names:

994 Entrez Gene Id

MPIP2_HUMAN Uniprot Id

CDC25B Uniprot Gene Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Rhodanese-like_dom

Gene Categories:

DRUGGABLE GENOME

Publications:
NCI: CDC25B
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Oguri et al., 2004, Induction of Cdc25B expression by epidermal growth factor and transforming growth factor-alpha., Biochem. Pharmacol.

DTC: CDC25B

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

George Rosenker KM et al., 2015, Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B., Bioorg Med Chem

Lavecchia A et al., 2012, Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening., J Med Chem

Mak LH et al., 2012, Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases., Bioorg Med Chem

HingoraniCasas: ENSG00000101224
- Version: 31-May-2017
Alternate Names:

ENSG00000101224 Gene Symbol

CDC25B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: CDC25B
- Version: 01-February-2022
Alternate Names:

CDC25HU2 GO Gene Synonym

Gene Info:

Gene Categories:

PROTEIN PHOSPHATASE

Publications:
dGene: CDC25B
- Version: 27-Jun-2013
Alternate Names:

994 Gene ID

- dGene Synonym

Gene Info:

Gene Categories:

PROTEIN PHOSPHATASE

Publications:
TTD: M-phase inducer phosphatase 2
- Version: 2020.06.01
Alternate Names:

MPIP2 TTD Gene Abbreviation

T46365 TTD Target ID

Gene Info:

Publications:
Pharos: CDC25B
- Version: 01-February-2022
Alternate Names:

M-phase inducer phosphatase 2 Gene Name

P30305 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:

ENSG00000101224	Ensembl Gene Id
M-PHASE INDUCER PHOSPHATASE 2 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25B). [SOURCE:UNIPROT/SWISSPROT;ACC:P30305]	Description
CDC25B	Display Id

994	Entrez Gene Id
MPIP2_HUMAN	Uniprot Id
CDC25B	Uniprot Gene Name

CDC25B Gene Record

CDC25B 994 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22705189

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22524450

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22705189

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25703307

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22524450

Sources:
DTC

Alternate Names:

CDC25B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000101224 Ensembl Gene Id

M-PHASE INDUCER PHOSPHATASE 2 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25B). [SOURCE:UNIPROT/SWISSPROT;ACC:P30305] Description

CDC25B Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

994 Entrez Gene Id

MPIP2_HUMAN Uniprot Id

CDC25B Uniprot Gene Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Rhodanese-like_dom

Gene Categories:

DRUGGABLE GENOME

Publications:

Oguri et al., 2004, Induction of Cdc25B expression by epidermal growth factor and transforming growth factor-alpha., Biochem. Pharmacol.

Alternate Names:

ENSG00000101224 Gene Symbol

CDC25B Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CDC25HU2 GO Gene Synonym

Gene Categories:

PROTEIN PHOSPHATASE

Alternate Names:

994 Gene ID

- dGene Synonym

Gene Categories:

PROTEIN PHOSPHATASE

Alternate Names:

MPIP2 TTD Gene Abbreviation

T46365 TTD Target ID

Alternate Names:

M-phase inducer phosphatase 2 Gene Name

P30305 UniProt ID