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CDC25B Gene Record

  • Summary
  • Interactions
  • Claims
  • CDC25B 994 Druggable Genome

    Alternate Names:

    994
    CELL DIVISION CYCLE 25B
    CDC25B
    116949
    1726
    ENSG00000101224
    OTTHUMG00000031764
    P30305
    M-PHASE INDUCER PHOSPHATASE 2
    MPIP2_HUMAN
    M-PHASE INDUCER PHOSPHATASE 2 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25B). [SOURCE:UNIPROT/SWISSPROT;ACC:P30305]
    MPIP2
    T46365
    -
    CDC25HU2

    Gene Info:

    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Rhodanese-like_dom
    Interpro Acc IPR001763
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Interpro Name Rhodanese-like domain
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    PROTEIN PHOSPHATASE
    KINASE
    DRUGGABLE GENOME

    Publications:

    George Rosenker KM et al., 2015, Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B., Bioorg Med Chem
    Lavecchia A et al., 2012, Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening., J Med Chem
    Mak LH et al., 2012, Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases., Bioorg Med Chem
  • CHEMBL357170   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL2059068   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL2059274   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL1333982   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL2003658   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL2059074   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL1600564   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL1414990   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL1270061   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL1331754   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL2059067   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL507159   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL1408031   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL1481453   CDC25B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL471004   CDC25B

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL2057662   CDC25B

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22705189


    Sources:
    DTC

  • CHEMBL1370674   CDC25B

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL1172911   CDC25B

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • CHEMBL337173   CDC25B

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25703307


    Sources:
    DTC

  • CHEMBL1481974   CDC25B

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22524450


    Sources:
    DTC

  • Ensembl: ENSG00000101224

    • Version: 101_38

    Alternate Names:
    CDC25B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000101224

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000101224 Ensembl Gene Id
    M-PHASE INDUCER PHOSPHATASE 2 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25B). [SOURCE:UNIPROT/SWISSPROT;ACC:P30305] Description
    CDC25B Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P30305

    • Version: 11-September-2012

    Alternate Names:
    994 Entrez Gene Id
    MPIP2_HUMAN Uniprot Id
    CDC25B Uniprot Gene Name

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Rhodanese-like_dom

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: CDC25B

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Oguri et al., 2004, Induction of Cdc25B expression by epidermal growth factor and transforming growth factor-alpha., Biochem. Pharmacol.

  • DTC: CDC25B

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    George Rosenker KM et al., 2015, Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B., Bioorg Med Chem
    Lavecchia A et al., 2012, Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening., J Med Chem
    Mak LH et al., 2012, Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases., Bioorg Med Chem

  • HingoraniCasas: ENSG00000101224

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000101224 Gene Symbol
    CDC25B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: CDC25B

    • Version: 01-February-2022

    Alternate Names:
    CDC25HU2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    PROTEIN PHOSPHATASE

    Publications:

  • dGene: CDC25B

    • Version: 27-Jun-2013

    Alternate Names:
    994 Gene ID
    - dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEIN PHOSPHATASE

    Publications:

  • TTD: M-phase inducer phosphatase 2

    • Version: 2020.06.01

    Alternate Names:
    MPIP2 TTD Gene Abbreviation
    T46365 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: CDC25B

    • Version: 01-February-2022

    Alternate Names:
    M-phase inducer phosphatase 2 Gene Name
    P30305 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21