• CDK12 51755 Druggable GenomeClinically Actionable

    Alternate Names:

    51755
    CYCLIN DEPENDENT KINASE 12
    CDK12
    CRK7
    CRKR
    CRKRS
    615514
    24224
    ENSG00000167258
    OTTHUMG00000133214
    CDK12_HUMAN
    Q9NYV4
    KIAA0904
    CDC2-related protein kinase 7
    hCDK12
    Cell division protein kinase 12
    Cell division cycle 2-related protein kinase 7
    Cdc2-related kinase, arginine/serine-rich
    Cyclin-dependent kinase 12
    12112
    CELL DIVISION CYCLE 2-RELATED PROTEIN KINASE 7 (EC 2.7.1.37) (CDC2- RELATED PROTEIN KINASE 7) (CRKRS). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NYV4]
    CD2L7_HUMAN
    1965
    NP_057591
    NM_016507

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name KINASE
    Interpro Acc IPR002290
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    GuideToPharmacology Gene Category Name CRK7 subfamily
    GuideToPharmacology Gene Category ID 490
    Gene Biotype PROTEIN_CODING
    (14 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
  • Interaction Score: 3.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    OncoKB

  • Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    OncoKB

  • Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24240700


    Sources:
    CIViC

  • Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    OncoKB

    • Version: 101_38

    Alternate Names:
    CDK12 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    CD2L7_HUMAN Display Id
    CELL DIVISION CYCLE 2-RELATED PROTEIN KINASE 7 (EC 2.7.1.37) (CDC2- RELATED PROTEIN KINASE 7) (CRKRS). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NYV4] Description
    ENSG00000167258 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    CDK12 Uniprot Gene Name
    51755 Entrez Gene Id
    Q9NYV4 Uniprot Accession

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name KINASE
    Interpro Acc IPR002290

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    24224 HUGO Gene ID
    24224 HUGO Gene Symbol
    cyclin dependent kinase 12 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name CRK7 subfamily
    GuideToPharmacology Gene Category ID 490

    Gene Categories:
    ENZYME

    Publications:

    • Version: 14-September-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000167258 Gene Symbol
    CDK12 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    CRKRS GENE_SYMBOL
    KIAA0904 GENE_SYMBOL
    CDK12 GENE_SYMBOL

    Gene Info:

    Publications:

    • Version: 23-July-2020

    Alternate Names:
    51755 OncoKB Entrez Id
    CRK7 OncoKB Gene Synonym
    CRKR OncoKB Gene Synonym

    Gene Info:

    Publications:

    • Version: 15-July-2019

    Alternate Names:
    CDK12 Gene Symbol

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: 19.3

    Alternate Names:
    ENSG00000167258 Ensembl Gene ID
    CRK7 Human Protein Atlas Gene Synonym
    CRKR Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

    • Version: 11-November-2018

    Alternate Names:
    CDK12 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    51755 Gene ID
    CRK7 dGene Synonym
    CRKR dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    CRK7 GO Gene Synonym
    CRKRS GO Gene Synonym
    KIAA0904 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Cyclin-dependent kinase 12 Gene Name
    Q9NYV4 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: