DGIdb - CDK2 Gene Record

CDK2 1017 Druggable GenomeClinically Actionable

Alternate Names:

1017
CYCLIN DEPENDENT KINASE 2
CDK2
CDKN2
p33(CDK2)
116953
1771
ENSG00000123374
OTTHUMG00000170575
cyclin-dependent kinase 2
P24941
CDK2_HUMAN
p33 protein kinase
Cell division protein kinase 2
CELL DIVISION PROTEIN KINASE 2 (EC 2.7.1.37) (P33 PROTEIN KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P24941]
906
CDK 2,7,9
CDK 1,2,5,9
CDK 1,2,4,5,6,7,9 (pan-CDK)
T70176

Gene Info:

CancerCommons Reported Gene Name	CDK1,2,5,9
CancerCommons Reported Gene Name	CDK2,7,9
CancerCommons Reported Gene Name	Pan CDK
Human Readable Name	DRUGGABLE GENOME
Initial Gene Query	CDK2
Counted Citations from 1950-2000	4281
Human Readable Name	KINASE
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Interpro Acc	IPR002290
Uniprot Status	Swiss-Prot
Target Class	Enzymes
Target Subclass	EC:2.7.11.22
Gene Biotype	PROTEIN_CODING

(15 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR COMPLEX
DNA REPAIR
KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Smith et al., 2000, Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes., J. Biol. Chem.
Kim H et al., 2008, A flavonoid gossypin binds to cyclin-dependent kinase 2., Bioorg Med Chem Lett
Abe et al., 1994, A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells., Cancer Res.
Schonbrunn E et al., 2013, Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases., J Med Chem
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Wyatt PG et al., 2008, Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design., J Med Chem
Heathcote DA et al., 2010, A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration., J Med Chem
Iurisci I et al., 2006, Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor., Cancer Res
Zvelebil, 1998, Flavopiridol Hoechst AG., IDrugs
Alagbala AA et al., 2006, Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines., J Med Chem
Garcia et al., 2005, Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex., J. Biol. Chem.
Lee SE et al., 2009, Synthesis and reactivity of novel gamma-phosphate modified ATP analogues., Bioorg Med Chem Lett
William AD et al., 2012, Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer., J Med Chem
Brasca MG et al., 2009, Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor., J Med Chem
Yin et al., 1999, Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex., Exp. Cell Res.
Choi et al., 2003, Suppression of human prostate cancer cell growth by beta-lapachone via down-regulation of pRB phosphorylation and induction of Cdk inhibitor p21(WAF1/CIP1)., J. Biochem. Mol. Biol.
Reagan-Shaw et al., 2004, Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin., Oncogene
Kaida D et al., 2007, Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA., Nat Chem Biol
Tsihlias et al., 2000, Involvement of p27Kip1 in G1 arrest by high dose 5 alpha-dihydrotestosterone in LNCaP human prostate cancer cells., Oncogene
Chiu et al., 2003, Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice., Toxicol. Appl. Pharmacol.
Lee et al., 1998, Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells., J. Biol. Chem.
Takahashi et al., 2005, Cyclin A-associated kinase activity is needed for paclitaxel sensitivity., Mol. Cancer Ther.
Kaklamani et al., 2015, Phase II neoadjuvant clinical trial of carboplatin and eribulin in women with triple negative early-stage breast cancer (NCT01372579)., Breast Cancer Res. Treat.

CHEMBL494107 CDK2

Interaction Score: 2.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17643111

Sources:
DTC
CHEMBL557670 CDK2

Interaction Score: 2.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19410453

Sources:
DTC
CHEMBL373822 CDK2

Interaction Score: 2.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17181166

Sources:
DTC
CHEMBL402915 CDK2

Interaction Score: 2.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18063365

Sources:
DTC
OLOMOUCINE CDK2

Interaction Score: 1.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10592235 17016423 17139284 11752352

Sources:
DTC
DINACICLIB CDK2

Interaction Score: 0.79

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

PMIDs:
23600925

Sources:
DTC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial
MILCICLIB CDK2

Interaction Score: 0.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

PMIDs:
19603809

Sources:
DTC ChemblInteractions
RG-547 CDK2

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

PMIDs:
10592235

Sources:
ChemblInteractions
AG-24322 CDK2

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
ZOTIRACICLIB CDK2

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

PMIDs:
22148278

Sources:
DTC ChemblInteractions TTD
O-CHLOROACETYLCARBAMOYLFUMAGILLOL CDK2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8012959

Sources:
NCI
SELICICLIB CDK2

Interaction Score: 0.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name seliciclib, R-roscovitine, CYC202

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

PMIDs:
21080703 17108108

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD
SU-9516 CDK2

Interaction Score: 0.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

PMIDs:
10592235 11752352 17139284 17016423

Sources:
ChemblInteractions
CYC-065 CDK2

Interaction Score: 0.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
ERIBULIN CDK2

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26006067

Sources:
CIViC
INDOLE-3-CARBINOL CDK2

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15611077

Sources:
NCI
BMS-387032 CDK2

Interaction Score: 0.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

Reported Cancer Type Melanoma

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions CancerCommons TTD
RALTITREXED CDK2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10047461

Sources:
NCI
RGB-286638 CDK2

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
AT-7519 CDK2

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name AT7519

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
18656911 10592235

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD
ALVOCIDIB CDK2

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name flavopiridol, alvocidib, HMR-1275

Novel drug target Novel Target

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

PMIDs:
18465538 11752352

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions
CHEMBL259850 CDK2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL210618 CDK2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GS 6201 CDK2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL365617 CDK2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BMS-345541 CDK2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZAKENPAULLONE CDK2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZD-5438 CDK2

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
PHA-793887 CDK2

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHIR-99021 CDK2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ANDROSTANOLONE CDK2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10698512

Sources:
NCI
(RS)-ROSCOVITINE CDK2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LAPACHONE CDK2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12689523

Sources:
NCI
AZD-1080 CDK2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACETAMINOPHEN CDK2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14644624

Sources:
NCI
UCN-01 CDK2

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RONICICLIB CDK2

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LOVASTATIN CDK2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9553123

Sources:
NCI
RESVERATROL CDK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15122319

Sources:
NCI
CHEMBL578061 CDK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LY-2090314 CDK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LAUROGUADINE CDK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL541400 CDK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBOPLATIN CDK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26006067

Sources:
CIViC
DEXAMETHASONE CDK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10867026

Sources:
NCI
GO-6976 CDK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-269962A CDK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL379975 CDK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KENPAULLONE CDK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PACLITAXEL CDK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16020661

Sources:
NCI
ALSTERPAULLONE CDK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SOTRASTAURIN CDK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X CDK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL225519 CDK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 CDK2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 CDK2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 CDK2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 CDK2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 CDK2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 CDK2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB CDK2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000123374
- Version: 101_38
Alternate Names:

CDK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P24941
- Version: 11-September-2012
Alternate Names:

CDK2_HUMAN Uniprot Id

P24941 Uniprot Accession

1017 Entrez Gene Id

Gene Info:

Human Readable Name KINASE

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P24941
- Version: January-2014
Alternate Names:

CDK2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.22

Publications:
CancerCommons: CDK2
- Version: 25-July-2013
Alternate Names:

1017 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name CDK1,2,5,9

CancerCommons Reported Gene Name CDK2,7,9

CancerCommons Reported Gene Name Pan CDK

Publications:
BaderLabGenes: CDK2
- Version: February-2014
Alternate Names:

1017 Entrez Gene ID

Gene Info:

Initial Gene Query CDK2

Counted Citations from 1950-2000 4281

Gene Categories:

KINASE

Publications:
RussLampel: ENSG00000123374
- Version: 26-July-2011
Alternate Names:

CELL DIVISION PROTEIN KINASE 2 (EC 2.7.1.37) (P33 PROTEIN KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P24941] Description

CDK2 Display Id

ENSG00000123374 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
CIViC: CDK2
- Version: 14-September-2020
Alternate Names:

1017 Entrez Gene ID

906 CIViC Gene ID

Gene Info:

Publications:

Kaklamani et al., 2015, Phase II neoadjuvant clinical trial of carboplatin and eribulin in women with triple negative early-stage breast cancer (NCT01372579)., Breast Cancer Res. Treat.

NCI: CDK2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Smith et al., 2000, Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes., J. Biol. Chem.

Abe et al., 1994, A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells., Cancer Res.

Choi et al., 2003, Suppression of human prostate cancer cell growth by beta-lapachone via down-regulation of pRB phosphorylation and induction of Cdk inhibitor p21(WAF1/CIP1)., J. Biochem. Mol. Biol.

DTC: CDK2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kim H et al., 2008, A flavonoid gossypin binds to cyclin-dependent kinase 2., Bioorg Med Chem Lett

Heathcote DA et al., 2010, A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration., J Med Chem

Schonbrunn E et al., 2013, Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases., J Med Chem

HingoraniCasas: ENSG00000123374
- Version: 31-May-2017
Alternate Names:

ENSG00000123374 Gene Symbol

CDK2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: CDK2
- Version: 20-Jun-2017
Alternate Names:

1017 Entrez Gene Id

CDK2 MyCancerGenome Gene Symbol

CDK 1,2,4,5,6,7,9 (pan-CDK) MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: CDKN2
- Version: chembl_23
Alternate Names:

CDKN2 GENE_SYMBOL

CDK2 GENE_SYMBOL

Cyclin-dependent kinase 2 UNIPROT

Gene Info:

Publications:
GO: CDK2
- Version: 01-February-2022
Alternate Names:

CDKN2 GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX, DNA REPAIR, SERINE THREONINE KINASE

Publications:
dGene: CDK2
- Version: 27-Jun-2013
Alternate Names:

1017 Gene ID

p33(CDK2) dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Cyclin-dependent kinase 2
- Version: 2020.06.01
Alternate Names:

CDK2 TTD Gene Abbreviation

T70176 TTD Target ID

Gene Info:

Publications:
Pharos: CDK2
- Version: 01-February-2022
Alternate Names:

Cyclin-dependent kinase 2 Gene Name

P24941 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MyCancerGenomeClinicalTrial: CDK2
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
ClearityFoundationClinicalTrial: CDK2
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
Oncomine: CDK2
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Reported Cancer Type	Melanoma
Mechanism of Interaction	Cyclin-dependent kinase 2 inhibitor
Direct Interaction	yes

Novel drug target	Novel Target
Trial Name	seliciclib, R-roscovitine, CYC202
Mechanism of Interaction	Cyclin-dependent kinase 2 inhibitor

Trial Name	flavopiridol, alvocidib, HMR-1275
Novel drug target	Novel Target
Mechanism of Interaction	Cyclin-dependent kinase 2 inhibitor

Mechanism of Interaction	Cyclin-dependent kinase inhibitor
Direct Interaction	yes

CDK2_HUMAN	Uniprot Id
P24941	Uniprot Accession
1017	Entrez Gene Id

CELL DIVISION PROTEIN KINASE 2 (EC 2.7.1.37) (P33 PROTEIN KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P24941]	Description
CDK2	Display Id
ENSG00000123374	Ensembl Gene Id

CDKN2	GENE_SYMBOL
CDK2	GENE_SYMBOL
Cyclin-dependent kinase 2	UNIPROT

CDK2 Gene Record

CDK2 1017 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17643111

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19410453

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17181166

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18063365

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 10592235 17016423 17139284 11752352

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Melanoma Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor Direct Interaction yes

PMIDs: 23600925

Sources: DTC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

PMIDs: 19603809

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor Direct Interaction yes

PMIDs: 10592235

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

PMIDs: 22148278

Sources: DTC ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8012959

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Novel Target Trial Name seliciclib, R-roscovitine, CYC202 Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

PMIDs: 21080703 17108108

Sources: DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor Direct Interaction yes

PMIDs: 10592235 11752352 17139284 17016423

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26006067

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15611077

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor Direct Interaction yes Reported Cancer Type Melanoma

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions CancerCommons TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10047461

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor Direct Interaction yes

Interaction Types & Directionality:

n/a

PMIDs:
17643111

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19410453

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17181166

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18063365

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
10592235 17016423 17139284 11752352

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

PMIDs:
23600925

Sources:
DTC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

PMIDs:
19603809

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

PMIDs:
10592235

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

PMIDs:
22148278

Sources:
DTC ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
8012959

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name seliciclib, R-roscovitine, CYC202

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

PMIDs:
21080703 17108108

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

PMIDs:
10592235 11752352 17139284 17016423

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
26006067

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
15611077

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

Reported Cancer Type Melanoma

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions CancerCommons TTD

Interaction Types & Directionality:

n/a

PMIDs:
10047461

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name AT7519

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
18656911 10592235

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name flavopiridol, alvocidib, HMR-1275

Novel drug target Novel Target

Mechanism of Interaction Cyclin-dependent kinase 2 inhibitor

PMIDs:
18465538 11752352

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC