• Interaction Score: 3.54

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 3.54

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of CDK6/cyclin D3 complex
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.77

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

    PMIDs:
    None found


  • Interaction Score: 1.77

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor
    Direct Interaction yes
    Drug family CDK4/6 inhibitor

  • Interaction Score: 1.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction CDK6/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

  • Interaction Score: 1.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of CDK6/cyclin D3
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.98

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor
    Direct Interaction yes
    Trial Name flavopiridol, alvocidib, HMR-1275

  • Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

  • Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27252418


    Sources:
    CIViC

  • Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of CDK6/cyclinD3.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29408328


    Sources:
    CIViC

    • Version: 101_38

    Alternate Names:
    CDK6 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    CDK6 Uniprot Gene Name
    Q00534 Uniprot Accession
    ENSG00000105810 Ensembl Gene Id

    Gene Info:
    Interpro Acc IPR002290
    Uniprot Status Swiss-Prot
    Interpro Type Domain

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    CDK6 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.22

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    CDK6 Display Id
    ENSG00000105810 Ensembl Gene Id
    CELL DIVISION PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE-PROTEIN KINASE PLSTIRE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q00534] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 25-July-2013

    Alternate Names:
    1021 Entrez Gene ID

    Gene Info:
    CancerCommons Reported Gene Name CDK4/6

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    1777 HUGO Gene ID
    1777 HUGO Gene Symbol
    cyclin dependent kinase 6 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name CDK4 subfamily
    GuideToPharmacology Gene Category ID 488

    Gene Categories:
    ENZYME

    Publications:

    • Version: 14-September-2020
    • Version: 12-May-2016

    Alternate Names:
    CDK6 Gene Symbol

    Gene Info:

    Publications:

    • Version: 20-Jun-2017

    Alternate Names:
    1021 Entrez Gene Id
    CDK6 MyCancerGenome Gene Symbol
    CDK 1,2,4,5,6,7,9 (pan-CDK) MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    CDKN6 GENE_SYMBOL
    CDK6 GENE_SYMBOL
    Cyclin-dependent kinase 6 UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000105810 Gene Symbol
    CDK6 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-November-2018

    Alternate Names:
    CDK6 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    1021 Gene ID
    PLSTIRE dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    CDK6 TTD Gene Abbreviation
    T89361 TTD Target ID

    Gene Info:

    Publications:

  • GO: CDK6

    • Version: 01-May-2021

    Alternate Names:
    CDKN6 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Cyclin-dependent kinase 6 Gene Name
    Q00534 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: 27-September-2017

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: