• CDK8 1024 Druggable GenomeClinically Actionable

    Alternate Names:

    1024
    CYCLIN DEPENDENT KINASE 8
    CDK8
    K35
    603184
    1779
    ENSG00000132964
    OTTHUMG00000016617
    CELL DIVISION PROTEIN KINASE 8 (EC 2.7.1.37) (PROTEIN KINASE K35). [SOURCE:UNIPROT/SWISSPROT;ACC:P49336]
    Cell division protein kinase 8
    Mediator complex subunit CDK8
    Mediator of RNA polymerase II transcription subunit CDK8
    Cyclin-dependent kinase 8
    Protein kinase K35
    P49336
    CDK8_HUMAN
    1980
    NP_001251
    NM_001260
    T10822
    IDDHBA

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002290
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    GuideToPharmacology Gene Category Name CDK8 subfamily
    GuideToPharmacology Gene Category ID 497
    Target Class Enzymes
    Target Subclass EC:2.7.11.22
    Target Subclass 2.7.11.23
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
    TRANSCRIPTION FACTOR
  • Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name flavopiridol, alvocidib, HMR-1275
    Novel drug target Novel Target

    PMIDs:
    11752352


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction CDK8/cyclin C.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction CDK8/cyclin C.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

    • Version: 101_38

    Alternate Names:
    CDK8 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    CELL DIVISION PROTEIN KINASE 8 (EC 2.7.1.37) (PROTEIN KINASE K35). [SOURCE:UNIPROT/SWISSPROT;ACC:P49336] Description
    ENSG00000132964 Ensembl Gene Id
    CDK8 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    CDK8 Uniprot Gene Name
    1024 Entrez Gene Id
    ENSG00000132964 Ensembl Gene Id

    Gene Info:
    Interpro Type Domain
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    CDK8 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.22
    Target Subclass 2.7.11.23

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    1779 HUGO Gene ID
    1779 HUGO Gene Symbol
    cyclin dependent kinase 8 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name CDK8 subfamily
    GuideToPharmacology Gene Category ID 497

    Gene Categories:
    ENZYME

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000132964 Gene Symbol
    CDK8 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    CDK8 GENE_SYMBOL
    Cyclin-dependent kinase 8 UNIPROT
    Cell division protein kinase 8 UNIPROT

    Gene Info:

    Publications:

    • Version: 11-November-2018

    Alternate Names:
    CDK8 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    1024 Gene ID
    K35 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    CDK8 TTD Gene Abbreviation
    T10822 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Cyclin-dependent kinase 8 Gene Name
    P49336 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • GO: CDK8

    • Version: 01-May-2021

    Alternate Names:

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR

    Publications: