DGIdb - CDKN1A Gene Record

CDKN1A 1026 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

1026
CYCLIN DEPENDENT KINASE INHIBITOR 1A
CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
116899
1784
ENSG00000124762
OTTHUMG00000014603
913
PA104
PIC1
MDA6
Cyclin-dependent kinase inhibitor 1
P38936

Gene Info:

Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
KINASE
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Keshelava et al., 2001, Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines., Cancer Res.
Yang et al., 2003, p21 Waf-1 (Cip-1) enhances apoptosis induced by manumycin and paclitaxel in anaplastic thyroid cancer cells., J. Clin. Endocrinol. Metab.
Flamm et al., Correlation of clinical outcome with p53 and p21 status in patients with advanced transitional-cell carcinoma treated with paclitaxel and carboplatin., Anticancer Res.
Lee et al., 2005, Effects of nicotine on proliferation, cell cycle, and differentiation in immortalized and malignant oral keratinocytes., J. Oral Pathol. Med.
Sim et al., 2014, P21 and CD166 as predictive markers of poor response and outcome after fluorouracil-based chemoradiotherapy for the patients with rectal cancer., BMC Cancer
de Angelis et al., 2004, Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil., Int. J. Oncol.
Galmarini et al., 2003, Influence of p53 and p21(WAF1) expression on sensitivity of cancer cells to cladribine., Biochem. Pharmacol.
Qiu et al., 1996, Induction of p21 mediated by reactive oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells., J. Biol. Chem.
Qiu et al., 1997, The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells., Arch. Biochem. Biophys.
Hsieh et al., 2000, Cell cycle exit during terminal erythroid differentiation is associated with accumulation of p27(Kip1) and inactivation of cdk2 kinase., Blood
Pyrzynska et al., 2002, Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A., J. Biol. Chem.
Tishler et al., 1996, The interaction of taxol and vinblastine with radiation induction of p53 and p21 WAF1/CIP1., Br. J. Cancer Suppl.
Nguyen et al., 2004, Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells., Clin. Cancer Res.
Lee et al., 2006, Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen., J. Pharmacol. Exp. Ther.
Bott et al., 2005, p21WAF1/CIP1 gene is inactivated in metastatic prostatic cancer cell lines by promoter methylation., Prostate Cancer Prostatic Dis.
Xiang et al., 2002, Enhanced tumor killing by Apo2L/TRAIL and CPT-11 co-treatment is associated with p21 cleavage and differential regulation of Apo2L/TRAIL ligand and its receptors., Oncogene
Wang et al., 2005, Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism., Asian J. Androl.

DIAZIQUONE CDKN1A

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8943236

Sources:
NCI
PENTETIC ACID CDKN1A

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9343371

Sources:
NCI
DEOXYCYTIDINE CDKN1A

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16276353

Sources:
NCI
IRINOTECAN HYDROCHLORIDE CDKN1A

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12032863

Sources:
NCI
DICUMAROL CDKN1A

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9343371

Sources:
NCI
EPOETIN BETA CDKN1A

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11023508

Sources:
NCI
CLADRIBINE CDKN1A

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12473386

Sources:
NCI
FLUTAMIDE CDKN1A

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16281084

Sources:
NCI
ROMIDEPSIN CDKN1A

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15014036

Sources:
NCI
MELPHALAN CDKN1A

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11507071

Sources:
NCI
VINBLASTINE CDKN1A

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8763853

Sources:
NCI
ACETAMINOPHEN CDKN1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16330492

Sources:
NCI
NICOTINE CDKN1A

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16011614

Sources:
NCI
FLUOROURACIL CDKN1A

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24708484 15067352

Sources:
NCI CIViC
CYCLOSPORINE CDKN1A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11827957

Sources:
NCI
CELECOXIB CDKN1A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CARBOPLATIN CDKN1A

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12168940

Sources:
NCI
PACLITAXEL CDKN1A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12574211

Sources:
NCI

Ensembl: ENSG00000124762
- Version: 101_38
Alternate Names:

CDKN1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
PharmGKB: CDKN1A
- Version: 18-August-2020
Alternate Names:

PA104 PharmGKB ID

Gene Info:

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
CIViC: CDKN1A
- Version: 14-September-2020
Alternate Names:

1026 Entrez Gene ID

913 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Sim et al., 2014, P21 and CD166 as predictive markers of poor response and outcome after fluorouracil-based chemoradiotherapy for the patients with rectal cancer., BMC Cancer

NCI: CDKN1A

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Lee et al., 2005, Effects of nicotine on proliferation, cell cycle, and differentiation in immortalized and malignant oral keratinocytes., J. Oral Pathol. Med.

de Angelis et al., 2004, Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil., Int. J. Oncol.

Qiu et al., 1997, The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells., Arch. Biochem. Biophys.

HingoraniCasas: ENSG00000124762
- Version: 31-May-2017
Alternate Names:

ENSG00000124762 Gene Symbol

CDKN1A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: CDKN1A
- Version: 01-February-2022
Alternate Names:

CAP20 GO Gene Synonym

CDKN1 GO Gene Synonym

CIP1 GO Gene Synonym

Gene Info:

Gene Categories:

TUMOR SUPPRESSOR

Publications:
Tempus: CDKN1A
- Version: 11-November-2018
Alternate Names:

CDKN1A Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: CDKN1A
- Version: 01-February-2022
Alternate Names:

Cyclin-dependent kinase inhibitor 1 Gene Name

P38936 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: CDKN1A
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: CDKN1A
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Cyclin-dependent kinase inhibitor 1	Gene Name
P38936	UniProt ID

CDKN1A Gene Record

CDKN1A 1026 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8943236

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9343371

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16276353

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12032863

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9343371

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11023508

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12473386

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16281084

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15014036

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11507071

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8763853

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16330492

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16011614

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24708484 15067352

Sources: NCI CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11827957

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12168940

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12574211

Sources: NCI

Ensembl: ENSG00000124762

Alternate Names: CDKN1A Ensembl Gene Name

Interaction Types & Directionality:

n/a

PMIDs:
8943236

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9343371

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16276353

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12032863

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9343371

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11023508

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12473386

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16281084

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15014036

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11507071

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8763853

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16330492

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16011614

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24708484 15067352

Sources:
NCI CIViC

Interaction Types & Directionality:

n/a

PMIDs:
11827957

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12168940

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12574211

Sources:
NCI

Alternate Names:

CDKN1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA104 PharmGKB ID

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

Alternate Names:

1026 Entrez Gene ID

913 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Publications:

Sim et al., 2014, P21 and CD166 as predictive markers of poor response and outcome after fluorouracil-based chemoradiotherapy for the patients with rectal cancer., BMC Cancer

Alternate Names:

ENSG00000124762 Gene Symbol

CDKN1A Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CAP20 GO Gene Synonym

CDKN1 GO Gene Synonym

CIP1 GO Gene Synonym

Gene Categories:

TUMOR SUPPRESSOR

Alternate Names:

CDKN1A Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Cyclin-dependent kinase inhibitor 1 Gene Name

P38936 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE