DGIdb - CDKN1B Gene Record

CDKN1B 1027 Clinically ActionableDrug Resistance

Alternate Names:

1027
CYCLIN DEPENDENT KINASE INHIBITOR 1B
CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
600778
1785
ENSG00000111276
OTTHUMG00000149914
914
PA105
Cyclin-dependent kinase inhibitor 1B
P46527

Gene Info:

Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
KINASE
DRUG RESISTANCE
CLINICALLY ACTIONABLE

Publications:

Hsieh et al., 2000, Cell cycle exit during terminal erythroid differentiation is associated with accumulation of p27(Kip1) and inactivation of cdk2 kinase., Blood
Musgrove et al., 2001, Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27(Kip1) association with cyclin E-Cdk2., J. Biol. Chem.
Pohl et al., 2003, High p27Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin., J. Clin. Oncol.
Filipits et al., 2003, Low p27Kip1 expression is an independent adverse prognostic factor in patients with multiple myeloma., Clin. Cancer Res.
Hoshino et al., 2001, Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1)., J. Biol. Chem.
Sasaki et al., 2000, Expression and role of p27(kip1) in neuronal differentiation of embryonal carcinoma cells., Brain Res. Mol. Brain Res.
Silveira et al., 2002, The genetics of hypertension modifies the renal cell replication response induced by experimental diabetes., Diabetes
Yin et al., 1999, Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex., Exp. Cell Res.
Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Zhao et al., 2014, Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy., Oncotarget
Winteringham et al., 2004, Myeloid Leukemia Factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation., Oncogene

RALTITREXED CDKN1B

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10047461

Sources:
NCI
EPOETIN BETA CDKN1B

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11023508

Sources:
NCI
EPOETIN ALFA CDKN1B

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15122318

Sources:
NCI
LAPATINIB CDKN1B

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25587029

Sources:
CIViC
TRETINOIN CDKN1B

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10837916

Sources:
NCI
CHEMBL35482 CDKN1B

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11031257

Sources:
NCI
STREPTOZOCIN CDKN1B

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11978652

Sources:
NCI
VINCRISTINE CDKN1B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12576455

Sources:
NCI
CELECOXIB CDKN1B

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
PROGESTERONE CDKN1B

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11590147

Sources:
NCI
DOXORUBICIN CDKN1B

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12576455

Sources:
NCI
METHOTREXATE CDKN1B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14512390

Sources:
NCI

Ensembl: ENSG00000111276
- Version: 101_38
Alternate Names:

CDKN1B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
PharmGKB: CDKN1B
- Version: 18-August-2020
Alternate Names:

PA105 PharmGKB ID

Gene Info:

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
CIViC: CDKN1B
- Version: 14-September-2020
Alternate Names:

1027 Entrez Gene ID

914 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Zhao et al., 2014, Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy., Oncotarget

NCI: CDKN1B

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Hsieh et al., 2000, Cell cycle exit during terminal erythroid differentiation is associated with accumulation of p27(Kip1) and inactivation of cdk2 kinase., Blood

Torchinsky et al., Regulation of p27Kip1 during gentamicin mediated hair cell death., J. Neurocytol.

Cariou et al., 2000, Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells., Proc. Natl. Acad. Sci. U.S.A.

GO: CDKN1B
- Version: 01-February-2022
Alternate Names:

KIP1 GO Gene Synonym

Gene Info:

Gene Categories:

TUMOR SUPPRESSOR

Publications:
Tempus: CDKN1B
- Version: 11-November-2018
Alternate Names:

CDKN1B Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: CDKN1B
- Version: 01-February-2022
Alternate Names:

Cyclin-dependent kinase inhibitor 1B Gene Name

P46527 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: CDKN1B
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: CDKN1B
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: CDKN1B
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: CDKN1B
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Cyclin-dependent kinase inhibitor 1B	Gene Name
P46527	UniProt ID

CDKN1B Gene Record

CDKN1B 1027 Clinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10047461

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11023508

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15122318

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25587029

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10837916

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11031257

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11978652

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12576455

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11590147

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12576455

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14512390

Sources: NCI

Ensembl: ENSG00000111276

Alternate Names: CDKN1B Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: CDKN1B

Alternate Names: PA105 PharmGKB ID

Gene Info:

Publications: Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

CIViC: CDKN1B

Alternate Names: 1027 Entrez Gene ID 914 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

Publications: Zhao et al., 2014, Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy., Oncotarget

NCI: CDKN1B

Alternate Names:

Gene Info:

GO: CDKN1B

Alternate Names: KIP1 GO Gene Synonym

Gene Info:

Gene Categories: TUMOR SUPPRESSOR

Publications:

Tempus: CDKN1B

Alternate Names: CDKN1B Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10047461

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11023508

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15122318

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25587029

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
10837916

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11031257

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11978652

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12576455

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11590147

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12576455

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14512390

Sources:
NCI

Alternate Names:

CDKN1B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA105 PharmGKB ID

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

Alternate Names:

1027 Entrez Gene ID

914 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Publications:

Zhao et al., 2014, Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy., Oncotarget

Alternate Names:

KIP1 GO Gene Synonym

Gene Categories:

TUMOR SUPPRESSOR

Alternate Names:

CDKN1B Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Cyclin-dependent kinase inhibitor 1B Gene Name

P46527 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE