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CDKN1B Gene Record

  • Summary
  • Interactions
  • Claims
  • CDKN1B 1027 Clinically ActionableDrug Resistance

    Alternate Names:

    1027
    CYCLIN DEPENDENT KINASE INHIBITOR 1B
    CDKN1B
    CDKN4
    KIP1
    MEN1B
    MEN4
    P27KIP1
    600778
    1785
    ENSG00000111276
    OTTHUMG00000149914
    914
    PA105
    Cyclin-dependent kinase inhibitor 1B
    P46527

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    KINASE
    DRUG RESISTANCE
    CLINICALLY ACTIONABLE

    Publications:

    Hsieh et al., 2000, Cell cycle exit during terminal erythroid differentiation is associated with accumulation of p27(Kip1) and inactivation of cdk2 kinase., Blood
    Musgrove et al., 2001, Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27(Kip1) association with cyclin E-Cdk2., J. Biol. Chem.
    Pohl et al., 2003, High p27Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin., J. Clin. Oncol.
    Filipits et al., 2003, Low p27Kip1 expression is an independent adverse prognostic factor in patients with multiple myeloma., Clin. Cancer Res.
    Hoshino et al., 2001, Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1)., J. Biol. Chem.
    Sasaki et al., 2000, Expression and role of p27(kip1) in neuronal differentiation of embryonal carcinoma cells., Brain Res. Mol. Brain Res.
    Silveira et al., 2002, The genetics of hypertension modifies the renal cell replication response induced by experimental diabetes., Diabetes
    Yin et al., 1999, Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex., Exp. Cell Res.
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Zhao et al., 2014, Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy., Oncotarget
    Winteringham et al., 2004, Myeloid Leukemia Factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation., Oncogene
  • RALTITREXED   CDKN1B

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10047461


    Sources:
    NCI

  • EPOETIN BETA   CDKN1B

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11023508


    Sources:
    NCI

  • EPOETIN ALFA   CDKN1B

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15122318


    Sources:
    NCI

  • LAPATINIB   CDKN1B

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25587029


    Sources:
    CIViC

  • TRETINOIN   CDKN1B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10837916


    Sources:
    NCI

  • CHEMBL35482   CDKN1B

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11031257


    Sources:
    NCI

  • STREPTOZOCIN   CDKN1B

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11978652


    Sources:
    NCI

  • VINCRISTINE   CDKN1B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12576455


    Sources:
    NCI

  • CELECOXIB   CDKN1B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

  • PROGESTERONE   CDKN1B

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11590147


    Sources:
    NCI

  • DOXORUBICIN   CDKN1B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12576455


    Sources:
    NCI

  • METHOTREXATE   CDKN1B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14512390


    Sources:
    NCI

  • Ensembl: ENSG00000111276

    • Version: 101_38

    Alternate Names:
    CDKN1B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: CDKN1B

    • Version: 18-August-2020

    Alternate Names:
    PA105 PharmGKB ID

    Gene Info:

    Publications:
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

  • CIViC: CDKN1B

    • Version: 14-September-2020

    Alternate Names:
    1027 Entrez Gene ID
    914 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Zhao et al., 2014, Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy., Oncotarget

  • NCI: CDKN1B

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Hsieh et al., 2000, Cell cycle exit during terminal erythroid differentiation is associated with accumulation of p27(Kip1) and inactivation of cdk2 kinase., Blood
    Torchinsky et al., Regulation of p27Kip1 during gentamicin mediated hair cell death., J. Neurocytol.
    Cariou et al., 2000, Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells., Proc. Natl. Acad. Sci. U.S.A.

  • GO: CDKN1B

    • Version: 01-February-2022

    Alternate Names:
    KIP1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR

    Publications:

  • Tempus: CDKN1B

    • Version: 11-November-2018

    Alternate Names:
    CDKN1B Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: CDKN1B

    • Version: 01-February-2022

    Alternate Names:
    Cyclin-dependent kinase inhibitor 1B Gene Name
    P46527 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MskImpact: CDKN1B

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: CDKN1B

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: CDKN1B

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: CDKN1B

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21