• Interaction Score: 5.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical - Cell line xenograft
    Response Type sensitive

    PMIDs:
    23347136


    Sources:
    JAX-CKB

  • Interaction Score: 2.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy GSK461364 + PD0332991
    Indication/Tumor Type pancreatic cancer
    Response Type decreased response

    PMIDs:
    25156567


    Sources:
    JAX-CKB

  • Interaction Score: 2.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy HMN-214 + PD0332991
    Indication/Tumor Type pancreatic cancer
    Response Type decreased response

    PMIDs:
    25156567


    Sources:
    JAX-CKB

  • Interaction Score: 1.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type non-small cell lung carcinoma
    Response Type sensitive
    Approval Status Phase I

  • Interaction Score: 0.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Palbociclib + Trametinib
    Indication/Tumor Type melanoma
    Response Type sensitive

  • Interaction Score: 0.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy PF3644022 + PF-477736
    Indication/Tumor Type Advanced Solid Tumor
    Response Type predicted – sensitive

    PMIDs:
    26140595


    Sources:
    JAX-CKB

  • Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type pancreatic ductal adenocarcinoma
    Response Type predicted – sensitive
    Approval Status Clinical Study

    PMIDs:
    28476735


    Sources:
    JAX-CKB

  • Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy ON-01910 + PD0332991
    Indication/Tumor Type pancreatic cancer
    Response Type decreased response

    PMIDs:
    25156567


    Sources:
    JAX-CKB

  • Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26715889


    Sources:
    CIViC

  • Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


  • Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical
    Response Type sensitive

    PMIDs:
    12777976


    Sources:
    JAX-CKB

  • Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24265155


    Sources:
    CIViC

  • Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type pancreatic ductal adenocarcinoma
    Response Type resistant
    Approval Status Clinical Study

    PMIDs:
    28476735


    Sources:
    JAX-CKB

  • Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23746666


    Sources:
    CIViC

  • Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Palbociclib + Trametinib
    Indication/Tumor Type melanoma
    Response Type sensitive


    Sources:
    JAX-CKB

  • Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type breast cancer
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    25261369


    Sources:
    JAX-CKB

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24265155


    Sources:
    CIViC

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Clinical Study
    Response Type sensitive

    PMIDs:
    28514312


    Sources:
    JAX-CKB

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Imatinib + Carboplatin + Paclitaxel
    Indication/Tumor Type melanoma
    Response Type sensitive

    PMIDs:
    28514312


    Sources:
    JAX-CKB

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy PD0332991 + Gemcitabine
    Indication/Tumor Type pancreatic cancer
    Response Type decreased response

    PMIDs:
    25156567


    Sources:
    JAX-CKB

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Imatinib + Carboplatin + Paclitaxel
    Indication/Tumor Type melanoma
    Response Type sensitive

    PMIDs:
    28514312


    Sources:
    JAX-CKB

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Drug family AURKA-VEGF inhibitor
    Alteration CDKN2A:.
    Alteration CDKN2A:del

    PMIDs:
    None found


    Sources:
    CGI