DGIdb - CES1 Gene Record

CES1 1066 Druggable Genome

Alternate Names:

1066
CARBOXYLESTERASE 1
CES1
ACAT
CE-1
CEH
CES2
HMSE
HMSE1
PCE-1
REH
SES1
TGH
hCE-1
114835
1863
ENSG00000198848
OTTHUMG00000176718
P23141
LIVER CARBOXYLESTERASE 1
EST1_HUMAN
PA107
ENSG00000196959
LIVER CARBOXYLESTERASE 1 PRECURSOR (EC 3.1.1.1) (ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE) (ACAT) (MONOCYTE/MACROPHAGE SERINE ESTERASE) (HMSE) (SERINE ESTERASE 1) (BRAIN CARBOXYLESTERASE HBR1) (TRIACYLGLYCEROL HYDROLASE) (TGH) (EGASYN). [SOURCE:UNIPROT
Liver carboxylesterase
T76369

Gene Info:

Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Short Name	CarbesteraseB
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR002018
Human Readable Name	DRUGGABLE GENOME
Interpro Name	Carboxylesterase, type B
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Zhao Z et al., 2016, Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis., Eur J Clin Pharmacol
Tarkiainen EK et al., 2015, Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans., Clin Pharmacol Ther
Xie C et al., 2014, The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease., Pharmacogenet Genomics
Zhu HJ et al., 2013, Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation., J Pharmacol Exp Ther
Zhu HJ et al., 2009, Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril., Biochem Pharmacol
Dimatteo C et al., 2016, Pharmacogenetics of dabigatran etexilate interindividual variability., Thromb Res
Paré G et al., 2013, Genetic determinants of dabigatran plasma levels and their relation to bleeding., Circulation
Tarkiainen EK et al., 2015, Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril., Br J Clin Pharmacol
Qian Y et al., 2020, The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin., Chem Biol Interact
Hamzic S et al., 2017, Novel Genetic Variants in Carboxylesterase 1 Predict Severe Early-Onset Capecitabine-Related Toxicity., Clin Pharmacol Ther
Nemoda Z et al., 2009, Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD., Neuropharmacology

PACTIMIBE CES1

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ELDACIMIBE CES1

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TRANDOLAPRIL CES1

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19185566

Sources:
PharmGKB
DABIGATRAN CES1

Interaction Score: 1.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27261537 23467860

Sources:
PharmGKB
CLOPIDOGREL CES1

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27450232 25704243 24535487 23275066

Sources:
PharmGKB
DIACETYLMORPHINE CES1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31837295

Sources:
PharmGKB
ENALAPRIL CES1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25919042

Sources:
PharmGKB
CAPECITABINE CES1

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28139840

Sources:
PharmGKB
METHYLPHENIDATE CES1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19733552

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN CES1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
IRINOTECAN CES1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000198848
- Version: 101_38
Alternate Names:

CES1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P23141
- Version: 11-September-2012
Alternate Names:

P23141 Uniprot Accession

EST1_HUMAN Uniprot Id

CES1 Uniprot Gene Name

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Domain

Interpro Short Name CarbesteraseB

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000196959

Version: 26-July-2011

Alternate Names:

CES1 Display Id

LIVER CARBOXYLESTERASE 1 PRECURSOR (EC 3.1.1.1) (ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE) (ACAT) (MONOCYTE/MACROPHAGE SERINE ESTERASE) (HMSE) (SERINE ESTERASE 1) (BRAIN CARBOXYLESTERASE HBR1) (TRIACYLGLYCEROL HYDROLASE) (TGH) (EGASYN). [SOURCE:UNIPROT Description

ENSG00000196959 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000198848
- Version: 26-July-2011
Alternate Names:

ENSG00000198848 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: CES1

Version: 18-August-2020

Alternate Names:

PA107 PharmGKB ID

Gene Info:

Publications:

Zhu HJ et al., 2013, Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation., J Pharmacol Exp Ther

Zhao Z et al., 2016, Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis., Eur J Clin Pharmacol

Tarkiainen EK et al., 2015, Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans., Clin Pharmacol Ther

HingoraniCasas: ENSG00000198848
- Version: 31-May-2017
Alternate Names:

ENSG00000198848 Gene Symbol

CES1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Liver carboxylesterase
- Version: 2020.06.01
Alternate Names:

CES1 TTD Gene Abbreviation

T76369 TTD Target ID

Gene Info:

Publications:
Pharos: CES1
- Version: 01-February-2022
Alternate Names:

Liver carboxylesterase 1 Gene Name

P23141 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

P23141	Uniprot Accession
EST1_HUMAN	Uniprot Id
CES1	Uniprot Gene Name

CES1	Display Id
LIVER CARBOXYLESTERASE 1 PRECURSOR (EC 3.1.1.1) (ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE) (ACAT) (MONOCYTE/MACROPHAGE SERINE ESTERASE) (HMSE) (SERINE ESTERASE 1) (BRAIN CARBOXYLESTERASE HBR1) (TRIACYLGLYCEROL HYDROLASE) (TGH) (EGASYN). [SOURCE:UNIPROT	Description
ENSG00000196959	Ensembl Gene Id

CES1 Gene Record

CES1 1066 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19185566

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27261537 23467860

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27450232 25704243 24535487 23275066

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31837295

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25919042

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28139840

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19733552

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000198848

Alternate Names: CES1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P23141

Alternate Names: P23141 Uniprot Accession EST1_HUMAN Uniprot Id CES1 Uniprot Gene Name

Gene Info: Uniprot Status Swiss-Prot Interpro Type Domain Interpro Short Name CarbesteraseB

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000196959

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000198848

Alternate Names: ENSG00000198848 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: CES1

Alternate Names: PA107 PharmGKB ID

Gene Info:

HingoraniCasas: ENSG00000198848

Alternate Names: ENSG00000198848 Gene Symbol CES1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Liver carboxylesterase

Alternate Names: CES1 TTD Gene Abbreviation T76369 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
19185566

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27261537 23467860

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27450232 25704243 24535487 23275066

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31837295

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25919042

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28139840

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19733552

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

CES1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

P23141 Uniprot Accession

EST1_HUMAN Uniprot Id

CES1 Uniprot Gene Name

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Domain

Interpro Short Name CarbesteraseB

Gene Categories:

DRUGGABLE GENOME

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000198848 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA107 PharmGKB ID

Alternate Names:

ENSG00000198848 Gene Symbol

CES1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CES1 TTD Gene Abbreviation

T76369 TTD Target ID

Alternate Names:

Liver carboxylesterase 1 Gene Name

P23141 UniProt ID

Gene Categories:

ENZYME