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CES1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CES1 1066 Druggable Genome

    Alternate Names:

    1066
    CARBOXYLESTERASE 1
    CES1
    ACAT
    CE-1
    CEH
    CES2
    HMSE
    HMSE1
    PCE-1
    REH
    SES1
    TGH
    hCE-1
    114835
    1863
    ENSG00000198848
    OTTHUMG00000176718
    2592
    P23141
    LIVER CARBOXYLESTERASE 1
    EST1_HUMAN
    PA107
    BE0002705
    ENSG00000196959
    LIVER CARBOXYLESTERASE 1 PRECURSOR (EC 3.1.1.1) (ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE) (ACAT) (MONOCYTE/MACROPHAGE SERINE ESTERASE) (HMSE) (SERINE ESTERASE 1) (BRAIN CARBOXYLESTERASE HBR1) (TRIACYLGLYCEROL HYDROLASE) (TGH) (EGASYN). [SOURCE:UNIPROT
    Liver carboxylesterase
    T76369
    NM_001025194
    NP_001020365

    Gene Info:

    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Interpro Short Name CarbesteraseB
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR002018
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Carboxylesterase, type B
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Hydrolases
    GuideToPharmacology Gene Category ID 799
    (6 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Zhu HJ et al., 2013, Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation., J Pharmacol Exp Ther
    Zhao Z et al., 2016, Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis., Eur J Clin Pharmacol
    Tarkiainen EK et al., 2015, Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans., Clin Pharmacol Ther
    Xie C et al., 2014, The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease., Pharmacogenet Genomics
    Bell, 1984, Carnitine ester hydrolysis in arteries from normal and cholesterol-fed rabbits and the effects of carnitine esters on arterial microsomal ACAT., Comp. Biochem. Physiol., B
    Zhu HJ et al., 2009, Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril., Biochem Pharmacol
    Paré G et al., 2013, Genetic determinants of dabigatran plasma levels and their relation to bleeding., Circulation
    Dimatteo C et al., 2016, Pharmacogenetics of dabigatran etexilate interindividual variability., Thromb Res
    Tarkiainen EK et al., 2015, Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril., Br J Clin Pharmacol
    Jeon et al., 2005, Vitamin E supplementation alters HDL-cholesterol concentration and paraoxonase activity in rabbits fed high-cholesterol diet: comparison with probucol., J. Biochem. Mol. Toxicol.
    Qian Y et al., 2020, The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin., Chem Biol Interact
    Hamzic S et al., 2017, Novel Genetic Variants in Carboxylesterase 1 Predict Severe Early-Onset Capecitabine-Related Toxicity., Clin Pharmacol Ther
    Heffron et al., 1990, Inhibition of acyl coenzyme A: cholesterol acyl transferase by trimethylcyclohexanylmandelate (cyclandelate)., Biochem. Pharmacol.
    Nemoda Z et al., 2009, Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD., Neuropharmacology
    Brzezinski MR et al., 1997, Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs., Drug Metab Dispos
    Bencharit S et al., 2003, Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition., Chem Biol
    Sudhop T et al., 2002, Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia., Drugs
    Delsing DJ et al., 2001, Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice., Circulation
    Bencharit S et al., 2003, Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme., Nat Struct Biol
    Zhang J et al., 1999, Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1., J Pharmacol Exp Ther
    Zhang et al., 2002, Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity., Biochem. Pharmacol.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
  • AVASIMIBE   CES1

    Interaction Score: 7.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12396226 11282910


    Sources:
    DrugBank

  • [1,4']BIPIPERIDINYL   CES1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1236433   CES1

    Interaction Score: 3.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11992644 10592235


    Sources:
    DrugBank

  • PACTIMIBE   CES1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ELDACIMIBE   CES1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CYCLANDELATE   CES1

    Interaction Score: 1.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2306268


    Sources:
    DrugBank

  • PROBUCOL   CES1

    Interaction Score: 1.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16292755


    Sources:
    DrugBank

  • TRANDOLAPRIL   CES1

    Interaction Score: 1.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19185566


    Sources:
    PharmGKB

  • DIACETYLMORPHINE HYDROCHLORIDE   CES1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9311626


    Sources:
    DrugBank

  • PROPOXYPHENE   CES1

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10381793


    Sources:
    DrugBank

  • DABIGATRAN   CES1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23467860 27261537


    Sources:
    PharmGKB

  • TACRINE   CES1

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12725862


    Sources:
    DrugBank

  • CLOPIDOGREL   CES1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23275066 27450232 25704243 24535487


    Sources:
    PharmGKB

  • LEVOCARNITINE   CES1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6509906


    Sources:
    DrugBank

  • DIACETYLMORPHINE   CES1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31837295


    Sources:
    PharmGKB

  • CHEMBL1234621   CES1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • NALOXONE   CES1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12679808


    Sources:
    DrugBank

  • MEPERIDINE   CES1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10381793


    Sources:
    DrugBank

  • ENALAPRIL   CES1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25919042


    Sources:
    PharmGKB

  • COCAINE   CES1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9311626


    Sources:
    DrugBank

  • CAPECITABINE   CES1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28139840


    Sources:
    PharmGKB

  • METHYLPHENIDATE   CES1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19733552


    Sources:
    PharmGKB

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   CES1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • IRINOTECAN   CES1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000198848

    • Version: 101_38

    Alternate Names:
    CES1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P23141

    • Version: 11-September-2012

    Alternate Names:
    P23141 Uniprot Accession
    EST1_HUMAN Uniprot Id
    CES1 Uniprot Gene Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Interpro Short Name CarbesteraseB

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000196959

    • Version: 26-July-2011

    Alternate Names:
    CES1 Display Id
    LIVER CARBOXYLESTERASE 1 PRECURSOR (EC 3.1.1.1) (ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE) (ACAT) (MONOCYTE/MACROPHAGE SERINE ESTERASE) (HMSE) (SERINE ESTERASE 1) (BRAIN CARBOXYLESTERASE HBR1) (TRIACYLGLYCEROL HYDROLASE) (TGH) (EGASYN). [SOURCE:UNIPROT Description
    ENSG00000196959 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000198848

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000198848 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 1066

    • Version: 29-September-2020

    Alternate Names:
    1863 HUGO Gene ID
    1863 HUGO Gene Symbol
    carboxylesterase 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Hydrolases
    GuideToPharmacology Gene Category ID 799

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: CES1

    • Version: 18-August-2020

    Alternate Names:
    PA107 PharmGKB ID

    Gene Info:

    Publications:
    Zhu HJ et al., 2013, Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation., J Pharmacol Exp Ther
    Zhao Z et al., 2016, Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis., Eur J Clin Pharmacol
    Tarkiainen EK et al., 2015, Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans., Clin Pharmacol Ther

  • DrugBank: BE0002705

    • Version: 5.1.7

    Alternate Names:
    CES1 DrugBank Gene Name
    P23141 UniProt Accession
    1066 Entrez Gene Id

    Gene Info:

    Publications:
    Zhang J et al., 1999, Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1., J Pharmacol Exp Ther
    Brzezinski MR et al., 1997, Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs., Drug Metab Dispos
    Bencharit S et al., 2003, Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme., Nat Struct Biol

  • HingoraniCasas: ENSG00000198848

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000198848 Gene Symbol
    CES1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: CES1

    • Version: 03-September-2020

    Alternate Names:
    Liver carboxylesterase 1 Gene Name
    P23141 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Liver carboxylesterase

    • Version: 2020.06.01

    Alternate Names:
    CES1 TTD Gene Abbreviation
    T76369 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21