DGIdb - CES1 Gene Record

CES1 1066 Druggable Genome

Alternate Names:

1066
CARBOXYLESTERASE 1
CES1
ACAT
CE-1
CEH
CES2
HMSE
HMSE1
PCE-1
REH
SES1
TGH
hCE-1
114835
1863
ENSG00000198848
OTTHUMG00000176718
2592
P23141
LIVER CARBOXYLESTERASE 1
EST1_HUMAN
PA107
BE0002705
ENSG00000196959
LIVER CARBOXYLESTERASE 1 PRECURSOR (EC 3.1.1.1) (ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE) (ACAT) (MONOCYTE/MACROPHAGE SERINE ESTERASE) (HMSE) (SERINE ESTERASE 1) (BRAIN CARBOXYLESTERASE HBR1) (TRIACYLGLYCEROL HYDROLASE) (TGH) (EGASYN). [SOURCE:UNIPROT
Liver carboxylesterase
T76369
NM_001025194
NP_001020365

Gene Info:

Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Short Name	CarbesteraseB
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR002018
Human Readable Name	DRUGGABLE GENOME
Interpro Name	Carboxylesterase, type B
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Hydrolases
GuideToPharmacology Gene Category ID	799

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Zhao Z et al., 2016, Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis., Eur J Clin Pharmacol
Tarkiainen EK et al., 2015, Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans., Clin Pharmacol Ther
Xie C et al., 2014, The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease., Pharmacogenet Genomics
Zhu HJ et al., 2013, Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation., J Pharmacol Exp Ther
Bell, 1984, Carnitine ester hydrolysis in arteries from normal and cholesterol-fed rabbits and the effects of carnitine esters on arterial microsomal ACAT., Comp. Biochem. Physiol., B
Zhu HJ et al., 2009, Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril., Biochem Pharmacol
Dimatteo C et al., 2016, Pharmacogenetics of dabigatran etexilate interindividual variability., Thromb Res
Paré G et al., 2013, Genetic determinants of dabigatran plasma levels and their relation to bleeding., Circulation
Tarkiainen EK et al., 2015, Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril., Br J Clin Pharmacol
Jeon et al., 2005, Vitamin E supplementation alters HDL-cholesterol concentration and paraoxonase activity in rabbits fed high-cholesterol diet: comparison with probucol., J. Biochem. Mol. Toxicol.
Qian Y et al., 2020, The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin., Chem Biol Interact
Hamzic S et al., 2017, Novel Genetic Variants in Carboxylesterase 1 Predict Severe Early-Onset Capecitabine-Related Toxicity., Clin Pharmacol Ther
Heffron et al., 1990, Inhibition of acyl coenzyme A: cholesterol acyl transferase by trimethylcyclohexanylmandelate (cyclandelate)., Biochem. Pharmacol.
Nemoda Z et al., 2009, Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD., Neuropharmacology
Brzezinski MR et al., 1997, Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs., Drug Metab Dispos
Bencharit S et al., 2003, Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition., Chem Biol
Delsing DJ et al., 2001, Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice., Circulation
Sudhop T et al., 2002, Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia., Drugs
Bencharit S et al., 2003, Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme., Nat Struct Biol
Zhang J et al., 1999, Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1., J Pharmacol Exp Ther
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Zhang et al., 2002, Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity., Biochem. Pharmacol.

AVASIMIBE CES1

Interaction Score: 7.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11282910 12396226

Sources:
DrugBank
[1,4']BIPIPERIDINYL CES1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1236433 CES1

Interaction Score: 3.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 11992644

Sources:
DrugBank
PACTIMIBE CES1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ELDACIMIBE CES1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CYCLANDELATE CES1

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2306268

Sources:
DrugBank
PROBUCOL CES1

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16292755

Sources:
DrugBank
TRANDOLAPRIL CES1

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19185566

Sources:
PharmGKB
DIACETYLMORPHINE HYDROCHLORIDE CES1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9311626

Sources:
DrugBank
PROPOXYPHENE CES1

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10381793

Sources:
DrugBank
DABIGATRAN CES1

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27261537 23467860

Sources:
PharmGKB
TACRINE CES1

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12725862

Sources:
DrugBank
CLOPIDOGREL CES1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27450232 25704243 24535487 23275066

Sources:
PharmGKB
LEVOCARNITINE CES1

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6509906

Sources:
DrugBank
DIACETYLMORPHINE CES1

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31837295

Sources:
PharmGKB
CHEMBL1234621 CES1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
NALOXONE CES1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12679808

Sources:
DrugBank
MEPERIDINE CES1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10381793

Sources:
DrugBank
ENALAPRIL CES1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25919042

Sources:
PharmGKB
COCAINE CES1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9311626

Sources:
DrugBank
CAPECITABINE CES1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28139840

Sources:
PharmGKB
METHYLPHENIDATE CES1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19733552

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN CES1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
IRINOTECAN CES1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000198848
- Version: 101_38
Alternate Names:

CES1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P23141
- Version: 11-September-2012
Alternate Names:

P23141 Uniprot Accession

EST1_HUMAN Uniprot Id

CES1 Uniprot Gene Name

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Domain

Interpro Short Name CarbesteraseB

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000196959

Version: 26-July-2011

Alternate Names:

CES1 Display Id

LIVER CARBOXYLESTERASE 1 PRECURSOR (EC 3.1.1.1) (ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE) (ACAT) (MONOCYTE/MACROPHAGE SERINE ESTERASE) (HMSE) (SERINE ESTERASE 1) (BRAIN CARBOXYLESTERASE HBR1) (TRIACYLGLYCEROL HYDROLASE) (TGH) (EGASYN). [SOURCE:UNIPROT Description

ENSG00000196959 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000198848
- Version: 26-July-2011
Alternate Names:

ENSG00000198848 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 1066
- Version: 29-September-2020
Alternate Names:

1863 HUGO Gene ID

1863 HUGO Gene Symbol

carboxylesterase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Hydrolases

GuideToPharmacology Gene Category ID 799

Gene Categories:

ENZYME

Publications:

PharmGKB: CES1

Version: 18-August-2020

Alternate Names:

PA107 PharmGKB ID

Gene Info:

Publications:

Zhu HJ et al., 2013, Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation., J Pharmacol Exp Ther

Xie C et al., 2014, The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease., Pharmacogenet Genomics

Tarkiainen EK et al., 2015, Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans., Clin Pharmacol Ther

DrugBank: BE0002705

Version: 5.1.7

Alternate Names:

CES1 DrugBank Gene Name

P23141 UniProt Accession

1066 Entrez Gene Id

Gene Info:

Publications:

Zhang J et al., 1999, Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1., J Pharmacol Exp Ther

Brzezinski MR et al., 1997, Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs., Drug Metab Dispos

Bencharit S et al., 2003, Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme., Nat Struct Biol

HingoraniCasas: ENSG00000198848
- Version: 31-May-2017
Alternate Names:

ENSG00000198848 Gene Symbol

CES1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: CES1
- Version: 03-September-2020
Alternate Names:

Liver carboxylesterase 1 Gene Name

P23141 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Liver carboxylesterase
- Version: 2020.06.01
Alternate Names:

CES1 TTD Gene Abbreviation

T76369 TTD Target ID

Gene Info:

Publications:

P23141	Uniprot Accession
EST1_HUMAN	Uniprot Id
CES1	Uniprot Gene Name

CES1	Display Id
LIVER CARBOXYLESTERASE 1 PRECURSOR (EC 3.1.1.1) (ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE) (ACAT) (MONOCYTE/MACROPHAGE SERINE ESTERASE) (HMSE) (SERINE ESTERASE 1) (BRAIN CARBOXYLESTERASE HBR1) (TRIACYLGLYCEROL HYDROLASE) (TGH) (EGASYN). [SOURCE:UNIPROT	Description
ENSG00000196959	Ensembl Gene Id

1863	HUGO Gene ID
1863	HUGO Gene Symbol
carboxylesterase 1	HUGO Gene Name

CES1	DrugBank Gene Name
P23141	UniProt Accession
1066	Entrez Gene Id

CES1 Gene Record

CES1 1066 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11282910 12396226

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 11992644

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2306268

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16292755

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19185566

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9311626

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10381793

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27261537 23467860

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12725862

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27450232 25704243 24535487 23275066

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6509906

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31837295

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12679808

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10381793

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
11282910 12396226

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 11992644

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
2306268

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16292755

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
19185566

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9311626

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10381793

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
27261537 23467860

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12725862

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
27450232 25704243 24535487 23275066

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
6509906

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
31837295

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12679808

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10381793

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
25919042

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9311626

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
28139840

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19733552

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

CES1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

P23141 Uniprot Accession

EST1_HUMAN Uniprot Id

CES1 Uniprot Gene Name

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Domain

Interpro Short Name CarbesteraseB

Gene Categories:

DRUGGABLE GENOME

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000198848 Ensembl Gene Id