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CETP Gene Record

  • Summary
  • Interactions
  • Claims
  • CETP 1071 Druggable Genome

    Alternate Names:

    1071
    CHOLESTERYL ESTER TRANSFER PROTEIN
    CETP
    BPIFF
    HDLCQ10
    118470
    1869
    ENSG00000087237
    OTTHUMG00000133279
    P11597
    LIPID TRANSFER PROTEIN I
    CETP_HUMAN
    PA108
    CHOLESTERYL ESTER TRANSFER PROTEIN PRECURSOR (LIPID TRANSFER PROTEIN I). [SOURCE:UNIPROT/SWISSPROT;ACC:P11597]
    T15334

    Gene Info:

    Target Class Miscellaneous
    Target Subclass BLI/LBP/Plunc superfamily
    Interpro Short Name Lipid-bd_serum_glycop_C
    Interpro Name Lipid-binding serum glycoprotein, C-terminal
    Interpro Type Domain
    Interpro Acc IPR001124
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Vadlamudi et al., 1998, Role of female sex steroids in regulating cholesteryl ester transfer protein in transgenic mice., Metab. Clin. Exp.
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Bercovich D et al., 2006, The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia., Atherosclerosis
    Kuivenhoven JA et al., 1998, The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group., N Engl J Med
    Regieli JJ et al., 2008, CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction., Eur Heart J
    Mohrschladt MF et al., 2005, TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia., Eur J Hum Genet
    Knoblauch H et al., 2004, Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol., Hum Mol Genet
    Carlquist JF et al., 2003, The cholesteryl ester transfer protein Taq1B gene polymorphism predicts clinical benefit of statin therapy in patients with significant coronary artery disease., Am Heart J
    Anagnostopoulou K et al., 2007, Pharmacogenetic study of cholesteryl ester transfer protein gene and simvastatin treatment in hypercholesterolaemic subjects., Expert Opin Pharmacother
    van Venrooij FV et al., 2003, Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in type 2 diabetes., Diabetes Care
    Suckling K, 2008, The ENHANCE Study: an unusual publication of trial data raises questions beyond ezetimibe., Expert Opin Pharmacother
    Pérez-Castrillon JL et al., 2006, New approaches to atherosclerotic cardiovascular disease. the potentialities of torcetrapib., Recent Pat Cardiovasc Drug Discov
  • TORCETRAPIB   CETP

    Interaction Score: 15.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Torcetrapib
    Novel drug target Novel Target

    PMIDs:
    18422466 18221079


    Sources:
    TdgClinicalTrial

  • ANACETRAPIB   CETP

    Interaction Score: 15.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Novel Target
    Trial Name Anacetrapib
    Mechanism of Interaction Cholesteryl ester transfer protein inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • EVACETRAPIB   CETP

    Interaction Score: 10.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cholesteryl ester transfer protein inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • OBICETRAPIB   CETP

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL1086624   CETP

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DALCETRAPIB   CETP

    Interaction Score: 5.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cholesteryl ester transfer protein inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • PRAVASTATIN   CETP

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9420339 18957472 15856070 15044381 14660992


    Sources:
    PharmGKB

  • FLUVASTATIN   CETP

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16002074


    Sources:
    PharmGKB

  • ATORVASTATIN   CETP

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16103896 15856070 12663600


    Sources:
    PharmGKB

  • SIMVASTATIN   CETP

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17931083 15856070


    Sources:
    PharmGKB

  • LOVASTATIN   CETP

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16103896


    Sources:
    PharmGKB

  • TAMOXIFEN   CETP

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9751231


    Sources:
    NCI

  • Ensembl: ENSG00000087237

    • Version: 101_38

    Alternate Names:
    CETP Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000087237

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000087237 Ensembl Gene Id
    CETP Display Id
    CHOLESTERYL ESTER TRANSFER PROTEIN PRECURSOR (LIPID TRANSFER PROTEIN I). [SOURCE:UNIPROT/SWISSPROT;ACC:P11597] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P11597

    • Version: 11-September-2012

    Alternate Names:
    CETP Uniprot Gene Name
    P11597 Uniprot Accession
    1071 Entrez Gene Id

    Gene Info:
    Interpro Short Name Lipid-bd_serum_glycop_C
    Interpro Name Lipid-binding serum glycoprotein, C-terminal
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P11597

    • Version: January-2014

    Alternate Names:
    CETP Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass BLI/LBP/Plunc superfamily

    Publications:

  • PharmGKB: CETP

    • Version: 18-August-2020

    Alternate Names:
    PA108 PharmGKB ID

    Gene Info:

    Publications:
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    van Venrooij FV et al., 2003, Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in type 2 diabetes., Diabetes Care
    Mohrschladt MF et al., 2005, TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia., Eur J Hum Genet

  • NCI: CETP

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Norata et al., 2005, Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells., Int. J. Mol. Med.
    Vadlamudi et al., 1998, Role of female sex steroids in regulating cholesteryl ester transfer protein in transgenic mice., Metab. Clin. Exp.

  • HingoraniCasas: ENSG00000087237

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000087237 Gene Symbol
    CETP Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CETP

    • Version: chembl_23

    Alternate Names:
    CETP GENE_SYMBOL
    Cholesteryl ester transfer protein UNIPROT
    Lipid transfer protein I UNIPROT

    Gene Info:

    Publications:

  • HumanProteinAtlas: CETP

    • Version: 19.3

    Alternate Names:
    ENSG00000087237 Ensembl Gene ID
    BPIFF Human Protein Atlas Gene Synonym
    Cholesteryl ester transfer protein Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • TTD: Cholesteryl ester transfer protein

    • Version: 2020.06.01

    Alternate Names:
    CETP TTD Gene Abbreviation
    T15334 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21