DGIdb - CETP Gene Record

CETP 1071 Druggable Genome

Alternate Names:

1071
CHOLESTERYL ESTER TRANSFER PROTEIN
CETP
BPIFF
HDLCQ10
118470
1869
ENSG00000087237
OTTHUMG00000133279
P11597
LIPID TRANSFER PROTEIN I
CETP_HUMAN
PA108
CHOLESTERYL ESTER TRANSFER PROTEIN PRECURSOR (LIPID TRANSFER PROTEIN I). [SOURCE:UNIPROT/SWISSPROT;ACC:P11597]
T15334
BE0003516

Gene Info:

Target Class	Miscellaneous
Target Subclass	BLI/LBP/Plunc superfamily
Interpro Short Name	Lipid-bd_serum_glycop_C
Interpro Name	Lipid-binding serum glycoprotein, C-terminal
Interpro Type	Domain
Interpro Acc	IPR001124
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUGGABLE GENOME

Publications:

Vadlamudi et al., 1998, Role of female sex steroids in regulating cholesteryl ester transfer protein in transgenic mice., Metab. Clin. Exp.
Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
Bercovich D et al., 2006, The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia., Atherosclerosis
Kuivenhoven JA et al., 1998, The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group., N Engl J Med
Regieli JJ et al., 2008, CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction., Eur Heart J
Mohrschladt MF et al., 2005, TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia., Eur J Hum Genet
Knoblauch H et al., 2004, Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol., Hum Mol Genet
Carlquist JF et al., 2003, The cholesteryl ester transfer protein Taq1B gene polymorphism predicts clinical benefit of statin therapy in patients with significant coronary artery disease., Am Heart J
Anagnostopoulou K et al., 2007, Pharmacogenetic study of cholesteryl ester transfer protein gene and simvastatin treatment in hypercholesterolaemic subjects., Expert Opin Pharmacother
van Venrooij FV et al., 2003, Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in type 2 diabetes., Diabetes Care
Suckling K, 2008, The ENHANCE Study: an unusual publication of trial data raises questions beyond ezetimibe., Expert Opin Pharmacother
Pérez-Castrillon JL et al., 2006, New approaches to atherosclerotic cardiovascular disease. the potentialities of torcetrapib., Recent Pat Cardiovasc Drug Discov

TORCETRAPIB CETP

Interaction Score: 18.94

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Torcetrapib

Novel drug target Novel Target

PMIDs:
18422466 18221079

Sources:
DrugBank TdgClinicalTrial
ANACETRAPIB CETP

Interaction Score: 14.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name Anacetrapib

Mechanism of Interaction Cholesteryl ester transfer protein inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
EVACETRAPIB CETP

Interaction Score: 9.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholesteryl ester transfer protein inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
OBICETRAPIB CETP

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1086624 CETP

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DALCETRAPIB CETP

Interaction Score: 4.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholesteryl ester transfer protein inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
PRAVASTATIN CETP

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9420339 18957472 15856070 15044381 14660992

Sources:
PharmGKB
FLUVASTATIN CETP

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16002074

Sources:
PharmGKB
ATORVASTATIN CETP

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16103896 15856070 12663600

Sources:
PharmGKB
SIMVASTATIN CETP

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17931083 15856070

Sources:
PharmGKB
LOVASTATIN CETP

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16103896

Sources:
PharmGKB
TAMOXIFEN CETP

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9751231

Sources:
NCI

Ensembl: ENSG00000087237
- Version: 101_38
Alternate Names:

CETP Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000087237
- Version: 26-July-2011
Alternate Names:

ENSG00000087237 Ensembl Gene Id

CETP Display Id

CHOLESTERYL ESTER TRANSFER PROTEIN PRECURSOR (LIPID TRANSFER PROTEIN I). [SOURCE:UNIPROT/SWISSPROT;ACC:P11597] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P11597
- Version: 11-September-2012
Alternate Names:

CETP Uniprot Gene Name

P11597 Uniprot Accession

1071 Entrez Gene Id

Gene Info:

Interpro Short Name Lipid-bd_serum_glycop_C

Interpro Name Lipid-binding serum glycoprotein, C-terminal

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P11597
- Version: January-2014
Alternate Names:

CETP Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass BLI/LBP/Plunc superfamily

Publications:

PharmGKB: CETP

Version: 18-August-2020

Alternate Names:

PA108 PharmGKB ID

Gene Info:

Publications:

van Venrooij FV et al., 2003, Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in type 2 diabetes., Diabetes Care

Mohrschladt MF et al., 2005, TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia., Eur J Hum Genet

Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J

DrugBank: BE0003516

Version: 5.1.7

Alternate Names:

CETP DrugBank Gene Name

P11597 UniProt Accession

1071 Entrez Gene Id

Gene Info:

Publications:

Pérez-Castrillon JL et al., 2006, New approaches to atherosclerotic cardiovascular disease. the potentialities of torcetrapib., Recent Pat Cardiovasc Drug Discov

Suckling K, 2008, The ENHANCE Study: an unusual publication of trial data raises questions beyond ezetimibe., Expert Opin Pharmacother

NCI: CETP

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Norata et al., 2005, Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells., Int. J. Mol. Med.

Vadlamudi et al., 1998, Role of female sex steroids in regulating cholesteryl ester transfer protein in transgenic mice., Metab. Clin. Exp.

HingoraniCasas: ENSG00000087237
- Version: 31-May-2017
Alternate Names:

ENSG00000087237 Gene Symbol

CETP Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CETP
- Version: chembl_23
Alternate Names:

CETP GENE_SYMBOL

Cholesteryl ester transfer protein UNIPROT

Lipid transfer protein I UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: CETP
- Version: 19.3
Alternate Names:

ENSG00000087237 Ensembl Gene ID

BPIFF Human Protein Atlas Gene Synonym

Cholesteryl ester transfer protein Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
TTD: Cholesteryl ester transfer protein
- Version: 2020.06.01
Alternate Names:

CETP TTD Gene Abbreviation

T15334 TTD Target ID

Gene Info:

Publications:

Novel drug target	Novel Target
Trial Name	Anacetrapib
Mechanism of Interaction	Cholesteryl ester transfer protein inhibitor

Mechanism of Interaction	Cholesteryl ester transfer protein inhibitor
Direct Interaction	yes

ENSG00000087237	Ensembl Gene Id
CETP	Display Id
CHOLESTERYL ESTER TRANSFER PROTEIN PRECURSOR (LIPID TRANSFER PROTEIN I). [SOURCE:UNIPROT/SWISSPROT;ACC:P11597]	Description

CETP	Uniprot Gene Name
P11597	Uniprot Accession
1071	Entrez Gene Id

CETP	DrugBank Gene Name
P11597	UniProt Accession
1071	Entrez Gene Id

CETP	GENE_SYMBOL
Cholesteryl ester transfer protein	UNIPROT
Lipid transfer protein I	UNIPROT

CETP Gene Record

CETP 1071 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Torcetrapib Novel drug target Novel Target

PMIDs: 18422466 18221079

Sources: DrugBank TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Novel Target Trial Name Anacetrapib Mechanism of Interaction Cholesteryl ester transfer protein inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cholesteryl ester transfer protein inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cholesteryl ester transfer protein inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9420339 18957472 15856070 15044381 14660992

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16002074

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16103896 15856070 12663600

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17931083 15856070

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16103896

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9751231

Sources: NCI

Ensembl: ENSG00000087237

Alternate Names: CETP Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000087237

Alternate Names: ENSG00000087237 Ensembl Gene Id CETP Display Id CHOLESTERYL ESTER TRANSFER PROTEIN PRECURSOR (LIPID TRANSFER PROTEIN I). [SOURCE:UNIPROT/SWISSPROT;ACC:P11597] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P11597

Alternate Names: CETP Uniprot Gene Name P11597 Uniprot Accession 1071 Entrez Gene Id

Gene Info: Interpro Short Name Lipid-bd_serum_glycop_C Interpro Name Lipid-binding serum glycoprotein, C-terminal Interpro Type Domain

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P11597

Alternate Names: CETP Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass BLI/LBP/Plunc superfamily

Publications:

PharmGKB: CETP

Alternate Names: PA108 PharmGKB ID

Gene Info:

DrugBank: BE0003516

Alternate Names: CETP DrugBank Gene Name P11597 UniProt Accession 1071 Entrez Gene Id

Gene Info:

NCI: CETP

Alternate Names:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Torcetrapib

Novel drug target Novel Target

PMIDs:
18422466 18221079

Sources:
DrugBank TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name Anacetrapib

Mechanism of Interaction Cholesteryl ester transfer protein inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholesteryl ester transfer protein inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholesteryl ester transfer protein inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
9420339 18957472 15856070 15044381 14660992

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16002074

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16103896 15856070 12663600

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17931083 15856070

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16103896

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9751231

Sources:
NCI

Alternate Names:

CETP Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000087237 Ensembl Gene Id

CETP Display Id

CHOLESTERYL ESTER TRANSFER PROTEIN PRECURSOR (LIPID TRANSFER PROTEIN I). [SOURCE:UNIPROT/SWISSPROT;ACC:P11597] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CETP Uniprot Gene Name

P11597 Uniprot Accession

1071 Entrez Gene Id

Gene Info:

Interpro Short Name Lipid-bd_serum_glycop_C

Interpro Name Lipid-binding serum glycoprotein, C-terminal

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CETP Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass BLI/LBP/Plunc superfamily

Alternate Names:

PA108 PharmGKB ID

Alternate Names:

CETP DrugBank Gene Name

P11597 UniProt Accession

1071 Entrez Gene Id

Alternate Names:

ENSG00000087237 Gene Symbol

CETP Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CETP GENE_SYMBOL

Cholesteryl ester transfer protein UNIPROT

Lipid transfer protein I UNIPROT

Alternate Names:

ENSG00000087237 Ensembl Gene ID

BPIFF Human Protein Atlas Gene Synonym

Cholesteryl ester transfer protein Human Protein Atlas Gene Description

Gene Categories:

TRANSPORTER

Alternate Names:

CETP TTD Gene Abbreviation

T15334 TTD Target ID