1080 |
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR |
CFTR |
ABC35 |
ABCC7 |
CF |
CFTR/MRP |
MRP7 |
TNR-CFTR |
dJ760C5.1 |
602421 |
1884 |
ENSG00000001626 |
OTTHUMG00000023076 |
707 |
P13569 |
cAMP-dependent chloride channel |
Channel conductance-controlling ATPase |
ATP-binding cassette sub-family C member 7 |
PA109 |
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) (CAMP- DEPENDENT CHLORIDE CHANNEL). [SOURCE:UNIPROT/SWISSPROT;ACC:P13569] |
BE0001195 |
CFTR_HUMAN |
T55654 |
CF transmembrane conductance regulator |
GuideToPharmacology Gene Category Name | CFTR |
GuideToPharmacology Gene Category ID | 129 |
Target Class | Transporters |
Target Subclass | TC:3.A.1.202.1 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Type | Domain |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | ABC TRANSPORTER |
Interpro Acc | IPR001140 |
Uniprot Status | Swiss-Prot |
Interpro Short Name | ABC_transptr_TM_dom |
Interpro Name | ABC transporter, transmembrane domain |
Gene Biotype | PROTEIN_CODING |
TRANSPORTER |
CELL SURFACE |
ION CHANNEL |
ABC TRANSPORTER |
DRUGGABLE GENOME |
modulator |
Trial Name | VX-809 |
Novel drug target | Established target |
Trial Name | VX-809 + VX-770 |
activator (activating) |
Mechanism of Interaction | Cystic fibrosis transmembrane conductance regulator positive modulator |
Direct Interaction | yes |
Details of the Assay for Interaction | Measuring the increase in cAMP/genistein-dependent current amplitude via the ΔF508-CFTR mutant expressed in NIH/3T3 cells by patch-clamp recording, in response to tezacaftor exposure. |
activator (activating) |
potentiator |
Trial Name | VX-809 + VX-770 |
Novel drug target | Established target |
Trial Name | VX-770 |
modulator |
Specific Action of the Ligand | Binding |
Endogenous Drug? | False |
Direct Interaction? | False |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Cystic fibrosis transmembrane conductance regulator inhibitor |
Direct Interaction | yes |
Trial Name | crofelemer |
n/a |
Specific Action of the Ligand | Binding |
Endogenous Drug? | False |
Direct Interaction? | False |
activator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Cystic fibrosis transmembrane conductance regulator activator |
activator (activating) |
Specific Action of the Ligand | Potentiation |
Endogenous Drug? | False |
activator (activating) |
Specific Action of the Ligand | Potentiation |
Endogenous Drug? | False |
activator (activating) |
Specific Action of the Ligand | Potentiation |
Endogenous Drug? | False |
activator (activating) |
Specific Action of the Ligand | Potentiation |
Endogenous Drug? | False |
Direct Interaction? | False |
activator (activating) |
Endogenous Drug? | False |
Specific Action of the Ligand | Potentiation |
activator (activating) |
Specific Action of the Ligand | Potentiation |
Endogenous Drug? | False |
CFTR | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
CFTR | Uniprot Gene Name |
CFTR_HUMAN | Uniprot Id |
1080 | Entrez Gene Id |
Human Readable Name | DRUGGABLE GENOME |
Interpro Type | Domain |
Uniprot Evidence | 1: Evidence at protein level |
ABC TRANSPORTER, DRUGGABLE GENOME |
CFTR | Gene Symbol |
Target Class | Transporters |
Target Subclass | TC:3.A.1.202.1 |
ENSG00000001626 | Ensembl Gene Id |
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) (CAMP- DEPENDENT CHLORIDE CHANNEL). [SOURCE:UNIPROT/SWISSPROT;ACC:P13569] | Description |
CFTR | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
1884 | HUGO Gene ID |
1884 | HUGO Gene Symbol |
CF transmembrane conductance regulator | HUGO Gene Name |
GuideToPharmacology Gene Category Name | CFTR |
GuideToPharmacology Gene Category ID | 129 |
ION CHANNEL |
PA109 | PharmGKB ID |
CFTR | DrugBank Gene Name |
P13569 | UniProt Accession |
1080 | Entrez Gene Id |
ENSG00000001626 | Gene Symbol |
CFTR | Ensembl Id |
DRUGGABLE GENOME |
ABCC7 | GENE_SYMBOL |
CFTR | GENE_SYMBOL |
Cystic fibrosis transmembrane conductance regulator | UNIPROT |
Cystic fibrosis transmembrane conductance regulator | Gene Name |
P13569 | UniProt ID |
TRANSPORTER, ION CHANNEL |
ABCC7 | GO Gene Synonym |
CELL SURFACE, ABC TRANSPORTER |
CFTR | Gene Symbol |
CLINICALLY ACTIONABLE |
CFTR | TTD Gene Abbreviation |
T55654 | TTD Target ID |