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CHAT Gene Record

  • Summary
  • Interactions
  • Claims
  • CHAT 1103 Druggable Genome

    Alternate Names:

    1103
    CHOLINE O-ACETYLTRANSFERASE
    CHAT
    CHOACTASE
    CMS1A
    CMS1A2
    CMS6
    118490
    1912
    ENSG00000070748
    OTTHUMG00000018198
    P28329
    CLAT_HUMAN
    CHOLINE O-ACETYLTRANSFERASE (EC 2.3.1.6) (CHOACTASE) (CHOLINE ACETYLASE) (CHAT). [SOURCE:UNIPROT/SWISSPROT;ACC:P28329]
    PA26448

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Carn_acyl_trans
    Interpro Type Family
    Interpro Acc IPR000542
    Interpro Name Acyltransferase ChoActase/COT/CPT
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Ekström, 1977, Choline acetyltransferase activity in parotid glands of rats after prolonged treatment with pilocarpine., Acta Physiol. Scand.
    Akuzawa et al., 1985, A serum-free culture of the neurons in the septal, preoptic, and hypothalamic region. Effects of triiodothyronine and estradiol., Endocrinol. Jpn.
    Yoon H et al., 2015, Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease., Pharmacopsychiatry
    Mancama D et al., 2007, Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response., Am J Med Genet B Neuropsychiatr Genet
    Casamenti et al., 1993, Long-term ethanol consumption by rats: effect on acetylcholine release in vivo, choline acetyltransferase activity, and behavior., Neuroscience
    Soliman et al., 1985, Brain cholinergic involvement in the rapid development of tolerance to the hypothermic action of ethanol., Gen. Pharmacol.
    Luine et al., 1980, Androgen affects cholinergic enzymes in syringeal motor neurons and muscle., Brain Res.
    Owasoyo, 1983, Effects of orchidectomy and dihydrotestosterone on the choline acetyltransferase activity of specific rat brain areas., Gen. Pharmacol.
    Wattanathorn et al., 1996, Ethanol alone or with dexamethasone alters the kinetics of choline acetyltransferase., Eur. J. Pharmacol.
  • RIVASTIGMINE   CHAT

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25730470


    Sources:
    PharmGKB

  • GALANTAMINE   CHAT

    Interaction Score: 2.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25730470


    Sources:
    PharmGKB

  • DONEPEZIL   CHAT

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25730470


    Sources:
    PharmGKB

  • PILOCARPINE   CHAT

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    842358


    Sources:
    NCI

  • ANDROSTANOLONE   CHAT

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6873629


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   CHAT

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    4017971


    Sources:
    NCI

  • TESTOSTERONE   CHAT

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7378793


    Sources:
    NCI

  • ALCOHOL   CHAT

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8247273 3996882


    Sources:
    NCI

  • OLANZAPINE   CHAT

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17503482


    Sources:
    PharmGKB

  • DEXAMETHASONE   CHAT

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8905330


    Sources:
    NCI

  • Ensembl: ENSG00000070748

    • Version: 101_38

    Alternate Names:
    CHAT Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000070748

    • Version: 26-July-2011

    Alternate Names:
    CHAT Display Id
    ENSG00000070748 Ensembl Gene Id
    CHOLINE O-ACETYLTRANSFERASE (EC 2.3.1.6) (CHOACTASE) (CHOLINE ACETYLASE) (CHAT). [SOURCE:UNIPROT/SWISSPROT;ACC:P28329] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P28329

    • Version: 11-September-2012

    Alternate Names:
    1103 Entrez Gene Id
    ENSG00000070748 Ensembl Gene Id
    CHAT Uniprot Gene Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Carn_acyl_trans
    Interpro Type Family

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: CHAT

    • Version: 18-August-2020

    Alternate Names:
    PA26448 PharmGKB ID

    Gene Info:

    Publications:
    Mancama D et al., 2007, Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response., Am J Med Genet B Neuropsychiatr Genet
    Yoon H et al., 2015, Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease., Pharmacopsychiatry

  • NCI: CHAT

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Owasoyo, 1983, Effects of orchidectomy and dihydrotestosterone on the choline acetyltransferase activity of specific rat brain areas., Gen. Pharmacol.
    Wattanathorn et al., 1996, Ethanol alone or with dexamethasone alters the kinetics of choline acetyltransferase., Eur. J. Pharmacol.
    Akuzawa et al., 1985, A serum-free culture of the neurons in the septal, preoptic, and hypothalamic region. Effects of triiodothyronine and estradiol., Endocrinol. Jpn.

  • HingoraniCasas: ENSG00000070748

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000070748 Gene Symbol
    CHAT Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: CHAT

    • Version: 19.3

    Alternate Names:
    ENSG00000070748 Ensembl Gene ID
    Choline O-acetyltransferase Human Protein Atlas Gene Description
    P28329 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: CHAT

    • Version: 01-February-2022

    Alternate Names:
    Choline O-acetyltransferase Gene Name
    P28329 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21