DGIdb - CHAT Gene Record

CHAT 1103 Druggable Genome

Alternate Names:

1103
CHOLINE O-ACETYLTRANSFERASE
CHAT
CHOACTASE
CMS1A
CMS1A2
CMS6
118490
1912
ENSG00000070748
OTTHUMG00000018198
BE0000519
P28329
CLAT_HUMAN
CHOLINE O-ACETYLTRANSFERASE (EC 2.3.1.6) (CHOACTASE) (CHOLINE ACETYLASE) (CHAT). [SOURCE:UNIPROT/SWISSPROT;ACC:P28329]
PA26448
2480
NM_020549
NP_065574

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Carn_acyl_trans
Interpro Type	Family
Interpro Acc	IPR000542
Interpro Name	Acyltransferase ChoActase/COT/CPT
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Acetylcholine turnover
GuideToPharmacology Gene Category ID	765

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Ekström, 1977, Choline acetyltransferase activity in parotid glands of rats after prolonged treatment with pilocarpine., Acta Physiol. Scand.
FAHMY et al., 1954, The inhibition of choline acetylase by nicotine., J. Pharm. Pharmacol.
Akuzawa et al., 1985, A serum-free culture of the neurons in the septal, preoptic, and hypothalamic region. Effects of triiodothyronine and estradiol., Endocrinol. Jpn.
Yoon H et al., 2015, Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease., Pharmacopsychiatry
Mancama D et al., 2007, Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response., Am J Med Genet B Neuropsychiatr Genet
Casamenti et al., 1993, Long-term ethanol consumption by rats: effect on acetylcholine release in vivo, choline acetyltransferase activity, and behavior., Neuroscience
Soliman et al., 1985, Brain cholinergic involvement in the rapid development of tolerance to the hypothermic action of ethanol., Gen. Pharmacol.
Luine et al., 1980, Androgen affects cholinergic enzymes in syringeal motor neurons and muscle., Brain Res.
Owasoyo, 1983, Effects of orchidectomy and dihydrotestosterone on the choline acetyltransferase activity of specific rat brain areas., Gen. Pharmacol.
Wattanathorn et al., 1996, Ethanol alone or with dexamethasone alters the kinetics of choline acetyltransferase., Eur. J. Pharmacol.

RIVASTIGMINE CHAT

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25730470

Sources:
PharmGKB
GALANTAMINE CHAT

Interaction Score: 2.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25730470

Sources:
PharmGKB
DONEPEZIL CHAT

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25730470

Sources:
PharmGKB
PILOCARPINE CHAT

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
842358

Sources:
NCI
ANDROSTANOLONE CHAT

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6873629

Sources:
NCI
LIOTHYRONINE SODIUM CHAT

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4017971

Sources:
NCI
TESTOSTERONE CHAT

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7378793

Sources:
NCI
NICOTINE CHAT

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
13192619

Sources:
DrugBank
OLANZAPINE CHAT

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17503482

Sources:
PharmGKB
DEXAMETHASONE CHAT

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8905330

Sources:
NCI
ALCOHOL CHAT

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8247273 3996882

Sources:
NCI

Ensembl: ENSG00000070748
- Version: 101_38
Alternate Names:

CHAT Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000070748
- Version: 26-July-2011
Alternate Names:

CHAT Display Id

ENSG00000070748 Ensembl Gene Id

CHOLINE O-ACETYLTRANSFERASE (EC 2.3.1.6) (CHOACTASE) (CHOLINE ACETYLASE) (CHAT). [SOURCE:UNIPROT/SWISSPROT;ACC:P28329] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P28329
- Version: 11-September-2012
Alternate Names:

1103 Entrez Gene Id

ENSG00000070748 Ensembl Gene Id

CHAT Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Carn_acyl_trans

Interpro Type Family

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 1103
- Version: 29-September-2020
Alternate Names:

1912 HUGO Gene ID

1912 HUGO Gene Symbol

choline O-acetyltransferase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Acetylcholine turnover

GuideToPharmacology Gene Category ID 765

Gene Categories:

ENZYME

Publications:

PharmGKB: CHAT

Version: 18-August-2020

Alternate Names:

PA26448 PharmGKB ID

Gene Info:

Publications:

Mancama D et al., 2007, Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response., Am J Med Genet B Neuropsychiatr Genet

Yoon H et al., 2015, Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease., Pharmacopsychiatry

DrugBank: BE0000519
- Version: 5.1.7
Alternate Names:

CHAT DrugBank Gene Name

P28329 UniProt Accession

1103 Entrez Gene Id

Gene Info:

Publications:

FAHMY et al., 1954, The inhibition of choline acetylase by nicotine., J. Pharm. Pharmacol.

NCI: CHAT

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Owasoyo, 1983, Effects of orchidectomy and dihydrotestosterone on the choline acetyltransferase activity of specific rat brain areas., Gen. Pharmacol.

Wattanathorn et al., 1996, Ethanol alone or with dexamethasone alters the kinetics of choline acetyltransferase., Eur. J. Pharmacol.

Akuzawa et al., 1985, A serum-free culture of the neurons in the septal, preoptic, and hypothalamic region. Effects of triiodothyronine and estradiol., Endocrinol. Jpn.

HingoraniCasas: ENSG00000070748
- Version: 31-May-2017
Alternate Names:

ENSG00000070748 Gene Symbol

CHAT Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: CHAT
- Version: 19.3
Alternate Names:

ENSG00000070748 Ensembl Gene ID

Choline O-acetyltransferase Human Protein Atlas Gene Description

P28329 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: CHAT
- Version: 03-September-2020
Alternate Names:

Choline O-acetyltransferase Gene Name

P28329 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

CHAT	Display Id
ENSG00000070748	Ensembl Gene Id
CHOLINE O-ACETYLTRANSFERASE (EC 2.3.1.6) (CHOACTASE) (CHOLINE ACETYLASE) (CHAT). [SOURCE:UNIPROT/SWISSPROT;ACC:P28329]	Description

1103	Entrez Gene Id
ENSG00000070748	Ensembl Gene Id
CHAT	Uniprot Gene Name

1912	HUGO Gene ID
1912	HUGO Gene Symbol
choline O-acetyltransferase	HUGO Gene Name

CHAT	DrugBank Gene Name
P28329	UniProt Accession
1103	Entrez Gene Id

CHAT Gene Record

CHAT 1103 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25730470

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25730470

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25730470

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 842358

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6873629

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 4017971

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7378793

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 13192619

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17503482

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8905330

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8247273 3996882

Sources: NCI

Ensembl: ENSG00000070748

Alternate Names: CHAT Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000070748

Alternate Names: CHAT Display Id ENSG00000070748 Ensembl Gene Id CHOLINE O-ACETYLTRANSFERASE (EC 2.3.1.6) (CHOACTASE) (CHOLINE ACETYLASE) (CHAT). [SOURCE:UNIPROT/SWISSPROT;ACC:P28329] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P28329

Alternate Names: 1103 Entrez Gene Id ENSG00000070748 Ensembl Gene Id CHAT Uniprot Gene Name

Gene Info: Human Readable Name DRUGGABLE GENOME Interpro Short Name Carn_acyl_trans Interpro Type Family

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 1103

Alternate Names: 1912 HUGO Gene ID 1912 HUGO Gene Symbol choline O-acetyltransferase HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Acetylcholine turnover GuideToPharmacology Gene Category ID 765

Gene Categories: ENZYME

Publications:

PharmGKB: CHAT

Alternate Names: PA26448 PharmGKB ID

Gene Info:

DrugBank: BE0000519

Alternate Names: CHAT DrugBank Gene Name P28329 UniProt Accession 1103 Entrez Gene Id

Gene Info:

Publications: FAHMY et al., 1954, The inhibition of choline acetylase by nicotine., J. Pharm. Pharmacol.

NCI: CHAT

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000070748

Interaction Types & Directionality:

n/a

PMIDs:
25730470

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25730470

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25730470

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
842358

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6873629

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
4017971

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7378793

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
13192619

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17503482

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8905330

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8247273 3996882

Sources:
NCI

Alternate Names:

CHAT Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CHAT Display Id

ENSG00000070748 Ensembl Gene Id

CHOLINE O-ACETYLTRANSFERASE (EC 2.3.1.6) (CHOACTASE) (CHOLINE ACETYLASE) (CHAT). [SOURCE:UNIPROT/SWISSPROT;ACC:P28329] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

1103 Entrez Gene Id

ENSG00000070748 Ensembl Gene Id

CHAT Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Carn_acyl_trans

Interpro Type Family

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

1912 HUGO Gene ID

1912 HUGO Gene Symbol

choline O-acetyltransferase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Acetylcholine turnover

GuideToPharmacology Gene Category ID 765

Gene Categories:

ENZYME

Alternate Names:

PA26448 PharmGKB ID

Alternate Names:

CHAT DrugBank Gene Name

P28329 UniProt Accession

1103 Entrez Gene Id

Publications:

FAHMY et al., 1954, The inhibition of choline acetylase by nicotine., J. Pharm. Pharmacol.

Alternate Names:

ENSG00000070748 Gene Symbol

CHAT Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000070748 Ensembl Gene ID

Choline O-acetyltransferase Human Protein Atlas Gene Description

P28329 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

Choline O-acetyltransferase Gene Name

P28329 UniProt ID

Gene Categories:

ENZYME