1128 |
CHOLINERGIC RECEPTOR MUSCARINIC 1 |
CHRM1 |
HM1 |
M1 |
M1R |
118510 |
1950 |
ENSG00000168539 |
OTTHUMG00000167765 |
P11229 |
ACM1_HUMAN |
MUSCARINIC ACETYLCHOLINE RECEPTOR M1 |
MUSCARINIC ACETYLCHOLINE RECEPTOR M1. [SOURCE:UNIPROT/SWISSPROT;ACC:P11229] |
T28893 |
Transmembrane Helix Count | 7 |
Target Subclass | GPCR |
Target Main Class | Receptors |
Target Subclass | Rhodopsin |
Target Class | Receptors |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR000276 |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Family |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Human Readable Name | DRUGGABLE GENOME |
Gene Biotype | PROTEIN_CODING |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
antagonist (inhibitory) |
Trial Name | NVA237, inhaled glycopyrronium bromide |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | trospium chloride,Sanctura |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Novel drug target | Established target |
n/a |
Trial Name | NGX267 |
Novel drug target | Established target |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
Trial Name | glycopyrrolate, FHPC-02,Cuvposa |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
agonist (activating) |
Novel drug target | Established target |
Trial Name | - |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
n/a |
Trial Name | - |
Novel drug target | Established target |
n/a |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | tiotropium bromide,Spiriva |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
Trial Name | inhaled atropine |
antagonist (inhibitory) |
Trial Name | ipratropium bromide + albuterol sulfate,DuoNeb |
Novel drug target | Established target |
n/a |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
agonist (activating) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 agonist |
Direct Interaction | yes |
Trial Name | THVD-201 |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | THVD-201 |
Novel drug target | Established target |
Trial Name | tolterodine extended release capsules,Detrol LA |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
agonist (activating) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | Silenor (SO-101) |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
n/a |
Trial Name | QVA149, glycopyrronium bromide + i/ |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | Aclidinium |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
n/a |
Novel drug target | Established target |
Trial Name | - |
allosteric modulator |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor M1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Muscarinic acetylcholine receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv |
Novel drug target | Established target |
Trial Name | Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac) |
CHRM1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
CHRM1 | Display Id |
MUSCARINIC ACETYLCHOLINE RECEPTOR M1. [SOURCE:UNIPROT/SWISSPROT;ACC:P11229] | Description |
ENSG00000168539 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
1128 | Entrez Gene Id |
MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | Uniprot Protein Name |
CHRM1 | Uniprot Gene Name |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR000276 |
Interpro Name | GPCR, rhodopsin-like, 7TM |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
CHRM1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
P11229 | Uniprot Accession |
1128 | Entrez Gene Id |
ENSG00000168539 | Ensembl Gene Id |
Transmembrane Helix Count | 7 |
Target Subclass | GPCR |
Target Main Class | Receptors |
CHRM1 | TTD Gene Abbreviation |
T28893 | TTD Target ID |
CHRM1 | GENE_SYMBOL |
Muscarinic acetylcholine receptor M1 | UNIPROT |
ENSG00000168539 | Gene Symbol |
CHRM1 | Ensembl Id |
DRUGGABLE GENOME |
1128 | Gene ID |
HM1 | dGene Synonym |
M1 | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |