• Interaction Score: 6.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19027295


    Sources:
    DTC

  • Interaction Score: 6.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19027295


    Sources:
    DTC

  • Interaction Score: 4.78

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    20337496 9454827


    Sources:
    DTC

  • Interaction Score: 3.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23352509


    Sources:
    DTC

  • Interaction Score: 3.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20337496


    Sources:
    DTC

  • Interaction Score: 1.59

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 1.59

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 partial agonist

    PMIDs:
    None found


  • Interaction Score: 1.59

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist

    PMIDs:
    None found


  • Interaction Score: 1.37

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Trial Name varenicline, CP-526
    Novel drug target Established target
    Specific Action of the Ligand Agonist

  • Interaction Score: 1.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction α3β4
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.8

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction α3β4
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.8

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Antagonism of ACh activation of human &alpha;3&beta;2 or &alpha;3&beta;4 nACh receptors expressed in <i>Xenopus</i> oocytes, at different ACh concentrations.
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.59

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Details of Interaction &alpha;3&beta;4
    Endogenous Drug? False

  • Interaction Score: 0.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Interaction Score: 0.32

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction &alpha;3&beta;4
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32152934


    Sources:
    PharmGKB

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:


    Sources:
    PharmGKB