DGIdb - CHRNA7 Gene Record

CHRNA7 1139 Druggable Genome

Alternate Names:

1139
CHOLINERGIC RECEPTOR NICOTINIC ALPHA 7 SUBUNIT
CHRNA7
CHRNA7-2
NACHRA7
118511
1960
ENSG00000175344
OTTHUMG00000129285
Neuronal acetylcholine receptor subunit alpha-7
P36544
ACHA7_HUMAN
1139; 89832
468
nicotinic acetylcholine receptor α7 subunit
NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-7 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P36544]
PA114
Neuronal acetylcholine receptor alpha-7
T34429
NM_000746
NP_000737

Gene Info:

Interpro Acc	IPR006202
Human Readable Name	ION CHANNEL
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR006201
Uniprot Status	Swiss-Prot
Interpro Name	Neurotransmitter-gated ion-channel
Interpro Type	Domain
Interpro Type	Family
Interpro Short Name	Neur_chan_lig-bd
Interpro Name	Neurotransmitter-gated ion-channel ligand-binding
Interpro Short Name	Neur_channel
Uniprot Evidence	1: Evidence at protein level
Target Class	Receptors
Target Subclass	TC:1.A.9.1.1
Target Subclass	Channels
Target Subclass	cys-loop
Target Subclass	Ligand_gated_ion_channels
Target Main Class	Receptors
Transmembrane Helix Count	4
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Nicotinic acetylcholine receptors
GuideToPharmacology Gene Category ID	76

(9 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
Mansvelder et al., 2009, Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits., Semin. Cell Dev. Biol.
Zaniewska et al., Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives., Pharmacol Rep
Mexal et al., 2007, alpha7 nicotinic receptor gene promoter polymorphisms in inbred mice affect expression in a cell type-specific fashion., J. Biol. Chem.
Narahashi et al., 2000, Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior., Toxicol. Sci.
Olincy et al., 2006, Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia., Arch. Gen. Psychiatry
Jackson et al., 2010, Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice., J. Pharmacol. Exp. Ther.
Rigbi A et al., 2011, Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions., Pharmacogenomics J
Pavlov et al., 2007, Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis., Crit. Care Med.
Stokes et al., 2004, The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors., Mol. Pharmacol.
Kim et al., 2007, Synthesis and positron emission tomography studies of C-11-labeled isotopomers and metabolites of GTS-21, a partial alpha7 nicotinic cholinergic agonist drug., Nucl. Med. Biol.
Barbier AJ et al., 2015, Pharmacodynamics, pharmacokinetics, safety, and tolerability of encenicline, a selective α7 nicotinic receptor partial agonist, in single ascending-dose and bioavailability studies., Clin Ther
Braga IL et al., 2015, Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease., Am J Alzheimers Dis Other Demen
Ng HJ et al., 2007, Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators., Proc Natl Acad Sci U S A
Olin et al., 2002, Galantamine for Alzheimer's disease., Cochrane Database Syst Rev
Woodruff-Pak et al., 2002, Nicotinic cholinergic modulation: galantamine as a prototype., CNS Drug Rev
Lilienfeld, 2002, Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease., CNS Drug Rev
Scott et al., 2000, Galantamine: a review of its use in Alzheimer's disease., Drugs
Lilienfeld et al., 2000, Galantamine: additional benefits to patients with Alzheimer's disease., Dement Geriatr Cogn Disord
Hansen et al.
Ludwig J et al., 2010, Localization by site-directed mutagenesis of a galantamine binding site on α7 nicotinic acetylcholine receptor extracellular domain., J Recept Signal Transduct Res
Woodruff-Pak DS et al., 2001, Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning., Proc Natl Acad Sci U S A
Walker et al., 2014, Cytisine versus nicotine for smoking cessation., N. Engl. J. Med.
Houlihan et al., 2001, Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors., J. Neurochem.
Mihalak et al., 2006, Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors., Mol. Pharmacol.
Briggs CA et al., 1999, Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant., Eur J Pharmacol
Bréthous L et al., 2012, Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711)., J Med Chem

ENCENICLINE CHRNA7

Interaction Score: 7.25

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name EVP-6124

Direct Interaction yes

PMIDs:
25438724

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
GTS-21 CHRNA7

Interaction Score: 7.25

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GTS-21

Novel drug target Established target

PMIDs:
17334244 15213292 17591554

Sources:
TdgClinicalTrial TTD
SSR180711 CHRNA7

Interaction Score: 4.35

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist

Direct Interaction yes

PMIDs:
22591063

Sources:
DTC ChemblInteractions
CHEMBL257591 CHRNA7

Interaction Score: 4.35

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Details of Interaction (α7)5:Type 2

Endogenous Drug? False

PMIDs:
17470817

Sources:
DTC GuideToPharmacology

TC-6987 CHRNA7

Interaction Score: 4.35

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name TC-6987Êby Targacept forÊasthmaÊandÊtype II diabetes

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

ABT-126 CHRNA7

Interaction Score: 2.9

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
AQW051 CHRNA7

Interaction Score: 2.9

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
JNJ-39393406 CHRNA7

Interaction Score: 2.9

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
AZD0328 CHRNA7

Interaction Score: 2.9

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Direct Interaction yes

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
GALANTAMINE CHRNA7

Interaction Score: 2.9

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

PMIDs:
12137632 12481195 12177686 11129124 10971048 20480924 24951635 21062106 11172080

Sources:
PharmGKB
AVL-3288 CHRNA7

Interaction Score: 2.9

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
PHA-543613 CHRNA7

Interaction Score: 2.9

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Direct Interaction yes

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
ABT-107 CHRNA7

Interaction Score: 1.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ND0801 CHRNA7

Interaction Score: 1.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHYLLYCACONITINE CHRNA7

Interaction Score: 1.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Details of Interaction (α7)5

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL526281 CHRNA7

Interaction Score: 1.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Details of Interaction (α7)5

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
APN1125 CHRNA7

Interaction Score: 1.45

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist

PMIDs:
None found

Sources:
ChemblInteractions
PNU-282987 CHRNA7

Interaction Score: 1.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Details of Interaction (α7)5

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
BRADANICLINE CHRNA7

Interaction Score: 1.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Trial Name TC-5619

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology
CYTISINICLINE CHRNA7

Interaction Score: 0.87

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
25517706 11553677

Sources:
TTD
RIVASTIGMINE CHRNA7

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24951635

Sources:
PharmGKB
SECOBARBITAL CHRNA7

Interaction Score: 0.72

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
BUTABARBITAL CHRNA7

Interaction Score: 0.72

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TdgClinicalTrial TEND
HEXOBARBITAL CHRNA7

Interaction Score: 0.72

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
BUTETHAL CHRNA7

Interaction Score: 0.72

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
THIOPENTAL CHRNA7

Interaction Score: 0.66

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
VARENICLINE CHRNA7

Interaction Score: 0.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name varenicline, CP-526

Novel drug target Established target

PMIDs:
16766716

Sources:
TdgClinicalTrial TEND
MEPHOBARBITAL CHRNA7

Interaction Score: 0.6

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TdgClinicalTrial TEND
IVERMECTIN CHRNA7

Interaction Score: 0.48

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Positive

PMIDs:
None found

Sources:
GuideToPharmacology
RG3487 CHRNA7

Interaction Score: 0.48

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHEMBL490153 CHRNA7

Interaction Score: 0.48

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Details of Interaction (α7)5:Type 2; also blocks α3β4 and α4β2

PMIDs:
None found

Sources:
GuideToPharmacology
DONEPEZIL CHRNA7

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24951635

Sources:
PharmGKB
METHARBITAL CHRNA7

Interaction Score: 0.36

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
BUTALBITAL CHRNA7

Interaction Score: 0.36

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
PENTOBARBITAL CHRNA7

Interaction Score: 0.36

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
TALBUTAL CHRNA7

Interaction Score: 0.36

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
NICOTINE CHRNA7

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19560048 20081230 17360707 11006350 16754836 20400469 20231857

Sources:
TdgClinicalTrial TEND PharmGKB
MECAMYLAMINE CHRNA7

Interaction Score: 0.29

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Details of Interaction (α7)5

PMIDs:
10082212

Sources:
GuideToPharmacology

ATRACURIUM CHRNA7

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Antagonism of ACh activation of human α7 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

ALCURONIUM CHRNA7

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PRIMIDONE CHRNA7

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
ASM-024 CHRNA7

Interaction Score: 0.21

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENOBARBITAL CHRNA7

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
ZIPRASIDONE CHRNA7

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000175344
- Version: 101_38
Alternate Names:

CHRNA7 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P36544
- Version: 11-September-2012
Alternate Names:

ENSG00000175344 Ensembl Gene Id

P36544 Uniprot Accession

1139 Entrez Gene Id

Gene Info:

Interpro Acc IPR006202

Human Readable Name ION CHANNEL

Human Readable Name DRUGGABLE GENOME

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P36544
- Version: January-2014
Alternate Names:

CHRNA7 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.9.1.1

Publications:
RussLampel: ENSG00000175344
- Version: 26-July-2011
Alternate Names:

NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-7 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P36544] Description

CHRNA7 Display Id

ENSG00000175344 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P36544
- Version: 01-August-2011
Alternate Names:

1139; 89832 Entrez Gene Id

ACHA7_HUMAN Uniprot Id

P36544 Uniprot Accession

Gene Info:

Target Subclass Channels

Target Subclass cys-loop

Target Subclass Ligand_gated_ion_channels

Publications:
GuideToPharmacology: 1139
- Version: 29-September-2020
Alternate Names:

1960 HUGO Gene ID

1960 HUGO Gene Symbol

cholinergic receptor nicotinic alpha 7 subunit HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Nicotinic acetylcholine receptors

GuideToPharmacology Gene Category ID 76

Gene Categories:

ION CHANNEL

Publications:

PharmGKB: CHRNA7

Version: 18-August-2020

Alternate Names:

PA114 PharmGKB ID

Gene Info:

Publications:

Braga IL et al., 2015, Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease., Am J Alzheimers Dis Other Demen

Rigbi A et al., 2011, Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions., Pharmacogenomics J

DTC: CHRNA7

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Ng HJ et al., 2007, Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators., Proc Natl Acad Sci U S A

Bréthous L et al., 2012, Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711)., J Med Chem

ChemblInteractions: NACHRA7
- Version: chembl_23
Alternate Names:

NACHRA7 GENE_SYMBOL

CHRNA7 GENE_SYMBOL

Neuronal acetylcholine receptor subunit alpha-7 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000175344
- Version: 31-May-2017
Alternate Names:

ENSG00000175344 Gene Symbol

CHRNA7 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Neuronal acetylcholine receptor alpha-7
- Version: 2020.06.01
Alternate Names:

CHRNA7 TTD Gene Abbreviation

T34429 TTD Target ID

Gene Info:

Publications:
GO: CHRNA7
- Version: 01-May-2021
Alternate Names:

NACHRA7 GO Gene Synonym

Gene Info:

Gene Categories:

ION CHANNEL

Publications:
Pharos: CHRNA7
- Version: 01-May-2021
Alternate Names:

Neuronal acetylcholine receptor subunit alpha-7 Gene Name

P36544 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Novel drug target	Established target
Trial Name	EVP-6124
Direct Interaction	yes

Mechanism of Interaction	Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist
Direct Interaction	yes

Specific Action of the Ligand	Positive
Details of Interaction	(α7)<sub>5</sub>:Type 2
Endogenous Drug?	False

Specific Action of the Ligand	Antagonist
Details of Interaction	(α7)<sub>5</sub>
Endogenous Drug?	False

Specific Action of the Ligand	Full agonist
Details of Interaction	(α7)<sub>5</sub>
Endogenous Drug?	False

Trial Name	varenicline, CP-526
Novel drug target	Established target

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Positive

Details of the Assay for Interaction	Antagonism of ACh activation of human α7 nACh receptors expressed in <i>Xenopus</i> oocytes, at different ACh concentrations.
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

ENSG00000175344	Ensembl Gene Id
P36544	Uniprot Accession
1139	Entrez Gene Id

NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-7 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P36544]	Description
CHRNA7	Display Id
ENSG00000175344	Ensembl Gene Id

1960	HUGO Gene ID
1960	HUGO Gene Symbol
cholinergic receptor nicotinic alpha 7 subunit	HUGO Gene Name

NACHRA7	GENE_SYMBOL
CHRNA7	GENE_SYMBOL
Neuronal acetylcholine receptor subunit alpha-7	UNIPROT

Neuronal acetylcholine receptor subunit alpha-7	Gene Name
P36544	UniProt ID

CHRNA7 Gene Record

CHRNA7 1139 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Novel drug target Established target Trial Name EVP-6124 Direct Interaction yes

PMIDs: 25438724

Sources: TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name GTS-21 Novel drug target Established target

PMIDs: 17334244 15213292 17591554

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist Direct Interaction yes

PMIDs: 22591063

Sources: DTC ChemblInteractions

Interaction Types & Directionality: allosteric modulator

Interaction Info: Specific Action of the Ligand Positive Details of Interaction (&alpha;7)<sub>5</sub>:Type 2 Endogenous Drug? False

PMIDs: 17470817

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name TC-6987Êby Targacept forÊasthmaÊandÊtype II diabetes Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist Specific Action of the Ligand Agonist

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist Direct Interaction yes Specific Action of the Ligand Full agonist

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: allosteric modulator

Interaction Info:

PMIDs: 12137632 12481195 12177686 11129124 10971048 20480924 24951635 21062106 11172080

Sources: PharmGKB

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist Direct Interaction yes Specific Action of the Ligand Full agonist

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Details of Interaction (&alpha;7)<sub>5</sub> Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Details of Interaction (&alpha;7)<sub>5</sub> Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Details of Interaction (&alpha;7)<sub>5</sub> Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist Trial Name TC-5619

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name EVP-6124

Direct Interaction yes

PMIDs:
25438724

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GTS-21

Novel drug target Established target

PMIDs:
17334244 15213292 17591554

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist

Direct Interaction yes

PMIDs:
22591063

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Details of Interaction (α7)<sub>5</sub>:Type 2

Endogenous Drug? False

PMIDs:
17470817

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name TC-6987Êby Targacept forÊasthmaÊandÊtype II diabetes

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Direct Interaction yes

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

allosteric modulator

PMIDs:
12137632 12481195 12177686 11129124 10971048 20480924 24951635 21062106 11172080

Sources:
PharmGKB

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Direct Interaction yes

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Details of Interaction (α7)<sub>5</sub>

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Details of Interaction (α7)<sub>5</sub>

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Details of Interaction (α7)<sub>5</sub>

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Trial Name TC-5619

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

PMIDs:
25517706 11553677

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
24951635