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CHRNA7 Gene Record

  • Summary
  • Interactions
  • Claims
  • CHRNA7 1139 Druggable Genome

    Alternate Names:

    1139
    CHOLINERGIC RECEPTOR NICOTINIC ALPHA 7 SUBUNIT
    CHRNA7
    CHRNA7-2
    NACHRA7
    118511
    1960
    ENSG00000175344
    OTTHUMG00000129285
    Neuronal acetylcholine receptor subunit alpha-7
    P36544
    ACHA7_HUMAN
    1139; 89832
    NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-7 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P36544]
    PA114
    Neuronal acetylcholine receptor alpha-7
    T34429

    Gene Info:

    Interpro Acc IPR006202
    Human Readable Name ION CHANNEL
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR006201
    Uniprot Status Swiss-Prot
    Interpro Name Neurotransmitter-gated ion-channel
    Interpro Type Domain
    Interpro Type Family
    Interpro Short Name Neur_chan_lig-bd
    Interpro Name Neurotransmitter-gated ion-channel ligand-binding
    Interpro Short Name Neur_channel
    Uniprot Evidence 1: Evidence at protein level
    Target Class Receptors
    Target Subclass TC:1.A.9.1.1
    Target Subclass Channels
    Target Subclass cys-loop
    Target Subclass Ligand_gated_ion_channels
    Target Main Class Receptors
    Transmembrane Helix Count 4
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Mansvelder et al., 2009, Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits., Semin. Cell Dev. Biol.
    Zaniewska et al., Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives., Pharmacol Rep
    Mexal et al., 2007, alpha7 nicotinic receptor gene promoter polymorphisms in inbred mice affect expression in a cell type-specific fashion., J. Biol. Chem.
    Narahashi et al., 2000, Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior., Toxicol. Sci.
    Olincy et al., 2006, Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia., Arch. Gen. Psychiatry
    Jackson et al., 2010, Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice., J. Pharmacol. Exp. Ther.
    Rigbi A et al., 2011, Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions., Pharmacogenomics J
    Pavlov et al., 2007, Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis., Crit. Care Med.
    Stokes et al., 2004, The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors., Mol. Pharmacol.
    Kim et al., 2007, Synthesis and positron emission tomography studies of C-11-labeled isotopomers and metabolites of GTS-21, a partial alpha7 nicotinic cholinergic agonist drug., Nucl. Med. Biol.
    Barbier AJ et al., 2015, Pharmacodynamics, pharmacokinetics, safety, and tolerability of encenicline, a selective α7 nicotinic receptor partial agonist, in single ascending-dose and bioavailability studies., Clin Ther
    Braga IL et al., 2015, Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease., Am J Alzheimers Dis Other Demen
    Ng HJ et al., 2007, Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators., Proc Natl Acad Sci U S A
    Olin et al., 2002, Galantamine for Alzheimer's disease., Cochrane Database Syst Rev
    Woodruff-Pak et al., 2002, Nicotinic cholinergic modulation: galantamine as a prototype., CNS Drug Rev
    Lilienfeld, 2002, Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease., CNS Drug Rev
    Scott et al., 2000, Galantamine: a review of its use in Alzheimer's disease., Drugs
    Lilienfeld et al., 2000, Galantamine: additional benefits to patients with Alzheimer's disease., Dement Geriatr Cogn Disord
    Hansen et al.
    Ludwig J et al., 2010, Localization by site-directed mutagenesis of a galantamine binding site on α7 nicotinic acetylcholine receptor extracellular domain., J Recept Signal Transduct Res
    Woodruff-Pak DS et al., 2001, Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning., Proc Natl Acad Sci U S A
    Walker et al., 2014, Cytisine versus nicotine for smoking cessation., N. Engl. J. Med.
    Houlihan et al., 2001, Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors., J. Neurochem.
    Mihalak et al., 2006, Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors., Mol. Pharmacol.
    Bréthous L et al., 2012, Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711)., J Med Chem
  • GTS-21   CHRNA7

    Interaction Score: 8.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name GTS-21
    Novel drug target Established target

    PMIDs:
    17334244 15213292 17591554


    Sources:
    TdgClinicalTrial TTD

  • ENCENICLINE   CHRNA7

    Interaction Score: 6.68

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name EVP-6124
    Direct Interaction yes

    PMIDs:
    25438724


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • SSR180711   CHRNA7

    Interaction Score: 5.01

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist
    Direct Interaction yes

    PMIDs:
    22591063


    Sources:
    DTC ChemblInteractions

  • TC-6987   CHRNA7

    Interaction Score: 5.01

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name TC-6987Êby Targacept forÊasthmaÊandÊtype II diabetes
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • ABT-126   CHRNA7

    Interaction Score: 3.34

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • JNJ-39393406   CHRNA7

    Interaction Score: 3.34

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • GALANTAMINE   CHRNA7

    Interaction Score: 3.34

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:

    PMIDs:
    12137632 12481195 12177686 11129124 10971048 20480924 24951635 21062106 11172080


    Sources:
    PharmGKB

  • CHEMBL257591   CHRNA7

    Interaction Score: 3.34

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:

    PMIDs:
    17470817


    Sources:
    DTC

  • AVL-3288   CHRNA7

    Interaction Score: 3.34

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ABT-107   CHRNA7

    Interaction Score: 1.67

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ND0801   CHRNA7

    Interaction Score: 1.67

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AQW051   CHRNA7

    Interaction Score: 1.67

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • APN1125   CHRNA7

    Interaction Score: 1.67

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AZD0328   CHRNA7

    Interaction Score: 1.67

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALCURONIUM   CHRNA7

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PHA-543613   CHRNA7

    Interaction Score: 1.67

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CYTISINICLINE   CHRNA7

    Interaction Score: 1.0

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    25517706 11553677


    Sources:
    TTD

  • RIVASTIGMINE   CHRNA7

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24951635


    Sources:
    PharmGKB

  • SECOBARBITAL   CHRNA7

    Interaction Score: 0.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • BRADANICLINE   CHRNA7

    Interaction Score: 0.84

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit agonist
    Trial Name TC-5619

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • BUTABARBITAL   CHRNA7

    Interaction Score: 0.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TdgClinicalTrial TEND

  • HEXOBARBITAL   CHRNA7

    Interaction Score: 0.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • BUTETHAL   CHRNA7

    Interaction Score: 0.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • THIOPENTAL   CHRNA7

    Interaction Score: 0.76

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • VARENICLINE   CHRNA7

    Interaction Score: 0.72

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name varenicline, CP-526
    Novel drug target Established target

    PMIDs:
    16766716


    Sources:
    TdgClinicalTrial TEND

  • MEPHOBARBITAL   CHRNA7

    Interaction Score: 0.7

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TdgClinicalTrial TEND

  • RG3487   CHRNA7

    Interaction Score: 0.56

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • DONEPEZIL   CHRNA7

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24951635


    Sources:
    PharmGKB

  • METHARBITAL   CHRNA7

    Interaction Score: 0.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • BUTALBITAL   CHRNA7

    Interaction Score: 0.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • PENTOBARBITAL   CHRNA7

    Interaction Score: 0.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • TALBUTAL   CHRNA7

    Interaction Score: 0.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • NICOTINE   CHRNA7

    Interaction Score: 0.35

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    19560048 20081230 17360707 11006350 16754836 20400469 20231857


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • PRIMIDONE   CHRNA7

    Interaction Score: 0.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • ASM-024   CHRNA7

    Interaction Score: 0.24

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor protein alpha-7 subunit modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENOBARBITAL   CHRNA7

    Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • ZIPRASIDONE   CHRNA7

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000175344

    • Version: 101_38

    Alternate Names:
    CHRNA7 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P36544

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000175344 Ensembl Gene Id
    P36544 Uniprot Accession
    1139 Entrez Gene Id

    Gene Info:
    Interpro Acc IPR006202
    Human Readable Name ION CHANNEL
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P36544

    • Version: January-2014

    Alternate Names:
    CHRNA7 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.9.1.1

    Publications:

  • RussLampel: ENSG00000175344

    • Version: 26-July-2011

    Alternate Names:
    NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-7 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P36544] Description
    CHRNA7 Display Id
    ENSG00000175344 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P36544

    • Version: 01-August-2011

    Alternate Names:
    1139; 89832 Entrez Gene Id
    ACHA7_HUMAN Uniprot Id
    P36544 Uniprot Accession

    Gene Info:
    Target Subclass Channels
    Target Subclass cys-loop
    Target Subclass Ligand_gated_ion_channels

    Publications:

  • PharmGKB: CHRNA7

    • Version: 18-August-2020

    Alternate Names:
    PA114 PharmGKB ID

    Gene Info:

    Publications:
    Braga IL et al., 2015, Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease., Am J Alzheimers Dis Other Demen
    Rigbi A et al., 2011, Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions., Pharmacogenomics J

  • DTC: CHRNA7

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Ng HJ et al., 2007, Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators., Proc Natl Acad Sci U S A
    Bréthous L et al., 2012, Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711)., J Med Chem

  • ChemblInteractions: NACHRA7

    • Version: chembl_23

    Alternate Names:
    NACHRA7 GENE_SYMBOL
    CHRNA7 GENE_SYMBOL
    Neuronal acetylcholine receptor subunit alpha-7 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000175344

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000175344 Gene Symbol
    CHRNA7 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: CHRNA7

    • Version: 01-February-2022

    Alternate Names:
    NACHRA7 GO Gene Synonym

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

  • TTD: Neuronal acetylcholine receptor alpha-7

    • Version: 2020.06.01

    Alternate Names:
    CHRNA7 TTD Gene Abbreviation
    T34429 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: CHRNA7

    • Version: 01-February-2022

    Alternate Names:
    Neuronal acetylcholine receptor subunit alpha-7 Gene Name
    P36544 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21