• Interaction Score: 5.98

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name TC-5214
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 antagonist

    PMIDs:
    None found


  • Interaction Score: 3.99

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Trial Name TC-1734, AZD-3480, ispronicline
    Novel drug target Established target
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

    PMIDs:
    None found


  • Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.99

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

    PMIDs:
    None found


  • Interaction Score: 1.99

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 modulator

    PMIDs:
    None found


  • Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.99

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Nicotinic acetylcholine receptor alpha4/beta2/alpha5 partial agonist
    Direct Interaction yes
    Trial Name pozanicline , ABT-089

    PMIDs:
    None found


  • Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name TC-6499
    Novel drug target Established target
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

    PMIDs:
    None found


  • Interaction Score: 1.59

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    20331614


    Sources:
    TTD

  • Interaction Score: 1.33

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

    PMIDs:
    None found


  • Interaction Score: 1.14

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Trial Name varenicline, CP-526
    Novel drug target Established target

    PMIDs:
    16883648


    Sources:
    TdgClinicalTrial

  • Interaction Score: 1.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist
    Direct Interaction yes
    Trial Name -

    • Version: 101_38

    Alternate Names:
    CHRNB2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, BETA-2 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P17787] Description
    ENSG00000160716 Ensembl Gene Id
    CHRNB2 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    ACHB2_HUMAN Uniprot Id
    1141 Entrez Gene Id
    CHRNB2 Gene Symbol

    Gene Info:
    Target Subclass Ligand_gated_ion_channels
    Target Subclass cys-loop
    Transmembrane Helix Count 4

    Publications:

    • Version: January-2014

    Alternate Names:
    CHRNB2 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.9

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ACHB2_HUMAN Uniprot Id
    NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 Uniprot Protein Name
    P17787 Uniprot Accession

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Neur_channel
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    1962 HUGO Gene ID
    1962 HUGO Gene Symbol
    cholinergic receptor nicotinic beta 2 subunit HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Nicotinic acetylcholine receptors
    GuideToPharmacology Gene Category ID 76

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 18-August-2020
    • Version: 02-September-2020
    • Version: chembl_23

    Alternate Names:
    CHRNB2 GENE_SYMBOL
    Neuronal acetylcholine receptor subunit beta-2 UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000160716 Gene Symbol
    CHRNB2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Alternate Names:
    CHRNB2 TTD Gene Abbreviation
    T82543 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Neuronal acetylcholine receptor subunit beta-2 Gene Name
    P17787 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 01-May-2021

    Alternate Names:

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications: