• Interaction Score: 7.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    20337496 9454827


    Sources:
    DTC

  • Interaction Score: 4.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20337496


    Sources:
    DTC

  • Interaction Score: 4.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23352509


    Sources:
    DTC

  • Interaction Score: 2.45

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 2.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 2.45

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 2.45

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 partial agonist

    PMIDs:
    None found


  • Interaction Score: 1.23

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name varenicline, CP-526
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.7

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist

    PMIDs:
    None found


  • Interaction Score: 0.6

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

  • Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB