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CHUK Gene Record

  • Summary
  • Interactions
  • Claims
  • CHUK 1147 Druggable GenomeDrug Resistance

    Alternate Names:

    1147
    CONSERVED HELIX-LOOP-HELIX UBIQUITOUS KINASE
    CHUK
    IKBKA
    IKK-alpha
    IKK1
    IKKA
    NFKBIKA
    TCF16
    600664
    1974
    ENSG00000213341
    OTTHUMG00000018899
    O15111
    1989
    NP_001269
    NM_001278
    BE0004655
    IKKA_HUMAN
    INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
    ENSG00000107566
    INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE ALPHA SUBUNIT (EC 2.7.1.-) (I KAPPA-B KINASE ALPHA) (IKBKA) (IKK-ALPHA) (IKK-A) (IKAPPAB KINASE) (I-KAPPA-B KINASE 1) (IKK1) (CONSERVED HELIX-LOOP-HELIX UBIQUITOUS KINASE) (NUCLEAR FACTOR NFKAPPAB INHIBITOR KINAS
    component of inhibitor of nuclear factor kappa B kinase complex

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.7.11.10
    GuideToPharmacology Gene Category Name IKK family
    GuideToPharmacology Gene Category ID 578
    Interpro Acc IPR002290
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name KINASE
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUG RESISTANCE
    DRUGGABLE GENOME
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
    Beutler JA et al., 2009, Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition., J Nat Prod
    Weber et al., 2000, Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta., Gastroenterology
    Bantel et al., 2000, Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis., Am. J. Gastroenterol.
    Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.
    Tsutsui C et al., 2009, Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway., Bioorg Med Chem Lett
    Oka et al., 2000, N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinases., FEBS Lett.
  • 2,6-DIDEHYDROPEPEROMIN B   CHUK

    Interaction Score: 9.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19559609


    Sources:
    DTC

  • AILANTHINONE   CHUK

    Interaction Score: 9.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19199792


    Sources:
    DTC

  • GLAUCARUBINONE   CHUK

    Interaction Score: 9.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19199792


    Sources:
    DTC

  • CHEMBL564009   CHUK

    Interaction Score: 9.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19199792


    Sources:
    DTC

  • PEPEROMIN E   CHUK

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19559609


    Sources:
    DTC

  • CHEMBL592893   CHUK

    Interaction Score: 2.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL8483   CHUK

    Interaction Score: 1.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18566250


    Sources:
    DTC

  • MESALAMINE   CHUK

    Interaction Score: 1.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name SPD476,Lialda
    Novel drug target Established target

    PMIDs:
    11054378 11151876 12950415


    Sources:
    TdgClinicalTrial DrugBank

  • SULFASALAZINE   CHUK

    Interaction Score: 0.49

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11054378 12950415


    Sources:
    DrugBank

  • BMS-345541   CHUK

    Interaction Score: 0.47

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ACETYLCYSTEINE   CHUK

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10788610


    Sources:
    DrugBank

  • LAUROGUADINE   CHUK

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000213341

    • Version: 101_38

    Alternate Names:
    CHUK Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: O15111

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000213341 Ensembl Gene Id
    IKKA_HUMAN Uniprot Id
    CHUK Uniprot Gene Name

    Gene Info:
    Interpro Acc IPR002290
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000107566

    • Version: 26-July-2011

    Alternate Names:
    CHUK Display Id
    INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE ALPHA SUBUNIT (EC 2.7.1.-) (I KAPPA-B KINASE ALPHA) (IKBKA) (IKK-ALPHA) (IKK-A) (IKAPPAB KINASE) (I-KAPPA-B KINASE 1) (IKK1) (CONSERVED HELIX-LOOP-HELIX UBIQUITOUS KINASE) (NUCLEAR FACTOR NFKAPPAB INHIBITOR KINAS Description
    ENSG00000107566 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: O15111

    • Version: January-2014

    Alternate Names:
    CHUK Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.10

    Publications:

  • GuideToPharmacology: 1147

    • Version: 29-September-2020

    Alternate Names:
    1974 HUGO Gene ID
    1974 HUGO Gene Symbol
    component of inhibitor of nuclear factor kappa B kinase complex HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name IKK family
    GuideToPharmacology Gene Category ID 578

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0004655

    • Version: 5.1.7

    Alternate Names:
    CHUK DrugBank Gene Name
    O15111 UniProt Accession
    1147 Entrez Gene Id

    Gene Info:

    Publications:
    Weber et al., 2000, Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta., Gastroenterology
    Bantel et al., 2000, Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis., Am. J. Gastroenterol.
    Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.

  • NCI: CHUK

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Bowie et al., 2000, Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase., J. Immunol.

  • DTC: CHUK

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
    Beutler JA et al., 2009, Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition., J Nat Prod
    Tsutsui C et al., 2009, Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000213341

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000213341 Gene Symbol
    CHUK Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: CHUK

    • Version: 19.3

    Alternate Names:
    ENSG00000213341 Ensembl Gene ID
    IkBKA Human Protein Atlas Gene Synonym
    IKK-alpha Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: CHUK

    • Version: 03-September-2020

    Alternate Names:
    Inhibitor of nuclear factor kappa-B kinase subunit alpha Gene Name
    O15111 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • GO: CHUK

    • Version: 05-September-2020

    Alternate Names:
    IKKA GO Gene Synonym
    TCF16 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE, DRUG RESISTANCE

    Publications:

  • dGene: CHUK

    • Version: 27-Jun-2013

    Alternate Names:
    1147 Gene ID
    IKBKA dGene Synonym
    IKK-alpha dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21