DGIdb - COL18A1 Gene Record

COL18A1 80781 Druggable GenomeDrug Resistance

Alternate Names:

80781
COLLAGEN TYPE XVIII ALPHA 1 CHAIN
COL18A1
KNO
KNO1
KS
120328
2195
ENSG00000182871
OTTHUMG00000090407
PA26711
collagen, type XVIII, alpha 1
Endostatin
Collagen alpha-1(XVIII) chain
COIA1_HUMAN
P39060
T75788
GLCC

Gene Info:

Has Variant Annotation	true
Is VIP	false
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
DRUGGABLE GENOME

Publications:

Zhou et al., 2006, [The effect of glutamine on the growth, metabolism and endostatin production of microencapsulated rCHO cells]., Sheng Wu Gong Cheng Xue Bao
Ma et al., 2001, Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release., Proc. Natl. Acad. Sci. U.S.A.
Nilsson et al., 2006, Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast cancer in vivo., Cancer Res.
Ma et al., 2005, Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets., Proc. Natl. Acad. Sci. U.S.A.
Hong et al., 2004, Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model., World J. Gastroenterol.
Ma et al., 2002, Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance., Proc. Natl. Acad. Sci. U.S.A.

OCRIPLASMIN COL18A1

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Collagen hydrolytic enzyme

Direct Interaction yes

Publications:
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM COL18A1

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Collagen hydrolytic enzyme

Direct Interaction yes

Publications:
GLUTAMINE COL18A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Zhou et al., 2006, [The effect of glutamine on the growth, metabolism and endostatin production of microencapsulated rCHO cells]., Sheng Wu Gong Cheng Xue Bao
ASPIRIN COL18A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ma et al., 2001, Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release., Proc. Natl. Acad. Sci. U.S.A.
TAMOXIFEN COL18A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Nilsson et al., 2006, Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast cancer in vivo., Cancer Res.
THROMBIN COL18A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ma et al., 2005, Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets., Proc. Natl. Acad. Sci. U.S.A.
CAMPTOTHECIN COL18A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hong et al., 2004, Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model., World J. Gastroenterol.
CELECOXIB COL18A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ma et al., 2002, Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance., Proc. Natl. Acad. Sci. U.S.A.

Ensembl: ENSG00000182871
- Version: 101_38
Alternate Names:

COL18A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

NCI: COL18A1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ma et al., 2001, Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release., Proc. Natl. Acad. Sci. U.S.A.

Ma et al., 2005, Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets., Proc. Natl. Acad. Sci. U.S.A.

Wu et al., 2004, The effects of surgery, with or without rhGM-CSF, on the angiogenic profile of patients treated for colorectal carcinoma., Cytokine

ChemblInteractions: COL18A1
- Version: chembl_23
Alternate Names:

COL18A1 GENE_SYMBOL

Collagen alpha-1(XVIII) chain UNIPROT

Endostatin UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000182871
- Version: 31-May-2017
Alternate Names:

ENSG00000182871 Gene Symbol

COL18A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Endostatin
- Version: 2020.06.01
Alternate Names:

COL18A1 TTD Gene Abbreviation

T75788 TTD Target ID

Gene Info:

Publications:
GO: COL18A1
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Mechanism of Interaction	Collagen hydrolytic enzyme
Direct Interaction	yes

COL18A1	GENE_SYMBOL
Collagen alpha-1(XVIII) chain	UNIPROT
Endostatin	UNIPROT

COL18A1 Gene Record

COL18A1 80781 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Collagen hydrolytic enzyme Direct Interaction yes

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Collagen hydrolytic enzyme Direct Interaction yes

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Zhou et al., 2006, [The effect of glutamine on the growth, metabolism and endostatin production of microencapsulated rCHO cells]., Sheng Wu Gong Cheng Xue Bao

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ma et al., 2001, Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release., Proc. Natl. Acad. Sci. U.S.A.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Nilsson et al., 2006, Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast cancer in vivo., Cancer Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ma et al., 2005, Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets., Proc. Natl. Acad. Sci. U.S.A.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Hong et al., 2004, Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model., World J. Gastroenterol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ma et al., 2002, Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance., Proc. Natl. Acad. Sci. U.S.A.

Ensembl: ENSG00000182871

Alternate Names: COL18A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

NCI: COL18A1

Alternate Names:

Gene Info:

ChemblInteractions: COL18A1

Alternate Names: COL18A1 GENE_SYMBOL Collagen alpha-1(XVIII) chain UNIPROT Endostatin UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000182871

Alternate Names: ENSG00000182871 Gene Symbol COL18A1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Endostatin

Alternate Names: COL18A1 TTD Gene Abbreviation T75788 TTD Target ID

Gene Info:

Publications:

GO: COL18A1

Alternate Names:

Gene Info:

Gene Categories: DRUG RESISTANCE

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Collagen hydrolytic enzyme

Direct Interaction yes

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Collagen hydrolytic enzyme

Direct Interaction yes

Interaction Types & Directionality:

n/a

Publications:

Zhou et al., 2006, [The effect of glutamine on the growth, metabolism and endostatin production of microencapsulated rCHO cells]., Sheng Wu Gong Cheng Xue Bao

Interaction Types & Directionality:

n/a

Publications:

Ma et al., 2001, Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release., Proc. Natl. Acad. Sci. U.S.A.

Interaction Types & Directionality:

n/a

Publications:

Nilsson et al., 2006, Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast cancer in vivo., Cancer Res.

Interaction Types & Directionality:

n/a

Publications:

Ma et al., 2005, Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets., Proc. Natl. Acad. Sci. U.S.A.

Interaction Types & Directionality:

n/a

Publications:

Hong et al., 2004, Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model., World J. Gastroenterol.

Interaction Types & Directionality:

n/a

Publications:

Ma et al., 2002, Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance., Proc. Natl. Acad. Sci. U.S.A.

Alternate Names:

COL18A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

COL18A1 GENE_SYMBOL

Collagen alpha-1(XVIII) chain UNIPROT

Endostatin UNIPROT

Alternate Names:

ENSG00000182871 Gene Symbol

COL18A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

COL18A1 TTD Gene Abbreviation

T75788 TTD Target ID

Gene Categories:

DRUG RESISTANCE