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COL18A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • COL18A1 80781 Druggable Genome

    Alternate Names:

    80781
    COLLAGEN TYPE XVIII ALPHA 1 CHAIN
    COL18A1
    KNO
    KNO1
    KS
    120328
    2195
    ENSG00000182871
    OTTHUMG00000090407
    Endostatin
    Collagen alpha-1(XVIII) chain
    T75788
    GLCC

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Zhou et al., 2006, [The effect of glutamine on the growth, metabolism and endostatin production of microencapsulated rCHO cells]., Sheng Wu Gong Cheng Xue Bao
    Ma et al., 2001, Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release., Proc. Natl. Acad. Sci. U.S.A.
    Nilsson et al., 2006, Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast cancer in vivo., Cancer Res.
    Ma et al., 2005, Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets., Proc. Natl. Acad. Sci. U.S.A.
    Hong et al., 2004, Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model., World J. Gastroenterol.
    Ma et al., 2002, Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance., Proc. Natl. Acad. Sci. U.S.A.
  • GLUTAMINE   COL18A1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16572858


    Sources:
    NCI

  • THROMBIN   COL18A1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15615851


    Sources:
    NCI

  • CAMPTOTHECIN   COL18A1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15069724


    Sources:
    NCI

  • COLLAGENASE CLOSTRIDIUM HISTOLYTICUM   COL18A1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Collagen hydrolytic enzyme
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TAMOXIFEN   COL18A1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16651433


    Sources:
    NCI

  • CELECOXIB   COL18A1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12232050


    Sources:
    NCI

  • ASPIRIN   COL18A1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11353854


    Sources:
    NCI

  • OCRIPLASMIN   COL18A1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Collagen hydrolytic enzyme
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000182871

    • Version: 101_38

    Alternate Names:
    COL18A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: COL18A1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ma et al., 2001, Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release., Proc. Natl. Acad. Sci. U.S.A.
    Ma et al., 2005, Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets., Proc. Natl. Acad. Sci. U.S.A.
    Wu et al., 2004, The effects of surgery, with or without rhGM-CSF, on the angiogenic profile of patients treated for colorectal carcinoma., Cytokine

  • ChemblInteractions: COL18A1

    • Version: chembl_23

    Alternate Names:
    COL18A1 GENE_SYMBOL
    Collagen alpha-1(XVIII) chain UNIPROT
    Endostatin UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000182871

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000182871 Gene Symbol
    COL18A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Endostatin

    • Version: 2020.06.01

    Alternate Names:
    COL18A1 TTD Gene Abbreviation
    T75788 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21