• Interaction Score: 21.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Details of the Assay for Interaction Inhibition of LPS-induced IL-1β production by human peripheral blood mononuclear cells.
    Specific Action of the Ligand Binding
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 21.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction CRL4(CRBN) E3 ubiquitin ligase inhibitor
    Direct Interaction yes
    Details of the Assay for Interaction Measuring displacement of a Cy5-conjugated cereblon modulating compound from the binding pocket of CRBN by pomalidomide.

  • Interaction Score: 10.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 10.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Details of the Assay for Interaction Measuring displacement of a Cy5-conjugated cereblon modulating compound from the binding pocket of CRBN by CC-220.
    Specific Action of the Ligand Binding
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 4.56

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Drug family Immunomodulator
    Alteration CRBN:under
    Alteration CRBN:Q100*,R283K

  • Interaction Score: 0.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Binding