DGIdb - CRBN Gene Record

CRBN 51185 Drug Resistance

Alternate Names:

51185
CEREBLON
CRBN
MRT2
MRT2A
609262
30185
ENSG00000113851
OTTHUMG00000090261
Q96SW2
Protein cereblon
11761
T27861
3086
NM_016302
NP_057386

Gene Info:

Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	E3 ubiquitin ligase components
GuideToPharmacology Gene Category ID	1023

(2 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
ENZYME

Publications:

Egan et al., 2013, Extramedullary myeloma whole genome sequencing reveals novel mutations in Cereblon, proteasome subunit G2 and the glucocorticoid receptor in multi drug resistant disease., Br. J. Haematol.
McCurdy et al., 2013, Pomalidomide and its clinical potential for relapsed or refractory multiple myeloma: an update for the hematologist., Ther Adv Hematol
Ito et al., 2010, Identification of a primary target of thalidomide teratogenicity., Science
Lopez-Girona et al., 2012, Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide., Leukemia
Zhu et al., 2013, Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma., Leuk. Lymphoma

AVADOMIDE CRBN

Interaction Score: 21.26

Interaction Types & Directionality:

n/a

Interaction Info:

Details of the Assay for Interaction Inhibition of LPS-induced IL-1β production by human peripheral blood mononuclear cells.

Specific Action of the Ligand Binding

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD

POMALIDOMIDE CRBN

Interaction Score: 21.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction CRL4(CRBN) E3 ubiquitin ligase inhibitor

Direct Interaction yes

Details of the Assay for Interaction Measuring displacement of a Cy5-conjugated cereblon modulating compound from the binding pocket of CRBN by pomalidomide.

PMIDs:
23480694 23730498 20223979 22552008

Sources:
ChemblInteractions CGI CIViC GuideToPharmacology

IBERDOMIDE HYDROCHLORIDE CRBN

Interaction Score: 10.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

IBERDOMIDE CRBN

Interaction Score: 10.63

Interaction Types & Directionality:

n/a

Interaction Info:

Details of the Assay for Interaction Measuring displacement of a Cy5-conjugated cereblon modulating compound from the binding pocket of CRBN by CC-220.

Specific Action of the Ligand Binding

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

LENALIDOMIDE CRBN

Interaction Score: 4.56

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Drug family Immunomodulator

Alteration CRBN:under

Alteration CRBN:Q100*,R283K

PMIDs:
22966948 23480694

Sources:
ChemblInteractions CGI CIViC GuideToPharmacology
THALIDOMIDE CRBN

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Binding

PMIDs:
22966948

Sources:
ChemblInteractions GuideToPharmacology

Ensembl: ENSG00000113851
- Version: 101_38
Alternate Names:

CRBN Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 51185
- Version: 29-September-2020
Alternate Names:

30185 HUGO Gene ID

30185 HUGO Gene Symbol

cereblon HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name E3 ubiquitin ligase components

GuideToPharmacology Gene Category ID 1023

Gene Categories:

ENZYME

Publications:

CIViC: CRBN

Version: 14-September-2020

Alternate Names:

51185 Entrez Gene ID

11761 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Egan et al., 2013, Extramedullary myeloma whole genome sequencing reveals novel mutations in Cereblon, proteasome subunit G2 and the glucocorticoid receptor in multi drug resistant disease., Br. J. Haematol.

ChemblInteractions: CRBN
- Version: chembl_23
Alternate Names:

CRBN GENE_SYMBOL

Protein cereblon UNIPROT

Gene Info:

Publications:
TTD: Protein cereblon
- Version: 2020.06.01
Alternate Names:

CRBN TTD Gene Abbreviation

T27861 TTD Target ID

Gene Info:

Publications:
CGI: CRBN
- Version: 27-September-2017
Alternate Names:

Gene Info:

Publications:

Details of the Assay for Interaction	Inhibition of LPS-induced IL-1β production by human peripheral blood mononuclear cells.
Specific Action of the Ligand	Binding
Endogenous Drug?	False

Mechanism of Interaction	CRL4(CRBN) E3 ubiquitin ligase inhibitor
Direct Interaction	yes
Details of the Assay for Interaction	Measuring displacement of a Cy5-conjugated cereblon modulating compound from the binding pocket of CRBN by pomalidomide.

Drug family	Immunomodulator
Alteration	CRBN:under
Alteration	CRBN:Q100*,R283K

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Binding

30185	HUGO Gene ID
30185	HUGO Gene Symbol
cereblon	HUGO Gene Name

CRBN	TTD Gene Abbreviation
T27861	TTD Target ID

CRBN Gene Record

CRBN 51185 Drug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

AVADOMIDE CRBN

Interaction Types & Directionality: n/a

Interaction Info: Details of the Assay for Interaction Inhibition of LPS-induced IL-1&beta; production by human peripheral blood mononuclear cells. Specific Action of the Ligand Binding Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology TTD

POMALIDOMIDE CRBN

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction CRL4(CRBN) E3 ubiquitin ligase inhibitor Direct Interaction yes Details of the Assay for Interaction Measuring displacement of a Cy5-conjugated cereblon modulating compound from the binding pocket of CRBN by pomalidomide.

PMIDs: 23480694 23730498 20223979 22552008

Sources: ChemblInteractions CGI CIViC GuideToPharmacology

IBERDOMIDE HYDROCHLORIDE CRBN

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

IBERDOMIDE CRBN

Interaction Types & Directionality: n/a

Interaction Info: Details of the Assay for Interaction Measuring displacement of a Cy5-conjugated cereblon modulating compound from the binding pocket of CRBN by CC-220. Specific Action of the Ligand Binding Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

LENALIDOMIDE CRBN

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Drug family Immunomodulator Alteration CRBN:under Alteration CRBN:Q100*,R283K

PMIDs: 22966948 23480694

Sources: ChemblInteractions CGI CIViC GuideToPharmacology

THALIDOMIDE CRBN

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Binding

PMIDs: 22966948

Sources: ChemblInteractions GuideToPharmacology

Ensembl: ENSG00000113851

Alternate Names: CRBN Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 51185

Alternate Names: 30185 HUGO Gene ID 30185 HUGO Gene Symbol cereblon HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name E3 ubiquitin ligase components GuideToPharmacology Gene Category ID 1023

Gene Categories: ENZYME

Publications:

CIViC: CRBN

Alternate Names: 51185 Entrez Gene ID 11761 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

Publications: Egan et al., 2013, Extramedullary myeloma whole genome sequencing reveals novel mutations in Cereblon, proteasome subunit G2 and the glucocorticoid receptor in multi drug resistant disease., Br. J. Haematol.

ChemblInteractions: CRBN

Alternate Names: CRBN GENE_SYMBOL Protein cereblon UNIPROT

Gene Info:

Publications:

TTD: Protein cereblon

Alternate Names: CRBN TTD Gene Abbreviation T27861 TTD Target ID

Gene Info:

Publications:

CGI: CRBN

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Details of the Assay for Interaction Inhibition of LPS-induced IL-1β production by human peripheral blood mononuclear cells.

Specific Action of the Ligand Binding

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction CRL4(CRBN) E3 ubiquitin ligase inhibitor

Direct Interaction yes

Details of the Assay for Interaction Measuring displacement of a Cy5-conjugated cereblon modulating compound from the binding pocket of CRBN by pomalidomide.

PMIDs:
23480694 23730498 20223979 22552008

Sources:
ChemblInteractions CGI CIViC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Details of the Assay for Interaction Measuring displacement of a Cy5-conjugated cereblon modulating compound from the binding pocket of CRBN by CC-220.

Specific Action of the Ligand Binding

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Drug family Immunomodulator

Alteration CRBN:under

Alteration CRBN:Q100*,R283K

PMIDs:
22966948 23480694

Sources:
ChemblInteractions CGI CIViC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Binding

PMIDs:
22966948

Sources:
ChemblInteractions GuideToPharmacology

Alternate Names:

CRBN Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

30185 HUGO Gene ID

30185 HUGO Gene Symbol

cereblon HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name E3 ubiquitin ligase components

GuideToPharmacology Gene Category ID 1023

Gene Categories:

ENZYME

Alternate Names:

51185 Entrez Gene ID

11761 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Publications:

Egan et al., 2013, Extramedullary myeloma whole genome sequencing reveals novel mutations in Cereblon, proteasome subunit G2 and the glucocorticoid receptor in multi drug resistant disease., Br. J. Haematol.

Alternate Names:

CRBN GENE_SYMBOL

Protein cereblon UNIPROT

Alternate Names:

CRBN TTD Gene Abbreviation

T27861 TTD Target ID