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CRBN Gene Record

  • Summary
  • Interactions
  • Claims
  • CRBN 51185 Drug Resistance

    Alternate Names:

    51185
    CEREBLON
    CRBN
    MRT2
    MRT2A
    609262
    30185
    ENSG00000113851
    OTTHUMG00000090261
    Protein cereblon
    11761
    T27861

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    DRUG RESISTANCE

    Publications:

    Egan et al., 2013, Extramedullary myeloma whole genome sequencing reveals novel mutations in Cereblon, proteasome subunit G2 and the glucocorticoid receptor in multi drug resistant disease., Br. J. Haematol.
    McCurdy et al., 2013, Pomalidomide and its clinical potential for relapsed or refractory multiple myeloma: an update for the hematologist., Ther Adv Hematol
    Ito et al., 2010, Identification of a primary target of thalidomide teratogenicity., Science
    Lopez-Girona et al., 2012, Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide., Leukemia
    Zhu et al., 2013, Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma., Leuk. Lymphoma
  • POMALIDOMIDE   CRBN

    Interaction Score: 18.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction CRL4(CRBN) E3 ubiquitin ligase inhibitor
    Direct Interaction yes

    PMIDs:
    23480694 23730498 20223979 22552008


    Sources:
    ChemblInteractions CIViC

  • IBERDOMIDE HYDROCHLORIDE   CRBN

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • AVADOMIDE   CRBN

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LENALIDOMIDE   CRBN

    Interaction Score: 3.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction CRL4(CRBN) E3 ubiquitin ligase inhibitor
    Direct Interaction yes

    PMIDs:
    22966948 23480694


    Sources:
    ChemblInteractions CIViC

  • THALIDOMIDE   CRBN

    Interaction Score: 0.71

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction CRL4(CRBN) E3 ubiquitin ligase inhibitor

    PMIDs:
    22966948


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000113851

    • Version: 101_38

    Alternate Names:
    CRBN Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: CRBN

    • Version: 14-September-2020

    Alternate Names:
    51185 Entrez Gene ID
    11761 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Egan et al., 2013, Extramedullary myeloma whole genome sequencing reveals novel mutations in Cereblon, proteasome subunit G2 and the glucocorticoid receptor in multi drug resistant disease., Br. J. Haematol.

  • ChemblInteractions: CRBN

    • Version: chembl_23

    Alternate Names:
    CRBN GENE_SYMBOL
    Protein cereblon UNIPROT

    Gene Info:

    Publications:

  • TTD: Protein cereblon

    • Version: 2020.06.01

    Alternate Names:
    CRBN TTD Gene Abbreviation
    T27861 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21