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CRKL Gene Record

  • Summary
  • Interactions
  • Claims
  • CRKL 1399 Clinically ActionableDrug Resistance

    Alternate Names:

    1399
    CRK LIKE PROTO-ONCOGENE, ADAPTOR PROTEIN
    CRKL
    602007
    2363
    ENSG00000099942
    OTTHUMG00000150807
    1204
    Crk-like protein
    P46109

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUG RESISTANCE
    CLINICALLY ACTIONABLE

    Publications:

    Cheung HW et al., 2011, Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers., Cancer Discov
    Natsume H et al., 2012, The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer., J Transl Med
  • GEFITINIB   CRKL

    Interaction Score: 0.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22586683


    Sources:
    CIViC

  • DASATINIB   CRKL

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22591714


    Sources:
    CIViC

  • Ensembl: ENSG00000099942

    • Version: 101_38

    Alternate Names:
    CRKL Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: CRKL

    • Version: 14-September-2020

    Alternate Names:
    1399 Entrez Gene ID
    1204 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Cheung HW et al., 2011, Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers., Cancer Discov
    Natsume H et al., 2012, The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer., J Transl Med

  • Tempus: CRKL

    • Version: 11-November-2018

    Alternate Names:
    CRKL Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: CRKL

    • Version: 01-February-2022

    Alternate Names:
    Crk-like protein Gene Name
    P46109 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MskImpact: CRKL

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: CRKL

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: CRKL

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21