DGIdb - CSF3R Gene Record

CSF3R 1441 Druggable GenomeClinically Actionable

Alternate Names:

1441
COLONY STIMULATING FACTOR 3 RECEPTOR
CSF3R
CD114
GCSFR
SCN7
138971
2439
ENSG00000119535
OTTHUMG00000008010
CD_antigen=CD114
G-CSF-R
Granulocyte colony-stimulating factor receptor
G-CSF receptor
1719
Q99062
CSF3R_HUMAN
BE0000793
1239
T98913

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	Type 1 cytokine receptor
Target Main Class	Receptors
Target Subclass	CytokineR
Transmembrane Helix Count	1
Target Subclass	Type1
Target Subclass	IG
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Prolactin receptor family
GuideToPharmacology Gene Category ID	309

(12 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Zhuang et al., 2005, Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1., J. Leukoc. Biol.
Cao et al., 2005, [The response of bone marrow hematopoietic cells to G-CSF in paroxysmal nocturnal hemoglobinuria patients]., Zhonghua Xue Ye Xue Za Zhi
Erkeland et al., 2007, Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling., Oncogene
Link et al., 2007, Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia., Blood
Ward, 2007, The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease., Front. Biosci.
Kotto-Kome et al., 2004, Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model., Pharmacol. Res.
Elsässer et al., 2003, The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner., Oncogene
Maxson et al., 2016, The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I., Clin. Cancer Res.
Dao KH et al., 2014, Significant clinical response to JAK1/2 inhibition in a patient with CSF3R-T618I-positive atypical chronic myeloid leukemia., Leuk Res Rep
Fleischman et al., 2013, The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition., Blood
2013, Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia., N. Engl. J. Med.
Maxson et al., 2013, Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML., N. Engl. J. Med.
Coniglio SJ et al., 2012, Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling., Mol Med

PEGFILGRASTIM CSF3R

Interaction Score: 68.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

Trial Name pegfilgrastim,N/

PMIDs:
16033816 15082029 17001306 15949269 17127322 12944913

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
LIPEGFILGRASTIM CSF3R

Interaction Score: 11.36

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
DrugBank ChemblInteractions
PLX-5622 CSF3R

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22294205

Sources:
TTD
BALUGRASTIM CSF3R

Interaction Score: 5.68

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DETUMOMAB CSF3R

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
LENOGRASTIM CSF3R

Interaction Score: 5.68

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
FILGRASTIM CSF3R

Interaction Score: 5.21

Interaction Types & Directionality:

agonist (activating)

stimulator (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? True

Trial Name topical filgrastim, Nupen

PMIDs:
16033816 15949269 17001306 17494858 17127322

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
RUXOLITINIB CSF3R

Interaction Score: 3.79

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical

PMIDs:
26475333 25180155 24081659 23634996 23656643

Sources:
JAX-CKB DoCM CIViC
PEXIDARTINIB CSF3R

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DASATINIB CSF3R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family BCR-ABL inhibitor 2nd gen

Alteration CSF3R:Q741.,Y752.,W791.,T615A,T618I

PMIDs:
None found

Sources:
CGI

Ensembl: ENSG00000119535
- Version: 101_38
Alternate Names:

CSF3R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: Q99062
- Version: 01-August-2011
Alternate Names:

CSF3R Gene Symbol

1441 Entrez Gene Id

ENSG00000119535 Ensembl Gene Id

Gene Info:

Target Main Class Receptors

Target Subclass CytokineR

Transmembrane Helix Count 1

Publications:
TdgClinicalTrial: Q99062
- Version: January-2014
Alternate Names:

CSF3R Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Publications:
GuideToPharmacology: 1441
- Version: 29-September-2020
Alternate Names:

2439 HUGO Gene ID

2439 HUGO Gene Symbol

colony stimulating factor 3 receptor HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Prolactin receptor family

GuideToPharmacology Gene Category ID 309

Publications:

JAX-CKB: CSF3R

Version: 27-September-2017

Alternate Names:

1441 CKB Entrez Id

CSF3R CKB Gene Synonym

CD114 CKB Gene Synonym

Gene Info:

Publications:

Fleischman et al., 2013, The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition., Blood

Maxson et al., 2013, Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML., N. Engl. J. Med.

Tefferi et al., 2014, An overview on CALR and CSF3R mutations and a proposal for revision of WHO diagnostic criteria for myeloproliferative neoplasms., Leukemia

CIViC: CSF3R

Version: 14-September-2020

Alternate Names:

1441 Entrez Gene ID

1239 CIViC Gene ID

Gene Info:

Publications:

Fleischman et al., 2013, The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition., Blood

Dao KH et al., 2014, Significant clinical response to JAK1/2 inhibition in a patient with CSF3R-T618I-positive atypical chronic myeloid leukemia., Leuk Res Rep

DrugBank: BE0000793

Version: 5.1.7

Alternate Names:

CSF3R DrugBank Gene Name

Q99062 UniProt Accession

1441 Entrez Gene Id

Gene Info:

Publications:

Ward, 2007, The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease., Front. Biosci.

Erkeland et al., 2007, Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling., Oncogene

Zhuang et al., 2005, Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1., J. Leukoc. Biol.

TTD: Granulocyte colony-stimulating factor receptor

Version: 2020.06.01

Alternate Names:

G-CSF-R TTD Gene Abbreviation

T98913 TTD Target ID

Gene Info:

Publications:

Varki R et al., 2009, A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study., BMC Clin Pharmacol

Coniglio SJ et al., 2012, Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling., Mol Med

DoCM: CSF3R

Version: 27-September-2017

Alternate Names:

Gene Info:

Publications:

Maxson et al., 2013, Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML., N. Engl. J. Med.

2013, Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia., N. Engl. J. Med.

ChemblInteractions: GCSFR
- Version: chembl_23
Alternate Names:

GCSFR GENE_SYMBOL

CSF3R GENE_SYMBOL

Granulocyte colony-stimulating factor receptor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000119535
- Version: 31-May-2017
Alternate Names:

ENSG00000119535 Gene Symbol

CSF3R Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: CSF3R
- Version: 05-September-2020
Alternate Names:

GCSFR GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
Tempus: CSF3R
- Version: 11-November-2018
Alternate Names:

CSF3R Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CGI: CSF3R
- Version: 27-September-2017
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: CSF3R
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: CSF3R
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Direct Interaction	yes
Mechanism of Interaction	Granulocyte colony stimulating factor receptor agonist
Trial Name	pegfilgrastim,N/

Specific Action of the Ligand	Agonist
Endogenous Drug?	True
Trial Name	topical filgrastim, Nupen

Indication/Tumor Type	Advanced Solid Tumor
Response Type	sensitive
Approval Status	Preclinical

Drug family	BCR-ABL inhibitor 2nd gen
Alteration	CSF3R:Q741.,Y752.,W791.,T615A,T618I

CSF3R	Gene Symbol
1441	Entrez Gene Id
ENSG00000119535	Ensembl Gene Id

2439	HUGO Gene ID
2439	HUGO Gene Symbol
colony stimulating factor 3 receptor	HUGO Gene Name

CSF3R	DrugBank Gene Name
Q99062	UniProt Accession
1441	Entrez Gene Id

GCSFR	GENE_SYMBOL
CSF3R	GENE_SYMBOL
Granulocyte colony-stimulating factor receptor	UNIPROT

agonist (activating)
stimulator (activating)

CSF3R Gene Record

CSF3R 1441 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist Trial Name pegfilgrastim,N/

PMIDs: 16033816 15082029 17001306 15949269 17127322 12944913

Sources: DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist Direct Interaction yes

PMIDs: None found

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22294205

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: agonist (activating) stimulator (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? True Trial Name topical filgrastim, Nupen

PMIDs: 16033816 15949269 17001306 17494858 17127322

Sources: DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type Advanced Solid Tumor Response Type sensitive Approval Status Preclinical

PMIDs: 26475333 25180155 24081659 23634996 23656643

Sources: JAX-CKB DoCM CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Drug family BCR-ABL inhibitor 2nd gen Alteration CSF3R:Q741.,Y752.,W791.,T615A,T618I

PMIDs: None found

Sources: CGI

Ensembl: ENSG00000119535

Alternate Names: CSF3R Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: Q99062

Alternate Names: CSF3R Gene Symbol 1441 Entrez Gene Id ENSG00000119535 Ensembl Gene Id

Gene Info: Target Main Class Receptors Target Subclass CytokineR Transmembrane Helix Count 1

Publications:

TdgClinicalTrial: Q99062

Alternate Names: CSF3R Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass Type 1 cytokine receptor

Publications:

GuideToPharmacology: 1441

Alternate Names: 2439 HUGO Gene ID 2439 HUGO Gene Symbol colony stimulating factor 3 receptor HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Prolactin receptor family GuideToPharmacology Gene Category ID 309

Publications:

JAX-CKB: CSF3R

Alternate Names: 1441 CKB Entrez Id CSF3R CKB Gene Synonym CD114 CKB Gene Synonym

Gene Info:

CIViC: CSF3R

Alternate Names: 1441 Entrez Gene ID 1239 CIViC Gene ID

Gene Info:

DrugBank: BE0000793

Alternate Names: CSF3R DrugBank Gene Name Q99062 UniProt Accession 1441 Entrez Gene Id

Gene Info:

TTD: Granulocyte colony-stimulating factor receptor

Alternate Names: G-CSF-R TTD Gene Abbreviation T98913 TTD Target ID

Gene Info:

DoCM: CSF3R

Alternate Names:

Gene Info:

Publications: Maxson et al., 2013, Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML., N. Engl. J. Med. 2013, Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia., N. Engl. J. Med.

ChemblInteractions: GCSFR

Alternate Names: GCSFR GENE_SYMBOL CSF3R GENE_SYMBOL Granulocyte colony-stimulating factor receptor UNIPROT

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

Trial Name pegfilgrastim,N/

PMIDs:
16033816 15082029 17001306 15949269 17127322 12944913

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22294205

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

stimulator (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? True

Trial Name topical filgrastim, Nupen

PMIDs:
16033816 15949269 17001306 17494858 17127322

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical

PMIDs:
26475333 25180155 24081659 23634996 23656643

Sources:
JAX-CKB DoCM CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family BCR-ABL inhibitor 2nd gen

Alteration CSF3R:Q741.,Y752.,W791.,T615A,T618I

PMIDs:
None found

Sources:
CGI

Alternate Names:

CSF3R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CSF3R Gene Symbol

1441 Entrez Gene Id

ENSG00000119535 Ensembl Gene Id

Gene Info:

Target Main Class Receptors

Target Subclass CytokineR

Transmembrane Helix Count 1

Alternate Names:

CSF3R Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Alternate Names:

2439 HUGO Gene ID

2439 HUGO Gene Symbol

colony stimulating factor 3 receptor HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Prolactin receptor family

GuideToPharmacology Gene Category ID 309

Alternate Names:

1441 CKB Entrez Id

CSF3R CKB Gene Synonym

CD114 CKB Gene Synonym

Alternate Names:

1441 Entrez Gene ID

1239 CIViC Gene ID

Alternate Names:

CSF3R DrugBank Gene Name

Q99062 UniProt Accession

1441 Entrez Gene Id

Alternate Names:

G-CSF-R TTD Gene Abbreviation

T98913 TTD Target ID

Publications:

Maxson et al., 2013, Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML., N. Engl. J. Med.

2013, Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia., N. Engl. J. Med.

Alternate Names:

GCSFR GENE_SYMBOL

CSF3R GENE_SYMBOL

Granulocyte colony-stimulating factor receptor UNIPROT

Alternate Names:

ENSG00000119535 Gene Symbol

CSF3R Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GCSFR GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

CSF3R Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE