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CSF3R Gene Record

  • Summary
  • Interactions
  • Claims
  • CSF3R 1441 Druggable GenomeClinically Actionable

    Alternate Names:

    1441
    COLONY STIMULATING FACTOR 3 RECEPTOR
    CSF3R
    CD114
    GCSFR
    SCN7
    138971
    2439
    ENSG00000119535
    OTTHUMG00000008010
    CD_antigen=CD114
    G-CSF-R
    Granulocyte colony-stimulating factor receptor
    G-CSF receptor
    Q99062
    CSF3R_HUMAN
    1239
    T98913

    Gene Info:

    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 1 cytokine receptor
    Target Main Class Receptors
    Target Subclass CytokineR
    Transmembrane Helix Count 1
    Target Subclass Type1
    Target Subclass IG
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Zhuang et al., 2005, Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1., J. Leukoc. Biol.
    Cao et al., 2005, [The response of bone marrow hematopoietic cells to G-CSF in paroxysmal nocturnal hemoglobinuria patients]., Zhonghua Xue Ye Xue Za Zhi
    Erkeland et al., 2007, Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling., Oncogene
    Link et al., 2007, Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia., Blood
    Ward, 2007, The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease., Front. Biosci.
    Kotto-Kome et al., 2004, Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model., Pharmacol. Res.
    Elsässer et al., 2003, The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner., Oncogene
    Maxson et al., 2016, The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I., Clin. Cancer Res.
    Dao KH et al., 2014, Significant clinical response to JAK1/2 inhibition in a patient with CSF3R-T618I-positive atypical chronic myeloid leukemia., Leuk Res Rep
    Fleischman et al., 2013, The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition., Blood
    2013, Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia., N. Engl. J. Med.
    Maxson et al., 2013, Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML., N. Engl. J. Med.
    Coniglio SJ et al., 2012, Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling., Mol Med
  • PEGFILGRASTIM   CSF3R

    Interaction Score: 88.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist
    Trial Name pegfilgrastim,N/

    PMIDs:
    16033816 15082029 17001306 15949269 17127322 12944913


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • PLX-5622   CSF3R

    Interaction Score: 8.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22294205


    Sources:
    TTD

  • LIPEGFILGRASTIM   CSF3R

    Interaction Score: 8.83

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BALUGRASTIM   CSF3R

    Interaction Score: 8.83

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FILGRASTIM   CSF3R

    Interaction Score: 7.95

    Interaction Types & Directionality:
    agonist (activating)
    stimulator (activating)

    Interaction Info:
    Trial Name topical filgrastim, Nupen
    Novel drug target Established target
    Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

    PMIDs:
    16033816 15949269 17001306 17494858 17127322


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • RUXOLITINIB   CSF3R

    Interaction Score: 7.85

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type Advanced Solid Tumor
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    26475333 25180155 24081659 23634996 23656643


    Sources:
    JAX-CKB DoCM CIViC

  • PEXIDARTINIB   CSF3R

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000119535

    • Version: 101_38

    Alternate Names:
    CSF3R Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: Q99062

    • Version: 01-August-2011

    Alternate Names:
    CSF3R Gene Symbol
    1441 Entrez Gene Id
    ENSG00000119535 Ensembl Gene Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass CytokineR
    Transmembrane Helix Count 1

    Publications:

  • TdgClinicalTrial: Q99062

    • Version: January-2014

    Alternate Names:
    CSF3R Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 1 cytokine receptor

    Publications:

  • JAX-CKB: CSF3R

    • Version: 27-September-2017

    Alternate Names:
    1441 CKB Entrez Id
    CSF3R CKB Gene Synonym
    CD114 CKB Gene Synonym

    Gene Info:

    Publications:
    Maxson et al., 2013, Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML., N. Engl. J. Med.
    Tefferi et al., 2014, An overview on CALR and CSF3R mutations and a proposal for revision of WHO diagnostic criteria for myeloproliferative neoplasms., Leukemia
    Fleischman et al., 2013, The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition., Blood

  • CIViC: CSF3R

    • Version: 14-September-2020

    Alternate Names:
    1441 Entrez Gene ID
    1239 CIViC Gene ID

    Gene Info:

    Publications:
    Dao KH et al., 2014, Significant clinical response to JAK1/2 inhibition in a patient with CSF3R-T618I-positive atypical chronic myeloid leukemia., Leuk Res Rep
    Fleischman et al., 2013, The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition., Blood

  • TTD: Granulocyte colony-stimulating factor receptor

    • Version: 2020.06.01

    Alternate Names:
    G-CSF-R TTD Gene Abbreviation
    T98913 TTD Target ID

    Gene Info:

    Publications:
    Varki R et al., 2009, A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study., BMC Clin Pharmacol
    Coniglio SJ et al., 2012, Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling., Mol Med

  • DoCM: CSF3R

    • Version: 27-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    2013, Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia., N. Engl. J. Med.
    Maxson et al., 2013, Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML., N. Engl. J. Med.

  • ChemblInteractions: GCSFR

    • Version: chembl_23

    Alternate Names:
    GCSFR GENE_SYMBOL
    CSF3R GENE_SYMBOL
    Granulocyte colony-stimulating factor receptor UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000119535

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000119535 Gene Symbol
    CSF3R Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: CSF3R

    • Version: 01-February-2022

    Alternate Names:
    GCSFR GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • Tempus: CSF3R

    • Version: 11-November-2018

    Alternate Names:
    CSF3R Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: CSF3R

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: CSF3R

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21