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CTSL Gene Record

  • Summary
  • Interactions
  • Claims
  • CTSL 1514 Druggable Genome

    Alternate Names:

    1514
    CATHEPSIN L
    CTSL
    CATL
    CTSL1
    MEP
    116880
    2537
    ENSG00000135047
    OTTHUMG00000020149
    P07711
    CATHEPSIN L PRECURSOR (EC 3.4.22.15) (MAJOR EXCRETED PROTEIN) (MEP). [SOURCE:UNIPROT/SWISSPROT;ACC:P07711]
    CATL1_HUMAN
    cathepsin L1
    T41141

    Gene Info:

    Human Readable Name PROTEASE
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Active_site
    Interpro Name Cysteine peptidase, cysteine active site
    Interpro Acc IPR000169
    Interpro Short Name Pept_cys_AS
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME

    Publications:

    Miller B et al., 2014, The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L., J Nat Prod
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
  • GALLINAMIDE A   CTSL

    Interaction Score: 61.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24364476


    Sources:
    DTC

  • BORTEZOMIB   CTSL

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20875739


    Sources:
    DTC

  • Ensembl: ENSG00000135047

    • Version: 101_38

    Alternate Names:
    CTSL Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P07711

    • Version: 11-September-2012

    Alternate Names:
    cathepsin L1 Uniprot Protein Name
    P07711 Uniprot Accession
    1514 Entrez Gene Id

    Gene Info:
    Interpro Type Active_site
    Interpro Name Cysteine peptidase, cysteine active site
    Interpro Acc IPR000169

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000135047

    • Version: 26-July-2011

    Alternate Names:
    CTSL Display Id
    ENSG00000135047 Ensembl Gene Id
    CATHEPSIN L PRECURSOR (EC 3.4.22.15) (MAJOR EXCRETED PROTEIN) (MEP). [SOURCE:UNIPROT/SWISSPROT;ACC:P07711] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: CTSL1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Song et al., 2005, Cathepsins in the ovine uterus: regulation by pregnancy, progesterone, and interferon tau., Endocrinology

  • DTC: CTSL

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
    Miller B et al., 2014, The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L., J Nat Prod

  • HingoraniCasas: ENSG00000135047

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000135047 Gene Symbol
    CTSL Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: CTSL1

    • Version: 27-Jun-2013

    Alternate Names:
    1514 Gene ID
    CATL dGene Synonym
    CTSL dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Cathepsin L

    • Version: 2020.06.01

    Alternate Names:
    CTSL TTD Gene Abbreviation
    T41141 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21