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CXCL10 Gene Record

  • Summary
  • Interactions
  • Claims
  • CXCL10 3627 Druggable Genome

    Alternate Names:

    3627
    C-X-C MOTIF CHEMOKINE LIGAND 10
    CXCL10
    C7
    IFI10
    INP10
    IP-10
    SCYB10
    crg-2
    gIP-10
    mob-1
    147310
    10637
    ENSG00000169245
    OTTHUMG00000160887
    CXCL10(1-73)
    C-X-C motif chemokine 10
    Gamma-IP10
    Small-inducible cytokine B10
    10 kDa interferon gamma-induced protein
    P02778
    PA35568
    T30635

    Gene Info:

    Target Class Ligand
    Target Subclass Ligand
    Target Subclass Chemokine
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Gisolf et al., 2000, Increasing cerebrospinal fluid chemokine concentrations despite undetectable cerebrospinal fluid HIV RNA in HIV-1-infected patients receiving antiretroviral therapy., J. Acquir. Immune Defic. Syndr.
    Zheng et al., 2004, Involvement of M3 cholinergic receptor signal transduction pathway in regulation of the expression of chemokine MOB-1, MCP-1 genes in pancreatic acinar cells., J. Huazhong Univ. Sci. Technol. Med. Sci.
    Olszyna et al., 1999, Sequential measurements of chemokines in urosepsis and experimental endotoxemia., J. Clin. Immunol.
    Ortego et al., 1999, Atorvastatin reduces NF-kappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells., Atherosclerosis
    Jinquan et al., 2001, CXCR3 expression on CD34(+) hemopoietic progenitors induced by granulocyte-macrophage colony-stimulating factor: II. Signaling pathways involved., J. Immunol.
    Michałowska-Wender et al., Effect of methylprednisolone treatment on expression of sPECAM-1 and CXCL10 chemokine in serum of MS patients., Pharmacol Rep
    Bellone et al., Circulating vascular endothelial growth factor and interferon-gamma-inducible protein-10 levels in pancreatic cancer during chemotherapy., Anticancer Res.
    Hu et al., 1998, Expression and regulation of interferon-gamma-inducible protein 10 gene in rat Leydig cells., Endocrinology
  • NI-0801   CXCL10

    Interaction Score: 10.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction C-X-C motif chemokine 10 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ELDELUMAB   CXCL10

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name MDX-1100
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • ANTIBIOTIC   CXCL10

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10634213


    Sources:
    NCI

  • ATROPINE   CXCL10

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15315164


    Sources:
    NCI

  • STAVUDINE   CXCL10

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11141242


    Sources:
    NCI

  • METHYLPREDNISOLONE   CXCL10

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17220550


    Sources:
    NCI

  • REGRAMOSTIM   CXCL10

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11591765


    Sources:
    NCI

  • RITONAVIR   CXCL10

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11141242


    Sources:
    NCI

  • ZIDOVUDINE   CXCL10

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11141242


    Sources:
    NCI

  • TESTOSTERONE   CXCL10

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9681518


    Sources:
    NCI

  • OXALIPLATIN   CXCL10

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16101140


    Sources:
    NCI

  • ATORVASTATIN   CXCL10

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10559511


    Sources:
    NCI

  • Ensembl: ENSG00000169245

    • Version: 101_38

    Alternate Names:
    CXCL10 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P02778

    • Version: January-2014

    Alternate Names:
    CXCL10 Gene Symbol

    Gene Info:
    Target Class Ligand
    Target Subclass Ligand
    Target Subclass Chemokine

    Publications:

  • NCI: CXCL10

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Gisolf et al., 2000, Increasing cerebrospinal fluid chemokine concentrations despite undetectable cerebrospinal fluid HIV RNA in HIV-1-infected patients receiving antiretroviral therapy., J. Acquir. Immune Defic. Syndr.
    Olszyna et al., 1999, Sequential measurements of chemokines in urosepsis and experimental endotoxemia., J. Clin. Immunol.
    Luster et al., 1995, The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation., J. Exp. Med.

  • HingoraniCasas: ENSG00000169245

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000169245 Gene Symbol
    CXCL10 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: INP10

    • Version: chembl_23

    Alternate Names:
    SCYB10 GENE_SYMBOL
    CXCL10 GENE_SYMBOL
    INP10 GENE_SYMBOL

    Gene Info:

    Publications:

  • PharmGKB: CXCL10

    • Version: 18-August-2020

    Alternate Names:
    PA35568 PharmGKB ID

    Gene Info:

    Publications:

  • GO: CXCL10

    • Version: 01-February-2022

    Alternate Names:
    INP10 GO Gene Synonym
    SCYB10 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: C-X-C motif chemokine 10

    • Version: 2020.06.01

    Alternate Names:
    CXCL10 TTD Gene Abbreviation
    T30635 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21