DGIdb - CXCL10 Gene Record

CXCL10 3627 Druggable Genome

Alternate Names:

3627
C-X-C MOTIF CHEMOKINE LIGAND 10
CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
147310
10637
ENSG00000169245
OTTHUMG00000160887
CXCL10(1-73)
C-X-C motif chemokine 10
Gamma-IP10
Small-inducible cytokine B10
10 kDa interferon gamma-induced protein
P02778
BE0000934
PA35568
T30635

Gene Info:

Target Class	Ligand
Target Subclass	Ligand
Target Subclass	Chemokine
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Gisolf et al., 2000, Increasing cerebrospinal fluid chemokine concentrations despite undetectable cerebrospinal fluid HIV RNA in HIV-1-infected patients receiving antiretroviral therapy., J. Acquir. Immune Defic. Syndr.
Zheng et al., 2004, Involvement of M3 cholinergic receptor signal transduction pathway in regulation of the expression of chemokine MOB-1, MCP-1 genes in pancreatic acinar cells., J. Huazhong Univ. Sci. Technol. Med. Sci.
Olszyna et al., 1999, Sequential measurements of chemokines in urosepsis and experimental endotoxemia., J. Clin. Immunol.
Ortego et al., 1999, Atorvastatin reduces NF-kappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells., Atherosclerosis
Jinquan et al., 2001, CXCR3 expression on CD34(+) hemopoietic progenitors induced by granulocyte-macrophage colony-stimulating factor: II. Signaling pathways involved., J. Immunol.
Michałowska-Wender et al., Effect of methylprednisolone treatment on expression of sPECAM-1 and CXCL10 chemokine in serum of MS patients., Pharmacol Rep
Bellone et al., Circulating vascular endothelial growth factor and interferon-gamma-inducible protein-10 levels in pancreatic cancer during chemotherapy., Anticancer Res.
Hu et al., 1998, Expression and regulation of interferon-gamma-inducible protein 10 gene in rat Leydig cells., Endocrinology
Han X et al., 2017, Anti-inflammatory activity of clove (Eugenia caryophyllata) essential oil in human dermal fibroblasts., Pharm Biol

ELDELUMAB CXCL10

Interaction Score: 13.11

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MDX-1100

Novel drug target Novel Target

PMIDs:
None found

Sources:
DrugBank TdgClinicalTrial TTD
NI-0801 CXCL10

Interaction Score: 8.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction C-X-C motif chemokine 10 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CLOVE OIL CXCL10

Interaction Score: 2.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28407719

Sources:
DrugBank
ANTIBIOTIC CXCL10

Interaction Score: 0.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10634213

Sources:
NCI
STAVUDINE CXCL10

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11141242

Sources:
NCI
ATROPINE CXCL10

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15315164

Sources:
NCI
METHYLPREDNISOLONE CXCL10

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17220550

Sources:
NCI
REGRAMOSTIM CXCL10

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11591765

Sources:
NCI
RITONAVIR CXCL10

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11141242

Sources:
NCI
ZIDOVUDINE CXCL10

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11141242

Sources:
NCI
TESTOSTERONE CXCL10

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9681518

Sources:
NCI
OXALIPLATIN CXCL10

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16101140

Sources:
NCI
ATORVASTATIN CXCL10

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10559511

Sources:
NCI

Ensembl: ENSG00000169245
- Version: 101_38
Alternate Names:

CXCL10 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P02778
- Version: January-2014
Alternate Names:

CXCL10 Gene Symbol

Gene Info:

Target Class Ligand

Target Subclass Ligand

Target Subclass Chemokine

Publications:

DrugBank: BE0000934

Version: 5.1.7

Alternate Names:

CXCL10 DrugBank Gene Name

P02778 UniProt Accession

3627 Entrez Gene Id

Gene Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Han X et al., 2017, Anti-inflammatory activity of clove (Eugenia caryophyllata) essential oil in human dermal fibroblasts., Pharm Biol

NCI: CXCL10

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Gisolf et al., 2000, Increasing cerebrospinal fluid chemokine concentrations despite undetectable cerebrospinal fluid HIV RNA in HIV-1-infected patients receiving antiretroviral therapy., J. Acquir. Immune Defic. Syndr.

Olszyna et al., 1999, Sequential measurements of chemokines in urosepsis and experimental endotoxemia., J. Clin. Immunol.

Luster et al., 1995, The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation., J. Exp. Med.

HingoraniCasas: ENSG00000169245
- Version: 31-May-2017
Alternate Names:

ENSG00000169245 Gene Symbol

CXCL10 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: INP10
- Version: chembl_23
Alternate Names:

SCYB10 GENE_SYMBOL

CXCL10 GENE_SYMBOL

INP10 GENE_SYMBOL

Gene Info:

Publications:
PharmGKB: CXCL10
- Version: 18-August-2020
Alternate Names:

PA35568 PharmGKB ID

Gene Info:

Publications:
GO: CXCL10
- Version: 05-September-2020
Alternate Names:

INP10 GO Gene Synonym

SCYB10 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: C-X-C motif chemokine 10
- Version: 2020.06.01
Alternate Names:

CXCL10 TTD Gene Abbreviation

T30635 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	C-X-C motif chemokine 10 inhibitor
Direct Interaction	yes

CXCL10	DrugBank Gene Name
P02778	UniProt Accession
3627	Entrez Gene Id

Trial Name	MDX-1100
Novel drug target	Novel Target

CXCL10 Gene Record

CXCL10 3627 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name MDX-1100 Novel drug target Novel Target

PMIDs: None found

Sources: DrugBank TdgClinicalTrial TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction C-X-C motif chemokine 10 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28407719

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10634213

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11141242

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15315164

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17220550

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11591765

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11141242

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11141242

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9681518

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16101140

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10559511

Sources: NCI

Ensembl: ENSG00000169245

Alternate Names: CXCL10 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P02778

Alternate Names: CXCL10 Gene Symbol

Gene Info: Target Class Ligand Target Subclass Ligand Target Subclass Chemokine

Publications:

DrugBank: BE0000934

Alternate Names: CXCL10 DrugBank Gene Name P02778 UniProt Accession 3627 Entrez Gene Id

Gene Info:

NCI: CXCL10

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000169245

Alternate Names: ENSG00000169245 Gene Symbol CXCL10 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: INP10

Alternate Names: SCYB10 GENE_SYMBOL CXCL10 GENE_SYMBOL INP10 GENE_SYMBOL

Gene Info:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MDX-1100

Novel drug target Novel Target

PMIDs:
None found

Sources:
DrugBank TdgClinicalTrial TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction C-X-C motif chemokine 10 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
28407719

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10634213

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11141242

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15315164

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17220550

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11591765

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11141242

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11141242

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9681518

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16101140

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10559511

Sources:
NCI

Alternate Names:

CXCL10 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CXCL10 Gene Symbol

Gene Info:

Target Class Ligand

Target Subclass Ligand

Target Subclass Chemokine

Alternate Names:

CXCL10 DrugBank Gene Name

P02778 UniProt Accession

3627 Entrez Gene Id

Alternate Names:

ENSG00000169245 Gene Symbol

CXCL10 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SCYB10 GENE_SYMBOL

CXCL10 GENE_SYMBOL

INP10 GENE_SYMBOL

Alternate Names:

PA35568 PharmGKB ID

Alternate Names:

INP10 GO Gene Synonym

SCYB10 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

CXCL10 TTD Gene Abbreviation

T30635 TTD Target ID