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CXCL12 Gene Record

  • Summary
  • Interactions
  • Claims
  • CXCL12 6387 Druggable Genome

    Alternate Names:

    6387
    C-X-C MOTIF CHEMOKINE LIGAND 12
    CXCL12
    IRH
    PBSF
    SCYB12
    SDF1
    TLSF
    TPAR1
    600835
    10672
    ENSG00000107562
    OTTHUMG00000018054
    BE0001150
    P48061
    SDF1A
    SDF1B
    PA35602
    Stromal cell-derived factor 1
    T04773

    Gene Info:

    Target Class Ligand
    Target Subclass Ligand
    Target Subclass Chemokine
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    KINASE
    GROWTH FACTOR
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Butrym A et al., 2016, Dual role of the CXCL12 polymorphism in patients with chronic lymphocytic leukemia., HLA
    Koo et al., 2008, Targeting heparan sulfate proteoglycans in breast cancer treatment., Recent Pat Anticancer Drug Discov
  • TINZAPARIN   CXCL12

    Interaction Score: 3.55

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    18991783


    Sources:
    DrugBank

  • ALEMTUZUMAB   CXCL12

    Interaction Score: 1.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27173875


    Sources:
    PharmGKB

  • CHLORAMBUCIL   CXCL12

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27173875


    Sources:
    PharmGKB

  • RITUXIMAB   CXCL12

    Interaction Score: 1.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27173875


    Sources:
    PharmGKB

  • FLUDARABINE   CXCL12

    Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27173875


    Sources:
    PharmGKB

  • PREDNISONE   CXCL12

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27173875


    Sources:
    PharmGKB

  • VINCRISTINE   CXCL12

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27173875


    Sources:
    PharmGKB

  • CYCLOPHOSPHAMIDE   CXCL12

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27173875


    Sources:
    PharmGKB

  • Ensembl: ENSG00000107562

    • Version: 101_38

    Alternate Names:
    CXCL12 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P48061

    • Version: January-2014

    Alternate Names:
    CXCL12 Gene Symbol

    Gene Info:
    Target Class Ligand
    Target Subclass Ligand
    Target Subclass Chemokine

    Publications:

  • PharmGKB: CXCL12

    • Version: 18-August-2020

    Alternate Names:
    PA35602 PharmGKB ID

    Gene Info:

    Publications:
    Butrym A et al., 2016, Dual role of the CXCL12 polymorphism in patients with chronic lymphocytic leukemia., HLA

  • DrugBank: BE0001150

    • Version: 5.1.7

    Alternate Names:
    CXCL12 DrugBank Gene Name
    P48061 UniProt Accession
    6387 Entrez Gene Id

    Gene Info:

    Publications:
    Koo et al., 2008, Targeting heparan sulfate proteoglycans in breast cancer treatment., Recent Pat Anticancer Drug Discov

  • HingoraniCasas: ENSG00000107562

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000107562 Gene Symbol
    CXCL12 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: CXCL12

    • Version: 03-September-2020

    Alternate Names:
    Stromal cell-derived factor 1 Gene Name
    P48061 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • GO: CXCL12

    • Version: 05-September-2020

    Alternate Names:
    SDF1 GO Gene Synonym
    SDF1A GO Gene Synonym
    SDF1B GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: Stromal cell-derived factor 1

    • Version: 2020.06.01

    Alternate Names:
    CXCL12 TTD Gene Abbreviation
    T04773 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21