DGIdb - CXCL8 Gene Record

CXCL8 3576 Druggable Genome

Alternate Names:

3576
C-X-C MOTIF CHEMOKINE LIGAND 8
CXCL8
GCP-1
GCP1
IL8
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
146930
6025
ENSG00000169429
OTTHUMG00000151316
PA29841
MDNCF-c
IL-8
IL8/NAP1 form VI
GCP/IL-8 protein III
IL8/NAP1 form V
GCP/IL-8 protein VI
IL8/NAP1 form IV
GCP/IL-8 protein V
Neutrophil-activating factor
Lymphocyte-derived neutrophil-activating factor
IL8/NAP1 form III
GCP/IL-8 protein I
(Ser-IL-8)72
MDNCF-b
IL8/NAP1 form II
IL-8(1-77)
GCP/IL-8 protein II
(Ala-IL-8)77
IL8/NAP1 form I
GCP/IL-8 protein IV
T-cell chemotactic factor
Protein 3-10C
Neutrophil-activating protein 1
Monocyte-derived neutrophil-activating peptide
Monocyte-derived neutrophil chemotactic factor
Granulocyte chemotactic protein 1
Emoctakin
Chemokine (C-X-C motif) ligand 8
C-X-C motif chemokine 8
IL-8(9-77)
IL-8(8-77)
IL-8(7-77)
IL-8(6-77)
IL-8(5-77)
MDNCF-a
Interleukin-8
T22658
SCYB8

Gene Info:

Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Bossowski et al., 2001, Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter., J. Pediatr. Endocrinol. Metab.
Brix-Christensen et al., 1998, Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery., Acta Anaesthesiol Scand
Oda et al., 2002, Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region., J. Immunol.
Neuman et al., 1999, Predictors of sustained response to alpha interferon therapy in chronic hepatitis C., Clin. Biochem.
Perrotte et al., 1999, Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice., Clin. Cancer Res.
Vallböhmer et al., 2005, Molecular determinants of cetuximab efficacy., J. Clin. Oncol.
Christensen et al., 2005, Plasma vascular endothelial growth factor and interleukin-8 as biomarkers of antitumor efficacy of a prototypical erbB family tyrosine kinase inhibitor., Mol. Cancer Ther.
Dimova et al., 2005, Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro., Int. J. Biochem. Cell Biol.
Cinatl et al., 2000, The antisense oligonucleotide ISIS 2922 prevents cytomegalovirus-induced upregulation of IL-8 and ICAM-1 in cultured human fibroblasts., J. Med. Virol.
Diekstra MH et al., 2015, Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic renal cell carcinoma., Eur J Clin Pharmacol
Simiti et al., Increased plasma levels of interleukin-8 in patients with unstable angina pectoris., Rom J Intern Med
Harant et al., 1996, Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic acid and tumor necrosis factor-alpha involves the transcription factor NF-kappaB., J. Biol. Chem.
Galley et al., 1998, The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes., Anesth. Analg.
Chen et al., 2003, Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer., Clin. Cancer Res.
Okamoto et al., 1994, The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization., J. Biol. Chem.
Tang et al., 2005, [Effects of xianggui pill on cytokine in endometriosis model rat]., Zhongguo Zhong Yao Za Zhi
Kraan et al., 2000, Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients., Arthritis Rheum.
Handa et al., 2006, Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors., Inflamm. Res.
Miyazawa et al., 2007, Phenotypic alterations and cytokine production in THP-1 cells in response to allergens., Toxicol In Vitro
Lappas et al., 2002, Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone., J. Clin. Endocrinol. Metab.
Hautamäki A et al., 2013, Interleukin 8 promoter polymorphism predicts the initial response to bevacizumab treatment for exudative age-related macular degeneration., Retina
Kikuchi et al., 2002, Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors., J. Antimicrob. Chemother.
Lee et al., 1997, Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter., Mol. Cell. Biol.
Kotyza et al., 2006, Pleural injury and pleurisy-induced progelatinase B/proMMP-9 is associated with markers of neutrophil degranulation., Scand. J. Clin. Lab. Invest.
Bacon et al., 1989, Potent and specific inhibition of IL-8-, IL-1 alpha- and IL-1 beta-induced in vitro human lymphocyte migration by calcium channel antagonists., Biochem. Biophys. Res. Commun.
Shiotani et al., 2002, NSAID gastric ulceration: predictive value of gastric pH, mucosal density of polymorphonuclear leukocytes, or levels of IL-8 or nitrite., Dig. Dis. Sci.
Santini et al., 2002, Pamidronate induces modifications of circulating angiogenetic factors in cancer patients., Clin. Cancer Res.
Vilela et al., 2006, Inhibition of IL-8 release from CFTR-deficient lung epithelial cells following pre-treatment with fenretinide., Int. Immunopharmacol.
Pacheco et al., 1994, Antibiotics and production of granulocyte-macrophage colony-stimulating factor by human bronchial epithelial cells in vitro. A comparison of cefodizime and ceftriaxone., Arzneimittelforschung
Amsellem et al., 1996, Antihistamines and production of granulocyte-macrophage colony-stimulating factor and interleukin-8 by human bronchial epithelial cells in vitro: evaluation of the effects of loratadine and cetirizine., Gen. Pharmacol.

TALC CXCL8

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17000556

Sources:
NCI
FOSCARNET CXCL8

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10630964

Sources:
NCI
ABX-IL8 CXCL8

Interaction Score: 2.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-8 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
HUMAX-IL8 CXCL8

Interaction Score: 1.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-8 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CIDOFOVIR CXCL8

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10630964

Sources:
NCI
PAMIDRONIC ACID CXCL8

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12006522

Sources:
NCI
HEPTACHLOR CXCL8

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
YANGONIN CXCL8

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CANERTINIB CXCL8

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15956251

Sources:
NCI
ALDRIN CXCL8

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DINITRO CRESOL CXCL8

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1579130 CXCL8

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICHLORVOS CXCL8

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CORONOPILIN CXCL8

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICYCLOHEXYLCARBODIIMIDE CXCL8

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BROXURIDINE CXCL8

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IONOMYCIN CXCL8

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7510691

Sources:
NCI
QUESTIOMYCIN B CXCL8

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENDOSULFAN CXCL8

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HARMINE HYDROCHLORIDE CXCL8

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDROQUINONE CXCL8

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17118622

Sources:
DTC NCI
CEFTRIAXONE CXCL8

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8011012

Sources:
NCI
NAPROXEN CXCL8

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11852880

Sources:
NCI
CHEMBL1902074 CXCL8

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LEFLUNOMIDE CXCL8

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10902750

Sources:
NCI
CHLORDANE CXCL8

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLARITHROMYCIN CXCL8

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12003967

Sources:
NCI
TERFENADINE CXCL8

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8919641

Sources:
NCI
RETINAL CXCL8

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DANAZOL CXCL8

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16161451

Sources:
NCI
METHIMAZOLE CXCL8

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11453524

Sources:
NCI
CETUXIMAB CXCL8

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10614716 10037173 15908664

Sources:
NCI
E319 CXCL8

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TROGLITAZONE CXCL8

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12364456

Sources:
NCI
FENTANYL CXCL8

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9527747

Sources:
NCI
FENRETINIDE CXCL8

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16979119

Sources:
NCI
DACARBAZINE CXCL8

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LANSOPRAZOLE CXCL8

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17122965

Sources:
NCI
RETINOL CXCL8

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRETINOIN CXCL8

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8900181

Sources:
NCI
PYROGALLOL CXCL8

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALPRAZOLAM CXCL8

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12218154

Sources:
NCI
BEVACIZUMAB CXCL8

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23584701

Sources:
PharmGKB
OMEPRAZOLE CXCL8

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17122965

Sources:
NCI
PENTOXIFYLLINE CXCL8

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12576442

Sources:
NCI
VERAPAMIL CXCL8

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2686646

Sources:
NCI
MIDAZOLAM CXCL8

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9620522

Sources:
NCI
SUNITINIB CXCL8

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26387812

Sources:
PharmGKB
ACETAMINOPHEN CXCL8

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15878691

Sources:
NCI
DIPYRIDAMOLE CXCL8

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10660968

Sources:
NCI
EMODIN CXCL8

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RIBAVIRIN CXCL8

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IBUPROFEN CXCL8

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ASPIRIN CXCL8

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12576442

Sources:
NCI
COLCHICINE CXCL8

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PACLITAXEL CXCL8

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9271387

Sources:
NCI

Ensembl: ENSG00000169429
- Version: 101_38
Alternate Names:

CXCL8 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: CXCL8

Version: 18-August-2020

Alternate Names:

PA29841 PharmGKB ID

Gene Info:

Publications:

Diekstra MH et al., 2015, Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic renal cell carcinoma., Eur J Clin Pharmacol

Hautamäki A et al., 2013, Interleukin 8 promoter polymorphism predicts the initial response to bevacizumab treatment for exudative age-related macular degeneration., Retina

NCI: IL8

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Bossowski et al., 2001, Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter., J. Pediatr. Endocrinol. Metab.

Brix-Christensen et al., 1998, Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery., Acta Anaesthesiol Scand

Cinatl et al., 2000, The antisense oligonucleotide ISIS 2922 prevents cytomegalovirus-induced upregulation of IL-8 and ICAM-1 in cultured human fibroblasts., J. Med. Virol.

HingoraniCasas: ENSG00000169429
- Version: 31-May-2017
Alternate Names:

ENSG00000169429 Gene Symbol

IL8 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: IL8
- Version: chembl_23
Alternate Names:

IL8 GENE_SYMBOL

CXCL8 GENE_SYMBOL

Interleukin-8 UNIPROT

Gene Info:

Publications:
TTD: Interleukin-8
- Version: 2020.06.01
Alternate Names:

IL8 TTD Gene Abbreviation

T22658 TTD Target ID

Gene Info:

Publications:
DTC: CXCL8
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Mechanism of Interaction	Interleukin-8 inhibitor
Direct Interaction	yes

CXCL8 Gene Record

CXCL8 3576 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17000556

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10630964

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-8 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-8 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10630964

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12006522

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15956251

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7510691

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
17000556

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10630964

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-8 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-8 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10630964

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12006522

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15956251

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
7510691

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17118622

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
8011012

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11852880

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10902750

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC