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CXCL8 Gene Record

  • Summary
  • Interactions
  • Claims
  • CXCL8 3576 Druggable Genome

    Alternate Names:

    3576
    C-X-C MOTIF CHEMOKINE LIGAND 8
    CXCL8
    GCP-1
    GCP1
    IL8
    LECT
    LUCT
    LYNAP
    MDNCF
    MONAP
    NAF
    NAP-1
    NAP1
    146930
    6025
    ENSG00000169429
    OTTHUMG00000151316
    PA29841
    MDNCF-c
    IL-8
    IL8/NAP1 form VI
    GCP/IL-8 protein III
    IL8/NAP1 form V
    GCP/IL-8 protein VI
    IL8/NAP1 form IV
    GCP/IL-8 protein V
    Neutrophil-activating factor
    Lymphocyte-derived neutrophil-activating factor
    IL8/NAP1 form III
    GCP/IL-8 protein I
    (Ser-IL-8)72
    MDNCF-b
    IL8/NAP1 form II
    IL-8(1-77)
    GCP/IL-8 protein II
    (Ala-IL-8)77
    IL8/NAP1 form I
    GCP/IL-8 protein IV
    T-cell chemotactic factor
    Protein 3-10C
    Neutrophil-activating protein 1
    Monocyte-derived neutrophil-activating peptide
    Monocyte-derived neutrophil chemotactic factor
    Granulocyte chemotactic protein 1
    Emoctakin
    Chemokine (C-X-C motif) ligand 8
    C-X-C motif chemokine 8
    IL-8(9-77)
    IL-8(8-77)
    IL-8(7-77)
    IL-8(6-77)
    IL-8(5-77)
    MDNCF-a
    Interleukin-8
    T22658
    SCYB8

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Bossowski et al., 2001, Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter., J. Pediatr. Endocrinol. Metab.
    Brix-Christensen et al., 1998, Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery., Acta Anaesthesiol Scand
    Oda et al., 2002, Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region., J. Immunol.
    Neuman et al., 1999, Predictors of sustained response to alpha interferon therapy in chronic hepatitis C., Clin. Biochem.
    Perrotte et al., 1999, Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice., Clin. Cancer Res.
    Vallböhmer et al., 2005, Molecular determinants of cetuximab efficacy., J. Clin. Oncol.
    Christensen et al., 2005, Plasma vascular endothelial growth factor and interleukin-8 as biomarkers of antitumor efficacy of a prototypical erbB family tyrosine kinase inhibitor., Mol. Cancer Ther.
    Dimova et al., 2005, Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro., Int. J. Biochem. Cell Biol.
    Cinatl et al., 2000, The antisense oligonucleotide ISIS 2922 prevents cytomegalovirus-induced upregulation of IL-8 and ICAM-1 in cultured human fibroblasts., J. Med. Virol.
    Diekstra MH et al., 2015, Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic renal cell carcinoma., Eur J Clin Pharmacol
    Simiti et al., Increased plasma levels of interleukin-8 in patients with unstable angina pectoris., Rom J Intern Med
    Harant et al., 1996, Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic acid and tumor necrosis factor-alpha involves the transcription factor NF-kappaB., J. Biol. Chem.
    Galley et al., 1998, The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes., Anesth. Analg.
    Chen et al., 2003, Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer., Clin. Cancer Res.
    Okamoto et al., 1994, The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization., J. Biol. Chem.
    Tang et al., 2005, [Effects of xianggui pill on cytokine in endometriosis model rat]., Zhongguo Zhong Yao Za Zhi
    Kraan et al., 2000, Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients., Arthritis Rheum.
    Handa et al., 2006, Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors., Inflamm. Res.
    Miyazawa et al., 2007, Phenotypic alterations and cytokine production in THP-1 cells in response to allergens., Toxicol In Vitro
    Lappas et al., 2002, Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone., J. Clin. Endocrinol. Metab.
    Hautamäki A et al., 2013, Interleukin 8 promoter polymorphism predicts the initial response to bevacizumab treatment for exudative age-related macular degeneration., Retina
    Kikuchi et al., 2002, Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors., J. Antimicrob. Chemother.
    Lee et al., 1997, Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter., Mol. Cell. Biol.
    Kotyza et al., 2006, Pleural injury and pleurisy-induced progelatinase B/proMMP-9 is associated with markers of neutrophil degranulation., Scand. J. Clin. Lab. Invest.
    Bacon et al., 1989, Potent and specific inhibition of IL-8-, IL-1 alpha- and IL-1 beta-induced in vitro human lymphocyte migration by calcium channel antagonists., Biochem. Biophys. Res. Commun.
    Shiotani et al., 2002, NSAID gastric ulceration: predictive value of gastric pH, mucosal density of polymorphonuclear leukocytes, or levels of IL-8 or nitrite., Dig. Dis. Sci.
    Santini et al., 2002, Pamidronate induces modifications of circulating angiogenetic factors in cancer patients., Clin. Cancer Res.
    Vilela et al., 2006, Inhibition of IL-8 release from CFTR-deficient lung epithelial cells following pre-treatment with fenretinide., Int. Immunopharmacol.
    Pacheco et al., 1994, Antibiotics and production of granulocyte-macrophage colony-stimulating factor by human bronchial epithelial cells in vitro. A comparison of cefodizime and ceftriaxone., Arzneimittelforschung
    Amsellem et al., 1996, Antihistamines and production of granulocyte-macrophage colony-stimulating factor and interleukin-8 by human bronchial epithelial cells in vitro: evaluation of the effects of loratadine and cetirizine., Gen. Pharmacol.
  • TALC   CXCL8

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17000556


    Sources:
    NCI

  • FOSCARNET   CXCL8

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10630964


    Sources:
    NCI

  • ABX-IL8   CXCL8

    Interaction Score: 2.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-8 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • HUMAX-IL8   CXCL8

    Interaction Score: 1.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-8 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CIDOFOVIR   CXCL8

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10630964


    Sources:
    NCI

  • PAMIDRONIC ACID   CXCL8

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12006522


    Sources:
    NCI

  • HEPTACHLOR   CXCL8

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • YANGONIN   CXCL8

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CANERTINIB   CXCL8

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15956251


    Sources:
    NCI

  • ALDRIN   CXCL8

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DINITRO CRESOL   CXCL8

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1579130   CXCL8

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DICHLORVOS   CXCL8

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CORONOPILIN   CXCL8

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DICYCLOHEXYLCARBODIIMIDE   CXCL8

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BROXURIDINE   CXCL8

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IONOMYCIN   CXCL8

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7510691


    Sources:
    NCI

  • QUESTIOMYCIN B   CXCL8

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ENDOSULFAN   CXCL8

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HARMINE HYDROCHLORIDE   CXCL8

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDROQUINONE   CXCL8

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17118622


    Sources:
    DTC NCI

  • CEFTRIAXONE   CXCL8

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8011012


    Sources:
    NCI

  • NAPROXEN   CXCL8

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11852880


    Sources:
    NCI

  • CHEMBL1902074   CXCL8

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LEFLUNOMIDE   CXCL8

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10902750


    Sources:
    NCI

  • CHLORDANE   CXCL8

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLARITHROMYCIN   CXCL8

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12003967


    Sources:
    NCI

  • TERFENADINE   CXCL8

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8919641


    Sources:
    NCI

  • RETINAL   CXCL8

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DANAZOL   CXCL8

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16161451


    Sources:
    NCI

  • METHIMAZOLE   CXCL8

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11453524


    Sources:
    NCI

  • CETUXIMAB   CXCL8

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10614716 10037173 15908664


    Sources:
    NCI

  • E319   CXCL8

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TROGLITAZONE   CXCL8

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12364456


    Sources:
    NCI

  • FENTANYL   CXCL8

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9527747


    Sources:
    NCI

  • FENRETINIDE   CXCL8

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16979119


    Sources:
    NCI

  • DACARBAZINE   CXCL8

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LANSOPRAZOLE   CXCL8

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17122965


    Sources:
    NCI

  • RETINOL   CXCL8

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRETINOIN   CXCL8

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8900181


    Sources:
    NCI

  • PYROGALLOL   CXCL8

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALPRAZOLAM   CXCL8

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12218154


    Sources:
    NCI

  • BEVACIZUMAB   CXCL8

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23584701


    Sources:
    PharmGKB

  • OMEPRAZOLE   CXCL8

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17122965


    Sources:
    NCI

  • PENTOXIFYLLINE   CXCL8

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12576442


    Sources:
    NCI

  • VERAPAMIL   CXCL8

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2686646


    Sources:
    NCI

  • MIDAZOLAM   CXCL8

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9620522


    Sources:
    NCI

  • SUNITINIB   CXCL8

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26387812


    Sources:
    PharmGKB

  • ACETAMINOPHEN   CXCL8

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15878691


    Sources:
    NCI

  • DIPYRIDAMOLE   CXCL8

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10660968


    Sources:
    NCI

  • EMODIN   CXCL8

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RIBAVIRIN   CXCL8

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IBUPROFEN   CXCL8

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ASPIRIN   CXCL8

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12576442


    Sources:
    NCI

  • COLCHICINE   CXCL8

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PACLITAXEL   CXCL8

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9271387


    Sources:
    NCI

  • Ensembl: ENSG00000169429

    • Version: 101_38

    Alternate Names:
    CXCL8 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: CXCL8

    • Version: 18-August-2020

    Alternate Names:
    PA29841 PharmGKB ID

    Gene Info:

    Publications:
    Diekstra MH et al., 2015, Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic renal cell carcinoma., Eur J Clin Pharmacol
    Hautamäki A et al., 2013, Interleukin 8 promoter polymorphism predicts the initial response to bevacizumab treatment for exudative age-related macular degeneration., Retina

  • NCI: IL8

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Bossowski et al., 2001, Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter., J. Pediatr. Endocrinol. Metab.
    Brix-Christensen et al., 1998, Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery., Acta Anaesthesiol Scand
    Cinatl et al., 2000, The antisense oligonucleotide ISIS 2922 prevents cytomegalovirus-induced upregulation of IL-8 and ICAM-1 in cultured human fibroblasts., J. Med. Virol.

  • HingoraniCasas: ENSG00000169429

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000169429 Gene Symbol
    IL8 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: IL8

    • Version: chembl_23

    Alternate Names:
    IL8 GENE_SYMBOL
    CXCL8 GENE_SYMBOL
    Interleukin-8 UNIPROT

    Gene Info:

    Publications:

  • TTD: Interleukin-8

    • Version: 2020.06.01

    Alternate Names:
    IL8 TTD Gene Abbreviation
    T22658 TTD Target ID

    Gene Info:

    Publications:

  • DTC: CXCL8

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21