• CXCR1 3577 Druggable Genome

    Alternate Names:

    3577
    C-X-C MOTIF CHEMOKINE RECEPTOR 1
    CXCR1
    C-C
    C-C-CKR-1
    CD128
    CD181
    CDw128a
    CKR-1
    CMKAR1
    IL8R1
    IL8RA
    IL8RBA
    146929
    6026
    ENSG00000163464
    OTTHUMG00000133108
    P25024
    C-X-C chemokine receptor type 1
    High affinity interleukin-8 receptor A
    IL-8 receptor type 1
    CD_antigen=CD181
    CXC-R1
    CXCR-1
    IL-8R A
    HIGH AFFINITY INTERLEUKIN-8 RECEPTOR A (IL-8R A) (IL-8 RECEPTOR TYPE 1) (CXCR-1) (CDW128A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25024]
    68
    CXCR1_HUMAN
    T00884
    NM_000634
    NP_000625

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Interpro Name GPCR, rhodopsin-like, 7TM
    Interpro Type Family
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Chemokine receptors
    GuideToPharmacology Gene Category ID 14
    (6 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

  • Interaction Score: 19.14

    Interaction Types & Directionality:
    allosteric modulator
    modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 12.76

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name SCH-527123, PS-291822, PS-938285
    Novel drug target Novel Target
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


  • Interaction Score: 6.38

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-8 receptor A antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 6.38

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Interleukin-8 receptor A modulator

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

    • Version: 101_38

    Alternate Names:
    CXCR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: January-2014

    Alternate Names:
    CXCR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    IL8RA Display Id
    HIGH AFFINITY INTERLEUKIN-8 RECEPTOR A (IL-8R A) (IL-8 RECEPTOR TYPE 1) (CXCR-1) (CDW128A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25024] Description
    ENSG00000163464 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    P25024 Uniprot Accession
    CXCR1 Uniprot Gene Name
    C-X-C CHEMOKINE RECEPTOR TYPE 1 Uniprot Protein Name

    Gene Info:
    Interpro Name GPCR, rhodopsin-like, 7TM
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Type Family

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    6026 HUGO Gene ID
    6026 HUGO Gene Symbol
    C-X-C motif chemokine receptor 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Chemokine receptors
    GuideToPharmacology Gene Category ID 14

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000163464 Gene Symbol
    CXCR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    IL8RA GENE_SYMBOL
    CXCR1 GENE_SYMBOL
    C-X-C chemokine receptor type 1 UNIPROT

    Gene Info:

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    3577 Gene ID
    C-C dGene Synonym
    C-C-CKR-1 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    CXCR1 TTD Gene Abbreviation
    T00884 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    CMKAR1 GO Gene Synonym
    IL8RA GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications: