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CYB5R3 Gene Record

  • Summary
  • Interactions
  • Claims
  • CYB5R3 1727 Druggable Genome

    Alternate Names:

    1727
    CYTOCHROME B5 REDUCTASE 3
    CYB5R3
    B5R
    DIA1
    613213
    2873
    ENSG00000100243
    OTTHUMG00000150745
    P00387
    NADH-CYTOCHROME B5 REDUCTASE (EC 1.6.2.2) (B5R) (DIAPHORASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P00387]
    NB5R3_HUMAN
    NADH-CYTOCHROME B5 REDUCTASE 3 MEMBRANE-BOUND FORM
    PA27331

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Name Oxidoreductase FAD/NAD(P)-binding
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name OxRdtase_FAD/NAD-bd
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001433
    Interpro Type Domain
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Kedar P et al., 2014, Primaquine-induced severe methemoglobinemia developed during treatment of Plasmodium vivax malarial infection in an Indian family associated with a novel mutation (p.Agr57Trp) in the CYB5R3 gene., Clin Chim Acta
    Karadsheh NS et al., 2001, Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment., Haematologica
  • ROPIVACAINE   CYB5R3

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CHLOROPROCAINE   CYB5R3

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PRIMAQUINE   CYB5R3

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25058800


    Sources:
    PharmGKB

  • RASBURICASE   CYB5R3

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METOCLOPRAMIDE   CYB5R3

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11418378


    Sources:
    PharmGKB

  • MEPIVACAINE   CYB5R3

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DAPSONE   CYB5R3

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CEFTRIAXONE   CYB5R3

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000100243

    • Version: 101_38

    Alternate Names:
    CYB5R3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P00387

    • Version: 11-September-2012

    Alternate Names:
    1727 Entrez Gene Id
    ENSG00000100243 Ensembl Gene Id
    CYB5R3 Uniprot Gene Name

    Gene Info:
    Interpro Name Oxidoreductase FAD/NAD(P)-binding
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name OxRdtase_FAD/NAD-bd

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000100243

    • Version: 26-July-2011

    Alternate Names:
    DIA1 Display Id
    NADH-CYTOCHROME B5 REDUCTASE (EC 1.6.2.2) (B5R) (DIAPHORASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P00387] Description
    ENSG00000100243 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: CYB5R3

    • Version: 18-August-2020

    Alternate Names:
    PA27331 PharmGKB ID

    Gene Info:

    Publications:
    Karadsheh NS et al., 2001, Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment., Haematologica
    Kedar P et al., 2014, Primaquine-induced severe methemoglobinemia developed during treatment of Plasmodium vivax malarial infection in an Indian family associated with a novel mutation (p.Agr57Trp) in the CYB5R3 gene., Clin Chim Acta

  • HingoraniCasas: ENSG00000100243

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000100243 Gene Symbol
    CYB5R3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: CYB5R3

    • Version: 19.3

    Alternate Names:
    ENSG00000100243 Ensembl Gene ID
    DIA1 Human Protein Atlas Gene Synonym
    Cytochrome b5 reductase 3 Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21