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CYP11B2 Gene Record

  • Summary
  • Interactions
  • Claims
  • CYP11B2 1585 Druggable Genome

    Alternate Names:

    1585
    CYTOCHROME P450 FAMILY 11 SUBFAMILY B MEMBER 2
    CYP11B2
    ALDOS
    CPN2
    CYP11B
    CYP11BL
    CYPXIB2
    P-450C18
    P450C18
    P450aldo
    124080
    2592
    ENSG00000179142
    OTTHUMG00000160254
    P19099
    C11B2_HUMAN
    CYTOCHROME P450 11B2, MITOCHONDRIAL
    CYTOCHROME P450 11B2, MITOCHONDRIAL PRECURSOR (EC 1.14.15.4) (EC 1.14.15.5) (CYPXIB2) (P-450ALDO) (ALDOSTERONE SYNTHASE) (ALDOS) (ALDOSTERONE-SYNTHESIZING ENZYME) (STEROID 18-HYDROXYLASE) (P-450C18). [SOURCE:UNIPROT/SWISSPROT;ACC:P19099]
    PA134
    Aldosterone synthase
    T59056

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Interpro Name Cytochrome P450
    Interpro Acc IPR001128
    Human Readable Name CYTOCHROME P450
    Interpro Short Name Cyt_P450
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CYTOCHROME P450
    ENZYME

    Publications:

    Yu HM et al., 2006, Associations between CYP11B2 gene polymorphisms and the response to angiotensin-converting enzyme inhibitors., Clin Pharmacol Ther
    Wu et al., 1995, Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma., J. Clin. Endocrinol. Metab.
    Ortlepp JR et al., 2002, Variants of the CYP11B2 gene predict response to therapy with candesartan., Eur J Pharmacol
  • IMIDAPRIL   CYP11B2

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16765146


    Sources:
    PharmGKB

  • BENAZEPRIL   CYP11B2

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16765146


    Sources:
    PharmGKB

  • CANDESARTAN   CYP11B2

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12065207


    Sources:
    PharmGKB

  • METOCLOPRAMIDE   CYP11B2

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7883831


    Sources:
    NCI

  • Ensembl: ENSG00000179142

    • Version: 101_38

    Alternate Names:
    CYP11B2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P19099

    • Version: 11-September-2012

    Alternate Names:
    CYP11B2 Uniprot Gene Name
    1585 Entrez Gene Id
    ENSG00000179142 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Interpro Name Cytochrome P450

    Gene Categories:
    DRUGGABLE GENOME, CYTOCHROME P450

    Publications:

  • RussLampel: ENSG00000179142

    • Version: 26-July-2011

    Alternate Names:
    CYTOCHROME P450 11B2, MITOCHONDRIAL PRECURSOR (EC 1.14.15.4) (EC 1.14.15.5) (CYPXIB2) (P-450ALDO) (ALDOSTERONE SYNTHASE) (ALDOS) (ALDOSTERONE-SYNTHESIZING ENZYME) (STEROID 18-HYDROXYLASE) (P-450C18). [SOURCE:UNIPROT/SWISSPROT;ACC:P19099] Description
    CYP11B2 Display Id
    ENSG00000179142 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: CYP11B2

    • Version: 18-August-2020

    Alternate Names:
    PA134 PharmGKB ID

    Gene Info:

    Publications:
    Yu HM et al., 2006, Associations between CYP11B2 gene polymorphisms and the response to angiotensin-converting enzyme inhibitors., Clin Pharmacol Ther
    Ortlepp JR et al., 2002, Variants of the CYP11B2 gene predict response to therapy with candesartan., Eur J Pharmacol

  • TTD: Aldosterone synthase

    • Version: 2020.06.01

    Alternate Names:
    CYP11B2 TTD Gene Abbreviation
    T59056 TTD Target ID

    Gene Info:

    Publications:
    Fleseriu M et al., 2012, Medical management of Cushing's disease: what is the future?, Pituitary

  • NCI: CYP11B2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Wu et al., 1995, Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma., J. Clin. Endocrinol. Metab.

  • HingoraniCasas: ENSG00000179142

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000179142 Gene Symbol
    CYP11B2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: CYP11B2

    • Version: 19.3

    Alternate Names:
    P19099 UniProt ID
    ENSG00000179142 Ensembl Gene ID
    ALDOS Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: CYP11B2

    • Version: 01-February-2022

    Alternate Names:
    Cytochrome P450 11B2, mitochondrial Gene Name
    P19099 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21