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CYP1A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CYP1A1 1543 Druggable Genome

    Alternate Names:

    1543
    CYTOCHROME P450 FAMILY 1 SUBFAMILY A MEMBER 1
    CYP1A1
    AHH
    AHRR
    CP11
    CYP1
    CYPIA1
    P1-450
    P450-C
    P450DX
    108330
    2595
    ENSG00000140465
    OTTHUMG00000142812
    P04798
    CP1A1_HUMAN
    CYTOCHROME P450 1A1
    CYTOCHROME P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1) (P450 FORM 6) (P450-C). [SOURCE:UNIPROT/SWISSPROT;ACC:P04798]
    PA27092

    Gene Info:

    Interpro Type Family
    Interpro Name Cytochrome P450
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Cyt_P450
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001128
    Human Readable Name CYTOCHROME P450
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CYTOCHROME P450
    ENZYME

    Publications:

    Lewis BC et al., 2016, Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy., Pharmacogenet Genomics
    Söderberg MM et al., 2013, Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure., Pharmacogenet Genomics
    Talwar P et al., 2017, Genetic contribution of CYP1A1 variant on treatment outcome in epilepsy patients: a functional and interethnic perspective., Pharmacogenomics J
    Grover S et al., 2010, Genetic polymorphisms in sex hormone metabolizing genes and drug response in women with epilepsy., Pharmacogenomics
    Androutsopoulos VP et al., 2011, Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids., Bioorg Med Chem
    Allegra S et al., 2016, Deferasirox AUC efficacy cutoff and role of pharmacogenetics., Eur J Clin Pharmacol
    Cusato J et al., 2015, Influence of single-nucleotide polymorphisms on deferasirox C trough levels and effectiveness., Pharmacogenomics J
    Fang et al., 1999, Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4., Naunyn Schmiedebergs Arch. Pharmacol.
    Schwarz et al., 2003, St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1., Cancer Res.
    Schröterová et al., 2004, The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro., Physiol Res
    Fujita et al., 1982, Effect of spironolactone on hepatic microsomal monooxygenase and azoreductase activities., Res. Commun. Chem. Pathol. Pharmacol.
    Bustos ML et al., 2016, Polymorphisms in CYP1A1 and CYP3A5 Genes Contribute to the Variability in Granisetron Clearance and Exposure in Pregnant Women with Nausea and Vomiting., Pharmacotherapy
    Ciolino et al., 1999, Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially., Biochem. J.
    Dong N et al., 2012, Pharmacogenetic assessment of clinical outcome in patients with metastatic breast cancer treated with docetaxel plus capecitabine., J Cancer Res Clin Oncol
    Taylor et al., 1985, Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone., Xenobiotica
    Zhang Z et al., 1995, Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe., Drug Metab Dispos
    Luo Z et al., 2017, Identification of novel variants associated with warfarin stable dosage by use of a two-stage extreme phenotype strategy., J Thromb Haemost
    Daujat et al., 1996, Induction of CYP1A1 gene by benzimidazole derivatives during Caco-2 cell differentiation. Evidence for an aryl-hydrocarbon receptor-mediated mechanism., Eur. J. Biochem.
  • DEFERASIROX   CYP1A1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27193993 25348619


    Sources:
    PharmGKB

  • AMODIAQUINE   CYP1A1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RUTIN   CYP1A1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14633740


    Sources:
    NCI

  • GRANISETRON   CYP1A1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27809336


    Sources:
    PharmGKB

  • HYPERICIN   CYP1A1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14633740


    Sources:
    NCI

  • DACARBAZINE   CYP1A1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27428168


    Sources:
    PharmGKB

  • PROMETHAZINE   CYP1A1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    4024659


    Sources:
    NCI

  • ACACETIN   CYP1A1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21482471


    Sources:
    DTC

  • SPIRONOLACTONE   CYP1A1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7079590


    Sources:
    NCI

  • WARFARIN   CYP1A1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8689941 27740732


    Sources:
    PharmGKB

  • PHENOBARBITAL   CYP1A1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26951882 21121773


    Sources:
    PharmGKB

  • LANSOPRAZOLE   CYP1A1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8647108


    Sources:
    NCI

  • PHENYTOIN   CYP1A1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26951882 21121773


    Sources:
    PharmGKB

  • CARBAMAZEPINE   CYP1A1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26951882 21121773


    Sources:
    PharmGKB

  • CAPECITABINE   CYP1A1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22426923


    Sources:
    PharmGKB

  • RISPERIDONE   CYP1A1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10048600


    Sources:
    NCI

  • DAUNORUBICIN   CYP1A1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15588138


    Sources:
    NCI

  • OLANZAPINE   CYP1A1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23492908


    Sources:
    PharmGKB

  • DOCETAXEL   CYP1A1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22426923


    Sources:
    PharmGKB

  • QUERCETIN   CYP1A1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10359656


    Sources:
    NCI

  • DOXORUBICIN   CYP1A1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15588138


    Sources:
    NCI

  • Ensembl: ENSG00000140465

    • Version: 101_38

    Alternate Names:
    CYP1A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P04798

    • Version: 11-September-2012

    Alternate Names:
    CP1A1_HUMAN Uniprot Id
    1543 Entrez Gene Id
    ENSG00000140465 Ensembl Gene Id

    Gene Info:
    Interpro Type Family
    Interpro Name Cytochrome P450
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME, CYTOCHROME P450

    Publications:

  • RussLampel: ENSG00000140465

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000140465 Ensembl Gene Id
    CYTOCHROME P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1) (P450 FORM 6) (P450-C). [SOURCE:UNIPROT/SWISSPROT;ACC:P04798] Description
    CYP1A1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: CYP1A1

    • Version: 18-August-2020

    Alternate Names:
    PA27092 PharmGKB ID

    Gene Info:

    Publications:
    Lewis BC et al., 2016, Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy., Pharmacogenet Genomics
    Söderberg MM et al., 2013, Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure., Pharmacogenet Genomics
    Talwar P et al., 2017, Genetic contribution of CYP1A1 variant on treatment outcome in epilepsy patients: a functional and interethnic perspective., Pharmacogenomics J

  • NCI: CYP1A1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Schröterová et al., 2004, The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro., Physiol Res
    Fujita et al., 1982, Effect of spironolactone on hepatic microsomal monooxygenase and azoreductase activities., Res. Commun. Chem. Pathol. Pharmacol.
    Ciolino et al., 1999, Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially., Biochem. J.

  • DTC: CYP1A1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Androutsopoulos VP et al., 2011, Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids., Bioorg Med Chem

  • HingoraniCasas: ENSG00000140465

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000140465 Gene Symbol
    CYP1A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: CYP1A1

    • Version: 01-February-2022

    Alternate Names:
    Cytochrome P450 1A1 Gene Name
    P04798 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21