DGIdb - CYP1A1 Gene Record

CYP1A1 1543 Druggable GenomeDrug Resistance

Alternate Names:

1543
CYTOCHROME P450 FAMILY 1 SUBFAMILY A MEMBER 1
CYP1A1
AHH
AHRR
CP11
CYP1
CYPIA1
P1-450
P450-C
P450DX
108330
2595
ENSG00000140465
OTTHUMG00000142812
P04798
CP1A1_HUMAN
CYTOCHROME P450 1A1
CYTOCHROME P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1) (P450 FORM 6) (P450-C). [SOURCE:UNIPROT/SWISSPROT;ACC:P04798]
BE0003543
1318
PA27092

Gene Info:

Interpro Type	Family
Interpro Name	Cytochrome P450
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Cyt_P450
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Acc	IPR001128
Human Readable Name	CYTOCHROME P450
GuideToPharmacology Gene Category Name	CYP1 family
GuideToPharmacology Gene Category ID	261
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
DRUGGABLE GENOME
DRUG METABOLISM
CYTOCHROME P450
ENZYME

Publications:

Lewis BC et al., 2016, Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy., Pharmacogenet Genomics
Söderberg MM et al., 2013, Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure., Pharmacogenet Genomics
Talwar P et al., 2017, Genetic contribution of CYP1A1 variant on treatment outcome in epilepsy patients: a functional and interethnic perspective., Pharmacogenomics J
Grover S et al., 2010, Genetic polymorphisms in sex hormone metabolizing genes and drug response in women with epilepsy., Pharmacogenomics
Androutsopoulos VP et al., 2011, Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids., Bioorg Med Chem
Allegra S et al., 2016, Deferasirox AUC efficacy cutoff and role of pharmacogenetics., Eur J Clin Pharmacol
Cusato J et al., 2015, Influence of single-nucleotide polymorphisms on deferasirox C trough levels and effectiveness., Pharmacogenomics J
Fang et al., 1999, Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4., Naunyn Schmiedebergs Arch. Pharmacol.
Schwarz et al., 2003, St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1., Cancer Res.
Schröterová et al., 2004, The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro., Physiol Res
Fujita et al., 1982, Effect of spironolactone on hepatic microsomal monooxygenase and azoreductase activities., Res. Commun. Chem. Pathol. Pharmacol.
Bustos ML et al., 2016, Polymorphisms in CYP1A1 and CYP3A5 Genes Contribute to the Variability in Granisetron Clearance and Exposure in Pregnant Women with Nausea and Vomiting., Pharmacotherapy
Ciolino et al., 1999, Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially., Biochem. J.
Dong N et al., 2012, Pharmacogenetic assessment of clinical outcome in patients with metastatic breast cancer treated with docetaxel plus capecitabine., J Cancer Res Clin Oncol
Dawling et al., 2003, Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1., Cancer Res.
Taylor et al., 1985, Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone., Xenobiotica
Zhang Z et al., 1995, Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe., Drug Metab Dispos
Luo Z et al., 2017, Identification of novel variants associated with warfarin stable dosage by use of a two-stage extreme phenotype strategy., J Thromb Haemost
Daujat et al., 1996, Induction of CYP1A1 gene by benzimidazole derivatives during Caco-2 cell differentiation. Evidence for an aryl-hydrocarbon receptor-mediated mechanism., Eur. J. Biochem.
Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
Stout SM et al., 2014, Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review., Drug Metab Rev
Adachi J et al., 2004, Comparison of gene expression patterns between 2,3,7,8-tetrachlorodibenzo-p-dioxin and a natural arylhydrocarbon receptor ligand, indirubin., Toxicol Sci

INDIRUBIN CYP1A1

Interaction Score: 2.27

Interaction Types & Directionality:

substrate

Interaction Info:

PMIDs:
15056799

Sources:
DrugBank
DEFERASIROX CYP1A1

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27193993 25348619

Sources:
PharmGKB
AMODIAQUINE CYP1A1

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
RUTIN CYP1A1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14633740

Sources:
NCI
GRANISETRON CYP1A1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27809336

Sources:
PharmGKB
DACARBAZINE CYP1A1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27428168

Sources:
PharmGKB
2-METHOXYESTRADIOL CYP1A1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12810639

Sources:
DrugBank
HYPERICIN CYP1A1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14633740

Sources:
NCI
ACACETIN CYP1A1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21482471

Sources:
DTC
PROMETHAZINE CYP1A1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4024659

Sources:
NCI
WARFARIN CYP1A1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8689941 27740732

Sources:
PharmGKB
PHENOBARBITAL CYP1A1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26951882 21121773

Sources:
PharmGKB
LANSOPRAZOLE CYP1A1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8647108

Sources:
NCI
SPIRONOLACTONE CYP1A1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7079590

Sources:
NCI
PHENYTOIN CYP1A1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26951882 21121773

Sources:
PharmGKB
NABIXIMOLS CYP1A1

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26264914 24160757

Sources:
DrugBank
CHRYSIN CYP1A1

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CARBAMAZEPINE CYP1A1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26951882 21121773

Sources:
PharmGKB
CAPECITABINE CYP1A1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22426923

Sources:
PharmGKB
DAUNORUBICIN CYP1A1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15588138

Sources:
NCI
RISPERIDONE CYP1A1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10048600

Sources:
NCI
OLANZAPINE CYP1A1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23492908

Sources:
PharmGKB
DOCETAXEL CYP1A1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22426923

Sources:
PharmGKB
DOXORUBICIN CYP1A1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15588138

Sources:
NCI
QUERCETIN CYP1A1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10359656

Sources:
NCI

Ensembl: ENSG00000140465
- Version: 101_38
Alternate Names:

CYP1A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P04798
- Version: 11-September-2012
Alternate Names:

CP1A1_HUMAN Uniprot Id

1543 Entrez Gene Id

ENSG00000140465 Ensembl Gene Id

Gene Info:

Interpro Type Family

Interpro Name Cytochrome P450

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Publications:
RussLampel: ENSG00000140465
- Version: 26-July-2011
Alternate Names:

ENSG00000140465 Ensembl Gene Id

CYTOCHROME P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1) (P450 FORM 6) (P450-C). [SOURCE:UNIPROT/SWISSPROT;ACC:P04798] Description

CYP1A1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 1543
- Version: 29-September-2020
Alternate Names:

2595 HUGO Gene ID

2595 HUGO Gene Symbol

cytochrome P450 family 1 subfamily A member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CYP1 family

GuideToPharmacology Gene Category ID 261

Gene Categories:

ENZYME

Publications:

PharmGKB: CYP1A1

Version: 18-August-2020

Alternate Names:

PA27092 PharmGKB ID

Gene Info:

Publications:

Lewis BC et al., 2016, Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy., Pharmacogenet Genomics

Söderberg MM et al., 2013, Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure., Pharmacogenet Genomics

Grover S et al., 2010, Genetic polymorphisms in sex hormone metabolizing genes and drug response in women with epilepsy., Pharmacogenomics

DrugBank: BE0003543

Version: 5.1.7

Alternate Names:

CYP1A1 DrugBank Gene Name

P04798 UniProt Accession

1543 Entrez Gene Id

Gene Info:

Publications:

Stout SM et al., 2014, Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review., Drug Metab Rev

Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

Dawling et al., 2003, Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1., Cancer Res.

NCI: CYP1A1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Schröterová et al., 2004, The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro., Physiol Res

Fujita et al., 1982, Effect of spironolactone on hepatic microsomal monooxygenase and azoreductase activities., Res. Commun. Chem. Pathol. Pharmacol.

Ciolino et al., 1999, Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially., Biochem. J.

DTC: CYP1A1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Androutsopoulos VP et al., 2011, Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids., Bioorg Med Chem
HingoraniCasas: ENSG00000140465
- Version: 31-May-2017
Alternate Names:

ENSG00000140465 Gene Symbol

CYP1A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: CYP1A1
- Version: 03-September-2020
Alternate Names:

Cytochrome P450 1A1 Gene Name

P04798 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: CYP1A1
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

DRUG METABOLISM, DRUG RESISTANCE

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

CP1A1_HUMAN	Uniprot Id
1543	Entrez Gene Id
ENSG00000140465	Ensembl Gene Id

2595	HUGO Gene ID
2595	HUGO Gene Symbol
cytochrome P450 family 1 subfamily A member 1	HUGO Gene Name

CYP1A1	DrugBank Gene Name
P04798	UniProt Accession
1543	Entrez Gene Id

CYP1A1 Gene Record

CYP1A1 1543 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: substrate

Interaction Info:

PMIDs: 15056799

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27193993 25348619

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14633740

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27809336

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27428168

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12810639

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14633740

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21482471

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 4024659

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8689941 27740732

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26951882 21121773

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8647108

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7079590

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26951882 21121773

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 26264914 24160757

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26951882 21121773

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

substrate

PMIDs:
15056799

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
27193993 25348619

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
14633740

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
27809336

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27428168

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12810639

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
14633740

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21482471

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
4024659

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8689941 27740732

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26951882 21121773

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8647108

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7079590

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26951882 21121773

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26264914 24160757

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
26951882 21121773

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22426923

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15588138

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10048600

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23492908

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22426923

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15588138

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10359656

Sources:
NCI

Alternate Names:

CYP1A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CP1A1_HUMAN Uniprot Id

1543 Entrez Gene Id

ENSG00000140465 Ensembl Gene Id

Gene Info:

Interpro Type Family

Interpro Name Cytochrome P450

Human Readable Name DRUGGABLE GENOME