DGIdb - CYP27B1 Gene Record

CYP27B1 1594 Druggable Genome

Alternate Names:

1594
CYTOCHROME P450 FAMILY 27 SUBFAMILY B MEMBER 1
CYP27B1
CP2B
CYP1
CYP1alpha
CYP27B
P450c1
PDDR
VDD1
VDDR
VDDRI
VDR
609506
2606
ENSG00000111012
OTTHUMG00000170457
25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.13.13) (CALCIDIOL 1-MONOOXYGENASE) (25-OHD-1 ALPHA- HYDROXYLASE) (25-HYDROXYVITAMIN D(3) 1-ALPHA-HYDROXYLASE) (VD3 1A HYDROXYLASE) (P450C1 ALPHA) (P450VD1-ALPHA). [SOURCE:UNIPROT/SW
O15528
25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
CP27B_HUMAN
PA27099

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Cyt_P450
Interpro Type	Family
Interpro Name	Cytochrome P450
Uniprot Status	Swiss-Prot
Human Readable Name	CYTOCHROME P450
Interpro Acc	IPR001128
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CYTOCHROME P450
ENZYME

Publications:

Lu Y et al., 2012, Design, synthesis, and biological action of 20R-hydroxyvitamin D3., J Med Chem
Lange CM et al., 2011, Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy., J Hepatol
Allegra S et al., 2019, The effect of vitamin D pathway genes and deferasirox pharmacogenetics on liver iron in thalassaemia major patients., Pharmacogenomics J

CHEMBL2036072 CYP27B1

Interaction Score: 41.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22404326

Sources:
DTC
DEFERASIROX CYP27B1

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30651574

Sources:
PharmGKB
RIBAVIRIN CYP27B1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21145801

Sources:
PharmGKB

Ensembl: ENSG00000111012
- Version: 101_38
Alternate Names:

CYP27B1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000111012

Version: 26-July-2011

Alternate Names:

CYP27B1 Display Id

ENSG00000111012 Ensembl Gene Id

25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.13.13) (CALCIDIOL 1-MONOOXYGENASE) (25-OHD-1 ALPHA- HYDROXYLASE) (25-HYDROXYVITAMIN D(3) 1-ALPHA-HYDROXYLASE) (VD3 1A HYDROXYLASE) (P450C1 ALPHA) (P450VD1-ALPHA). [SOURCE:UNIPROT/SW Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: O15528
- Version: 11-September-2012
Alternate Names:

CP27B_HUMAN Uniprot Id

1594 Entrez Gene Id

25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Cyt_P450

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Publications:

PharmGKB: CYP27B1

Version: 18-August-2020

Alternate Names:

PA27099 PharmGKB ID

Gene Info:

Publications:

Lange CM et al., 2011, Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy., J Hepatol

Cusato J et al., 2020, Pharmacogenetic determinants of kidney-associated urinary and serum abnormalities in antiretroviral-treated HIV-positive patients., Pharmacogenomics J

Allegra S et al., 2019, The effect of vitamin D pathway genes and deferasirox pharmacogenetics on liver iron in thalassaemia major patients., Pharmacogenomics J

NCI: CYP27B1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kállay et al., 2002, Phytoestrogens regulate vitamin D metabolism in the mouse colon: relevance for colon tumor prevention and therapy., J. Nutr.

Khorchide et al., 2005, Epigenetic regulation of vitamin D hydroxylase expression and activity in normal and malignant human prostate cells., J. Steroid Biochem. Mol. Biol.

Omdahl et al., 2002, Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation., Annu. Rev. Nutr.

DTC: CYP27B1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Lu Y et al., 2012, Design, synthesis, and biological action of 20R-hydroxyvitamin D3., J Med Chem
HingoraniCasas: ENSG00000111012
- Version: 31-May-2017
Alternate Names:

ENSG00000111012 Gene Symbol

CYP27B1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: CYP27B1
- Version: 19.3
Alternate Names:

ENSG00000111012 Ensembl Gene ID

CYP1 Human Protein Atlas Gene Synonym

P450c1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: CYP27B1
- Version: 01-February-2022
Alternate Names:

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Gene Name

O15528 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

CYP27B1	Display Id
ENSG00000111012	Ensembl Gene Id
25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.13.13) (CALCIDIOL 1-MONOOXYGENASE) (25-OHD-1 ALPHA- HYDROXYLASE) (25-HYDROXYVITAMIN D(3) 1-ALPHA-HYDROXYLASE) (VD3 1A HYDROXYLASE) (P450C1 ALPHA) (P450VD1-ALPHA). [SOURCE:UNIPROT/SW	Description

CP27B_HUMAN	Uniprot Id
1594	Entrez Gene Id
25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL	Uniprot Protein Name

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	Gene Name
O15528	UniProt ID

CYP27B1 Gene Record

CYP27B1 1594 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CHEMBL2036072 CYP27B1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22404326

Sources: DTC

DEFERASIROX CYP27B1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30651574

Sources: PharmGKB

RIBAVIRIN CYP27B1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21145801

Sources: PharmGKB

Ensembl: ENSG00000111012

Alternate Names: CYP27B1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000111012

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: O15528

Alternate Names: CP27B_HUMAN Uniprot Id 1594 Entrez Gene Id 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL Uniprot Protein Name

Gene Info: Uniprot Evidence 1: Evidence at protein level Human Readable Name DRUGGABLE GENOME Interpro Short Name Cyt_P450

Gene Categories: DRUGGABLE GENOME, CYTOCHROME P450

Publications:

PharmGKB: CYP27B1

Alternate Names: PA27099 PharmGKB ID

Gene Info:

NCI: CYP27B1

Alternate Names:

Gene Info:

DTC: CYP27B1

Alternate Names:

Gene Info:

Publications: Lu Y et al., 2012, Design, synthesis, and biological action of 20R-hydroxyvitamin D3., J Med Chem

HingoraniCasas: ENSG00000111012

Alternate Names: ENSG00000111012 Gene Symbol CYP27B1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: CYP27B1

Alternate Names: ENSG00000111012 Ensembl Gene ID CYP1 Human Protein Atlas Gene Synonym P450c1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

Pharos: CYP27B1

Alternate Names: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Gene Name O15528 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
22404326

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
30651574

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21145801

Sources:
PharmGKB

Alternate Names:

CYP27B1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CP27B_HUMAN Uniprot Id

1594 Entrez Gene Id

25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Cyt_P450

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Alternate Names:

PA27099 PharmGKB ID

Publications:

Lu Y et al., 2012, Design, synthesis, and biological action of 20R-hydroxyvitamin D3., J Med Chem

Alternate Names:

ENSG00000111012 Gene Symbol

CYP27B1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000111012 Ensembl Gene ID

CYP1 Human Protein Atlas Gene Synonym

P450c1 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Gene Name

O15528 UniProt ID

Gene Categories:

ENZYME