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CYP27B1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CYP27B1 1594 Druggable Genome

    Alternate Names:

    1594
    CYTOCHROME P450 FAMILY 27 SUBFAMILY B MEMBER 1
    CYP27B1
    CP2B
    CYP1
    CYP1alpha
    CYP27B
    P450c1
    PDDR
    VDD1
    VDDR
    VDDRI
    VDR
    609506
    2606
    ENSG00000111012
    OTTHUMG00000170457
    25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.13.13) (CALCIDIOL 1-MONOOXYGENASE) (25-OHD-1 ALPHA- HYDROXYLASE) (25-HYDROXYVITAMIN D(3) 1-ALPHA-HYDROXYLASE) (VD3 1A HYDROXYLASE) (P450C1 ALPHA) (P450VD1-ALPHA). [SOURCE:UNIPROT/SW
    O15528
    25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
    CP27B_HUMAN
    PA27099

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Cyt_P450
    Interpro Type Family
    Interpro Name Cytochrome P450
    Uniprot Status Swiss-Prot
    Human Readable Name CYTOCHROME P450
    Interpro Acc IPR001128
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CYTOCHROME P450
    ENZYME

    Publications:

    Lu Y et al., 2012, Design, synthesis, and biological action of 20R-hydroxyvitamin D3., J Med Chem
    Lange CM et al., 2011, Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy., J Hepatol
    Allegra S et al., 2019, The effect of vitamin D pathway genes and deferasirox pharmacogenetics on liver iron in thalassaemia major patients., Pharmacogenomics J
  • CHEMBL2036072   CYP27B1

    Interaction Score: 41.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22404326


    Sources:
    DTC

  • DEFERASIROX   CYP27B1

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30651574


    Sources:
    PharmGKB

  • RIBAVIRIN   CYP27B1

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21145801


    Sources:
    PharmGKB

  • Ensembl: ENSG00000111012

    • Version: 101_38

    Alternate Names:
    CYP27B1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000111012

    • Version: 26-July-2011

    Alternate Names:
    CYP27B1 Display Id
    ENSG00000111012 Ensembl Gene Id
    25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.13.13) (CALCIDIOL 1-MONOOXYGENASE) (25-OHD-1 ALPHA- HYDROXYLASE) (25-HYDROXYVITAMIN D(3) 1-ALPHA-HYDROXYLASE) (VD3 1A HYDROXYLASE) (P450C1 ALPHA) (P450VD1-ALPHA). [SOURCE:UNIPROT/SW Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: O15528

    • Version: 11-September-2012

    Alternate Names:
    CP27B_HUMAN Uniprot Id
    1594 Entrez Gene Id
    25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL Uniprot Protein Name

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Cyt_P450

    Gene Categories:
    DRUGGABLE GENOME, CYTOCHROME P450

    Publications:

  • PharmGKB: CYP27B1

    • Version: 18-August-2020

    Alternate Names:
    PA27099 PharmGKB ID

    Gene Info:

    Publications:
    Lange CM et al., 2011, Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy., J Hepatol
    Cusato J et al., 2020, Pharmacogenetic determinants of kidney-associated urinary and serum abnormalities in antiretroviral-treated HIV-positive patients., Pharmacogenomics J
    Allegra S et al., 2019, The effect of vitamin D pathway genes and deferasirox pharmacogenetics on liver iron in thalassaemia major patients., Pharmacogenomics J

  • NCI: CYP27B1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kállay et al., 2002, Phytoestrogens regulate vitamin D metabolism in the mouse colon: relevance for colon tumor prevention and therapy., J. Nutr.
    Khorchide et al., 2005, Epigenetic regulation of vitamin D hydroxylase expression and activity in normal and malignant human prostate cells., J. Steroid Biochem. Mol. Biol.
    Omdahl et al., 2002, Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation., Annu. Rev. Nutr.

  • DTC: CYP27B1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Lu Y et al., 2012, Design, synthesis, and biological action of 20R-hydroxyvitamin D3., J Med Chem

  • HingoraniCasas: ENSG00000111012

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000111012 Gene Symbol
    CYP27B1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: CYP27B1

    • Version: 19.3

    Alternate Names:
    ENSG00000111012 Ensembl Gene ID
    CYP1 Human Protein Atlas Gene Synonym
    P450c1 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: CYP27B1

    • Version: 01-February-2022

    Alternate Names:
    25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Gene Name
    O15528 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21