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CYP2J2 Gene Record

  • Summary
  • Interactions
  • Claims
  • CYP2J2 1573 Druggable Genome

    Alternate Names:

    1573
    CYTOCHROME P450 FAMILY 2 SUBFAMILY J MEMBER 2
    CYP2J2
    CPJ2
    CYPIIJ2
    601258
    2634
    ENSG00000134716
    OTTHUMG00000008991
    P51589
    CYTOCHROME P450 2J2 (EC 1.14.14.1) (CYPIIJ2) (ARACHIDONIC ACID EPOXYGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P51589]
    CP2J2_HUMAN
    CYTOCHROME P450 2J2
    PA27112

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Name Cytochrome P450
    Interpro Short Name Cyt_P450
    Interpro Acc IPR001128
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Human Readable Name CYTOCHROME P450
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CYTOCHROME P450
    ENZYME

    Publications:

    Lee SS et al., 2005, Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity., Pharmacogenet Genomics
    Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos
    Genvigir FDV et al., 2017, Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients., Pharmacotherapy
  • MESORIDAZINE   CYP2J2

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19923256


    Sources:
    PharmGKB

  • ALBENDAZOLE   CYP2J2

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19923256


    Sources:
    PharmGKB

  • NABUMETONE   CYP2J2

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19923256


    Sources:
    PharmGKB

  • ASTEMIZOLE   CYP2J2

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15861034


    Sources:
    PharmGKB

  • TERFENADINE   CYP2J2

    Interaction Score: 0.88

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    15861034


    Sources:
    PharmGKB

  • THIORIDAZINE   CYP2J2

    Interaction Score: 0.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19923256


    Sources:
    PharmGKB

  • DANAZOL   CYP2J2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19923256


    Sources:
    PharmGKB

  • AMIODARONE   CYP2J2

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19923256


    Sources:
    PharmGKB

  • DICLOFENAC   CYP2J2

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15861034


    Sources:
    PharmGKB

  • TACROLIMUS   CYP2J2

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28316087


    Sources:
    PharmGKB

  • Ensembl: ENSG00000134716

    • Version: 101_38

    Alternate Names:
    CYP2J2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P51589

    • Version: 11-September-2012

    Alternate Names:
    1573 Entrez Gene Id
    ENSG00000134716 Ensembl Gene Id
    CYP2J2 Uniprot Gene Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Cytochrome P450
    Interpro Short Name Cyt_P450

    Gene Categories:
    DRUGGABLE GENOME, CYTOCHROME P450

    Publications:

  • RussLampel: ENSG00000134716

    • Version: 26-July-2011

    Alternate Names:
    CYP2J2 Display Id
    ENSG00000134716 Ensembl Gene Id
    CYTOCHROME P450 2J2 (EC 1.14.14.1) (CYPIIJ2) (ARACHIDONIC ACID EPOXYGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P51589] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: CYP2J2

    • Version: 18-August-2020

    Alternate Names:
    PA27112 PharmGKB ID

    Gene Info:

    Publications:
    Lee SS et al., 2005, Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity., Pharmacogenet Genomics
    Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos
    Genvigir FDV et al., 2017, Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients., Pharmacotherapy

  • HingoraniCasas: ENSG00000134716

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000134716 Gene Symbol
    CYP2J2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: CYP2J2

    • Version: 01-February-2022

    Alternate Names:
    Cytochrome P450 2J2 Gene Name
    P51589 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21