10800 |
CYSTEINYL LEUKOTRIENE RECEPTOR 1 |
CYSLTR1 |
CYSLT1 |
CYSLT1R |
CYSLTR |
HMTMF81 |
300201 |
17451 |
ENSG00000173198 |
OTTHUMG00000021889 |
LTD4 receptor |
Cysteinyl leukotriene D4 receptor |
G-protein coupled receptor HG55 |
Q9Y271 |
HG55 |
CLTR1_HUMAN |
269 |
NP_006630 |
NM_006639 |
CysLT<sub>1</sub> receptor |
BE0000705 |
CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLTR1) (CYSTEINYL LEUKOTRIENE D4 RECEPTOR) (LTD4 RECEPTOR) (HG55) (HMTMF81). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y271] |
PA38453 |
Leukotriene CysLT1 receptor |
T71192 |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Transmembrane Helix Count | 7 |
Target Main Class | Receptors |
Interpro Acc | IPR000276 |
Uniprot Evidence | 2: Evidence at transcript level |
Uniprot Status | Swiss-Prot |
Interpro Type | Family |
Human Readable Name | DRUGGABLE GENOME |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Interpro Name | GPCR, rhodopsin-like, 7TM |
GuideToPharmacology Gene Category Name | Leukotriene receptors |
GuideToPharmacology Gene Category ID | 35 |
Gene Biotype | PROTEIN_CODING |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
antagonist (inhibitory) |
Mechanism of Interaction | Cysteinyl leukotriene receptor 1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Details of the Assay for Interaction | against [<sup>3</sup>H]LTD<sub>4</sub> in human lung parenchyma |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Details of Interaction | against [<sup>3</sup>H]LTD<sub>4</sub> in human lung parenchyma |
Endogenous Drug? | False |
antagonist (inhibitory) |
Details of Interaction | against 10nM LTD<sub>4</sub> aequorin-based Ca<sup>2+</sup> assay in CHO cells |
Details of Interaction | zafirlukast is only about 100-fold selective for CysLT<sub>1</sub> |
Details of the Assay for Interaction | against [<sup>3</sup>H]LTD<sub>4</sub> in human lung parenchyma |
antagonist (inhibitory) |
Details of the Assay for Interaction | against [<sup>3</sup>H]LTD4 in COS-7 or HEK-293 cells |
Details of Interaction | against 33nM LTD<sub>4</sub> Ca<sup>2+</sup> mobilization assay in HEK-293 |
Direct Interaction? | True |
antagonist (inhibitory) |
Details of the Assay for Interaction | against [<sup>3</sup>H]LTD<sub>4</sub> in human lung homogenate |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Details of Interaction | against [<sup>3</sup>H]LTD<sub>4</sub> in HEK-293 |
Endogenous Drug? | False |
antagonist (inhibitory) |
Details of the Assay for Interaction | Antagonism of [<sup>3</sup>H]LTD<sub>4</sub> binding in COS-7 cells. |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Cysteinyl leukotriene receptor 1 antagonist |
Direct Interaction | yes |
CYSLTR1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000173198 | Ensembl Gene Id |
CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLTR1) (CYSTEINYL LEUKOTRIENE D4 RECEPTOR) (LTD4 RECEPTOR) (HG55) (HMTMF81). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y271] | Description |
CYSLTR1 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
10800 | Entrez Gene Id |
CLTR1_HUMAN | Uniprot Id |
CYSLTR1 | Gene Symbol |
Transmembrane Helix Count | 7 |
Target Main Class | Receptors |
Target Subclass | GPCR |
CYSLTR1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
ENSG00000173198 | Ensembl Gene Id |
Q9Y271 | Uniprot Accession |
CLTR1_HUMAN | Uniprot Id |
Interpro Acc | IPR000276 |
Uniprot Evidence | 2: Evidence at transcript level |
Uniprot Status | Swiss-Prot |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
17451 | HUGO Gene ID |
17451 | HUGO Gene Symbol |
cysteinyl leukotriene receptor 1 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | Leukotriene receptors |
GuideToPharmacology Gene Category ID | 35 |
G PROTEIN COUPLED RECEPTOR |
CYSLTR1 | DrugBank Gene Name |
Q9Y271 | UniProt Accession |
10800 | Entrez Gene Id |
CYSLT1 | GENE_SYMBOL |
CYSLTR1 | GENE_SYMBOL |
Cysteinyl leukotriene receptor 1 | UNIPROT |
ENSG00000173198 | Gene Symbol |
CYSLTR1 | Ensembl Id |
DRUGGABLE GENOME |
PA38453 | PharmGKB ID |
10800 | Gene ID |
CYSLT1 | dGene Synonym |
CYSLT1R | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
CYSLTR1 | TTD Gene Abbreviation |
T71192 | TTD Target ID |