• Interaction Score: 25.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction against [<sup>3</sup>H]LTD<sub>4</sub> in human lung parenchyma
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

  • Interaction Score: 15.95

    Interaction Types & Directionality:
    suppressor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 9.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 9.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 4.56

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


  • Interaction Score: 4.56

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Details of Interaction against [<sup>3</sup>H]LTD<sub>4</sub> in human lung parenchyma
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 3.22

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of Interaction against 10nM LTD<sub>4</sub> aequorin-based Ca<sup>2+</sup> assay in CHO cells
    Details of Interaction zafirlukast is only about 100-fold selective for CysLT<sub>1</sub>
    Details of the Assay for Interaction against [<sup>3</sup>H]LTD<sub>4</sub> in human lung parenchyma

  • Interaction Score: 2.78

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction against [<sup>3</sup>H]LTD4 in COS-7 or HEK-293 cells
    Details of Interaction against 33nM LTD<sub>4</sub> Ca<sup>2+</sup> mobilization assay in HEK-293
    Direct Interaction? True

  • Interaction Score: 2.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 2.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction against [<sup>3</sup>H]LTD<sub>4</sub> in human lung homogenate
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 2.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 2.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Details of Interaction against [<sup>3</sup>H]LTD<sub>4</sub> in HEK-293
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.91

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Antagonism of [<sup>3</sup>H]LTD<sub>4</sub> binding in COS-7 cells.
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.91

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    CYSLTR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000173198 Ensembl Gene Id
    CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLTR1) (CYSTEINYL LEUKOTRIENE D4 RECEPTOR) (LTD4 RECEPTOR) (HG55) (HMTMF81). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y271] Description
    CYSLTR1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    10800 Entrez Gene Id
    CLTR1_HUMAN Uniprot Id
    CYSLTR1 Gene Symbol

    Gene Info:
    Transmembrane Helix Count 7
    Target Main Class Receptors
    Target Subclass GPCR

    Publications:

    • Version: January-2014

    Alternate Names:
    CYSLTR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000173198 Ensembl Gene Id
    Q9Y271 Uniprot Accession
    CLTR1_HUMAN Uniprot Id

    Gene Info:
    Interpro Acc IPR000276
    Uniprot Evidence 2: Evidence at transcript level
    Uniprot Status Swiss-Prot

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    17451 HUGO Gene ID
    17451 HUGO Gene Symbol
    cysteinyl leukotriene receptor 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Leukotriene receptors
    GuideToPharmacology Gene Category ID 35

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

    • Version: 14-September-2017
    • Version: chembl_23

    Alternate Names:
    CYSLT1 GENE_SYMBOL
    CYSLTR1 GENE_SYMBOL
    Cysteinyl leukotriene receptor 1 UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000173198 Gene Symbol
    CYSLTR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 18-August-2020

    Alternate Names:
    PA38453 PharmGKB ID

    Gene Info:

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    10800 Gene ID
    CYSLT1 dGene Synonym
    CYSLT1R dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    CYSLTR1 TTD Gene Abbreviation
    T71192 TTD Target ID

    Gene Info:

    Publications: