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CYSLTR1 10800 Druggable Genome
Alternate Names:
10800 CYSTEINYL LEUKOTRIENE RECEPTOR 1 CYSLTR1 CYSLT1 CYSLT1R CYSLTR HMTMF81 300201 17451 ENSG00000173198 OTTHUMG00000021889 LTD4 receptor Cysteinyl leukotriene D4 receptor G-protein coupled receptor HG55 Q9Y271 HG55 CLTR1_HUMAN 269 NP_006630 NM_006639 CysLT<sub>1</sub> receptor BE0000705 CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLTR1) (CYSTEINYL LEUKOTRIENE D4 RECEPTOR) (LTD4 RECEPTOR) (HG55) (HMTMF81). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y271] PA38453 Leukotriene CysLT1 receptor T71192 Gene Info:
Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin Human Readable Name G PROTEIN COUPLED RECEPTOR Transmembrane Helix Count 7 Target Main Class Receptors Interpro Acc IPR000276 Uniprot Evidence 2: Evidence at transcript level Uniprot Status Swiss-Prot Interpro Type Family Human Readable Name DRUGGABLE GENOME Interpro Short Name 7TM_GPCR_Rhodpsn Interpro Name GPCR, rhodopsin-like, 7TM GuideToPharmacology Gene Category Name Leukotriene receptors GuideToPharmacology Gene Category ID 35 Gene Biotype PROTEIN_CODING Gene Categories: Category Details
G PROTEIN COUPLED RECEPTOR DRUGGABLE GENOME Publications:
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Interaction Score: 8.28
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Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist Direct Interaction yes -
Interaction Score: 6.09
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Details of the Assay for Interaction against [<sup>3</sup>H]LTD<sub>4</sub> in human lung parenchyma Specific Action of the Ligand Antagonist Endogenous Drug? False -
Interaction Score: 4.73
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Interaction Score: 4.73
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Interaction Score: 4.73
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Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Antagonist -
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Details of Interaction against [<sup>3</sup>H]LTD<sub>4</sub> in human lung parenchyma Endogenous Drug? False -
Interaction Score: 2.71
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Details of Interaction against 10nM LTD<sub>4</sub> aequorin-based Ca<sup>2+</sup> assay in CHO cells Details of Interaction zafirlukast is only about 100-fold selective for CysLT<sub>1</sub> Details of the Assay for Interaction against [<sup>3</sup>H]LTD<sub>4</sub> in human lung parenchyma -
Interaction Score: 2.37
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Details of the Assay for Interaction against [<sup>3</sup>H]LTD4 in COS-7 or HEK-293 cells Details of Interaction against 33nM LTD<sub>4</sub> Ca<sup>2+</sup> mobilization assay in HEK-293 Direct Interaction? True -
Interaction Score: 1.78
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Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Details of the Assay for Interaction against [<sup>3</sup>H]LTD<sub>4</sub> in human lung homogenate Specific Action of the Ligand Antagonist Endogenous Drug? False -
Interaction Score: 1.78
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Interaction Score: 1.78
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Details of Interaction against [<sup>3</sup>H]LTD<sub>4</sub> in HEK-293 Endogenous Drug? False -
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Details of the Assay for Interaction Antagonism of [<sup>3</sup>H]LTD<sub>4</sub> binding in COS-7 cells. Specific Action of the Ligand Antagonist Endogenous Drug? False -
Interaction Score: 0.71
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist Direct Interaction yes
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- Version: 101_38
Alternate Names:
CYSLTR1 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 26-July-2011
Alternate Names:
ENSG00000173198 Ensembl Gene Id CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLTR1) (CYSTEINYL LEUKOTRIENE D4 RECEPTOR) (LTD4 RECEPTOR) (HG55) (HMTMF81). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y271] Description CYSLTR1 Display Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
10800 Entrez Gene Id CLTR1_HUMAN Uniprot Id CYSLTR1 Gene Symbol Gene Info:
Transmembrane Helix Count 7 Target Main Class Receptors Target Subclass GPCR Publications:
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- Version: January-2014
Alternate Names:
CYSLTR1 Gene Symbol Gene Info:
Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin Publications:
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- Version: 11-September-2012
Alternate Names:
ENSG00000173198 Ensembl Gene Id Q9Y271 Uniprot Accession CLTR1_HUMAN Uniprot Id Gene Info:
Interpro Acc IPR000276 Uniprot Evidence 2: Evidence at transcript level Uniprot Status Swiss-Prot Gene Categories:
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME Publications:
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- Version: 29-September-2020
Alternate Names:
17451 HUGO Gene ID 17451 HUGO Gene Symbol cysteinyl leukotriene receptor 1 HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name Leukotriene receptors GuideToPharmacology Gene Category ID 35 Gene Categories:
G PROTEIN COUPLED RECEPTOR Publications:
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Alternate Names:
CYSLTR1 DrugBank Gene Name Q9Y271 UniProt Accession 10800 Entrez Gene Id Gene Info:
Publications:
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Alternate Names:
Gene Info:
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- Version: chembl_23
Alternate Names:
CYSLT1 GENE_SYMBOL CYSLTR1 GENE_SYMBOL Cysteinyl leukotriene receptor 1 UNIPROT Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000173198 Gene Symbol CYSLTR1 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
PA38453 PharmGKB ID Gene Info:
Publications:
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Alternate Names:
10800 Gene ID CYSLT1 dGene Synonym CYSLT1R dGene Synonym Gene Info:
Gene Categories:
G PROTEIN COUPLED RECEPTOR Publications:
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- Version: 2020.06.01
Alternate Names:
CYSLTR1 TTD Gene Abbreviation T71192 TTD Target ID Gene Info:
Publications: