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DKK1 Gene Record

  • Summary
  • Interactions
  • Claims
  • DKK1 22943 Druggable GenomeDrug Resistance

    Alternate Names:

    22943
    DICKKOPF WNT SIGNALING PATHWAY INHIBITOR 1
    DKK1
    DKK-1
    SK
    605189
    2891
    ENSG00000107984
    OTTHUMG00000018247
    Dickkopf-related protein 1
    Dickkopf-1
    hDkk-1
    SPHK
    SPHINGOSINE KINASE
    9171
    T56697
    T16224
    UNQ492/PRO1008

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUG RESISTANCE
    DRUGGABLE GENOME

    Publications:

    Aguilera et al., 2015, Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer., Oncotarget
    Kwack et al., 2008, Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes., J. Invest. Dermatol.
  • LEVOLEUCOVORIN   DKK1

    Interaction Score: 20.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25788273


    Sources:
    CIViC

  • BHQ-880   DKK1

    Interaction Score: 20.61

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Dickkopf-related protein 1 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ANDROSTANOLONE   DKK1

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17657240


    Sources:
    NCI

  • OXALIPLATIN   DKK1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25788273


    Sources:
    CIViC

  • IRINOTECAN   DKK1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25788273


    Sources:
    CIViC

  • FLUOROURACIL   DKK1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25788273


    Sources:
    CIViC

  • Ensembl: ENSG00000107984

    • Version: 101_38

    Alternate Names:
    DKK1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: DKK1

    • Version: 14-September-2020

    Alternate Names:
    22943 Entrez Gene ID
    9171 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Aguilera et al., 2015, Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer., Oncotarget

  • NCI: DKK1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Oyajobi et al., 2007, Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease., Br. J. Haematol.
    Kwack et al., 2008, Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes., J. Invest. Dermatol.

  • ChemblInteractions: DKK1

    • Version: chembl_23

    Alternate Names:
    DKK1 GENE_SYMBOL
    Dickkopf-related protein 1 UNIPROT
    SK UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000107984

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000107984 Gene Symbol
    DKK1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: DKK1

    • Version: 01-February-2022

    Alternate Names:
    UNQ492/PRO1008 GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

  • TTD: Dickkopf-related protein 1

    • Version: 2020.06.01

    Alternate Names:
    DKK1 TTD Gene Abbreviation
    T56697 TTD Target ID

    Gene Info:

    Publications:

  • TTD: Sphingosine kinase

    • Version: 2020.06.01

    Alternate Names:
    SphK TTD Gene Abbreviation
    T16224 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21