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DPYD 1806 Druggable GenomeClinically Actionable
Alternate Names:
1806 DIHYDROPYRIMIDINE DEHYDROGENASE DPYD DHP DHPDHASE DPD 612779 3012 ENSG00000188641 OTTHUMG00000039683 1526 Q12882 DIHYDROPYRIMIDINE DEHYDROGENASE [NADP+] PRECURSOR (EC 1.3.1.2) (DPD) (DHPDHASE) (DIHYDROURACIL DEHYDROGENASE) (DIHYDROTHYMINE DEHYDROGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q12882] PA145 Dihydrothymine dehydrogenase T75890 3102 NM_000110 NP_000101 Dihydropyrimidine dehydrogenase [NADP(+)] Gene Info:
Target Class Enzymes Target Subclass EC:1.3.1.2 Human Readable Name DRUGGABLE GENOME Gene Biotype PROTEIN_CODING GuideToPharmacology Gene Category Name Nucleotide turnover GuideToPharmacology Gene Category ID 1029 Gene Categories: Category Details
DRUGGABLE GENOME CLINICALLY ACTIONABLE ENZYME Publications:
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Interaction Types & Directionality:
n/a Interaction Info:
Alteration DPYD:I560S,D949V Alteration DPYD:. Drug family Fluoropyrimidine PMIDs:
9470816 9439663 9323575 32378051 31382864 30858516 30723313 30114658 29889674 29846282 29134491 28950804 28929491 28295243 27995989 27864592 27454530 27122156 26846104 26804652 26794347 26603945 26265035 26216193 26099996 25796495 25677447 25410891 24923815 24817302 23988873 23942539 23930673 23603345 23585145 22490566 21498394 21077799 20819423 20665215 20385995 19858398 19795123 19530960 19473056 18600527 18452418 18443386 18299612 17848752 17700593 17417073 17203168 17165084 17121937 17064846 17000685 16361556 16151913 16115930 15944764 15132136 15017333 14635116 12360106 12209976 11895907 11555601 11350878 11156223 10803677 10071185 8521418
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Interaction Score: 10.63
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name eniluracil Novel drug target Novel Target -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name S-1, TS1 Novel drug target Novel Target -
Interaction Score: 3.54
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Interaction Score: 1.52
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Interaction Score: 1.18
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Interaction Score: 0.74
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Interaction Score: 0.38
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Interaction Score: 0.27
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- Version: 101_38
Alternate Names:
DPYD Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: January-2014
Alternate Names:
DPYD Gene Symbol Gene Info:
Target Class Enzymes Target Subclass EC:1.3.1.2 Publications:
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- Version: 26-July-2011
Alternate Names:
ENSG00000188641 Ensembl Gene Id DIHYDROPYRIMIDINE DEHYDROGENASE [NADP+] PRECURSOR (EC 1.3.1.2) (DPD) (DHPDHASE) (DIHYDROURACIL DEHYDROGENASE) (DIHYDROTHYMINE DEHYDROGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q12882] Description DPYD Display Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 29-September-2020
Alternate Names:
3012 HUGO Gene ID 3012 HUGO Gene Symbol dihydropyrimidine dehydrogenase HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name Nucleotide turnover GuideToPharmacology Gene Category ID 1029 Gene Categories:
ENZYME Publications:
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Alternate Names:
PA145 PharmGKB ID Gene Info:
Publications:
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Alternate Names:
1806 Entrez Gene ID 1526 CIViC Gene ID Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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Alternate Names:
Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000188641 Gene Symbol DPYD Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
DPYD Gene Symbol Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 2020.06.01
Alternate Names:
DPYD TTD Gene Abbreviation T75890 TTD Target ID Gene Info:
Publications:
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Alternate Names:
Dihydropyrimidine dehydrogenase [NADP(+)] Gene Name Q12882 UniProt ID Gene Info:
Gene Categories:
ENZYME Publications:
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Alternate Names:
Gene Info:
Publications:
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Alternate Names:
Gene Info:
Publications: