DGIdb - DRD1 Gene Record

DRD1 1812 Druggable GenomeDrug Resistance

Alternate Names:

1812
DOPAMINE RECEPTOR D1
DRD1
DADR
DRD1A
126449
3020
ENSG00000184845
OTTHUMG00000130557
DRD1_HUMAN
P21728
D(1A) dopamine receptor
Dopamine D1 receptor
D(1A) DOPAMINE RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P21728]
PA147
214
D<sub>1</sub> receptor
NM_000794
NP_000785
D1R
T22118

Gene Info:

Target Subclass	GPCR
Target Main Class	Receptors
Transmembrane Helix Count	6
Target Subclass	Rhodopsin
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
GuideToPharmacology Gene Category Name	Dopamine receptors
GuideToPharmacology Gene Category ID	20
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
Interpro Type	Family
Interpro Acc	IPR000276
Interpro Short Name	7TM_GPCR_Rhodpsn
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

KINASE
DRUG RESISTANCE
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
Van Kampen et al., 2000, Dopamine D(1A) receptor function in a rodent model of tardive dyskinesia., Neuroscience
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Cai et al., 1999, Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein., Mol. Pharmacol.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Hübner et al., 2000, Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype., J. Med. Chem.
Dolzan et al., 2007, Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment., Am. J. Med. Genet. B Neuropsychiatr. Genet.
Fu et al., 2007, Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations., Biophys. J.
Ostadali et al., 2004, The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR., Iran J Allergy Asthma Immunol
Hoenicka et al., 2007, From dopaminergic genes to psychiatric disorders., Neurotox Res
da Silva Lobo et al., 2007, Dopamine genes and pathological gambling in discordant sib-pairs., J Gambl Stud
Seeman et al., 1993, Dopamine receptor pharmacology., Curr Opin Neurol Neurosurg
Kanba et al., 1994, Affinity of neuroleptics for D1 receptor of human brain striatum., J Psychiatry Neurosci
Hwang R et al., 2007, Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response., J Psychopharmacol
Reimold et al., 2007, Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol., Psychopharmacology (Berl.)
Huang W et al., 2008, Significant association of DRD1 with nicotine dependence., Hum Genet
Dhasmana et al., The role of dopamine (D2), alpha and beta-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the rat., Pharmacol. Res.
Zeng et al., 2009, D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression., J. Hypertens.
Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Tauscher J et al., 2004, Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics., Am J Psychiatry
Moallem N et al., 2012, Quetiapine improves response inhibition in alcohol dependent patients: a placebo-controlled pilot study., Pharmacol Biochem Behav
Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
Fernández et al., 2005, Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents., J. Med. Chem.
Bymaster et al., 1999, Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro., Schizophr. Res.
Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics
Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
Berger et al., 1996, Trimipramine: a challenge to current concepts on antidepressives., Eur Arch Psychiatry Clin Neurosci
Guo et al., 2002, Apomorphine induces trophic factors that support fetal rat mesencephalic dopaminergic neurons in cultures., Eur. J. Neurosci.
LeWitt PA, 2004, Subcutaneously administered apomorphine: pharmacokinetics and metabolism., Neurology
Hammock et al., 1995, The effect of clozapine on self-injurious behavior., J Autism Dev Disord
Bobo, 2013, Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults., Expert Rev Clin Pharmacol
Schulze M et al., 2009, Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?, Bioorg Med Chem
Manzaneque et al., An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice., Methods Find Exp Clin Pharmacol
Lublin et al., 1991, Zuclopenthixol, a combined dopamine D1/D2 antagonist, versus haloperidol, a dopamine D2 antagonist, in tardive dyskinesia., Eur Neuropsychopharmacol
Reyes et al., Reinforcement in an in vitro analog of appetitive classical conditioning of feeding behavior in Aplysia: blockade by a dopamine antagonist., Learn. Mem.
Nargeot et al., 1999, Dopaminergic synapses mediate neuronal changes in an analogue of operant conditioning., J. Neurophysiol.
Levy F et al., 2013, Dopamine receptors and the pharmacogenetics of side-effects of stimulant treatment for attention-deficit/hyperactivity disorder., J Child Adolesc Psychopharmacol
Toll et al., 1998, Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications., NIDA Res. Monogr.
Vinar et al., 1967, Carphenazine in the treatment of schizophrenic psychoses. Controlled clinical trial., Act Nerv Super (Praha)
Platz et al., 1967, Selective drug action related to chronic schizophrenic subtype. (A comparative study of carphenazine, chlorpromazine, and trifluoperazine)., Dis Nerv Syst
Bora, 1968, Comparison of dosage ranges of carphenazine and trifluoperazine in elderly chronic schizophrenics., Dis Nerv Syst
Farde et al., 1989, D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics., Psychopharmacology (Berl.)
Puglisi-Allegra S et al., 1994, Post-training minaprine enhances memory storage in mice: involvement of D1 and D2 dopamine receptors., Psychopharmacology (Berl)
Kvernmo et al., 2006, A review of the receptor-binding and pharmacokinetic properties of dopamine agonists., Clin Ther
Ichikawa et al., 2001, [Pharmacological effects of cabergoline against parkinsonism]., Nippon Yakurigaku Zasshi
Millan et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes., J. Pharmacol. Exp. Ther.
Nasu et al., 2000, Quantitative prediction of catalepsy induced by amoxapine, cinnarizine and cyclophosphamide in mice., Biopharm Drug Dispos
Koller et al., 1998, Mechanism of action of dopaminergic agents in Parkinson's disease., Neurology
Onofrj et al., 2008, An expert opinion on safinamide in Parkinson's disease., Expert Opin Investig Drugs
Deleu et al., 2002, Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease., Clin Pharmacokinet
Ryman-Rasmussen JP et al., 2005, Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists., Mol Pharmacol
Creese I et al., 1996, Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs., J Neuropsychiatry Clin Neurosci
Chokhawala K et al., 2020, Antipsychotic Medications,
Horn AS et al., 1975, Dopamine receptor blockade and the neuroleptics, a crystallographic study., J Pharm Pharmacol
Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
Coppi G, 1992, [Dihydroergocristine. A review of pharmacology and toxicology]., Arzneimittelforschung
Fux et al., 1991, A controlled comparative study of chlorprothixene vs. haloperidol in chronic schizophrenia., Isr J Psychiatry Relat Sci
Leysen et al., 1994, Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity., J Clin Psychiatry
Megens et al., 1994, Survey on the pharmacodynamics of the new antipsychotic risperidone., Psychopharmacology (Berl.)

ECOPIPAM DRD1

Interaction Score: 0.58

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ecopipam

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology TTD
ACETOPHENAZINE DRD1

Interaction Score: 0.52

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
CARPHENAZINE DRD1

Interaction Score: 0.49

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
4889058 4861216 4887393

Sources:
TdgClinicalTrial TEND
CHEMBL123349 DRD1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIPECOTIC ACID DRD1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIFLUPROMAZINE DRD1

Interaction Score: 0.39

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 9081563 30137788 239169

Sources:
DTC TdgClinicalTrial TEND
CHEMBL305195 DRD1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OPIPRAMOL DRD1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PRECLAMOL DRD1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL25554 DRD1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZIMELDINE DRD1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
STEPHOLIDINE DRD1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19744859

Sources:
DTC
FENOLDOPAM DRD1

Interaction Score: 0.35

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name fenoldopam mesylate, SKF-82526,Corlopam

Specific Action of the Ligand Full agonist

PMIDs:
8103596 11752352 19293728

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology TTD

FLUPENTIXOL DRD1

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Note that this assay uses the cis form of the compound, whereas the approved drug is a racemic mixture of cis and trans molecules.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
17111172 17016423 17139284 10531405

Sources:
DTC GuideToPharmacology

MINAPRINE DRD1

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 7862862

Sources:
TdgClinicalTrial TEND
METHYLERGONOVINE DRD1

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352 17016423 17139284 15930499 10200235

Sources:
DTC TdgClinicalTrial TEND TTD
ZUCLOPENTHIXOL DRD1

Interaction Score: 0.31

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10222441 1822319

Sources:
TdgClinicalTrial TEND
CHLORPROTHIXENE DRD1

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1830565 17016423 17139284

Sources:
TdgClinicalTrial TEND
DIHYDREXIDINE DRD1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19744859 15985612

Sources:
DTC TTD
PERGOLIDE DRD1

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Full agonist

PMIDs:
18691132 10641988 11752352

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology TTD
FLUPHENAZINE DRD1

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Trial Name -

PMIDs:
11873706 11113312 11752352 10531405

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology
CHEMBL22778 DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
APOCIDEINE DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35354 DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZOXATHIAN DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROTIGOTINE DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
18691132

Sources:
TEND GuideToPharmacology
BUTACLAMOL DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMPEROZIDE DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIHYDROERGOCRISTINE DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

PMIDs:
1492857

Sources:
DTC
CHEMBL111545 DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL63329 DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IFENPRODIL DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL336208 DRD1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERICIAZINE DRD1

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
7918347

Sources:
GuideToPharmacology
CABERGOLINE DRD1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
16982285 11436517 18691132 10641988 12388666

Sources:
GuideToPharmacology
LISURIDE DRD1

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Partial agonist

PMIDs:
18691132 17016423 17139284

Sources:
TdgClinicalTrial TEND GuideToPharmacology
THIETHYLPERAZINE DRD1

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
DOPAMINE DRD1

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

Direct Interaction? True

PMIDs:
10691700 17455212 17468175 17301410 17449449 17394052

Sources:
DTC GuideToPharmacology
PALIPERIDONE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7520908 7531353

Sources:
DTC
TYRAMINE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOROTEPINE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KETOTIFEN DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EPINASTINE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NAN-190 DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOBUTAMINE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

CHEMBL520992 DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction Biased towards G-protein signalling in a cellular assay expressing only D1 receptor.

Specific Action of the Ligand Biased agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

BP-897 DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEXTROAMPHETAMINE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23952191

Sources:
PharmGKB
RACEPINEPHRINE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EFAROXAN DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LOXAPINE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

PMIDs:
11752352

Sources:
DTC TEND
METHYLERGONOVINE MALEATE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine D1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CGS-21680 DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
APOMORPHINE DRD1

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
12453049 18691132 10641988 11752352 15037665

Sources:
TEND GuideToPharmacology
PROPIOMAZINE DRD1

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
PROMAZINE DRD1

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17139284 17016423

Sources:
DTC TdgClinicalTrial TEND
ENOXIMONE DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIRENPERONE DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SKF-38393 DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
DTC GuideToPharmacology
PALMITOYL-CARNITINE DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLIC ADENOSINE MONOPHOSPHATE DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENYLTOLOXAMINE DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PHENAMIL DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL86931 DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
E-DOXEPIN DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZICRONAPINE DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PERPHENAZINE DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2573104 17455212

Sources:
DTC TdgClinicalTrial TEND
THIORIDAZINE DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Endogenous Drug? False

PMIDs:
8720030

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology
TRIMIPRAMINE DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
8863001

Sources:
DTC
E-FLUPENTIXOL DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
METIZOLINE DRD1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOBENZAPRINE DRD1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-242084 DRD1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMOXAPINE DRD1

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine receptor antagonist

PMIDs:
11180191

Sources:
DTC ChemblInteractions
VINPOCETINE DRD1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MOLINDONE DRD1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL291143 DRD1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ETILEVODOPA DRD1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name etilevodopa, TV-1203

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
DEOXIEPINEPHRINE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
N-DESMETHYLCLOZAPINE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SCH-23390 DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL1368696 DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-N-PROPYLNORAPOMORPHINE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LEVODOPA DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name DM-1992

Novel drug target Established target

Trial Name entacapone/levodopa/carbidopa,Stalevo

PMIDs:
9633680 18549347 11978145

Sources:
DTC TdgClinicalTrial TEND
IMIPRAMINE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
9686407

Sources:
DTC
ASENAPINE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial
CHEMBL1256697 DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CGS-15943 DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MELEVODOPA DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name V-1512, CHF-1512,Levomet Complex, Sirio

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
FENOLDOPAM MESYLATE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine D1 receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
PERGOLIDE MESYLATE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROTRIPTYLINE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILOPERIDONE DRD1

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs:
23272794

Sources:
TdgClinicalTrial
QUETIAPINE DRD1

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17848919 15337652 22037407

Sources:
TEND
CHEMBL284609 DRD1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIRENZEPINE DRD1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL445102 DRD1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZAMIL DRD1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESORIDAZINE DRD1

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
DIHYDROERGOTAMINE DRD1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OLANZAPINE DRD1

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ALKS 3831

Trial Name OREX-003, olanzapine plus zonisamide SR

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
18308814 15771415 10227113 17848919 11752352 25032030

Sources:
TdgClinicalTrial TEND
CYPROHEPTADINE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUINACRINE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICYCLOMINE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SPIPERONE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
DTC GuideToPharmacology
SPERMINE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BROMOCRIPTINE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
DTC GuideToPharmacology
CHEMBL403183 DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KETANSERIN DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
DTC GuideToPharmacology
CLOZAPINE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Trial Name -

PMIDs:
17092969 11752352

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology PharmGKB
CHLORPROMAZINE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
8104554 7918347

Sources:
GuideToPharmacology
(R,S)-INDATRALINE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROPAFENONE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HALOPERIDOL DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
10531405 11752352 27023437

Sources:
DTC GuideToPharmacology PharmGKB
BAY-11-7085 DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MAPROTILINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ERGOLOID MESYLATES DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NORTRIPTYLINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TEND GuideToPharmacology
CLOMIPRAMINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL601364 DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-216763 DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
YOHIMBINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRAZODONE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE BITARTRATE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology
PHENYLEPHRINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SEMAXANIB DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROMETHAZINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMSACRINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIANSERIN DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUPROPION DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CHEMBL605003 DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYSERGIDE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METERGOLINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OLEOYL DOPAMINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARVEDILOL DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SEROTONIN DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? True

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CALCIMYCIN DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIFEPRISTONE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL322970 DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GR-127935 DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMITRIPTYLINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SERTRALINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PICEATANNOL DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COCAINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
METITEPINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CAPSAZEPINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYLPHENIDATE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23952191

Sources:
PharmGKB
NOREPINEPHRINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LITHIUM DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21047205

Sources:
PharmGKB
NICOTINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18092181

Sources:
PharmGKB
TRIFLUOPERAZINE DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW7647 DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUOXETINE DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EPINEPHRINE DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ELLIPTECINE DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IDARUBICIN DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL429095 DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN DRD1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000184845
- Version: 101_38
Alternate Names:

DRD1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000184845
- Version: 26-July-2011
Alternate Names:

ENSG00000184845 Ensembl Gene Id

DRD1 Display Id

D(1A) DOPAMINE RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P21728] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P21728
- Version: January-2014
Alternate Names:

DRD1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: P21728
- Version: 11-September-2012
Alternate Names:

D(1A) DOPAMINE RECEPTOR Uniprot Protein Name

DRD1 Uniprot Gene Name

P21728 Uniprot Accession

Gene Info:

Interpro Name GPCR, rhodopsin-like, 7TM

Uniprot Status Swiss-Prot

Interpro Type Family

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TEND: P21728
- Version: 01-August-2011
Alternate Names:

1812 Entrez Gene Id

DRD1 Gene Symbol

P21728 Uniprot Accession

Gene Info:

Target Subclass GPCR

Target Main Class Receptors

Transmembrane Helix Count 6

Publications:
GuideToPharmacology: 1812
- Version: 29-September-2020
Alternate Names:

3020 HUGO Gene ID

3020 HUGO Gene Symbol

dopamine receptor D1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Dopamine receptors

GuideToPharmacology Gene Category ID 20

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

PharmGKB: DRD1

Version: 18-August-2020

Alternate Names:

PA147 PharmGKB ID

Gene Info:

Publications:

Huang W et al., 2008, Significant association of DRD1 with nicotine dependence., Hum Genet

McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics

Levy F et al., 2013, Dopamine receptors and the pharmacogenetics of side-effects of stimulant treatment for attention-deficit/hyperactivity disorder., J Child Adolesc Psychopharmacol

DTC: DRD1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Schulze M et al., 2009, Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?, Bioorg Med Chem
ChemblInteractions: DRD1
- Version: chembl_23
Alternate Names:

DRD1 GENE_SYMBOL

D(1A) dopamine receptor UNIPROT

Dopamine D1 receptor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000184845
- Version: 31-May-2017
Alternate Names:

ENSG00000184845 Gene Symbol

DRD1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: DRD1
- Version: 27-Jun-2013
Alternate Names:

1812 Gene ID

DADR dGene Synonym

DRD1A dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Dopamine D1 receptor
- Version: 2020.06.01
Alternate Names:

D1R TTD Gene Abbreviation

T22118 TTD Target ID

Gene Info:

Publications:
Pharos: DRD1
- Version: 01-May-2021
Alternate Names:

D(1A) dopamine receptor Gene Name

P21728 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: DRD1
- Version: 01-May-2021
Alternate Names:

Gene Info:

Gene Categories:

DRUG RESISTANCE, G PROTEIN COUPLED RECEPTOR

Publications:

Trial Name	ecopipam
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

Details of the Assay for Interaction	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Direct Interaction?	False
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

Details of the Assay for Interaction	Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.
Specific Action of the Ligand	Biased agonist
Endogenous Drug?	False

Mechanism of Interaction	Dopamine D1 receptor antagonist
Direct Interaction	yes

Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False
Direct Interaction?	False

Direct Interaction	yes
Mechanism of Interaction	Dopamine receptor antagonist

Trial Name	etilevodopa, TV-1203
Novel drug target	Established target

Trial Name	DM-1992
Novel drug target	Established target
Trial Name	entacapone/levodopa/carbidopa,Stalevo

Trial Name	V-1512, CHF-1512,Levomet Complex, Sirio
Novel drug target	Established target

Direct Interaction	yes
Mechanism of Interaction	Dopamine D1 receptor agonist

Mechanism of Interaction	Dopamine receptor agonist
Direct Interaction	yes

Trial Name	ALKS 3831
Trial Name	OREX-003, olanzapine plus zonisamide SR
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

ENSG00000184845	Ensembl Gene Id
DRD1	Display Id
D(1A) DOPAMINE RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P21728]	Description

D(1A) DOPAMINE RECEPTOR	Uniprot Protein Name
DRD1	Uniprot Gene Name
P21728	Uniprot Accession

3020	HUGO Gene ID
3020	HUGO Gene Symbol
dopamine receptor D1	HUGO Gene Name

DRD1	GENE_SYMBOL
D(1A) dopamine receptor	UNIPROT
Dopamine D1 receptor	UNIPROT

DRD1 Gene Record

DRD1 1812 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name ecopipam Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 4889058 4861216 4887393

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 9081563 30137788 239169

Sources: DTC TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19744859

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name fenoldopam mesylate, SKF-82526,Corlopam Specific Action of the Ligand Full agonist

PMIDs: 8103596 11752352 19293728

Sources: DTC TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Details of the Assay for Interaction Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules. Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 17111172 17016423 17139284 10531405

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 7862862

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752352 17016423 17139284 15930499 10200235

Sources: DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10222441 1822319

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1830565 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ecopipam

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
4889058 4861216 4887393

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 9081563 30137788 239169

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19744859

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name fenoldopam mesylate, SKF-82526,Corlopam

Specific Action of the Ligand Full agonist

PMIDs:
8103596 11752352 19293728

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
17111172 17016423 17139284 10531405

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 7862862

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352 17016423 17139284 15930499 10200235

Sources:
DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10222441 1822319

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1830565 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
19744859 15985612

Sources:
DTC TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Full agonist

PMIDs:
18691132 10641988 11752352

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Trial Name -

PMIDs:
11873706 11113312 11752352 10531405

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found