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DRD1 Gene Record

  • Summary
  • Interactions
  • Claims
  • DRD1 1812 Druggable GenomeDrug Resistance

    Alternate Names:

    1812
    DOPAMINE RECEPTOR D1
    DRD1
    DADR
    DRD1A
    126449
    3020
    ENSG00000184845
    OTTHUMG00000130557
    DRD1_HUMAN
    P21728
    BE0004889
    BE0000020
    D(1A) dopamine receptor
    Dopamine D1 receptor
    D(1A) DOPAMINE RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P21728]
    PA147
    214
    D<sub>1</sub> receptor
    NM_000794
    NP_000785
    D1R
    T22118
    BE0009376

    Gene Info:

    Target Subclass GPCR
    Target Main Class Receptors
    Transmembrane Helix Count 6
    Target Subclass Rhodopsin
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Target Class Receptors
    GuideToPharmacology Gene Category Name Dopamine receptors
    GuideToPharmacology Gene Category ID 20
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (13 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUG RESISTANCE
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Van Kampen et al., 2000, Dopamine D(1A) receptor function in a rodent model of tardive dyskinesia., Neuroscience
    Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
    Cai et al., 1999, Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein., Mol. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Fu et al., 2007, Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations., Biophys. J.
    Ostadali et al., 2004, The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR., Iran J Allergy Asthma Immunol
    Hoenicka et al., 2007, From dopaminergic genes to psychiatric disorders., Neurotox Res
    Dolzan et al., 2007, Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment., Am. J. Med. Genet. B Neuropsychiatr. Genet.
    Hübner et al., 2000, Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype., J. Med. Chem.
    da Silva Lobo et al., 2007, Dopamine genes and pathological gambling in discordant sib-pairs., J Gambl Stud
    Seeman et al., 1993, Dopamine receptor pharmacology., Curr Opin Neurol Neurosurg
    Kanba et al., 1994, Affinity of neuroleptics for D1 receptor of human brain striatum., J Psychiatry Neurosci
    Hwang R et al., 2007, Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response., J Psychopharmacol
    Reimold et al., 2007, Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol., Psychopharmacology (Berl.)
    Huang W et al., 2008, Significant association of DRD1 with nicotine dependence., Hum Genet
    Dhasmana et al., The role of dopamine (D2), alpha and beta-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the rat., Pharmacol. Res.
    Zeng et al., 2009, D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression., J. Hypertens.
    Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
    Moallem N et al., 2012, Quetiapine improves response inhibition in alcohol dependent patients: a placebo-controlled pilot study., Pharmacol Biochem Behav
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Tauscher J et al., 2004, Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics., Am J Psychiatry
    Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
    Fernández et al., 2005, Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents., J. Med. Chem.
    Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
    Bymaster et al., 1999, Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro., Schizophr. Res.
    McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics
    Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
    Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
    Berger et al., 1996, Trimipramine: a challenge to current concepts on antidepressives., Eur Arch Psychiatry Clin Neurosci
    LeWitt PA, 2004, Subcutaneously administered apomorphine: pharmacokinetics and metabolism., Neurology
    Guo et al., 2002, Apomorphine induces trophic factors that support fetal rat mesencephalic dopaminergic neurons in cultures., Eur. J. Neurosci.
    Hammock et al., 1995, The effect of clozapine on self-injurious behavior., J Autism Dev Disord
    Bobo, 2013, Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults., Expert Rev Clin Pharmacol
    Schulze M et al., 2009, Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?, Bioorg Med Chem
    Manzaneque et al., An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice., Methods Find Exp Clin Pharmacol
    Lublin et al., 1991, Zuclopenthixol, a combined dopamine D1/D2 antagonist, versus haloperidol, a dopamine D2 antagonist, in tardive dyskinesia., Eur Neuropsychopharmacol
    Reyes et al., Reinforcement in an in vitro analog of appetitive classical conditioning of feeding behavior in Aplysia: blockade by a dopamine antagonist., Learn. Mem.
    Nargeot et al., 1999, Dopaminergic synapses mediate neuronal changes in an analogue of operant conditioning., J. Neurophysiol.
    Levy F et al., 2013, Dopamine receptors and the pharmacogenetics of side-effects of stimulant treatment for attention-deficit/hyperactivity disorder., J Child Adolesc Psychopharmacol
    Toll et al., 1998, Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications., NIDA Res. Monogr.
    Bora, 1968, Comparison of dosage ranges of carphenazine and trifluoperazine in elderly chronic schizophrenics., Dis Nerv Syst
    Vinar et al., 1967, Carphenazine in the treatment of schizophrenic psychoses. Controlled clinical trial., Act Nerv Super (Praha)
    Platz et al., 1967, Selective drug action related to chronic schizophrenic subtype. (A comparative study of carphenazine, chlorpromazine, and trifluoperazine)., Dis Nerv Syst
    Farde et al., 1989, D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics., Psychopharmacology (Berl.)
    Puglisi-Allegra S et al., 1994, Post-training minaprine enhances memory storage in mice: involvement of D1 and D2 dopamine receptors., Psychopharmacology (Berl)
    Ichikawa et al., 2001, [Pharmacological effects of cabergoline against parkinsonism]., Nippon Yakurigaku Zasshi
    Kvernmo et al., 2006, A review of the receptor-binding and pharmacokinetic properties of dopamine agonists., Clin Ther
    Millan et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes., J. Pharmacol. Exp. Ther.
    Nasu et al., 2000, Quantitative prediction of catalepsy induced by amoxapine, cinnarizine and cyclophosphamide in mice., Biopharm Drug Dispos
    Deleu et al., 2002, Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease., Clin Pharmacokinet
    Onofrj et al., 2008, An expert opinion on safinamide in Parkinson's disease., Expert Opin Investig Drugs
    Koller et al., 1998, Mechanism of action of dopaminergic agents in Parkinson's disease., Neurology
    Ryman-Rasmussen JP et al., 2005, Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists., Mol Pharmacol
    Horn AS et al., 1975, Dopamine receptor blockade and the neuroleptics, a crystallographic study., J Pharm Pharmacol
    Chokhawala K et al., 2020, Antipsychotic Medications,
    Creese I et al., 1996, Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs., J Neuropsychiatry Clin Neurosci
    Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
    Coppi G, 1992, [Dihydroergocristine. A review of pharmacology and toxicology]., Arzneimittelforschung
    Fux et al., 1991, A controlled comparative study of chlorprothixene vs. haloperidol in chronic schizophrenia., Isr J Psychiatry Relat Sci
    Shultz et al., 1987, Dopaminergic stimulation of cAMP accumulation in cultured rat mesangial cells., Am. J. Physiol.
    Keks et al., 1999, Risperidone (Risperdal): clinical experience with a new antipsychosis drug., Expert Opin Investig Drugs
    Leysen et al., 1994, Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity., J Clin Psychiatry
    Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
    Cheng et al., 2003, Both alpha1-adrenergic and D(1)-dopaminergic neurotransmissions are involved in phenylpropanolamine-mediated feeding suppression in mice., Neurosci. Lett.
    Bigal et al., 2003, Ergotamine and dihydroergotamine: a review., Curr Pain Headache Rep
    Megens et al., 1994, Survey on the pharmacodynamics of the new antipsychotic risperidone., Psychopharmacology (Berl.)
    de Bartolomeis A et al., 2015, Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism., CNS Drugs
    Barlier A et al., 2006, Quinagolide--a valuable treatment option for hyperprolactinaemia., Eur J Endocrinol
    Abelaira HM et al., 2012, Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats., Pharmacol Biochem Behav
    Foster RH et al., 1997, Paroxetine : a review of its pharmacology and therapeutic potential in the management of panic disorder., CNS Drugs
    Kobayashi K et al., 2012, Chronic fluoxetine selectively upregulates dopamine D₁-like receptors in the hippocampus., Neuropsychopharmacology
    Kumar B et al., 2018, Lumateperone: a new treatment approach for neuropsychiatric disorders., Drugs Today (Barc)
    Mantsch JR et al., 2007, Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats., Psychopharmacology (Berl)
    Gerlach M et al., 2003, Dopamine receptor agonists in current clinical use: comparative dopamine receptor binding profiles defined in the human striatum., J Neural Transm (Vienna)
  • ECOPIPAM   DRD1

    Interaction Score: 0.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ecopipam
    Novel drug target Established target
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD GuideToPharmacology

  • CARPHENAZINE   DRD1

    Interaction Score: 0.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    4887393 4889058 4861216


    Sources:
    TEND TdgClinicalTrial DrugBank

  • ACETOPHENAZINE   DRD1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17139284 17016423


    Sources:
    TEND TdgClinicalTrial

  • TRIFLUPROMAZINE   DRD1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    239169 30137788 17139284 9081563 17016423


    Sources:
    TEND DTC TdgClinicalTrial DrugBank

  • TETRAHYDROPALMATINE   DRD1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17361394


    Sources:
    DrugBank

  • EPICRIPTINE   DRD1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • PIPRADROL   DRD1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • QUINAGOLIDE   DRD1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16452531


    Sources:
    DrugBank

  • CHEMBL123349   DRD1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIPECOTIC ACID   DRD1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL305195   DRD1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OPIPRAMOL   DRD1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PRECLAMOL   DRD1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL25554   DRD1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • STEPHOLIDINE   DRD1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19744859


    Sources:
    DTC

  • METHYLERGONOVINE   DRD1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15930499 10200235 11752352 17139284 17016423


    Sources:
    TEND DTC TdgClinicalTrial TTD DrugBank

  • FENOLDOPAM   DRD1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name fenoldopam mesylate, SKF-82526,Corlopam
    Specific Action of the Ligand Full agonist

    PMIDs:
    8103596 19293728 11752352


    Sources:
    TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • DIHYDREXIDINE   DRD1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15985612 19744859


    Sources:
    DTC TTD DrugBank

  • FLUPENTIXOL   DRD1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    10531405 17111172 17139284 17016423


    Sources:
    DTC DrugBank GuideToPharmacology

  • MINAPRINE   DRD1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7862862 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • ROTIGOTINE   DRD1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    18691132


    Sources:
    TEND DrugBank GuideToPharmacology

  • ZUCLOPENTHIXOL   DRD1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10222441 1822319


    Sources:
    TEND TdgClinicalTrial DrugBank

  • DIHYDROERGOCRYPTINE   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    14523624


    Sources:
    DrugBank

  • CHEMBL22778   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • APOCIDEINE   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35354   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BENZOXATHIAN   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERICIAZINE   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    7918347


    Sources:
    DrugBank GuideToPharmacology

  • BUTACLAMOL   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIOTHIXENE   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    3039860 7918347


    Sources:
    DrugBank

  • PIPOTIAZINE   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7918347


    Sources:
    DrugBank

  • CHEMBL111545   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL63329   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERGOLIDE   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Full agonist

    PMIDs:
    18691132 10641988 11752352


    Sources:
    TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • CHEMBL336208   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUPHENAZINE   DRD1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Trial Name -

    PMIDs:
    11113312 11873706 10531405 11752352


    Sources:
    TEND DTC TdgClinicalTrial DrugBank GuideToPharmacology

  • CHLORPROTHIXENE   DRD1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    1830565 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • DIHYDROERGOCRISTINE   DRD1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    1492857


    Sources:
    DTC DrugBank

  • LISURIDE   DRD1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Partial agonist

    PMIDs:
    18691132 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • PHENYLPROPANOLAMINE   DRD1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    12873745


    Sources:
    DrugBank

  • THIETHYLPERAZINE   DRD1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17139284 17016423


    Sources:
    TEND TdgClinicalTrial

  • CABERGOLINE   DRD1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    18691132 10641988 11436517 16982285 12388666


    Sources:
    DrugBank GuideToPharmacology

  • TYRAMINE   DRD1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOROTEPINE   DRD1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NAN-190   DRD1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL520992   DRD1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.
    Specific Action of the Ligand Biased agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BP-897   DRD1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AMPEROZIDE   DRD1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIOPROPERAZINE   DRD1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7918347


    Sources:
    DrugBank

  • EFAROXAN   DRD1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • APOMORPHINE   DRD1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    15037665 18691132 12453049 10641988 11752352


    Sources:
    TEND DrugBank GuideToPharmacology

  • METHYLERGONOVINE MALEATE   DRD1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Dopamine D1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CGS-21680   DRD1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LUMATEPERONE   DRD1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30596390


    Sources:
    DrugBank

  • PROPIOMAZINE   DRD1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17139284 17016423


    Sources:
    TEND TdgClinicalTrial

  • PERPHENAZINE   DRD1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    2573104 17455212


    Sources:
    TEND DTC TdgClinicalTrial DrugBank

  • THIORIDAZINE   DRD1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Endogenous Drug? False

    PMIDs:
    8720030


    Sources:
    TEND DTC TdgClinicalTrial DrugBank GuideToPharmacology

  • DOPAMINE   DRD1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True
    Direct Interaction? True

    PMIDs:
    17468175 17301410 17449449 17455212 10691700 17394052


    Sources:
    DTC DrugBank GuideToPharmacology

  • PROMAZINE   DRD1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    17139284 17016423


    Sources:
    TEND DTC TdgClinicalTrial

  • ENOXIMONE   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PIRENPERONE   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KETOTIFEN   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SKF-38393   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    DTC GuideToPharmacology

  • PALMITOYL-CARNITINE   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ACEPROMAZINE   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7918347


    Sources:
    DrugBank

  • PHENYLTOLOXAMINE   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DEXTROAMPHETAMINE   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23952191


    Sources:
    PharmGKB

  • PHENAMIL   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL86931   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZIMELDINE   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • E-DOXEPIN   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZICRONAPINE   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • IFENPRODIL   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • E-FLUPENTIXOL   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • METIZOLINE   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SB-242084   DRD1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • VINPOCETINE   DRD1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL291143   DRD1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ETILEVODOPA   DRD1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name etilevodopa, TV-1203
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PALIPERIDONE   DRD1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7520908 7531353


    Sources:
    DTC DrugBank

  • LEVODOPA   DRD1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name DM-1992
    Novel drug target Established target
    Trial Name entacapone/levodopa/carbidopa,Stalevo

    PMIDs:
    11978145 18549347 9633680


    Sources:
    TEND DTC TdgClinicalTrial DrugBank

  • ILOPERIDONE   DRD1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril

    PMIDs:
    23272794


    Sources:
    TdgClinicalTrial DrugBank

  • ASENAPINE   DRD1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814 21655346


    Sources:
    TdgClinicalTrial DrugBank

  • DEOXIEPINEPHRINE   DRD1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOBUTAMINE   DRD1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • N-DESMETHYLCLOZAPINE   DRD1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SCH-23390   DRD1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL1368696   DRD1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • R-N-PROPYLNORAPOMORPHINE   DRD1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1256697   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CGS-15943   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINASTINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYCLIC ADENOSINE MONOPHOSPHATE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MELEVODOPA   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name V-1512, CHF-1512,Levomet Complex, Sirio
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MOLINDONE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FENOLDOPAM MESYLATE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Dopamine D1 receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PERGOLIDE MESYLATE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Dopamine receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRIMIPRAMINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    8863001


    Sources:
    DTC DrugBank

  • PROTRIPTYLINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AMOXAPINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Dopamine receptor antagonist

    PMIDs:
    11180191


    Sources:
    DTC DrugBank ChemblInteractions

  • OLANZAPINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ALKS 3831
    Trial Name OREX-003, olanzapine plus zonisamide SR
    Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

    PMIDs:
    18308814 17848919 15771415 11752352 25032030 10227113


    Sources:
    TEND TdgClinicalTrial DrugBank

  • CHEMBL284609   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PIRENZEPINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL445102   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BROMOCRIPTINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18691132


    Sources:
    DTC DrugBank GuideToPharmacology

  • BENZAMIL   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESORIDAZINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • LOXAPINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11752352


    Sources:
    TEND DTC DrugBank

  • ERGOTAMINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    12525272


    Sources:
    DrugBank

  • CINNARIZINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    11180191


    Sources:
    DrugBank

  • DICYCLOMINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SPIPERONE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    DTC GuideToPharmacology

  • QUETIAPINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    22037407 17848919 15337652


    Sources:
    TEND DrugBank

  • CHEMBL403183   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KETANSERIN   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    DTC GuideToPharmacology

  • DIHYDROERGOTAMINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOZAPINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Trial Name -

    PMIDs:
    17092969 11752352


    Sources:
    TEND DTC PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

  • CHLORPROMAZINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    8104554 7918347


    Sources:
    DrugBank GuideToPharmacology

  • LEVOMEPROMAZINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15701205


    Sources:
    DrugBank

  • IMIPRAMINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    9686407


    Sources:
    DTC DrugBank

  • (R,S)-INDATRALINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPAFENONE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HALOPERIDOL   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    27023437 10531405 11752352


    Sources:
    DTC PharmGKB DrugBank GuideToPharmacology

  • PAROXETINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    23338224 22278095


    Sources:
    DrugBank

  • PIPAMPERONE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • BAY-11-7085   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • QUINACRINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ERGOLOID MESYLATES   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Dopamine receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RACEPINEPHRINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYCLOBENZAPRINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYPROHEPTADINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL601364   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SB-216763   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROCHLORPERAZINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    TEND GuideToPharmacology

  • MIANSERIN   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC DrugBank

  • TRAZODONE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SPERMINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE BITARTRATE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PHENYLEPHRINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SEMAXANIB   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ARIPIPRAZOLE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    ligand
    partial agonist (activating)
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919 26346901


    Sources:
    DrugBank

  • ZOTEPINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CLOMIPRAMINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • METHYSERGIDE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZIPRASIDONE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919


    Sources:
    DrugBank

  • AMSACRINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OLEOYL DOPAMINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BUPROPION   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • YOHIMBINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • METERGOLINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CALCIMYCIN   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL605003   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MIFEPRISTONE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL322970   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GR-127935   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROMETHAZINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LAMOTRIGINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22306746


    Sources:
    DrugBank

  • METITEPINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CAPSAZEPINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RISPERIDONE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15992090 7520908


    Sources:
    DrugBank

  • SEROTONIN   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? True
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • METHYLPHENIDATE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23952191


    Sources:
    PharmGKB

  • MAPROTILINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SERTRALINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PICEATANNOL   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NORTRIPTYLINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LITHIUM   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21047205


    Sources:
    PharmGKB

  • COCAINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • NOREPINEPHRINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NICOTINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18092181


    Sources:
    PharmGKB

  • GW7647   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NICARDIPINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIFLUOPERAZINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PIMOZIDE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • EPINEPHRINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CARVEDILOL   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ELLIPTECINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUOXETINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IDARUBICIN   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AMITRIPTYLINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GOSSYPOL   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL429095   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIPYRIDAMOLE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • QUERCETIN   DRD1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000184845

    • Version: 101_38

    Alternate Names:
    DRD1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000184845

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000184845 Ensembl Gene Id
    DRD1 Display Id
    D(1A) DOPAMINE RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P21728] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P21728

    • Version: January-2014

    Alternate Names:
    DRD1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • HopkinsGroom: P21728

    • Version: 11-September-2012

    Alternate Names:
    D(1A) DOPAMINE RECEPTOR Uniprot Protein Name
    DRD1 Uniprot Gene Name
    P21728 Uniprot Accession

    Gene Info:
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    Interpro Type Family

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: P21728

    • Version: 01-August-2011

    Alternate Names:
    1812 Entrez Gene Id
    DRD1 Gene Symbol
    P21728 Uniprot Accession

    Gene Info:
    Target Subclass GPCR
    Target Main Class Receptors
    Transmembrane Helix Count 6

    Publications:

  • GuideToPharmacology: 1812

    • Version: 29-September-2020

    Alternate Names:
    3020 HUGO Gene ID
    3020 HUGO Gene Symbol
    dopamine receptor D1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Dopamine receptors
    GuideToPharmacology Gene Category ID 20

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • PharmGKB: DRD1

    • Version: 18-August-2020

    Alternate Names:
    PA147 PharmGKB ID

    Gene Info:

    Publications:
    Huang W et al., 2008, Significant association of DRD1 with nicotine dependence., Hum Genet
    McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics
    Levy F et al., 2013, Dopamine receptors and the pharmacogenetics of side-effects of stimulant treatment for attention-deficit/hyperactivity disorder., J Child Adolesc Psychopharmacol

  • DrugBank: BE0004889

    • Version: 5.1.7

    Alternate Names:
    DRD1 DrugBank Gene Name
    P21728 UniProt Accession
    1812 Entrez Gene Id

    Gene Info:

    Publications:
    Toll et al., 1998, Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications., NIDA Res. Monogr.
    Seeman et al., 1993, Dopamine receptor pharmacology., Curr Opin Neurol Neurosurg
    Abelaira HM et al., 2012, Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats., Pharmacol Biochem Behav

  • DrugBank: BE0000020

    • Version: 5.1.7

    Alternate Names:
    DRD1 DrugBank Gene Name
    P21728 UniProt Accession
    1812 Entrez Gene Id

    Gene Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol

  • DrugBank: BE0009376

    • Version: 5.1.7

    Alternate Names:
    DRD1 DrugBank Gene Name
    P21728 UniProt Accession
    1812 Entrez Gene Id

    Gene Info:

    Publications:
    Coppi G, 1992, [Dihydroergocristine. A review of pharmacology and toxicology]., Arzneimittelforschung

  • DTC: DRD1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Schulze M et al., 2009, Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?, Bioorg Med Chem

  • ChemblInteractions: DRD1

    • Version: chembl_23

    Alternate Names:
    DRD1 GENE_SYMBOL
    D(1A) dopamine receptor UNIPROT
    Dopamine D1 receptor UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000184845

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000184845 Gene Symbol
    DRD1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: DRD1

    • Version: 03-September-2020

    Alternate Names:
    D(1A) dopamine receptor Gene Name
    P21728 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • dGene: DRD1

    • Version: 27-Jun-2013

    Alternate Names:
    1812 Gene ID
    DADR dGene Synonym
    DRD1A dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Dopamine D1 receptor

    • Version: 2020.06.01

    Alternate Names:
    D1R TTD Gene Abbreviation
    T22118 TTD Target ID

    Gene Info:

    Publications:

  • GO: DRD1

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE, G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21