DGIdb - DRD3 Gene Record

DRD3 1814 Druggable Genome

Alternate Names:

1814
DOPAMINE RECEPTOR D3
DRD3
D3DR
ETM1
FET1
126451
3024
ENSG00000151577
OTTHUMG00000159334
D(3) DOPAMINE RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P35462]
P35462
D(3) DOPAMINE RECEPTOR
DRD3_HUMAN
Dopamine D3 receptor
PA27479
D3R
T02551

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Name	GPCR, rhodopsin-like, 7TM
Interpro Acc	IPR000276
Interpro Type	Family
Interpro Short Name	7TM_GPCR_Rhodpsn
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Uniprot Status	Swiss-Prot
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Transmembrane Helix Count	6
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Gupta S et al., 2011, Dopamine receptor D3 genetic polymorphism (rs6280TC) is associated with rates of cognitive impairment in methamphetamine-dependent men with HIV: preliminary findings., J Neurovirol
Damasceno Dos Santos EU et al., 2019, Pharmacogenetic Profile and the Occurrence of Visual Hallucinations in Patients With Sporadic Parkinson's Disease., J Clin Pharmacol
Rieck M et al., 2018, Association between DRD2 and DRD3 gene polymorphisms and gastrointestinal symptoms induced by levodopa therapy in Parkinson's disease., Pharmacogenomics J
Koller et al., 1998, Mechanism of action of dopaminergic agents in Parkinson's disease., Neurology
Onofrj et al., 2008, An expert opinion on safinamide in Parkinson's disease., Expert Opin Investig Drugs
Deleu et al., 2002, Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease., Clin Pharmacokinet
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Cabaleiro T et al., 2015, Pharmacogenetics of quetiapine in healthy volunteers: association with pharmacokinetics, pharmacodynamics, and adverse effects., Int Clin Psychopharmacol
Vernaleken I et al., 2010, Dopamine D2/3 receptor occupancy by quetiapine in striatal and extrastriatal areas., Int J Neuropsychopharmacol
Bressan RA et al., 2003, Optimizing limbic selective D2/D3 receptor occupancy by risperidone: a [123I]-epidepride SPET study., J Clin Psychopharmacol
Rosenzweig et al., 2002, A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers., Hum Psychopharmacol
Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
Horacek et al., 2006, Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia., CNS Drugs
George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
Correia CT et al., 2010, Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions., Pharmacogenomics J
Gassó P et al., 2009, A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms., Pharmacogenomics J
Leysen et al., 1994, Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity., J Clin Psychiatry
Megens et al., 1994, Survey on the pharmacodynamics of the new antipsychotic risperidone., Psychopharmacology (Berl.)
Freedman et al., 1994, Expression and pharmacological characterization of the human D3 dopamine receptor., J. Pharmacol. Exp. Ther.
Vangveravong S et al., 2011, Synthesis and characterization of selective dopamine D₂ receptor ligands using aripiprazole as the lead compound., Bioorg Med Chem
Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Shill HA et al., 2009, Update on ropinirole in the treatment of Parkinson's disease., Neuropsychiatr Dis Treat
Nashatizadeh MM et al., 2009, A review of ropinirole prolonged release in Parkinson's disease., Clin Interv Aging
Adams DH et al., 2008, Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder., Hum Psychopharmacol
Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
Liu YZ et al., 2009, Association of the DRD2 and DRD3 polymorphisms with response to pramipexole in Parkinson's disease patients., Eur J Clin Pharmacol
Chernoloz O et al., 2012, Long-term administration of the dopamine D3/2 receptor agonist pramipexole increases dopamine and serotonin neurotransmission in the male rat forebrain., J Psychiatry Neurosci
Dooley M et al., 1998, Pramipexole. A review of its use in the management of early and advanced Parkinson's disease., Drugs Aging
Piercey MF, 1998, Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease., Clin Neuropharmacol
Merlino G et al., 2008, Clinical experience with pramipexole in the treatment of restless legs syndrome., Expert Opin Drug Metab Toxicol
Kessler et al., 2005, Occupancy of striatal and extrastriatal dopamine D2/D3 receptors by olanzapine and haloperidol., Neuropsychopharmacology
Malmberg et al., 1998, Agonist and inverse agonist activity at the dopamine D3 receptor measured by guanosine 5'--gamma-thio-triphosphate--35S- binding., J. Pharmacol. Exp. Ther.
Tuppurainen et al., 2009, Dopamine D2/3 receptor binding potential and occupancy in midbrain and temporal cortex by haloperidol, olanzapine and clozapine., Psychiatry Clin. Neurosci.
Tadori et al., 2008, Characterization of aripiprazole partial agonist activity at human dopamine D3 receptors., Eur. J. Pharmacol.
Hwang R et al., 2011, Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response., Pharmacogenomics
Hwang R et al., 2010, Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant., Pharmacogenomics J
Collo et al., 2008, Dopamine D3 receptor-preferring agonists increase dendrite arborization of mesencephalic dopaminergic neurons via extracellular signal-regulated kinase phosphorylation., Eur. J. Neurosci.
Lipina et al., [Effect of sulpiride on immobility reflex and pinch-induced catalepsy in CBA/Lac male mice with various social status]., Zh Vyssh Nerv Deiat Im I P Pavlova
Newman AH et al., 2012, Molecular determinants of selectivity and efficacy at the dopamine D3 receptor., J Med Chem
Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
Fux et al., 1991, A controlled comparative study of chlorprothixene vs. haloperidol in chronic schizophrenia., Isr J Psychiatry Relat Sci
Burstein et al., 2005, Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist., J. Pharmacol. Exp. Ther.
Citrome, 2013, Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability., Expert Opin Drug Metab Toxicol
LeWitt PA, 2004, Subcutaneously administered apomorphine: pharmacokinetics and metabolism., Neurology
Perlis RH et al., 2013, Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder., Pharmacogenomics J
Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
Tadori et al., 2011, Functional potencies of dopamine agonists and antagonists at human dopamine D₂ and D₃ receptors., Eur. J. Pharmacol.
Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
Tsuchimine S et al., 2012, DRD3, but not BDNF, genotype affects treatment response to paroxetine in major depressive disorder: a preliminary study., J Clin Psychopharmacol
McCracken JT et al., 2014, Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders., Pharmacogenomics J

PRAMIPEXOLE DRD3

Interaction Score: 3.8

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name Mirapex

PMIDs:
18691132 10641988 11752352 19396436 22023785 9638397 9617505 18248314

Sources:
TdgClinicalTrial TEND PharmGKB TTD
ROPINIROLE DRD3

Interaction Score: 1.9

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name ReQuip

Novel drug target Established target

Trial Name JZP-7

PMIDs:
18691132 10641988 11752352 19557097 19503779

Sources:
TdgClinicalTrial TEND TTD
CARIPRAZINE DRD3

Interaction Score: 0.95

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name cariprazine, RGH-188

PMIDs:
23320989

Sources:
TdgClinicalTrial TTD
PRECLAMOL HYDROCHLORIDE DRD3

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1256778 DRD3

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORPROTHIXENE DRD3

Interaction Score: 0.82

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine D3 receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
1830565 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
ROTIGOTINE DRD3

Interaction Score: 0.57

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name Neupro

Mechanism of Interaction D2-like dopamine receptor agonist

PMIDs:
18691132

Sources:
TdgClinicalTrial ChemblInteractions
AMISULPRIDE DRD3

Interaction Score: 0.53

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name amisulpride,Solian

PMIDs:
12404702 11873706 16696579

Sources:
TdgClinicalTrial TEND
CARIPRAZINE HYDROCHLORIDE DRD3

Interaction Score: 0.48

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Dopamine D3 receptor modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SULPIRIDE DRD3

Interaction Score: 0.48

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
18973551 19795811 22632094

Sources:
DTC
QUINPIROLE DRD3

Interaction Score: 0.38

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
21536445

Sources:
DTC
ETILEVODOPA DRD3

Interaction Score: 0.38

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name etilevodopa, TV-1203

Mechanism of Interaction Dopamine D3 receptor agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CHEMBL1256698 DRD3

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PRAMIPEXOLE DIHYDROCHLORIDE DRD3

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DEXPRAMIPEXOLE DRD3

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name dexpramipexole, KNS-760704

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
APOMORPHINE HYDROCHLORIDE DRD3

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TALIPEXOLE HYDROCHLORIDE DRD3

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
APOMORPHINE DRD3

Interaction Score: 0.27

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name apomorphine HCl,Uprima, Ixense

Novel drug target Established target

Trial Name apomorphine hydrochloride,Apokyn, APO-go

PMIDs:
11752352 15037665

Sources:
TdgClinicalTrial TEND
PARDOPRUNOX DRD3

Interaction Score: 0.27

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Trial Name pardoprunox, SLV 308

Novel drug target Established target

Mechanism of Interaction Dopamine receptors; D2 & D3 partial agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
LEVOMEPROMAZINE DRD3

Interaction Score: 0.27

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
15701205

Sources:
TdgClinicalTrial ChemblInteractions TEND
PERGOLIDE MESYLATE DRD3

Interaction Score: 0.27

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions
HALOPERIDOL LACTATE DRD3

Interaction Score: 0.24

Interaction Types & Directionality:

inverse agonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor inverse agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL1255656 DRD3

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1256876 DRD3

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SARIZOTAN HYDROCHLORIDE DRD3

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Dopamine D3 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ROPINIROLE HYDROCHLORIDE DRD3

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HALOPERIDOL DECANOATE DRD3

Interaction Score: 0.24

Interaction Types & Directionality:

inverse agonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor inverse agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ASENAPINE DRD3

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21658377 21655346

Sources:
TdgClinicalTrial
ZIPRASIDONE DRD3

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17016423 17139284 17848919

Sources:
TEND
LEVODOPA DRD3

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Dopamine D3 receptor agonist

Direct Interaction yes

Trial Name entacapone/levodopa/carbidopa,Stalevo

PMIDs:
30794329 27779245 9633680 18549347 11978145

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB
AGROCLAVINE DRD3

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OLANZAPINE PAMOATE DRD3

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ONC-201 DRD3

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LOXAPINE HYDROCHLORIDE DRD3

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL544115 DRD3

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BROMOCRIPTINE DRD3

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name bromocriptine mesylate,Cycloset, Ergoset

Novel drug target Established target

PMIDs:
18691132 10641988

Sources:
TdgClinicalTrial
QUETIAPINE DRD3

Interaction Score: 0.18

Interaction Types & Directionality:

ligand

antagonist (inhibitory)

Interaction Info:

PMIDs:
17848919 25025989 20392299 12544369

Sources:
PharmGKB
BIFEPRUNOX DRD3

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bifeprunox, DU127090

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
LOXAPINE DRD3

Interaction Score: 0.16

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DROPERIDOL DRD3

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LOXAPINE SUCCINATE DRD3

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
AMOXAPINE DRD3

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
16135699

Sources:
ChemblInteractions
BROMOCRIPTINE MESYLATE DRD3

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MELEVODOPA DRD3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name V-1512, CHF-1512,Levomet Complex, Sirio

PMIDs:
None found

Sources:
TdgClinicalTrial
ILOPERIDONE DRD3

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23545936

Sources:
TdgClinicalTrial
PROMAZINE HYDROCHLORIDE DRD3

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL284609 DRD3

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OLANZAPINE DRD3

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv

PMIDs:
17848919 11752352 18320559 25032030

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB
DULOXETINE DRD3

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22249355

Sources:
PharmGKB
DOPAMINE HYDROCHLORIDE DRD3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORPROMAZINE DRD3

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
8301582

Sources:
ChemblInteractions
COCAINE DRD3

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
HALOPERIDOL DRD3

Interaction Score: 0.09

Interaction Types & Directionality:

inverse agonist (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor inverse agonist

Direct Interaction yes

PMIDs:
16123775 7520908 9536001 19496999 18831971

Sources:
ChemblInteractions
TRIFLUOPERAZINE HYDROCHLORIDE DRD3

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RISPERIDONE DRD3

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
19997080 19506579 7520908 7531353

Sources:
PharmGKB
PAROXETINE DRD3

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22926616

Sources:
PharmGKB
ERGOLOID MESYLATES DRD3

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
PIMOZIDE DRD3

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
8301582

Sources:
ChemblInteractions
METHAMPHETAMINE DRD3

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21491142

Sources:
PharmGKB
CLOZAPINE DRD3

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
21332319 20029384 17848919

Sources:
PharmGKB
THIORIDAZINE DRD3

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THIORIDAZINE HYDROCHLORIDE DRD3

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
CHLORPROMAZINE HYDROCHLORIDE DRD3

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OLEOYL DOPAMINE DRD3

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYLPHENIDATE DRD3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23856854

Sources:
PharmGKB

Ensembl: ENSG00000151577
- Version: 101_38
Alternate Names:

DRD3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000151577
- Version: 26-July-2011
Alternate Names:

DRD3 Display Id

D(3) DOPAMINE RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P35462] Description

ENSG00000151577 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P35462
- Version: 11-September-2012
Alternate Names:

P35462 Uniprot Accession

D(3) DOPAMINE RECEPTOR Uniprot Protein Name

ENSG00000151577 Ensembl Gene Id

Gene Info:

Interpro Name GPCR, rhodopsin-like, 7TM

Interpro Acc IPR000276

Interpro Type Family

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P35462
- Version: January-2014
Alternate Names:

DRD3 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
TEND: P35462
- Version: 01-August-2011
Alternate Names:

P35462 Uniprot Accession

DRD3 Gene Symbol

1814 Entrez Gene Id

Gene Info:

Target Subclass GPCR

Transmembrane Helix Count 6

Target Subclass Rhodopsin

Publications:

PharmGKB: DRD3

Version: 18-August-2020

Alternate Names:

PA27479 PharmGKB ID

Gene Info:

Publications:

Gupta S et al., 2011, Dopamine receptor D3 genetic polymorphism (rs6280TC) is associated with rates of cognitive impairment in methamphetamine-dependent men with HIV: preliminary findings., J Neurovirol

Correia CT et al., 2010, Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions., Pharmacogenomics J

Gassó P et al., 2009, A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms., Pharmacogenomics J

DTC: DRD3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Vangveravong S et al., 2011, Synthesis and characterization of selective dopamine D₂ receptor ligands using aripiprazole as the lead compound., Bioorg Med Chem

Newman AH et al., 2012, Molecular determinants of selectivity and efficacy at the dopamine D3 receptor., J Med Chem

ChemblInteractions: DRD3
- Version: chembl_23
Alternate Names:

DRD3 GENE_SYMBOL

D(3) dopamine receptor UNIPROT

Dopamine D3 receptor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000151577
- Version: 31-May-2017
Alternate Names:

ENSG00000151577 Gene Symbol

DRD3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: DRD3
- Version: 27-Jun-2013
Alternate Names:

1814 Gene ID

D3DR dGene Synonym

ETM1 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Dopamine D3 receptor
- Version: 2020.06.01
Alternate Names:

D3R TTD Gene Abbreviation

T02551 TTD Target ID

Gene Info:

Publications:
GO: DRD3
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Trial Name	ReQuip
Novel drug target	Established target
Trial Name	JZP-7

Mechanism of Interaction	Dopamine D3 receptor antagonist
Direct Interaction	yes
Trial Name	-

Mechanism of Interaction	Dopamine D3 receptor modulator
Direct Interaction	yes

Mechanism of Interaction	D2-like dopamine receptor agonist
Direct Interaction	yes

Trial Name	dexpramipexole, KNS-760704
Novel drug target	Established target

Trial Name	apomorphine HCl,Uprima, Ixense
Novel drug target	Established target
Trial Name	apomorphine hydrochloride,Apokyn, APO-go

Trial Name	pardoprunox, SLV 308
Novel drug target	Established target
Mechanism of Interaction	Dopamine receptors; D2 & D3 partial agonist

Mechanism of Interaction	Dopamine receptor agonist
Direct Interaction	yes

Mechanism of Interaction	D2-like dopamine receptor inverse agonist
Direct Interaction	yes

Mechanism of Interaction	Dopamine D3 receptor agonist
Direct Interaction	yes

Mechanism of Interaction	D2-like dopamine receptor antagonist
Direct Interaction	yes

Trial Name	bromocriptine mesylate,Cycloset, Ergoset
Novel drug target	Established target

Trial Name	bifeprunox, DU127090
Novel drug target	Established target

Mechanism of Interaction	Dopamine receptor antagonist
Direct Interaction	yes

Trial Name	iloperidone,Fanapt, Fiapta, Zomaril
Novel drug target	Established target

DRD3	Display Id
D(3) DOPAMINE RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P35462]	Description
ENSG00000151577	Ensembl Gene Id

P35462	Uniprot Accession
D(3) DOPAMINE RECEPTOR	Uniprot Protein Name
ENSG00000151577	Ensembl Gene Id

DRD3	GENE_SYMBOL
D(3) dopamine receptor	UNIPROT
Dopamine D3 receptor	UNIPROT

DRD3 Gene Record

DRD3 1814 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name Mirapex

PMIDs: 18691132 10641988 11752352 19396436 22023785 9638397 9617505 18248314

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name ReQuip Novel drug target Established target Trial Name JZP-7

PMIDs: 18691132 10641988 11752352 19557097 19503779

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Novel drug target Established target Trial Name cariprazine, RGH-188

PMIDs: 23320989

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Dopamine D3 receptor antagonist Direct Interaction yes Trial Name -

PMIDs: 1830565 17016423 17139284

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name Neupro Mechanism of Interaction D2-like dopamine receptor agonist

PMIDs: 18691132

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name amisulpride,Solian

PMIDs: 12404702 11873706 16696579

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Dopamine D3 receptor modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 18973551 19795811 22632094

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 21536445

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name etilevodopa, TV-1203 Mechanism of Interaction Dopamine D3 receptor agonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction D2-like dopamine receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name dexpramipexole, KNS-760704 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction D2-like dopamine receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name apomorphine HCl,Uprima, Ixense Novel drug target Established target Trial Name apomorphine hydrochloride,Apokyn, APO-go

PMIDs: 11752352 15037665

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Trial Name pardoprunox, SLV 308 Novel drug target Established target Mechanism of Interaction Dopamine receptors; D2 & D3 partial agonist

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name Mirapex

PMIDs:
18691132 10641988 11752352 19396436 22023785 9638397 9617505 18248314

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name ReQuip

Novel drug target Established target

Trial Name JZP-7

PMIDs:
18691132 10641988 11752352 19557097 19503779

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name cariprazine, RGH-188

PMIDs:
23320989

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine D3 receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
1830565 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name Neupro

Mechanism of Interaction D2-like dopamine receptor agonist

PMIDs:
18691132

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name amisulpride,Solian

PMIDs:
12404702 11873706 16696579

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Dopamine D3 receptor modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
18973551 19795811 22632094

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
21536445

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name etilevodopa, TV-1203

Mechanism of Interaction Dopamine D3 receptor agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name dexpramipexole, KNS-760704

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name apomorphine HCl,Uprima, Ixense

Novel drug target Established target

Trial Name apomorphine hydrochloride,Apokyn, APO-go

PMIDs:
11752352 15037665

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Trial Name pardoprunox, SLV 308

Novel drug target Established target

Mechanism of Interaction Dopamine receptors; D2 & D3 partial agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
15701205

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inverse agonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor inverse agonist

Direct Interaction yes