1814 |
DOPAMINE RECEPTOR D3 |
DRD3 |
D3DR |
ETM1 |
FET1 |
126451 |
3024 |
ENSG00000151577 |
OTTHUMG00000159334 |
D(3) DOPAMINE RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P35462] |
P35462 |
D(3) DOPAMINE RECEPTOR |
DRD3_HUMAN |
Dopamine D3 receptor |
PA27479 |
D3R |
T02551 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Acc | IPR000276 |
Interpro Type | Family |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Uniprot Status | Swiss-Prot |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
Transmembrane Helix Count | 6 |
Target Main Class | Receptors |
Gene Biotype | PROTEIN_CODING |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
partial agonist (activating) |
agonist (activating) |
Novel drug target | Established target |
Trial Name | cariprazine, RGH-188 |
antagonist (inhibitory) |
Mechanism of Interaction | Dopamine D3 receptor antagonist |
Direct Interaction | yes |
Trial Name | - |
agonist (activating) |
Novel drug target | Established target |
Trial Name | Neupro |
Mechanism of Interaction | D2-like dopamine receptor agonist |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | amisulpride,Solian |
modulator |
Mechanism of Interaction | Dopamine D3 receptor modulator |
Direct Interaction | yes |
agonist (activating) |
Novel drug target | Established target |
Trial Name | etilevodopa, TV-1203 |
Mechanism of Interaction | Dopamine D3 receptor agonist |
agonist (activating) |
Mechanism of Interaction | D2-like dopamine receptor agonist |
Direct Interaction | yes |
n/a |
Trial Name | dexpramipexole, KNS-760704 |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | D2-like dopamine receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Trial Name | apomorphine HCl,Uprima, Ixense |
Novel drug target | Established target |
Trial Name | apomorphine hydrochloride,Apokyn, APO-go |
partial agonist (activating) |
Trial Name | pardoprunox, SLV 308 |
Novel drug target | Established target |
Mechanism of Interaction | Dopamine receptors; D2 & D3 partial agonist |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
agonist (activating) |
Mechanism of Interaction | Dopamine receptor agonist |
Direct Interaction | yes |
inverse agonist (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor inverse agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Dopamine D3 receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | D2-like dopamine receptor agonist |
Direct Interaction | yes |
inverse agonist (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor inverse agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | Asenapine |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Dopamine D3 receptor agonist |
Direct Interaction | yes |
Trial Name | entacapone/levodopa/carbidopa,Stalevo |
antagonist (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Trial Name | bromocriptine mesylate,Cycloset, Ergoset |
Novel drug target | Established target |
n/a |
Trial Name | bifeprunox, DU127090 |
Novel drug target | Established target |
binder |
antagonist (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Dopamine receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | D2-like dopamine receptor agonist |
Direct Interaction | yes |
n/a |
Novel drug target | Established target |
Trial Name | V-1512, CHF-1512,Levomet Complex, Sirio |
antagonist (inhibitory) |
Trial Name | iloperidone,Fanapt, Fiapta, Zomaril |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
Direct Interaction | yes |
Trial Name | olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
Direct Interaction | yes |
n/a |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Dopamine receptor agonist |
antagonist (inhibitory) |
Mechanism of Interaction | Dopamine receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | D2-like dopamine receptor antagonist |
Direct Interaction | yes |
DRD3 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
DRD3 | Display Id |
D(3) DOPAMINE RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P35462] | Description |
ENSG00000151577 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
P35462 | Uniprot Accession |
D(3) DOPAMINE RECEPTOR | Uniprot Protein Name |
ENSG00000151577 | Ensembl Gene Id |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Acc | IPR000276 |
Interpro Type | Family |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
DRD3 | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
P35462 | Uniprot Accession |
DRD3 | Gene Symbol |
1814 | Entrez Gene Id |
Target Subclass | GPCR |
Transmembrane Helix Count | 6 |
Target Subclass | Rhodopsin |
PA27479 | PharmGKB ID |
DRD3 | GENE_SYMBOL |
D(3) dopamine receptor | UNIPROT |
Dopamine D3 receptor | UNIPROT |
ENSG00000151577 | Gene Symbol |
DRD3 | Ensembl Id |
DRUGGABLE GENOME |
1814 | Gene ID |
D3DR | dGene Synonym |
ETM1 | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
D3R | TTD Gene Abbreviation |
T02551 | TTD Target ID |
G PROTEIN COUPLED RECEPTOR |