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EIF2AK4 Gene Record

  • Summary
  • Interactions
  • Claims
  • EIF2AK4 440275 Druggable Genome

    Alternate Names:

    440275
    EUKARYOTIC TRANSLATION INITIATION FACTOR 2 ALPHA KINASE 4
    EIF2AK4
    GCN2
    PVOD2
    609280
    19687
    ENSG00000128829
    OTTHUMG00000172403
    Q9P2K8
    KIAA1338
    EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 4 (EC 2.7.1.37) (GCN2-LIKE PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9P2K8]
    PA134947616
    eIF-2-alpha kinase GCN2

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Drago A et al., 2014, Genome-wide association study supports the role of the immunological system and of the neurodevelopmental processes in response to haloperidol treatment., Pharmacogenet Genomics
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
  • ZIPRASIDONE   EIF2AK4

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24751813


    Sources:
    PharmGKB

  • QUETIAPINE   EIF2AK4

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24751813


    Sources:
    PharmGKB

  • HALOPERIDOL   EIF2AK4

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27023437 24751813


    Sources:
    PharmGKB

  • RISPERIDONE   EIF2AK4

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24751813


    Sources:
    PharmGKB

  • OLANZAPINE   EIF2AK4

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24751813


    Sources:
    PharmGKB

  • HESPERADIN   EIF2AK4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • Ensembl: ENSG00000128829

    • Version: 101_38

    Alternate Names:
    EIF2AK4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000128829

    • Version: 26-July-2011

    Alternate Names:
    EIF2AK4 Display Id
    EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 4 (EC 2.7.1.37) (GCN2-LIKE PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9P2K8] Description
    ENSG00000128829 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: EIF2AK4

    • Version: 18-August-2020

    Alternate Names:
    PA134947616 PharmGKB ID

    Gene Info:

    Publications:
    Drago A et al., 2014, Genome-wide association study supports the role of the immunological system and of the neurodevelopmental processes in response to haloperidol treatment., Pharmacogenet Genomics
    Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

  • DTC: EIF2AK4

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

  • HingoraniCasas: ENSG00000128829

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000128829 Gene Symbol
    EIF2AK4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: EIF2AK4

    • Version: 19.3

    Alternate Names:
    ENSG00000128829 Ensembl Gene ID
    GCN2 Human Protein Atlas Gene Synonym
    KIAA1338 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: EIF2AK4

    • Version: 01-February-2022

    Alternate Names:
    GCN2 GO Gene Synonym
    KIAA1338 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: EIF2AK4

    • Version: 27-Jun-2013

    Alternate Names:
    440275 Gene ID
    GCN2 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • Pharos: EIF2AK4

    • Version: 01-February-2022

    Alternate Names:
    eIF-2-alpha kinase GCN2 Gene Name
    Q9P2K8 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21