• EPHA3 2042 Druggable GenomeClinically Actionable

    Alternate Names:

    2042
    EPH RECEPTOR A3
    EPHA3
    EK4
    ETK
    ETK1
    HEK
    HEK4
    TYRO4
    179611
    3387
    ENSG00000044524
    OTTHUMG00000159040
    EPHRIN TYPE-A RECEPTOR 3 PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR ETK1) (HEK) (HEK4). [SOURCE:UNIPROT/SWISSPROT;ACC:P29320]
    1823
    NP_005224
    NM_005233
    P29320
    EPHA3_HUMAN
    Eph-like tyrosine kinase 1
    Human embryo kinase
    Tyrosine-protein kinase receptor ETK1
    Tyrosine-protein kinase TYRO4
    EPH-like kinase 4
    Ephrin type-A receptor 3
    T28413

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category Name Type XIII RTKs: Ephrin receptor family
    GuideToPharmacology Gene Category ID 327
    Target Class Receptors
    Target Subclass EC:2.7.10.1
    Uniprot Status Swiss-Prot
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Interpro Type Domain
    Interpro Acc IPR001245
    Gene Biotype PROTEIN_CODING
    (11 More Sources)

    Gene Categories: Category Details

    KINASE
    TYROSINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
  • Interaction Score: 15.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 1.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction In a biochemical enzyme activity assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Ephrin receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    EPHA3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    EPHRIN TYPE-A RECEPTOR 3 PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR ETK1) (HEK) (HEK4). [SOURCE:UNIPROT/SWISSPROT;ACC:P29320] Description
    ENSG00000044524 Ensembl Gene Id
    EPHA3 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    EPHA3 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass EC:2.7.10.1

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    P29320 Uniprot Accession
    2042 Entrez Gene Id
    EPHA3 Uniprot Gene Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    3387 HUGO Gene ID
    3387 HUGO Gene Symbol
    EPH receptor A3 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Type XIII RTKs: Ephrin receptor family
    GuideToPharmacology Gene Category ID 327

    Publications:

    • Version: 02-September-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000044524 Gene Symbol
    EPHA3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    ETK1 GENE_SYMBOL
    HEK GENE_SYMBOL
    TYRO4 GENE_SYMBOL

    Gene Info:

    Publications:

    • Version: 19.3

    Alternate Names:
    ENSG00000044524 Ensembl Gene ID
    ETK Human Protein Atlas Gene Synonym
    ETK1 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    2042 Gene ID
    EK4 dGene Synonym
    ETK dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, TYROSINE KINASE

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    EPHA3 TTD Gene Abbreviation
    T28413 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Ephrin type-A receptor 3 Gene Name
    P29320 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: