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ERBB3 2065 Druggable GenomeClinically ActionableDrug Resistance
Alternate Names:
2065 ERB-B2 RECEPTOR TYROSINE KINASE 3 ERBB3 ErbB-3 HER3 LCCS2 MDA-BF-1 c-erbB-3 c-erbB3 erbB3-S p180-ErbB3 p45-sErbB3 p85-sErbB3 190151 3431 ENSG00000065361 OTTHUMG00000170140 RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 PRECURSOR (EC 2.7.1.112) (C- ERBB3) (TYROSINE KINASE-TYPE CELL SURFACE RECEPTOR HER3). [SOURCE:UNIPROT/SWISSPROT;ACC:P21860] 1733 1798 P21860 Receptor tyrosine-protein kinase erbB-3 Proto-oncogene-like protein c-ErbB-3 Tyrosine kinase-type cell surface receptor HER3 ERBB3_HUMAN NP_001005915 NM_001005915 EGFR (HER1/ERBB1)HER2 (ERBB2/neu)HER3 (ERBB3) HER3 (ERBB3) PA27846 Erbb3 tyrosine kinase receptor T86350 FERLK Gene Info:
Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain Interpro Type Domain Uniprot Status Swiss-Prot Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom Human Readable Name KINASE Interpro Acc IPR001245 GuideToPharmacology Gene Category Name Type I RTKs: ErbB (epidermal growth factor) receptor family GuideToPharmacology Gene Category ID 320 Target Class Receptors Target Subclass EC:2.7.10.1 Gene Biotype PROTEIN_CODING Gene Categories: Category Details
KINASE TYROSINE KINASE DRUG RESISTANCE DRUGGABLE GENOME CLINICALLY ACTIONABLE ENZYME Publications:
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Interaction Types & Directionality:
antibody (inhibitory) antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Receptor tyrosine-protein kinase erbB-3 antagonist Direct Interaction yes -
Interaction Types & Directionality:
antibody (inhibitory) Interaction Info:
Notes -
Interaction Types & Directionality:
antibody (inhibitory) Interaction Info:
Specific Action of the Ligand Binding Endogenous Drug? False Direct Interaction? True -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True -
Interaction Score: 2.13
Interaction Types & Directionality:
antibody (inhibitory) Interaction Info:
Specific Action of the Ligand Binding Endogenous Drug? False Direct Interaction? True -
Interaction Score: 2.13
Interaction Types & Directionality:
antibody (inhibitory) Interaction Info:
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Interaction Score: 2.13
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Receptor tyrosine-protein kinase erbB-3 inhibitor -
Interaction Score: 1.59
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Interaction Score: 1.42
Interaction Types & Directionality:
antibody (inhibitory) Interaction Info:
Specific Action of the Ligand Binding Endogenous Drug? False Direct Interaction? True -
Interaction Score: 1.42
Interaction Types & Directionality:
antibody (inhibitory) Interaction Info:
Specific Action of the Ligand Binding Endogenous Drug? False Direct Interaction? True -
Interaction Score: 1.06
Interaction Types & Directionality:
n/a Interaction Info:
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Interaction Score: 1.06
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Interaction Score: 1.06
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Interaction Score: 0.85
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Epidermal growth factor receptor inhibitor Direct Interaction yes -
Interaction Score: 0.85
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Epidermal growth factor receptor inhibitor Direct Interaction yes -
Interaction Score: 0.62
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Interaction Types & Directionality:
n/a Interaction Info:
Trial Name AC480 Novel drug target Novel Target -
Interaction Score: 0.53
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Epidermal growth factor receptor inhibitor Direct Interaction yes -
Interaction Score: 0.18
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Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
-
Interaction Score: 0.1
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Interaction Score: 0.05
-
Interaction Score: 0.04
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Epidermal growth factor receptor inhibitor Direct Interaction yes
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- Version: 101_38
Alternate Names:
ERBB3 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 11-September-2012
Alternate Names:
P21860 Uniprot Accession ERBB3 Uniprot Gene Name ENSG00000065361 Ensembl Gene Id Gene Info:
Uniprot Evidence 1: Evidence at protein level Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain Human Readable Name DRUGGABLE GENOME Gene Categories:
KINASE, DRUGGABLE GENOME Publications:
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- Version: 26-July-2011
Alternate Names:
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 PRECURSOR (EC 2.7.1.112) (C- ERBB3) (TYROSINE KINASE-TYPE CELL SURFACE RECEPTOR HER3). [SOURCE:UNIPROT/SWISSPROT;ACC:P21860] Description ERBB3 Display Id ENSG00000065361 Ensembl Gene Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
ERBB3 Gene Symbol Gene Info:
Target Class Receptors Target Subclass EC:2.7.10.1 Publications:
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- Version: 29-September-2020
Alternate Names:
3431 HUGO Gene ID 3431 HUGO Gene Symbol erb-b2 receptor tyrosine kinase 3 HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name Type I RTKs: ErbB (epidermal growth factor) receptor family GuideToPharmacology Gene Category ID 320 Publications:
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Alternate Names:
PA27846 PharmGKB ID Gene Info:
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Alternate Names:
2065 Entrez Gene ID 1733 CIViC Gene ID Gene Info:
Gene Categories:
DRUG RESISTANCE Publications:
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- Version: 2020.06.01
Alternate Names:
Erbb-3 TTD Gene Abbreviation T86350 TTD Target ID Gene Info:
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Alternate Names:
Gene Info:
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Alternate Names:
Gene Info:
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- Version: chembl_23
Alternate Names:
HER3 GENE_SYMBOL ERBB3 GENE_SYMBOL Receptor tyrosine-protein kinase erbB-3 UNIPROT Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000065361 Gene Symbol ERBB3 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 20-Jun-2017
Alternate Names:
2065 Entrez Gene Id ERBB3 MyCancerGenome Gene Symbol HER3 (ERBB3) MyCancerGenome Reported Gene Name Gene Info:
Publications:
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Alternate Names:
HER3 Gene Symbol Gene Info:
Publications:
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- Version: 19.3
Alternate Names:
ENSG00000065361 Ensembl Gene ID HER3 Human Protein Atlas Gene Synonym LCCS2 Human Protein Atlas Gene Synonym Gene Info:
Gene Categories:
ENZYME Publications:
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Alternate Names:
ERBB3 Gene Symbol Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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Alternate Names:
2065 Gene ID ErbB-3 dGene Synonym HER3 dGene Synonym Gene Info:
Gene Categories:
KINASE, TYROSINE KINASE Publications:
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Alternate Names:
HER3 GO Gene Synonym Gene Info:
Gene Categories:
TYROSINE KINASE Publications:
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Alternate Names:
Receptor tyrosine-protein kinase erbB-3 Gene Name P21860 UniProt ID Gene Info:
Gene Categories:
KINASE Publications:
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- Version: 30-February-2014
Alternate Names:
Gene Info:
Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
Alternate Names:
Gene Info:
Publications:
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- Version: 15-June-2013
Alternate Names:
Gene Info:
Publications:
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- Version: 03-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 04-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications: