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ESR1 Gene Record

  • Summary
  • Interactions
  • Claims
  • ESR1 2099 Druggable GenomeClinically ActionableDrug Resistance

    Alternate Names:

    2099
    ESTROGEN RECEPTOR 1
    ESR1
    ER
    ESR
    ESRA
    ESTRR
    Era
    NR3A1
    133430
    3467
    ENSG00000091831
    OTTHUMG00000016103
    ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR) (ER-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P03372]
    P03372
    ESR1_HUMAN
    21
    Nuclear receptor subfamily 3 group A member 1
    Estradiol receptor
    ER-alpha
    Estrogen receptor
    PA156
    T89534

    Gene Info:

    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Target Main Class Receptors
    Target Subclass Nuclear receptor
    Initial Gene Query NR3A1
    Counted Citations from 1950-2000 29833
    Target Class Receptors
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Interpro Type Domain
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Interpro Acc IPR000536
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (22 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR COMPLEX
    KINASE
    DRUG RESISTANCE
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Dulos et al., 2010, Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor beta., Arthritis Res. Ther.
    Cleuren et al., 2010, 17α-Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor α., J. Thromb. Haemost.
    Fujii S et al., 2013, Increased hydrophobicity and estrogenic activity of simple phenols with silicon and germanium-containing substituents., J Med Chem
    Oesterreich S et al., 2015, Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover., Breast Cancer Res Treat
    Dang Z, 2010, Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications., Toxicol Lett
    Finn et al., 2015, The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study., Lancet Oncol.
    Rivera-Guevara C et al., 2010, Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha., Bioorg Med Chem
    Lin HR et al., 2007, Identification of a series of tetrahydroisoquinoline derivatives as potential therapeutic agents for breast cancer., Bioorg Med Chem Lett
    Agouridas V et al., 2009, Effect of fluorination on the pharmacological profile of 11beta isomers of fulvestrant in breast carcinoma cells., J Med Chem
    Lai A et al., 2015, Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts., J Med Chem
    Calogeropoulou T et al., 2009, Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity., J Med Chem
    De Savi C et al., 2015, Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist., J Med Chem
    Jacquot Y et al., 2007, Synthesis, structure, and estrogenic activity of 4-amino-3-(2-methylbenzyl)coumarins on human breast carcinoma cells., Bioorg Med Chem
    Toy et al., 2013, ESR1 ligand-binding domain mutations in hormone-resistant breast cancer., Nat. Genet.
    Robinson et al., 2013, Activating ESR1 mutations in hormone-resistant metastatic breast cancer., Nat. Genet.
    Bundred et al., 2002, Fulvestrant (Faslodex): current status in the therapy of breast cancer., Expert Rev Anticancer Ther
    Dow, 2002, Existing and emerging endocrine therapies for breast cancer., Cancer Nurs
    Curran et al., 2001, Fulvestrant., Drugs
    Elkak et al., 2001, Pure antiestrogens and breast cancer., Curr Med Res Opin
    McKeage et al., 2004, Fulvestrant: a review of its use in hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following antiestrogen therapy., Drugs
    Jones et al., 2005, Effectiveness and tolerability of fulvestrant in postmenopausal women with hormone receptor-positive breast cancer., Clin. Breast Cancer
    Morris et al., 2002, Fulvestrant ('Faslodex')--a new treatment option for patients progressing on prior endocrine therapy., Endocr. Relat. Cancer
    Kabos et al., 2010, Fulvestrant: a unique antiendocrine agent for estrogen-sensitive breast cancer., Expert Opin Pharmacother
    Jeselsohn et al., 2014, Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer., Clin. Cancer Res.
    Ogawa T et al., 2006, m-Carborane bisphenol structure as a pharmacophore for selective estrogen receptor modulators., Bioorg Med Chem Lett
    Jain D et al., 2010, A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements., Bioorg Med Chem Lett
    Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.
    Cyrus et al., 2010, Jostling for position: optimizing linker location in the design of estrogen receptor-targeting PROTACs., ChemMedChem
    Fabian et al., Chemoprevention for high-risk women: tamoxifen and beyond., Breast J
    Ntukidem NI et al., 2008, Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen., Clin Pharmacol Ther
    Maximov PY et al., 2010, Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen., J Med Chem
    Maximov PY et al., 2014, Influence of the length and positioning of the antiestrogenic side chain of endoxifen and 4-hydroxytamoxifen on gene activation and growth of estrogen receptor positive cancer cells., J Med Chem
    Reed et al., 2005, Dose-dependent effects of 4-hydroxytamoxifen, the active metabolite of tamoxifen, on estrogen receptor-alpha expression in the rat uterus., Anticancer Drugs
    Matsumoto, 2006, [Selective estrogen receptor modulators (SERMs)]., Clin Calcium
    Moen et al., 2008, Raloxifene: a review of its use in the prevention of invasive breast cancer., Drugs
    Bryant et al., An estrogen receptor basis for raloxifene action in bone., J. Steroid Biochem. Mol. Biol.
    Khovidhunkit et al., 1999, Clinical effects of raloxifene hydrochloride in women., Ann. Intern. Med.
    Scott et al., 1999, Raloxifene: a selective estrogen receptor modulator., Am Fam Physician
    Schafer et al., 1999, The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor., Cancer Res.
    Figtree et al., 1999, Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor-dependent and nitric oxide-dependent mechanism., Circulation
    Cummings et al., 1999, The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation., JAMA
    Labad J et al., 2016, Pharmacogenetic study of the effects of raloxifene on negative symptoms of postmenopausal women with schizophrenia: A double-blind, randomized, placebo-controlled trial., Eur Neuropsychopharmacol
    Margeat et al., 2003, Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta., J. Mol. Biol.
    Grove et al., 1987, Estrogen stimulation of phosphatidylinositol metabolism in mouse uterine tissue., Endocrinology
    Juriansz et al., 1988, Interactions of putative estrogens with the intracellular receptor complex in mouse Leydig cells: relationship to preneoplastic hyperplasia., Cancer Res.
    Chae et al., 1998, Estrogen-dependent gene regulation by an oxidative metabolite of diethylstilbestrol, diethylstilbestrol-4',4"-quinone., Steroids
    Kuiper et al., 1997, Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta., Endocrinology
    Bovee et al., 2004, Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types., J. Steroid Biochem. Mol. Biol.
    Maru et al., 2009, Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity., Bone
    Wurz et al., 2005, Ospemifene inhibits the growth of dimethylbenzanthracene-induced mammary tumors in Sencar mice., J. Steroid Biochem. Mol. Biol.
    Komi et al., 2004, Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in healthy postmenopausal women., Gynecol. Endocrinol.
    Lehnes et al., 2007, The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway., Endocrinology
    Brama et al., 2007, Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism., Mol. Cell. Endocrinol.
    Chang FR et al., 2005, The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists., J Nat Prod
    Bologa et al., 2006, Virtual and biomolecular screening converge on a selective agonist for GPR30., Nat. Chem. Biol.
    Renner S et al., 2009, Bioactivity-guided mapping and navigation of chemical space., Nat Chem Biol
    Banerjee M et al., 2013, Modulation of xenobiotic receptors by steroids., Molecules
    Paterni I et al., 2014, Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential., Steroids
    Ariazi et al., 2006, Estrogen receptors as therapeutic targets in breast cancer., Curr Top Med Chem
    Jones et al., 2004, A review of adjuvant hormonal therapy in breast cancer., Endocr. Relat. Cancer
    Locci et al., 2001, Synthesis and secretion of transforming growth factor-beta1 by human desmoid fibroblast cell line and its modulation by toremifene., J. Interferon Cytokine Res.
    Shelly et al., 2008, Selective estrogen receptor modulators: an update on recent clinical findings., Obstet Gynecol Surv
    Goldstein, 2006, Controversies in adjuvant endocrine treatment of premenopausal women., Clin. Breast Cancer
    Lewis-Wambi et al., Treatment of Postmenopausal Breast Cancer with Selective Estrogen Receptor Modulators (SERMs)., Breast Dis
    Taneja et al., 2006, Toremifene--a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy., Expert Opin Investig Drugs
    Liu et al., 2003, Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites., Chem. Res. Toxicol.
    Smith, 2006, Treatment-related osteoporosis in men with prostate cancer., Clin. Cancer Res.
    Gennari et al., 2007, Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development., Drugs Aging
    Kwok et al., 2010, Measuring binding kinetics of ligands with tethered receptors by fluorescence polarization and total internal reflection fluorescence., Anal. Chem.
    Hart et al., 2007, Estrogen mobilizes a subset of estrogen receptor-alpha-immunoreactive vesicles in inhibitory presynaptic boutons in hippocampal CA1., J. Neurosci.
    Muñoz et al., Association with litter size of new polymorphisms on ESR1 and ESR2 genes in a Chinese-European pig line., Genet. Sel. Evol.
    Baron et al., 2007, Estrogen receptor alpha and the activating protein-1 complex cooperate during insulin-like growth factor-I-induced transcriptional activation of the pS2/TFF1 gene., J. Biol. Chem.
    Dixon et al., 2007, Renoprotective effects of a selective estrogen receptor modulator, raloxifene, in an animal model of diabetic nephropathy., Am. J. Nephrol.
    Bains et al., 2007, Neuroprotection by estrogen against MPP+-induced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalon., Exp. Neurol.
    Hodnik Ž et al., 2015, Diethylstilbestrol-scaffold-based pregnane X receptor modulators., Eur J Med Chem
    Kupfer et al., 1990, Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor., FEBS Lett.
    Jordan et al., 1983, Inhibition of the uterotropic activity of estrogens and antiestrogens by the short acting antiestrogen LY117018., Endocrinology
    Wang et al., 2006, [Clinical characteristics and potential prognostic factors of breast cancer patients with liver metastases]., Zhonghua Zhong Liu Za Zhi
    Shyu et al., 2011, Computational estimation of rainbow trout estrogen receptor binding affinities for environmental estrogens., Toxicol. Appl. Pharmacol.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Jung J et al., 2004, Anti-estrogenic activity of fifty chemicals evaluated by in vitro assays., Life Sci
    Poutiainen PK et al., 2010, Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor alpha and beta agonists., Bioorg Med Chem
    Kumar et al., 2007, Type and duration of exogenous hormone use affects breast cancer histology., Ann. Surg. Oncol.
    Montero Girard et al., 2007, Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment., Breast Cancer Res.
    Yuri et al., Effects of different durations of estrogen and progesterone treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats., In Vivo
    Lessey et al., 2006, Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women., Reprod. Biol. Endocrinol.
    Ghebeh et al., 2007, Expression of B7-H1 in breast cancer patients is strongly associated with high proliferative Ki-67-expressing tumor cells., Int. J. Cancer
    Jayaraman A et al., 2009, Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones., J Neuroendocrinol
    Mohammed H et al., 2015, Progesterone receptor modulates ERα action in breast cancer., Nature
    Tessier C et al., 2000, Estrogen receptors alpha and beta in rat decidua cells: cell-specific expression and differential regulation by steroid hormones and prolactin., Endocrinology
    Ravdin PM et al., 1987, Estrogenic effects of phenolphthalein on human breast cancer cells in vitro., Breast Cancer Res Treat
    Vijayanathan et al., 2006, Physiologic levels of 2-methoxyestradiol interfere with nongenomic signaling of 17beta-estradiol in human breast cancer cells., Clin. Cancer Res.
    Mirkin et al., 2005, Effect of 17 beta-estradiol, progesterone, synthetic progestins, tibolone, and tibolone metabolites on vascular endothelial growth factor mRNA in breast cancer cells., Fertil. Steril.
    Vereide et al., 2006, Effect of levonorgestrel IUD and oral medroxyprogesterone acetate on glandular and stromal progesterone receptors (PRA and PRB), and estrogen receptors (ER-alpha and ER-beta) in human endometrial hyperplasia., Gynecol. Oncol.
    Sun et al., 2007, Contribution of epoxyeicosatrienoic acids to flow-induced dilation in arteries of male ERalpha knockout mice: role of aromatase., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Abdel-Aleem et al., 2005, Tamoxifen treatment of bleeding irregularities associated with Norplant use., Contraception
    Lv XH et al., 2011, Effects of levonorgestrel on reproductive hormone levels and their receptor expression in Mongolian gerbils (Meriones unguiculatus)., Exp Anim
    Lemus AE et al., 1992, Mechanism of action of levonorgestrel: in vitro metabolism and specific interactions with steroid receptors in target organs., J Steroid Biochem Mol Biol
    García-Becerra R et al., 2002, The intrinsic transcriptional estrogenic activity of a non-phenolic derivative of levonorgestrel is mediated via the estrogen receptor-alpha., J Steroid Biochem Mol Biol
    Micevych et al., 2007, Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures., Endocrinology
    Bennink, Reprint of Are all estrogens the same?, Maturitas
    Garcia-Segura et al., 2006, Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection., Neuroendocrinology
    Notch et al., 2009, 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells., Aquat. Toxicol.
    Mukai et al., 2006, Local neurosteroid production in the hippocampus: influence on synaptic plasticity of memory., Neuroendocrinology
    Kojima H et al., 2003, Effects of a diphenyl ether-type herbicide, chlornitrofen, and its amino derivative on androgen and estrogen receptor activities., Environ Health Perspect
    Gruber et al., 2004, Bazedoxifene (Wyeth)., Curr Opin Investig Drugs
    Shen J et al., 2012, Discovery and structure-activity analysis of selective estrogen receptor modulators via similarity-based virtual screening., Eur J Med Chem
    Sanfilippo et al., 1985, Evaluation of danazol influence upon the uterus using scanning electron microscopic morphometric and biochemical analyses., Surg Gynecol Obstet
    Snyder et al., 1990, Danazol suppression of luteinizing hormone in the rat: evidence for mediation by both androgen and estrogen receptors., Proc. Soc. Exp. Biol. Med.
    Fujimoto et al., 1995, Danazol decreases transcription of estrogen receptor gene in human monocytes., Gen. Pharmacol.
    Vajdos FF et al., 2007, The 2.0 A crystal structure of the ERalpha ligand-binding domain complexed with lasofoxifene., Protein Sci
    Kieser KJ et al., 2010, Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs)., J Med Chem
    Hughes et al., 2010, Clomiphene citrate for unexplained subfertility in women., Cochrane Database Syst Rev
    Homburg, 2008, Oral agents for ovulation induction--clomiphene citrate versus aromatase inhibitors., Hum Fertil (Camb)
    Homburg, 2005, Clomiphene citrate--end of an era? A mini-review., Hum. Reprod.
    2006, Use of clomiphene citrate in women., Fertil. Steril.
    Kurosawa et al., 2010, Clomiphene citrate elicits estrogen agonistic/antagonistic effects differentially via estrogen receptors alpha and beta., Endocr. J.
    Overbeek et al., 2009, Pharmacogenomics of ovulation induction: facilitating decisions on who, when and how to treat., Pharmacogenomics
    Brown et al., 2009, Clomiphene and anti-oestrogens for ovulation induction in PCOS., Cochrane Database Syst Rev
    Pasqualini, 2003, Differential effects of progestins on breast tissue enzymes., Maturitas
    Juchem et al., 1990, Binding of oral contraceptive progestogens to serum proteins and cytoplasmic receptor., Am. J. Obstet. Gynecol.
    Shields-Botella et al., 2003, An overview of nomegestrol acetate selective receptor binding and lack of estrogenic action on hormone-dependent cancer cells., J. Steroid Biochem. Mol. Biol.
    Paris F et al., 2015, Molecular action of norgestimate: new developments., Gynecol Endocrinol
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Kishi T et al., 2009, A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis., Prog Neuropsychopharmacol Biol Psychiatry
    Fuhrmann et al., 1995, Characterization of the novel progestin gestodene by receptor binding studies and transactivation assays., Contraception
    Rabe et al., 2000, Induction of estrogen receptor-alpha and -beta activities by synthetic progestins., Gynecol. Endocrinol.
    Deng HW et al., 1998, Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes., Hum Genet
    Romerius P et al., 2011, Estrogen receptor α single nucleotide polymorphism modifies the risk of azoospermia in childhood cancer survivors., Pharmacogenet Genomics
    Huang R et al., 2014, Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway., Sci Rep
    Scippo ML et al., 2004, Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors., Anal Bioanal Chem
    Dziedziejko V et al., 2011, The effect of ESR1 and ESR2 gene polymorphisms on the outcome of rheumatoid arthritis treatment with leflunomide., Pharmacogenomics
    Spannhoff A et al., 2007, Target-based approach to inhibitors of histone arginine methyltransferases., J Med Chem
    Zhou J et al., 2000, Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression., FASEB J
    Lappano R et al., 2009, Structure-activity relationships of resveratrol and derivatives in breast cancer cells., Mol Nutr Food Res
  • ENDOXIFEN   ESR1

    Interaction Score: 1.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24805199


    Sources:
    DTC ClearityFoundationClinicalTrial TTD

  • CLOMIPHENE   ESR1

    Interaction Score: 1.27

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Androxal
    Novel drug target Established target

    PMIDs:
    20091498 18320435 15878925 17055820 20379036 19761360 2011412 11752352 19821295


    Sources:
    TdgClinicalTrial TEND TTD

  • LEVONORGESTREL   ESR1

    Interaction Score: 1.06

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:
    Trial Name ethinyl estradiol + levonorgestrel,Seasonale, Lo Seasonale, Seasonique
    Novel drug target Established target
    Trial Name AG-200-15

    PMIDs:
    16609013 16084894 16325240 17634204 16307966 21791876 1562565 12589940


    Sources:
    TdgClinicalTrial TEND

  • LASOFOXIFENE   ESR1

    Interaction Score: 0.96

    Interaction Types & Directionality:
    negative modulator (inhibitory)
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name lasofoxifene,Fablyn, Oporia
    Novel drug target Established target

    PMIDs:
    17456742


    Sources:
    TdgClinicalTrial TTD

  • ESTRIOL   ESR1

    Interaction Score: 0.8

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2011412 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • TOREMIFENE   ESR1

    Interaction Score: 0.73

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Trial Name Acapodene
    Novel drug target Established target
    Trial Name atamestane-plus-toremifene

    PMIDs:
    16515478 15369444 11747628 18279543 16595024 16917142 16503765 12870885 11752352 17062721 17503894


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD FDA

  • FULVESTRANT   ESR1

    Interaction Score: 0.69

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name fulvestrant,Faslodex
    Mechanism of Interaction Estrogen receptor antagonist

    PMIDs:
    20621492 17337183 19133777 25879485 19845386 26407012 17275315 24185512 24185510 12113237 12080538 11398912 11922402 15018596 15865850 12542403 11752352 20151846


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions TEND CIViC PharmGKB TTD FDA OncoKB

  • CHEMBL2313445   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23214428


    Sources:
    DTC

  • 4-TRIETHYLGERMYLPHENOL   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23214428


    Sources:
    DTC

  • GLYCITEIN   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16038533


    Sources:
    DTC

  • ESTROPIPATE   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    2011412 17138652 17125913 11752352


    Sources:
    ChemblInteractions TTD

  • BRILANESTRANT   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor alpha antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • RAD1901   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name RAD1901
    Novel drug target Established target
    Mechanism of Interaction Estrogen receptor alpha degrader

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • AZD-9496   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD OncoKB

  • NORGESTIMATE   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    14670645 2175153 14672731 25970022


    Sources:
    TdgClinicalTrial TEND

  • CHEMBL195515   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20334372


    Sources:
    DTC

  • CHEMBL2071180   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22647217


    Sources:
    DTC

  • 1-HYDROXY-6-(4-HYDROXY-PHENYL)-1-PHENYL-HEXAN-3-ONE (ENANTIOMERIC MIX)   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20430632


    Sources:
    DTC

  • CHEMBL2313444   ESR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23214428


    Sources:
    DTC

  • DIENESTROL   ESR1

    Interaction Score: 0.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha agonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    3622377 3334987 9558716 11752352 9048584 15276617 18976723


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • QUINESTROL   ESR1

    Interaction Score: 0.51

    Interaction Types & Directionality:
    agonist (activating)
    modulator

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Direct Interaction yes

    PMIDs:
    21075131 17016423 17139284 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • CHLOROTRIANISENE   ESR1

    Interaction Score: 0.51

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2307235 6872937 11752352 17236558


    Sources:
    DTC TdgClinicalTrial TEND TTD

  • DESOGESTREL   ESR1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7750284 2175153 10836199


    Sources:
    TdgClinicalTrial TEND

  • OSPEMIFENE   ESR1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    16153821 15255284


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • SULFENTRAZONE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1222035   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20659801


    Sources:
    DTC

  • POLYESTRADIOL PHOSPHATE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEGESTROL   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • IODINE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name molecular iodine,IoGen
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • BORIC ACID   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ETHYLENEDIAMINE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALFADEX   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROMESTRIENE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PUERARIN   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16038533


    Sources:
    DTC

  • 4-METHYLBENZOIC ACID METHYL ESTER   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL354663   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL384441   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ESTETROL   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ELACESTRANT   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • N-PROPYL BROMIDE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIETHYLSTILBESTROL DIPHOSPHATE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CLOMIPHENE CITRATE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FISPEMIFENE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Trial Name fispemifene, HM-101
    Novel drug target Established target
    Mechanism of Interaction Estrogen receptor modulator

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ARZOXIFENE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name Arzoxifene, LY353381

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • ETONOGESTREL   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name etonogestrel implant,Implanon
    Novel drug target Established target
    Trial Name etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • ICARITIN   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • METHYLISOTHIOCYANATE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHF4227   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CHEMBL1432305   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SR16234   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha antagonist
    Direct Interaction yes
    Trial Name TAS-108

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ESTROGEN   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase
    Novel drug target Established target
    Trial Name oral contraceptive,Pill-Plus

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • MONOETHANOLAMINE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ACRYLAMIDE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MK-6913   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes
    Trial Name MK-6913

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ESTRADIOL ACETATE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PALMITIC ACID   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ESTRONE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha agonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    12547192 11752352 2011412


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • ACOLBIFENE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CENESTIN   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GTX-758   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ETHINYL ESTRADIOL   ESR1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    17125913 17095591 17138652 19434891 17124377 19237207 11752352 17142999


    Sources:
    ChemblInteractions

  • MESTRANOL   ESR1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor alpha agonist
    Trial Name -

    PMIDs:
    11752352 20497523 20524981


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • BAZEDOXIFENE   ESR1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name bazedoxifene, bazedoxifene/conjugated estrogens, TSE-424,Viviant, Aprela, Conbriza
    Novel drug target Established target

    PMIDs:
    15535430


    Sources:
    TdgClinicalTrial TTD

  • CHEMBL221047   ESR1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17432842


    Sources:
    DTC

  • ESTRADIOL   ESR1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor alpha agonist
    Trial Name transdermal estradiol,Divigel

    PMIDs:
    2011412 17138652 17125913 11752352 20659801 20334368 16038533 16520733 19561619 25879485 24805199 23884115 24971815


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • RALOXIFENE   ESR1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16951478 18778124 10418979 10068418 10507743 10485477 11752352 10477535 10376571 27546373 20659801


    Sources:
    DTC TdgClinicalTrial TEND PharmGKB TTD FDA

  • HYDROXYPROGESTERONE   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GESTRINONE   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LY2245461   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ARSANILIC ACID   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CAMPHOR   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL503990   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIENOGEST   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name estradiol valerate + dienogest,Natazia, Qlaira
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • BENZODODECINIUM CHLORIDE   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SYNTHETIC CONJUGATED ESTROGENS, B   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METHIOCARB   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALFATRADIOL   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ESTROGENS, ESTERIFIED   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESTROGENS, CONJUGATED   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RALOXIFEN   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Evista
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • TRIADIMEFON   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DANAZOL   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    4039467 2326286 7540578 11752352


    Sources:
    DTC TdgClinicalTrial TEND TTD

  • ESTRADIOL CYPIONATE   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIETHYLSTILBESTROL DIPROPIONATE   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SIVIFENE   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name A-007
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ESTROGENS, CONJUGATED SYNTHETIC A   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINTAFOLIDE   ESR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationClinicalTrial

  • AFIMOXIFENE   ESR1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    20334368 24805199 15846122


    Sources:
    DTC ChemblInteractions TTD

  • DIETHYLSTILBESTROL   ESR1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Direct Interaction yes

    PMIDs:
    20387803 17314305 17306201 17317669 11752352 17308373 17320868 26408814


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • LETROZOLE   ESR1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26536870 25524798


    Sources:
    ClearityFoundationBiomarkers CIViC PharmGKB FDA

  • METHYLTESTOSTERONE   ESR1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25012808


    Sources:
    DTC

  • TAMOXIFEN   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    24185510 24398047 24185512 16735120 20659801 20621492 2011412 20512796 11906441 11752352 17713466


    Sources:
    DTC ClearityFoundationBiomarkers TdgClinicalTrial ClearityFoundationClinicalTrial TEND CIViC PharmGKB TTD FDA

  • ESTRADIOL VALERATE   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor alpha agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALACHLOR   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CUMENE HYDROPEROXIDE   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BAZEDOXIFENE ACETATE   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ERIBULIN   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TRIS(2,3-DIBROMOPROPYL)PHOSPHATE   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NORGESTREL   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • CYCLOFENIL   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PHENYLALANINE   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • STANOLONE   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12676605


    Sources:
    DTC

  • CHEMBL259327   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GOSERELIN   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • NORELGESTROMIN   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name norelgestromin/ethinyl estradiol,Ortho Evra
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ZERANOL   ESR1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19913605


    Sources:
    DTC

  • HYDRAMETHYLNON   ESR1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1579130   ESR1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MITOTANE   ESR1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14579009


    Sources:
    TTD

  • ALOE-EMODIN   ESR1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1523215   ESR1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BISPHENOL A   ESR1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERTUZUMAB   ESR1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • ORTHOTOLIDINE   ESR1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENOLPHTHALEIN   ESR1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    3620717


    Sources:
    DTC

  • IDOXIFENE   ESR1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ANASTROZOLE   ESR1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers PharmGKB FDA

  • EXEMESTANE   ESR1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26536870


    Sources:
    PharmGKB FDA

  • GUGGULSTERONE   ESR1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ACETOCHLOR   ESR1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ENDOSULFAN   ESR1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CETRIMONIUM BROMIDE   ESR1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TESTOSTERONE PROPIONATE   ESR1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPYLPARABEN   ESR1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 4-NONYLPHENOL   ESR1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIPHENYLSTANNANOL   ESR1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NERATINIB   ESR1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • DOXYCYCLINE   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24185512


    Sources:
    PharmGKB

  • LEFLUNOMIDE   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21174621


    Sources:
    PharmGKB

  • DROLOXIFENE   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROGESTERONE   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    negative modulator (inhibitory)
    agonist (activating)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase
    Novel drug target Established target
    Trial Name BHR-100

    PMIDs:
    17103262 17341305 17203775 17118173 17415709 19094096 26153859 11014241


    Sources:
    TdgClinicalTrial TEND

  • RETINAL   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOMIPHEN BROMIDE   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MEDROXYPROGESTERONE ACETATE   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9860300


    Sources:
    PharmGKB

  • OXYTETRACYCLINE HYDROCHLORIDE   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TOREMIFENE CITRATE   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPACHLOR   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ABEMACICLIB   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • PROTOAPIGENONE   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16038533


    Sources:
    DTC

  • RIBOCICLIB   ESR1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • METHOXSALEN   ESR1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TESTOSTERONE   ESR1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16038533 12676605 10973921


    Sources:
    DTC

  • CHEMBL85826   ESR1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 3R14S-OCHRATOXIN A   ESR1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OXYMETHOLONE   ESR1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • COUMESTROL   ESR1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAMOXIFEN CITRATE   ESR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    DTC ChemblInteractions

  • DAIDZEIN   ESR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16038533


    Sources:
    DTC

  • TRASTUZUMAB   ESR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • IXABEPILONE   ESR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • CHEMBL329673   ESR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CADMIUM DICHLORIDE   ESR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPYLPYRAZOLETRIOL   ESR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PALBOCICLIB   ESR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25524798


    Sources:
    CIViC PharmGKB FDA

  • CHOLECALCIFEROL   ESR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KEPONE   ESR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GUTHION   ESR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RETINOL   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PENTABROMOPHENOL   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZIRAM   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • METHAMPHETAMINE   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19386276


    Sources:
    PharmGKB

  • CAPTAN   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZEARALENONE   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LAPATINIB   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • OLAPARIB   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • PYRITHIONE ZINC   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL184450   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORANIL   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PYROGALLOL   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BENZETHONIUM CHLORIDE   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DACTINOMYCIN   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENAZOPYRIDINE HYDROCHLORIDE   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALPELISIB   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • GENISTEIN   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16038533 10592235


    Sources:
    DTC

  • GENTIAN VIOLET   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KAEMPFEROL   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DICHLOROPHEN   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EVEROLIMUS   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • MERCURIC CHLORIDE   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENYLMERCURIC ACETATE   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HEXACHLOROPHENE   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15081572


    Sources:
    DTC

  • CATECHOL   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19496085


    Sources:
    DTC

  • BITHIONOL   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FENRETINIDE   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • APIGENIN   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW7647   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DAUNORUBICIN HYDROCHLORIDE   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOXORUBICIN HYDROCHLORIDE   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NORDIHYDROGUAIARETIC ACID   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOCETAXEL   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • GOSSYPOL   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CISPLATIN   ESR1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21430602


    Sources:
    PharmGKB

  • Ensembl: ENSG00000091831

    • Version: 101_38

    Alternate Names:
    ESR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000091831

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000091831 Ensembl Gene Id
    ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR) (ER-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P03372] Description
    ESR1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: ESR1

    • Version: February-2014

    Alternate Names:
    2099 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR3A1
    Counted Citations from 1950-2000 29833

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • HopkinsGroom: P03372

    • Version: 11-September-2012

    Alternate Names:
    P03372 Uniprot Accession
    ENSG00000091831 Ensembl Gene Id
    ESR1 Uniprot Gene Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: P03372

    • Version: 01-August-2011

    Alternate Names:
    2099 Entrez Gene Id
    ENSG00000091831 Ensembl Gene Id
    ESR1_HUMAN Uniprot Id

    Gene Info:
    Target Subclass Nuclear receptor
    Target Main Class Receptors

    Publications:

  • TdgClinicalTrial: P03372

    • Version: January-2014

    Alternate Names:
    ESR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • PharmGKB: ESR1

    • Version: 18-August-2020

    Alternate Names:
    PA156 PharmGKB ID

    Gene Info:

    Publications:
    Toy et al., 2013, ESR1 ligand-binding domain mutations in hormone-resistant breast cancer., Nat. Genet.
    Robinson et al., 2013, Activating ESR1 mutations in hormone-resistant metastatic breast cancer., Nat. Genet.
    Oesterreich S et al., 2015, Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover., Breast Cancer Res Treat

  • CIViC: ESR1

    • Version: 14-September-2020

    Alternate Names:
    2099 Entrez Gene ID
    21 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Toy et al., 2013, ESR1 ligand-binding domain mutations in hormone-resistant breast cancer., Nat. Genet.
    Robinson et al., 2013, Activating ESR1 mutations in hormone-resistant metastatic breast cancer., Nat. Genet.
    Finn et al., 2015, The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study., Lancet Oncol.

  • TTD: Estrogen receptor

    • Version: 2020.06.01

    Alternate Names:
    ESR TTD Gene Abbreviation
    T89534 TTD Target ID

    Gene Info:

    Publications:
    Fugh-Berman AJ, 2010, The haunting of medical journals: how ghostwriting sold "HRT"., PLoS Med

  • DTC: ESR1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Shen J et al., 2012, Discovery and structure-activity analysis of selective estrogen receptor modulators via similarity-based virtual screening., Eur J Med Chem
    Jain D et al., 2010, A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements., Bioorg Med Chem Lett
    Maximov PY et al., 2010, Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen., J Med Chem

  • TALC: ESR1

    • Version: 12-May-2016

    Alternate Names:
    ESR1 Gene Symbol

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000091831

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000091831 Gene Symbol
    ESR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ESR

    • Version: chembl_23

    Alternate Names:
    NR3A1 GENE_SYMBOL
    ESR1 GENE_SYMBOL
    Estrogen receptor UNIPROT

    Gene Info:

    Publications:

  • OncoKB: ESR1

    • Version: 23-July-2020

    Alternate Names:
    2099 OncoKB Entrez Id
    ESR OncoKB Gene Synonym
    ESTRR OncoKB Gene Synonym

    Gene Info:

    Publications:

  • GO: ESR1

    • Version: 01-February-2022

    Alternate Names:
    ESR GO Gene Synonym
    NR3A1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR

    Publications:

  • Tempus: ESR1

    • Version: 11-November-2018

    Alternate Names:
    ESR1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: ESR1

    • Version: 27-Jun-2013

    Alternate Names:
    2099 Gene ID
    ER dGene Synonym
    ESR dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • Pharos: ESR1

    • Version: 01-February-2022

    Alternate Names:
    Estrogen receptor Gene Name
    P03372 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • ClearityFoundationClinicalTrial: ESR1

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

  • ClearityFoundationBiomarkers: ESR1

    • Version: 26-July-2013

    Alternate Names:

    Gene Info:

    Publications:

  • MskImpact: ESR1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: ESR1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: ESR1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FDA: ESR

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

  • Oncomine: ESR1

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • COSMIC: ESR1

    • Version: 4-Sep-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21