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ESRRG Gene Record

  • Summary
  • Interactions
  • Claims
  • ESRRG 2104 Druggable Genome

    Alternate Names:

    2104
    ESTROGEN RELATED RECEPTOR GAMMA
    ESRRG
    ERR3
    ERRgamma
    NR3B3
    602969
    3474
    ENSG00000196482
    OTTHUMG00000037025
    Estrogen-related receptor gamma
    KIAA0832
    ERRG2
    ERR gamma-2
    Nuclear receptor subfamily 3 group B member 3
    Estrogen receptor-related protein 3
    BE0002088
    P62508
    ESTROGEN-RELATED RECEPTOR GAMMA (ESTROGEN RECEPTOR RELATED PROTEIN 3) (ERR GAMMA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P62508]
    ERR3_HUMAN
    624
    NP_001429|NP_996317|NP_996318
    NM_206595
    Estrogen-related receptor-γ

    Gene Info:

    Initial Gene Query NR3B3
    Counted Citations from 1950-2000 119
    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category Name 3B. Estrogen-related receptors
    GuideToPharmacology Gene Category ID 97
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Interpro Acc IPR000536
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Nam et al., 2003, Simulation of the different biological activities of diethylstilbestrol (DES) on estrogen receptor alpha and estrogen-related receptor gamma., Biopolymers
    Greschik et al., 2004, Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity., J. Biol. Chem.
    Tremblay et al., 2001, Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta., Genes Dev.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Wang et al., 2010, Troglitazone is an estrogen-related receptor alpha and gamma inverse agonist., Biochem. Pharmacol.
    Gowda K et al., 2006, Development of a coactivator displacement assay for the orphan receptor estrogen-related receptor-gamma using time-resolved fluorescence resonance energy transfer., Anal Biochem
    Babu S et al., 2012, Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma., Biochem Biophys Res Commun
  • CHEMBL1231453   ESRRG

    Interaction Score: 8.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL194805   ESRRG

    Interaction Score: 8.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL193836   ESRRG

    Interaction Score: 4.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL201013   ESRRG

    Interaction Score: 2.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Inverse agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BISPHENOL A   ESRRG

    Interaction Score: 1.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • AFIMOXIFENE   ESRRG

    Interaction Score: 1.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Inverse agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DIETHYLSTILBESTROL   ESRRG

    Interaction Score: 0.93

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    12579585 15161930 11297507 10592235


    Sources:
    NCI DrugBank GuideToPharmacology

  • AFIMOXIFENE   ESRRG

    Interaction Score: 0.77

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Estrogen-related receptor gamma antagonist
    Direct Interaction yes

    PMIDs:
    10592235


    Sources:
    DrugBank ChemblInteractions

  • ESTRADIOL BENZOATE   ESRRG

    Interaction Score: 0.67

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    22935422


    Sources:
    DrugBank

  • TROGLITAZONE   ESRRG

    Interaction Score: 0.26

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:

    PMIDs:
    20298676


    Sources:
    DrugBank

  • DAIDZEIN   ESRRG

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TAMOXIFEN   ESRRG

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16889744


    Sources:
    DrugBank

  • GENISTEIN   ESRRG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • Ensembl: ENSG00000196482

    • Version: 101_38

    Alternate Names:
    ESRRG Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P62508

    • Version: 11-September-2012

    Alternate Names:
    P62508 Uniprot Accession
    ESRRG Uniprot Gene Name
    ENSG00000196482 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Nuclear hormone receptor, ligand-binding, core

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: ESRRG

    • Version: February-2014

    Alternate Names:
    2104 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR3B3
    Counted Citations from 1950-2000 119

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • RussLampel: ENSG00000196482

    • Version: 26-July-2011

    Alternate Names:
    ESRRG Display Id
    ENSG00000196482 Ensembl Gene Id
    ESTROGEN-RELATED RECEPTOR GAMMA (ESTROGEN RECEPTOR RELATED PROTEIN 3) (ERR GAMMA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P62508] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 2104

    • Version: 29-September-2020

    Alternate Names:
    3474 HUGO Gene ID
    3474 HUGO Gene Symbol
    estrogen related receptor gamma HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 3B. Estrogen-related receptors
    GuideToPharmacology Gene Category ID 97

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • DrugBank: BE0002088

    • Version: 5.1.7

    Alternate Names:
    ESRRG DrugBank Gene Name
    P62508 UniProt Accession
    2104 Entrez Gene Id

    Gene Info:

    Publications:
    Wang et al., 2010, Troglitazone is an estrogen-related receptor alpha and gamma inverse agonist., Biochem. Pharmacol.
    Gowda K et al., 2006, Development of a coactivator displacement assay for the orphan receptor estrogen-related receptor-gamma using time-resolved fluorescence resonance energy transfer., Anal Biochem
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • NCI: ESRRG

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Nam et al., 2003, Simulation of the different biological activities of diethylstilbestrol (DES) on estrogen receptor alpha and estrogen-related receptor gamma., Biopolymers

  • HingoraniCasas: ENSG00000196482

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000196482 Gene Symbol
    ESRRG Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ERR3

    • Version: chembl_23

    Alternate Names:
    ERRG2 GENE_SYMBOL
    KIAA0832 GENE_SYMBOL
    NR3B3 GENE_SYMBOL

    Gene Info:

    Publications:

  • Pharos: ESRRG

    • Version: 03-September-2020

    Alternate Names:
    Estrogen-related receptor gamma Gene Name
    P62508 UniProt ID

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • GO: ESRRG

    • Version: 05-September-2020

    Alternate Names:
    ERR3 GO Gene Synonym
    ERRG2 GO Gene Synonym
    KIAA0832 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: ESRRG

    • Version: 27-Jun-2013

    Alternate Names:
    2104 Gene ID
    ERR3 dGene Synonym
    ERRgamma dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21