• Interaction Score: 28.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

  • Interaction Score: 11.83

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

  • Interaction Score: 7.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of enzyme function in a biochemical assay using the (activating) Y641N mutant form of EZH2.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Approval Status Preclinical - Cell line xenograft
    Indication/Tumor Type colon cancer
    Indication/Tumor Type pancreatic cancer

    PMIDs:
    26676756


    Sources:
    JAX-CKB

  • Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27135738


    Sources:
    CIViC

  • Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy DZNep + Selumetinib
    Indication/Tumor Type lung adenocarcinoma
    Response Type sensitive

    PMIDs:
    26676756


    Sources:
    JAX-CKB

  • Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type diffuse large B-cell lymphoma
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    25605023


    Sources:
    JAX-CKB

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy ACY-957 + Doxorubicin
    Indication/Tumor Type diffuse large B-cell lymphoma
    Response Type sensitive

    PMIDs:
    25605023


    Sources:
    JAX-CKB