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F9 Gene Record

  • Summary
  • Interactions
  • Claims
  • F9 2158 Druggable Genome

    Alternate Names:

    2158
    COAGULATION FACTOR IX
    F9
    F9 p22
    FIX
    HEMB
    P19
    PTC
    THPH8
    300746
    3551
    ENSG00000101981
    OTTHUMG00000022536
    PLASMA THROMBOPLASTIN COMPONENT
    P00740
    CHRISTMAS FACTOR
    P08709
    F7
    Coagulation factor IXa heavy chain
    Coagulation factor IXa light chain
    FA9_HUMAN
    COAGULATION FACTOR IX PRECURSOR (EC 3.4.21.22) (CHRISTMAS FACTOR) (PLASMA THROMBOPLASTIN COMPONENT) (PTC). [SOURCE:UNIPROT/SWISSPROT;ACC:P00740]
    2155
    ENSG00000057593
    FA7_HUMAN
    T83369

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.4.21.21
    Target Subclass 3.4.21.22
    Target Main Class Enzymes
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Human Readable Name PROTEASE
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001254
    Uniprot Status Swiss-Prot
    Interpro Short Name Peptidase_S1_S6
    Human Readable Name DRUGGABLE GENOME
    Target Subclass EC:3.4.21.22
    Target Subclass 3.4.21.21
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME

    Publications:

    Shima M et al., 2016, Factor VIII-Mimetic Function of Humanized Bispecific Antibody in Hemophilia A., N Engl J Med
    Chavin SI, 1984, Factor VIII: structure and function in blood clotting., Am J Hematol
    Uchida N et al., 2016, A first-in-human phase 1 study of ACE910, a novel factor VIII-mimetic bispecific antibody, in healthy subjects., Blood
    Nogami K, 2016, Bispecific antibody mimicking factor VIII., Thromb Res
    Berkessel et al., 2007, Highly enantioselective epoxidation of 2-methylnaphthoquinone (vitamin K3) mediated by new cinchona alkaloid phase-transfer catalysts., Chemistry
    Negrev et al., 1995, Somatotropin and somatostatin effects on vitamin K-dependent plasma coagulation factors., Eur. J. Pharmacol.
    Neuhaus et al., 2001, [An uncommon cause of severe soft tissue bleeding during phenprocoumon treatment]., Dtsch. Med. Wochenschr.
    Olson et al., 1991, Negative regulation of angiotensinogen gene expression by glucocorticoids in fetal sheep liver., Pediatr. Res.
    Mazzucconi et al., 1999, Acquired inhibitor against factor IX in a child: successful treatment with high-dose immunoglobulin and dexamethasone., Haemophilia
    Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.
  • EMICIZUMAB   F9

    Interaction Score: 23.19

    Interaction Types & Directionality:
    antibody (inhibitory)
    cofactor (activating)

    Interaction Info:
    Mechanism of Interaction Coagulation factor IX and X other
    Direct Interaction yes

    PMIDs:
    27223146 6424437 26626991 27207420


    Sources:
    ChemblInteractions TTD

  • PEGNIVACOGIN   F9

    Interaction Score: 15.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Coagulation factor IX inhibitor
    Trial Name REG2, pegnivacogin SC + anivamersen IV, RB006 SC + RB007 IV

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • HUMAN GROWTH HORMONE   F9

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7493602


    Sources:
    NCI

  • LEVOTHYROXINE   F9

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16075920


    Sources:
    NCI

  • COUMARIN   F9

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11455667


    Sources:
    NCI

  • MENADIONE   F9

    Interaction Score: 0.55

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    17348045


    Sources:
    TEND

  • HYDROCORTISONE   F9

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1945565


    Sources:
    NCI

  • DEXAMETHASONE   F9

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10215963


    Sources:
    NCI

  • Ensembl: ENSG00000101981

    • Version: 101_38

    Alternate Names:
    F9 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P00740

    • Version: January-2014

    Alternate Names:
    F9 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.21.22

    Publications:

  • TdgClinicalTrial: P08709

    • Version: January-2014

    Alternate Names:
    F7 Gene Symbol
    F9 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.21.21

    Publications:

  • TEND: P08709

    • Version: 01-August-2011

    Alternate Names:
    FA7_HUMAN Uniprot Id
    F9 Gene Symbol
    P08709 Uniprot Accession

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 3.4.21.21

    Publications:

  • HopkinsGroom: P00740

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000101981 Ensembl Gene Id
    2158 Entrez Gene Id
    COAGULATION FACTOR IXA LIGHT CHAIN Uniprot Protein Name

    Gene Info:
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Human Readable Name PROTEASE
    Interpro Type Domain

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000101981

    • Version: 26-July-2011

    Alternate Names:
    COAGULATION FACTOR IX PRECURSOR (EC 3.4.21.22) (CHRISTMAS FACTOR) (PLASMA THROMBOPLASTIN COMPONENT) (PTC). [SOURCE:UNIPROT/SWISSPROT;ACC:P00740] Description
    F9 Display Id
    ENSG00000101981 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P00740

    • Version: 01-August-2011

    Alternate Names:
    P00740 Uniprot Accession
    F9 Gene Symbol
    2158 Entrez Gene Id

    Gene Info:
    Target Subclass 3.4.21.22
    Target Main Class Enzymes

    Publications:

  • TTD: Coagulation factor IX

    • Version: 2020.06.01

    Alternate Names:
    F9 TTD Gene Abbreviation
    T83369 TTD Target ID

    Gene Info:

    Publications:
    Li H et al., 2011, Assessing the potential for AAV vector genotoxicity in a murine model., Blood
    Santagostino E et al., 2012, Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients., Blood

  • NCI: F9

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Negrev et al., 1995, Somatotropin and somatostatin effects on vitamin K-dependent plasma coagulation factors., Eur. J. Pharmacol.
    Olson et al., 1991, Negative regulation of angiotensinogen gene expression by glucocorticoids in fetal sheep liver., Pediatr. Res.
    Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.

  • HingoraniCasas: ENSG00000101981

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000101981 Gene Symbol
    F9 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: F9

    • Version: chembl_23

    Alternate Names:
    F9 GENE_SYMBOL
    Coagulation factor IX UNIPROT
    Coagulation factor IXa light chain UNIPROT

    Gene Info:

    Publications:

  • dGene: F9

    • Version: 27-Jun-2013

    Alternate Names:
    2158 Gene ID
    FIX dGene Synonym
    HEMB dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21