DGIdb - FAAH Gene Record

FAAH 2166 Druggable Genome

Alternate Names:

2166
FATTY ACID AMIDE HYDROLASE
FAAH
FAAH-1
PSAB
602935
3553
ENSG00000117480
OTTHUMG00000007811
1400
O00519
FAAH1
Oleamide hydrolase 1
Anandamide amidohydrolase 1
Fatty-acid amide hydrolase 1
PA27955
BE0002194
T34389
T11754

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.5.1.99
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category ID	799
GuideToPharmacology Gene Category Name	Hydrolases
GuideToPharmacology Gene Category Name	<i>N</i>-Acylethanolamine turnover
GuideToPharmacology Gene Category ID	273

(7 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Johnson et al., 2011, Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor., ACS Med Chem Lett
Högestätt et al., 2005, Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system., J. Biol. Chem.
Meyers MJ et al., 2011, Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain., Bioorg Med Chem Lett
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Feledziak M et al., 2013, An unprecedented reversible mode of action of β-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH)., Eur J Med Chem
Johnson DS et al., 2009, Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)., Bioorg Med Chem Lett
Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol
Vincent F et al., 2009, Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors., Bioorg Med Chem Lett
Patel et al., 2003, The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Schuel, 2006, Tuning the oviduct to the anandamide tone., J. Clin. Invest.
Zhang W et al., 2020, FAAH levels and its genetic polymorphism association with susceptibility to methamphetamine dependence., Ann Hum Genet
Sim MS et al., 2013, Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population., Pharmacogenomics
Feledziak M et al., 2011, SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process., J Med Chem
Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
Tyndale RF et al., 2007, The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians., Am J Med Genet B Neuropsychiatr Genet
Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

PF-04457845 FAAH

Interaction Score: 9.88

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of human FAAH <i>in vitro</i>.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
21666860

Sources:
DTC GuideToPharmacology TTD
JNJ-42165279 FAAH

Interaction Score: 4.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD
CHEMBL367966 FAAH

Interaction Score: 4.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23287055

Sources:
DTC
CHEMBL560590 FAAH

Interaction Score: 4.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23287055

Sources:
DTC
DODECANOL FAAH

Interaction Score: 4.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1915783 FAAH

Interaction Score: 4.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21924613

Sources:
DTC
URB-597 FAAH

Interaction Score: 3.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
23287055 19386497 21666860

Sources:
DTC GuideToPharmacology
PHENMEDIPHAM FAAH

Interaction Score: 1.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19850474

Sources:
DTC
THIOPENTAL FAAH

Interaction Score: 0.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
12839875 11752352

Sources:
DrugBank TTD
DRONABINOL FAAH

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16886056

Sources:
NCI
ANANDAMIDE FAAH

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21899370

Sources:
DTC
METHAMPHETAMINE FAAH

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31789429 23556448

Sources:
PharmGKB
NABIXIMOLS FAAH

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

inducer (activating)

Interaction Info:

PMIDs:
17290447 26264914

Sources:
DrugBank PharmGKB
ACETAMINOPHEN FAAH

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Anandamide amidohydrolase inhibitor

Direct Interaction yes

PMIDs:
15987694

Sources:
ChemblInteractions NCI
IBUPROFEN FAAH

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25502615

Sources:
PharmGKB
QUETIAPINE FAAH

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
ARIPIPRAZOLE FAAH

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
PROPOFOL FAAH

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
RISPERIDONE FAAH

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
OLANZAPINE FAAH

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
HALOPERIDOL FAAH

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
CLOZAPINE FAAH

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
FOSTAMATINIB FAAH

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000117480
- Version: 101_38
Alternate Names:

FAAH Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: O00519
- Version: January-2014
Alternate Names:

FAAH Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.99

Publications:
GuideToPharmacology: 2166
- Version: 29-September-2020
Alternate Names:

3553 HUGO Gene ID

3553 HUGO Gene Symbol

fatty acid amide hydrolase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Hydrolases

GuideToPharmacology Gene Category ID 799

GuideToPharmacology Gene Category Name <i>N</i>-Acylethanolamine turnover

Gene Categories:

ENZYME

Publications:

PharmGKB: FAAH

Version: 18-August-2020

Alternate Names:

PA27955 PharmGKB ID

Gene Info:

Publications:

Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol

Sim MS et al., 2013, Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population., Pharmacogenomics

Zhang W et al., 2020, FAAH levels and its genetic polymorphism association with susceptibility to methamphetamine dependence., Ann Hum Genet

DrugBank: BE0002194

Version: 5.1.7

Alternate Names:

FAAH DrugBank Gene Name

O00519 UniProt Accession

2166 Entrez Gene Id

Gene Info:

Publications:

Patel et al., 2003, The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase., Br. J. Pharmacol.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

TTD: Fatty acid amide hydrolase
- Version: 2020.06.01
Alternate Names:

FAAH TTD Gene Abbreviation

T11754 TTD Target ID

Gene Info:

Publications:

Otrubova K et al., 2011, The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)., Bioorg Med Chem Lett

NCI: FAAH

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Högestätt et al., 2005, Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system., J. Biol. Chem.

Maccarrone et al., 2003, Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism., J. Neurochem.

Schuel, 2006, Tuning the oviduct to the anandamide tone., J. Clin. Invest.

DTC: FAAH

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Johnson et al., 2011, Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor., ACS Med Chem Lett

Johnson DS et al., 2009, Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)., Bioorg Med Chem Lett

Feledziak M et al., 2013, An unprecedented reversible mode of action of β-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH)., Eur J Med Chem

HingoraniCasas: ENSG00000117480
- Version: 31-May-2017
Alternate Names:

ENSG00000117480 Gene Symbol

FAAH Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: FAAH1
- Version: chembl_23
Alternate Names:

FAAH GENE_SYMBOL

FAAH1 GENE_SYMBOL

Fatty-acid amide hydrolase 1 UNIPROT

Gene Info:

Publications:
TTD: Fatty-acid amide hydrolase 1
- Version: 2020.06.01
Alternate Names:

FAAH1 TTD Gene Abbreviation

T34389 TTD Target ID

Gene Info:

Publications:

Details of the Assay for Interaction	Inhibition of human FAAH <i>in vitro</i>.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Mechanism of Interaction	Anandamide amidohydrolase inhibitor
Direct Interaction	yes

3553	HUGO Gene ID
3553	HUGO Gene Symbol
fatty acid amide hydrolase	HUGO Gene Name

FAAH	DrugBank Gene Name
O00519	UniProt Accession
2166	Entrez Gene Id

FAAH	GENE_SYMBOL
FAAH1	GENE_SYMBOL
Fatty-acid amide hydrolase 1	UNIPROT

inhibitor (inhibitory)
inducer (activating)

FAAH Gene Record

FAAH 2166 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of human FAAH <i>in vitro</i>. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 21666860

Sources: DTC GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23287055

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23287055

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21924613

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 23287055 19386497 21666860

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19850474

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 12839875 11752352

Sources: DrugBank TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16886056

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21899370

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31789429 23556448

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory) inducer (activating)

Interaction Info:

PMIDs: 17290447 26264914

Sources: DrugBank PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Anandamide amidohydrolase inhibitor Direct Interaction yes

PMIDs: 15987694

Sources: ChemblInteractions NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25502615

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20631561

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20631561

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of human FAAH <i>in vitro</i>.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
21666860

Sources:
DTC GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
23287055

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23287055

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21924613

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
23287055 19386497 21666860

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
19850474

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
12839875 11752352

Sources:
DrugBank TTD

Interaction Types & Directionality:

n/a

PMIDs:
16886056

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21899370

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
31789429 23556448

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

inducer (activating)

PMIDs:
17290447 26264914

Sources:
DrugBank PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Anandamide amidohydrolase inhibitor

Direct Interaction yes

PMIDs:
15987694

Sources:
ChemblInteractions NCI

Interaction Types & Directionality:

n/a

PMIDs:
25502615

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26516587

Sources:
DrugBank

Alternate Names:

FAAH Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

FAAH Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.99

Alternate Names:

3553 HUGO Gene ID

3553 HUGO Gene Symbol

fatty acid amide hydrolase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Hydrolases

GuideToPharmacology Gene Category ID 799

GuideToPharmacology Gene Category Name <i>N</i>-Acylethanolamine turnover

Gene Categories:

ENZYME