DGIdb - FAAH Gene Record

FAAH 2166 Druggable Genome

Alternate Names:

2166
FATTY ACID AMIDE HYDROLASE
FAAH
FAAH-1
PSAB
602935
3553
ENSG00000117480
OTTHUMG00000007811
O00519
FAAH1
Oleamide hydrolase 1
Anandamide amidohydrolase 1
Fatty-acid amide hydrolase 1
PA27955
T34389
T11754

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.5.1.99
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Johnson et al., 2011, Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor., ACS Med Chem Lett
Högestätt et al., 2005, Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system., J. Biol. Chem.
Meyers MJ et al., 2011, Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain., Bioorg Med Chem Lett
Feledziak M et al., 2013, An unprecedented reversible mode of action of β-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH)., Eur J Med Chem
Johnson DS et al., 2009, Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)., Bioorg Med Chem Lett
Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol
Vincent F et al., 2009, Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors., Bioorg Med Chem Lett
Patel et al., 2003, The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Schuel, 2006, Tuning the oviduct to the anandamide tone., J. Clin. Invest.
Zhang W et al., 2020, FAAH levels and its genetic polymorphism association with susceptibility to methamphetamine dependence., Ann Hum Genet
Sim MS et al., 2013, Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population., Pharmacogenomics
Feledziak M et al., 2011, SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process., J Med Chem
Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
Tyndale RF et al., 2007, The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians., Am J Med Genet B Neuropsychiatr Genet
Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

PF-04457845 FAAH

Interaction Score: 8.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
21666860

Sources:
DTC TTD
CHEMBL367966 FAAH

Interaction Score: 5.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23287055

Sources:
DTC
CHEMBL560590 FAAH

Interaction Score: 5.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23287055

Sources:
DTC
URB-597 FAAH

Interaction Score: 5.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
23287055 19386497 21666860

Sources:
DTC
CHEMBL1915783 FAAH

Interaction Score: 5.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21924613

Sources:
DTC
NABIXIMOLS FAAH

Interaction Score: 2.94

Interaction Types & Directionality:

inducer (activating)

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17290447 26264914

Sources:
PharmGKB
JNJ-42165279 FAAH

Interaction Score: 2.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
ANANDAMIDE FAAH

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21899370

Sources:
DTC
PHENMEDIPHAM FAAH

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19850474

Sources:
DTC
THIOPENTAL FAAH

Interaction Score: 0.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
12839875 11752352

Sources:
TTD
DRONABINOL FAAH

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16886056

Sources:
NCI
ARIPIPRAZOLE FAAH

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
METHAMPHETAMINE FAAH

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31789429 23556448

Sources:
PharmGKB
ACETAMINOPHEN FAAH

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Anandamide amidohydrolase inhibitor

Direct Interaction yes

PMIDs:
15987694

Sources:
ChemblInteractions NCI
QUETIAPINE FAAH

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
IBUPROFEN FAAH

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25502615

Sources:
PharmGKB
RISPERIDONE FAAH

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
PROPOFOL FAAH

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CLOZAPINE FAAH

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
HALOPERIDOL FAAH

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
OLANZAPINE FAAH

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB

Ensembl: ENSG00000117480
- Version: 101_38
Alternate Names:

FAAH Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: O00519
- Version: January-2014
Alternate Names:

FAAH Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.99

Publications:

PharmGKB: FAAH

Version: 18-August-2020

Alternate Names:

PA27955 PharmGKB ID

Gene Info:

Publications:

Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol

Sim MS et al., 2013, Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population., Pharmacogenomics

Zhang W et al., 2020, FAAH levels and its genetic polymorphism association with susceptibility to methamphetamine dependence., Ann Hum Genet

TTD: Fatty acid amide hydrolase
- Version: 2020.06.01
Alternate Names:

FAAH TTD Gene Abbreviation

T11754 TTD Target ID

Gene Info:

Publications:

Otrubova K et al., 2011, The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)., Bioorg Med Chem Lett

NCI: FAAH

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Högestätt et al., 2005, Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system., J. Biol. Chem.

Maccarrone et al., 2003, Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism., J. Neurochem.

Schuel, 2006, Tuning the oviduct to the anandamide tone., J. Clin. Invest.

DTC: FAAH

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Johnson DS et al., 2009, Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)., Bioorg Med Chem Lett

Feledziak M et al., 2013, An unprecedented reversible mode of action of β-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH)., Eur J Med Chem

Johnson et al., 2011, Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor., ACS Med Chem Lett

HingoraniCasas: ENSG00000117480
- Version: 31-May-2017
Alternate Names:

ENSG00000117480 Gene Symbol

FAAH Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: FAAH1
- Version: chembl_23
Alternate Names:

FAAH GENE_SYMBOL

FAAH1 GENE_SYMBOL

Fatty-acid amide hydrolase 1 UNIPROT

Gene Info:

Publications:
TTD: Fatty-acid amide hydrolase 1
- Version: 2020.06.01
Alternate Names:

FAAH1 TTD Gene Abbreviation

T34389 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Anandamide amidohydrolase inhibitor
Direct Interaction	yes

FAAH	GENE_SYMBOL
FAAH1	GENE_SYMBOL
Fatty-acid amide hydrolase 1	UNIPROT

inducer (activating)
inhibitor (inhibitory)

FAAH Gene Record

FAAH 2166 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 21666860

Sources: DTC TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23287055

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23287055

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 23287055 19386497 21666860

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21924613

Sources: DTC

Interaction Types & Directionality: inducer (activating) inhibitor (inhibitory)

Interaction Info:

PMIDs: 17290447 26264914

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21899370

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19850474

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 12839875 11752352

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16886056

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20631561

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31789429 23556448

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Anandamide amidohydrolase inhibitor Direct Interaction yes

PMIDs: 15987694

Sources: ChemblInteractions NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20631561

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25502615

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20631561

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
21666860

Sources:
DTC TTD

Interaction Types & Directionality:

n/a

PMIDs:
23287055

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23287055

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
23287055 19386497 21666860

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21924613

Sources:
DTC

Interaction Types & Directionality:

inducer (activating)

inhibitor (inhibitory)

PMIDs:
17290447 26264914

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
21899370

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19850474

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
12839875 11752352

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
16886056

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31789429 23556448

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Anandamide amidohydrolase inhibitor

Direct Interaction yes

PMIDs:
15987694

Sources:
ChemblInteractions NCI

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25502615

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Alternate Names:

FAAH Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

FAAH Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.99

Alternate Names:

PA27955 PharmGKB ID

Alternate Names:

FAAH TTD Gene Abbreviation

T11754 TTD Target ID

Publications:

Otrubova K et al., 2011, The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)., Bioorg Med Chem Lett

Alternate Names:

ENSG00000117480 Gene Symbol

FAAH Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

FAAH GENE_SYMBOL

FAAH1 GENE_SYMBOL

Fatty-acid amide hydrolase 1 UNIPROT

Alternate Names:

FAAH1 TTD Gene Abbreviation

T34389 TTD Target ID