DGIdb - FAS Gene Record

FAS 355 Druggable GenomeClinically Actionable

Alternate Names:

355
FAS CELL SURFACE DEATH RECEPTOR
FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
134637
11920
ENSG00000026103
OTTHUMG00000018701
P25445
1875
Apoptosis mediating surface antigen FAS
T14592

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	Fas-Ligand receptor
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Tumour necrosis factor (TNF) receptor family
GuideToPharmacology Gene Category ID	334

(6 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Barten et al., 2003, Assessment of immunosuppressive drug interactions: inhibition of lymphocyte function in peripheral human blood., J. Immunol. Methods
Seitz et al., 1998, Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes., Arthritis Rheum.
Winter et al., 1998, Synergy of CD95 ligand and teniposide: no role of cleavable complex formation and enhanced CD95 expression., Eur. J. Pharmacol.
Lazarus et al., 1997, Vesnarinone inhibits immune-mediated but not Fas (CD95) agonist-mediated hepatic injury., Int. J. Immunopharmacol.
Mahiou et al., 2001, In vivo blockade of the Fas-Fas ligand pathway inhibits cyclophosphamide-induced diabetes in NOD mice., J. Autoimmun.
Beurel et al., 2004, GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression., Exp. Cell Res.
Domhan et al., 2004, Role of apoptosis and CD95-receptor/ligand system in aspirin- and Helicobacter pylori-induced cell death., Eur. J. Clin. Invest.
Oria de Suárez et al., 2006, [Effect of atorvastatin on Fas (CD95/Apo-1) expression in normal or ischemic brain]., An Med Interna
Furuya et al., 2000, Histochemical study of apoptotic epithelial cells depending on testosterone in primary cultured rat prostatic tissues., Histol. Histopathol.
Moers et al., 1999, Regulation of CD95 (Apo-1/Fas) ligand and receptor expression in squamous-cell carcinoma by interferon-gamma and cisplatin., Int. J. Cancer
Iwase et al., 2003, Enhanced susceptibility of oral squamous cell carcinoma cell lines to FAS-mediated apoptosis by cisplatin and 5-fluorouracil., Int. J. Cancer
Wesselborg et al., 1999, Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction., Blood
Méndez-Samperio et al., 2001, Protein tyrosine kinase regulates FAS-mediated apoptosis in human BCG-infected monocytes., J. Interferon Cytokine Res.
Kalechman et al., 1998, Up-regulation by ammonium trichloro(dioxoethylene-0,0') tellurate (AS101) of Fas/Apo-1 expression on B16 melanoma cells: implications for the antitumor effects of AS101., J. Immunol.
Muñoz-Pinedo et al., 2001, Apoptosis of haematopoietic cells upon thymidylate synthase inhibition is independent of p53 accumulation and CD95-CD95 ligand interaction., Biochem. J.
Nieto-Miguel et al., 2006, Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells., J. Biol. Chem.
Weinstein et al., 2005, Unraveling thrombin's true microglia-activating potential: markedly disparate profiles of pharmaceutical-grade and commercial-grade thrombin preparations., J. Neurochem.

EDELFOSINE FAS

Interaction Score: 6.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16540473

Sources:
NCI
OFRANERGENE OBADENOVEC FAS

Interaction Score: 3.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ASUNERCEPT FAS

Interaction Score: 1.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AMMONIUM TRICHLOROTELLURATE FAS

Interaction Score: 1.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9759874

Sources:
NCI
VESNARINONE FAS

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9226479

Sources:
NCI
TENIPOSIDE FAS

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9543255

Sources:
NCI
BCG VACCINE FAS

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11359651

Sources:
NCI
CHOLECALCIFEROL FAS

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9811059

Sources:
NCI
FLOXURIDINE FAS

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11115403

Sources:
NCI
THROMBIN FAS

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16271051

Sources:
NCI
TESTOSTERONE FAS

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10809356

Sources:
NCI
LITHIUM FAS

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15475000

Sources:
NCI
ATORVASTATIN FAS

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16796407

Sources:
NCI
DAUNORUBICIN FAS

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10216102

Sources:
NCI
PROGESTERONE FAS

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14659903

Sources:
NCI
ASPIRIN FAS

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15200494

Sources:
NCI
CYCLOPHOSPHAMIDE FAS

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11437491

Sources:
NCI
FLUOROURACIL FAS

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12845662

Sources:
NCI
CISPLATIN FAS

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9935158

Sources:
NCI

Ensembl: ENSG00000026103
- Version: 101_38
Alternate Names:

FAS Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P25445
- Version: January-2014
Alternate Names:

FAS Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Fas-Ligand receptor

Publications:
GuideToPharmacology: 355
- Version: 29-September-2020
Alternate Names:

11920 HUGO Gene ID

11920 HUGO Gene Symbol

Fas cell surface death receptor HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Tumour necrosis factor (TNF) receptor family

GuideToPharmacology Gene Category ID 334

Publications:

NCI: FAS

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Seitz et al., 1998, Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes., Arthritis Rheum.

Winter et al., 1998, Synergy of CD95 ligand and teniposide: no role of cleavable complex formation and enhanced CD95 expression., Eur. J. Pharmacol.

Moers et al., 1999, Regulation of CD95 (Apo-1/Fas) ligand and receptor expression in squamous-cell carcinoma by interferon-gamma and cisplatin., Int. J. Cancer

HingoraniCasas: ENSG00000026103
- Version: 31-May-2017
Alternate Names:

ENSG00000026103 Gene Symbol

FAS Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: FAS
- Version: 11-November-2018
Alternate Names:

FAS Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Apoptosis mediating surface antigen FAS
- Version: 2020.06.01
Alternate Names:

FAS TTD Gene Abbreviation

T14592 TTD Target ID

Gene Info:

Publications:
GO: FAS
- Version: 01-May-2021
Alternate Names:

APT1 GO Gene Synonym

FAS1 GO Gene Synonym

TNFRSF6 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
FoundationOneGenes: FAS
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: FAS
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

11920	HUGO Gene ID
11920	HUGO Gene Symbol
Fas cell surface death receptor	HUGO Gene Name

APT1	GO Gene Synonym
FAS1	GO Gene Synonym
TNFRSF6	GO Gene Synonym

FAS Gene Record

FAS 355 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16540473

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9759874

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9226479

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9543255

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11359651

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9811059

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11115403

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16271051

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10809356

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15475000

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16796407

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10216102

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14659903

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15200494

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11437491

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12845662

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
16540473

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
9759874

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9226479

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9543255

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11359651

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9811059

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11115403

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16271051

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10809356

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15475000

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16796407

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10216102

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14659903

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15200494

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11437491

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12845662

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9935158

Sources:
NCI

Alternate Names:

FAS Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

FAS Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Fas-Ligand receptor

Alternate Names:

11920 HUGO Gene ID

11920 HUGO Gene Symbol

Fas cell surface death receptor HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Tumour necrosis factor (TNF) receptor family

GuideToPharmacology Gene Category ID 334

Alternate Names:

ENSG00000026103 Gene Symbol

FAS Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

FAS Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

FAS TTD Gene Abbreviation

T14592 TTD Target ID

Alternate Names:

APT1 GO Gene Synonym

FAS1 GO Gene Synonym

TNFRSF6 GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE