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FAS Gene Record

  • Summary
  • Interactions
  • Claims
  • FAS 355 Druggable GenomeClinically Actionable

    Alternate Names:

    355
    FAS CELL SURFACE DEATH RECEPTOR
    FAS
    ALPS1A
    APO-1
    APT1
    CD95
    FAS1
    FASTM
    TNFRSF6
    134637
    11920
    ENSG00000026103
    OTTHUMG00000018701
    P25445
    Apoptosis mediating surface antigen FAS
    T14592

    Gene Info:

    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Fas-Ligand receptor
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Barten et al., 2003, Assessment of immunosuppressive drug interactions: inhibition of lymphocyte function in peripheral human blood., J. Immunol. Methods
    Seitz et al., 1998, Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes., Arthritis Rheum.
    Winter et al., 1998, Synergy of CD95 ligand and teniposide: no role of cleavable complex formation and enhanced CD95 expression., Eur. J. Pharmacol.
    Lazarus et al., 1997, Vesnarinone inhibits immune-mediated but not Fas (CD95) agonist-mediated hepatic injury., Int. J. Immunopharmacol.
    Mahiou et al., 2001, In vivo blockade of the Fas-Fas ligand pathway inhibits cyclophosphamide-induced diabetes in NOD mice., J. Autoimmun.
    Beurel et al., 2004, GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression., Exp. Cell Res.
    Domhan et al., 2004, Role of apoptosis and CD95-receptor/ligand system in aspirin- and Helicobacter pylori-induced cell death., Eur. J. Clin. Invest.
    Oria de Suárez et al., 2006, [Effect of atorvastatin on Fas (CD95/Apo-1) expression in normal or ischemic brain]., An Med Interna
    Furuya et al., 2000, Histochemical study of apoptotic epithelial cells depending on testosterone in primary cultured rat prostatic tissues., Histol. Histopathol.
    Moers et al., 1999, Regulation of CD95 (Apo-1/Fas) ligand and receptor expression in squamous-cell carcinoma by interferon-gamma and cisplatin., Int. J. Cancer
    Iwase et al., 2003, Enhanced susceptibility of oral squamous cell carcinoma cell lines to FAS-mediated apoptosis by cisplatin and 5-fluorouracil., Int. J. Cancer
    Wesselborg et al., 1999, Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction., Blood
    Méndez-Samperio et al., 2001, Protein tyrosine kinase regulates FAS-mediated apoptosis in human BCG-infected monocytes., J. Interferon Cytokine Res.
    Kalechman et al., 1998, Up-regulation by ammonium trichloro(dioxoethylene-0,0') tellurate (AS101) of Fas/Apo-1 expression on B16 melanoma cells: implications for the antitumor effects of AS101., J. Immunol.
    Muñoz-Pinedo et al., 2001, Apoptosis of haematopoietic cells upon thymidylate synthase inhibition is independent of p53 accumulation and CD95-CD95 ligand interaction., Biochem. J.
    Nieto-Miguel et al., 2006, Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells., J. Biol. Chem.
    Weinstein et al., 2005, Unraveling thrombin's true microglia-activating potential: markedly disparate profiles of pharmaceutical-grade and commercial-grade thrombin preparations., J. Neurochem.
  • EDELFOSINE   FAS

    Interaction Score: 6.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16540473


    Sources:
    NCI

  • OFRANERGENE OBADENOVEC   FAS

    Interaction Score: 3.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • AMMONIUM TRICHLOROTELLURATE   FAS

    Interaction Score: 2.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9759874


    Sources:
    NCI

  • ASUNERCEPT   FAS

    Interaction Score: 1.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • VESNARINONE   FAS

    Interaction Score: 0.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9226479


    Sources:
    NCI

  • TENIPOSIDE   FAS

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9543255


    Sources:
    NCI

  • BCG VACCINE   FAS

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11359651


    Sources:
    NCI

  • CHOLECALCIFEROL   FAS

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9811059


    Sources:
    NCI

  • FLOXURIDINE   FAS

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11115403


    Sources:
    NCI

  • THROMBIN   FAS

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16271051


    Sources:
    NCI

  • TESTOSTERONE   FAS

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10809356


    Sources:
    NCI

  • LITHIUM   FAS

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15475000


    Sources:
    NCI

  • ATORVASTATIN   FAS

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16796407


    Sources:
    NCI

  • DAUNORUBICIN   FAS

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10216102


    Sources:
    NCI

  • PROGESTERONE   FAS

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14659903


    Sources:
    NCI

  • ASPIRIN   FAS

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15200494


    Sources:
    NCI

  • CYCLOPHOSPHAMIDE   FAS

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11437491


    Sources:
    NCI

  • FLUOROURACIL   FAS

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12845662


    Sources:
    NCI

  • CISPLATIN   FAS

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9935158


    Sources:
    NCI

  • Ensembl: ENSG00000026103

    • Version: 101_38

    Alternate Names:
    FAS Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P25445

    • Version: January-2014

    Alternate Names:
    FAS Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Fas-Ligand receptor

    Publications:

  • NCI: FAS

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Seitz et al., 1998, Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes., Arthritis Rheum.
    Winter et al., 1998, Synergy of CD95 ligand and teniposide: no role of cleavable complex formation and enhanced CD95 expression., Eur. J. Pharmacol.
    Moers et al., 1999, Regulation of CD95 (Apo-1/Fas) ligand and receptor expression in squamous-cell carcinoma by interferon-gamma and cisplatin., Int. J. Cancer

  • HingoraniCasas: ENSG00000026103

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000026103 Gene Symbol
    FAS Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: FAS

    • Version: 01-February-2022

    Alternate Names:
    APT1 GO Gene Synonym
    FAS1 GO Gene Synonym
    TNFRSF6 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • Tempus: FAS

    • Version: 11-November-2018

    Alternate Names:
    FAS Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Apoptosis mediating surface antigen FAS

    • Version: 2020.06.01

    Alternate Names:
    FAS TTD Gene Abbreviation
    T14592 TTD Target ID

    Gene Info:

    Publications:

  • FoundationOneGenes: FAS

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: FAS

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21