• FDFT1 2222 Druggable Genome

    Alternate Names:

    2222
    FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE 1
    FDFT1
    DGPT
    ERG9
    SQS
    SS
    184420
    3629
    ENSG00000079459
    OTTHUMG00000090801
    Farnesyl-diphosphate farnesyltransferase
    FPP:FPP farnesyltransferase
    Squalene synthase
    P37268
    FDFT_HUMAN
    FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE (EC 2.5.1.21) (SQUALENE SYNTHETASE) (SQS) (SS) (FPP:FPP FARNESYLTRANSFERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P37268]
    645
    NM_004462
    NP_004453
    SQSD

    Gene Info:

    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Short Name Squ/phyt_synthse
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR002060
    Interpro Name Squalene/phytoene synthase
    Interpro Type Family
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Lanosterol biosynthesis pathway
    GuideToPharmacology Gene Category ID 104
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME
  • Interaction Score: 15.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintillation
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 15.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 15.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Squalene synthetase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7685352


    Sources:
    NCI

    • Version: 101_38

    Alternate Names:
    FDFT1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000079459 Ensembl Gene Id
    P37268 Uniprot Accession
    SQUALENE SYNTHASE Uniprot Protein Name

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Short Name Squ/phyt_synthse

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000079459 Ensembl Gene Id
    FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE (EC 2.5.1.21) (SQUALENE SYNTHETASE) (SQS) (SS) (FPP:FPP FARNESYLTRANSFERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P37268] Description
    FDFT1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    3629 HUGO Gene ID
    3629 HUGO Gene Symbol
    farnesyl-diphosphate farnesyltransferase 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Lanosterol biosynthesis pathway
    GuideToPharmacology Gene Category ID 104

    Gene Categories:
    ENZYME

    Publications:

    • Version: 14-September-2017
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000079459 Gene Symbol
    FDFT1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    FDFT1 GENE_SYMBOL
    Squalene synthase UNIPROT
    FPP:FPP farnesyltransferase UNIPROT

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Squalene synthase Gene Name
    P37268 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications: