DGIdb - FGF2 Gene Record

FGF2 2247 Druggable GenomeDrug Resistance

Alternate Names:

2247
FIBROBLAST GROWTH FACTOR 2
FGF2
BFGF
FGF-2
FGFB
HBGF-2
134920
3676
ENSG00000138685
OTTHUMG00000039506
P09038
FGF2_HUMAN
1872
Heparin-binding growth factor 2
Basic fibroblast growth factor
PA28115
Fibroblast growth factor-2
T31621

Gene Info:

Target Subclass	Growth factor
Target Main Class	Other
Target Subclass	Ligand
Target Class	Miscellaneous
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
GROWTH FACTOR
DRUG RESISTANCE
DRUGGABLE GENOME

Publications:

Nakamura et al., 1995, Increased immunoreactivity and concentration of basic fibroblast growth factor in lansoprazole-treated gastric mucosa., J. Clin. Gastroenterol.
Spandau et al., 2005, Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo., Br J Ophthalmol
Xu et al., 2002, Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin., Biochem. Pharmacol.
Wróbel T et al., 2017, <i>bFGF</i> Polymorphism Is Associated with Disease Progression and Response to Chemotherapy in Multiple Myeloma Patients., Anticancer Res
Esaki et al., 2002, Effects of omeprazole and famotidine on fibroblast growth factor-2 during artificial gastric ulcer healing in humans., Eur J Gastroenterol Hepatol
Mehiri et al., 2005, Time-based gene expression programme following diaphragm injury in a rat model., Eur. Respir. J.
Sehgal, 2003, Sirolimus: its discovery, biological properties, and mechanism of action., Transplant. Proc.
Hoekstra et al., 2005, Phase I safety, pharmacokinetic, and pharmacodynamic study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced cancer., J. Clin. Oncol.
Hull et al., 1997, Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration., Gut
Traer et al., 2016, FGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia., Cancer Res.
Hill et al., 1994, Basic fibroblast growth factor (basic FGF) in isolated ovine thyroid follicles: thyrotropin stimulation and effects of basic FGF on DNA synthesis, iodine uptake and organification, and the release of insulin-like growth factors (IGFs) and IGF-binding proteins., Thyroid
Szabo et al., 1995, Growth factors: new 'endogenous drugs' for ulcer healing., Scand. J. Gastroenterol. Suppl.
Szabo, 1991, The mode of action of sucralfate: the 1 x 1 x 1 mechanism of action., Scand. J. Gastroenterol. Suppl.
Tarnawski et al., 1995, Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment?, Scand. J. Gastroenterol. Suppl.
Korman et al., Sucralfate: the Bangkok review., J. Gastroenterol. Hepatol.
Konturek, 1990, Role of growth factors in gastroduodenal protection and healing of peptic ulcers., Gastroenterol. Clin. North Am.
Klauber et al., 1997, Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol., Cancer Res.
Xiao et al., 2005, Effects of isoliensinine on proliferation of porcine coronary arterial smooth muscle cells induced by phenylephrine., Yao Xue Xue Bao
Manetti et al., 1998, Synthesis and binding mode of heterocyclic analogues of suramin inhibiting the human basic fibroblast growth factor., Bioorg. Med. Chem.

SUCRALFATE FGF2

Interaction Score: 5.89

Interaction Types & Directionality:

agonist (activating)

inducer (activating)

Interaction Info:

PMIDs:
8578198 1957124 8578218 7948825 1970337

Sources:
TTD
REBAMIPIDE FGF2

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8774986

Sources:
NCI
PYRAZOLE FGF2

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9730230

Sources:
NCI
ABT-510 FGF2

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16051960

Sources:
NCI
FAMOTIDINE FGF2

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11943947

Sources:
NCI
THYROTROPIN FGF2

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7519916

Sources:
NCI
SQUALAMINE FGF2

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
QUIZARTINIB FGF2

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27671675

Sources:
CIViC
FP-1039 FGF2

Interaction Score: 0.59

Interaction Types & Directionality:

suppressor (inhibitory)

Interaction Info:

Notes Targets other FGF ligands as well

PMIDs:
None found

Sources:
TALC
PHENYLEPHRINE FGF2

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15875663

Sources:
NCI
LENALIDOMIDE FGF2

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28373444

Sources:
PharmGKB
MUPARFOSTAT FGF2

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Basic fibroblast growth factor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
TRIAMCINOLONE FGF2

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15923512

Sources:
NCI
FLUVOXAMINE FGF2

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CAFFEINE FGF2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15738284

Sources:
NCI
THALIDOMIDE FGF2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28373444

Sources:
PharmGKB
INDOMETHACIN FGF2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9071932

Sources:
NCI
SIROLIMUS FGF2

Interaction Score: 0.11

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name LCP-Siro, sirolimus

Novel drug target Established target

PMIDs:
12742462

Sources:
TdgClinicalTrial
VINCRISTINE FGF2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8988045

Sources:
NCI
ATORVASTATIN FGF2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12147302

Sources:
NCI
ASPIRIN FGF2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9071932

Sources:
NCI

Ensembl: ENSG00000138685
- Version: 101_38
Alternate Names:

FGF2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P09038
- Version: 01-August-2011
Alternate Names:

FGF2 Gene Symbol

P09038 Uniprot Accession

FGF2_HUMAN Uniprot Id

Gene Info:

Target Subclass Growth factor

Target Main Class Other

Target Subclass Ligand

Publications:
TdgClinicalTrial: P09038
- Version: January-2014
Alternate Names:

FGF2 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Ligand

Target Subclass Growth factor

Publications:
PharmGKB: FGF2
- Version: 18-August-2020
Alternate Names:

PA28115 PharmGKB ID

Gene Info:

Publications:

Wróbel T et al., 2017, <i>bFGF</i> Polymorphism Is Associated with Disease Progression and Response to Chemotherapy in Multiple Myeloma Patients., Anticancer Res
CIViC: FGF2
- Version: 14-September-2020
Alternate Names:

2247 Entrez Gene ID

1872 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Traer et al., 2016, FGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia., Cancer Res.

NCI: FGF2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Nakamura et al., 1995, Increased immunoreactivity and concentration of basic fibroblast growth factor in lansoprazole-treated gastric mucosa., J. Clin. Gastroenterol.

Spandau et al., 2005, Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo., Br J Ophthalmol

Hull et al., 1997, Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration., Gut

ChemblInteractions: FGFB
- Version: chembl_23
Alternate Names:

FGFB GENE_SYMBOL

FGF2 GENE_SYMBOL

Fibroblast growth factor 2 UNIPROT

Gene Info:

Publications:
TALC: FGF2
- Version: 12-May-2016
Alternate Names:

FGF2 Gene Symbol

Gene Info:

Publications:
HingoraniCasas: ENSG00000138685
- Version: 31-May-2017
Alternate Names:

ENSG00000138685 Gene Symbol

FGF2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: FGF2
- Version: 01-February-2022
Alternate Names:

FGFB GO Gene Synonym

Gene Info:

Gene Categories:

TUMOR SUPPRESSOR, GROWTH FACTOR

Publications:
Tempus: FGF2
- Version: 11-November-2018
Alternate Names:

FGF2 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Fibroblast growth factor-2
- Version: 2020.06.01
Alternate Names:

FGF2 TTD Gene Abbreviation

T31621 TTD Target ID

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Basic fibroblast growth factor inhibitor

Trial Name	LCP-Siro, sirolimus
Novel drug target	Established target

FGFB	GENE_SYMBOL
FGF2	GENE_SYMBOL
Fibroblast growth factor 2	UNIPROT

agonist (activating)
inducer (activating)

FGF2 Gene Record

FGF2 2247 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating) inducer (activating)

Interaction Info:

PMIDs: 8578198 1957124 8578218 7948825 1970337

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8774986

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9730230

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16051960

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11943947

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7519916

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27671675

Sources: CIViC

Interaction Types & Directionality: suppressor (inhibitory)

Interaction Info: Notes Targets other FGF ligands as well

PMIDs: None found

Sources: TALC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15875663

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28373444

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Basic fibroblast growth factor inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15923512

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15738284

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28373444

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9071932

Sources: NCI

Interaction Types & Directionality: other/unknown

Interaction Info: Trial Name LCP-Siro, sirolimus Novel drug target Established target

PMIDs: 12742462

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

agonist (activating)

inducer (activating)

PMIDs:
8578198 1957124 8578218 7948825 1970337

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
8774986

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9730230

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16051960

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11943947

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7519916

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
27671675

Sources:
CIViC

Interaction Types & Directionality:

suppressor (inhibitory)

Interaction Info:

Notes Targets other FGF ligands as well

PMIDs:
None found

Sources:
TALC

Interaction Types & Directionality:

n/a

PMIDs:
15875663

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
28373444

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Basic fibroblast growth factor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
15923512

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15738284

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
28373444

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9071932

Sources:
NCI

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name LCP-Siro, sirolimus

Novel drug target Established target

PMIDs:
12742462

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
8988045

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12147302

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9071932

Sources:
NCI

Alternate Names:

FGF2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

FGF2 Gene Symbol

P09038 Uniprot Accession

FGF2_HUMAN Uniprot Id

Gene Info:

Target Subclass Growth factor

Target Main Class Other

Target Subclass Ligand

Alternate Names:

FGF2 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Ligand

Target Subclass Growth factor

Alternate Names:

PA28115 PharmGKB ID

Publications:

Wróbel T et al., 2017, <i>bFGF</i> Polymorphism Is Associated with Disease Progression and Response to Chemotherapy in Multiple Myeloma Patients., Anticancer Res

Alternate Names:

2247 Entrez Gene ID

1872 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Publications:

Traer et al., 2016, FGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia., Cancer Res.

Alternate Names:

FGFB GENE_SYMBOL

FGF2 GENE_SYMBOL

Fibroblast growth factor 2 UNIPROT

Alternate Names:

FGF2 Gene Symbol

Alternate Names:

ENSG00000138685 Gene Symbol

FGF2 Ensembl Id