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FGF2 Gene Record

  • Summary
  • Interactions
  • Claims
  • FGF2 2247 Druggable GenomeDrug Resistance

    Alternate Names:

    2247
    FIBROBLAST GROWTH FACTOR 2
    FGF2
    BFGF
    FGF-2
    FGFB
    HBGF-2
    134920
    3676
    ENSG00000138685
    OTTHUMG00000039506
    P09038
    FGF2_HUMAN
    1872
    Heparin-binding growth factor 2
    Basic fibroblast growth factor
    PA28115
    Fibroblast growth factor-2
    T31621

    Gene Info:

    Target Subclass Growth factor
    Target Main Class Other
    Target Subclass Ligand
    Target Class Miscellaneous
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    GROWTH FACTOR
    DRUG RESISTANCE
    DRUGGABLE GENOME

    Publications:

    Nakamura et al., 1995, Increased immunoreactivity and concentration of basic fibroblast growth factor in lansoprazole-treated gastric mucosa., J. Clin. Gastroenterol.
    Spandau et al., 2005, Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo., Br J Ophthalmol
    Xu et al., 2002, Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin., Biochem. Pharmacol.
    Wróbel T et al., 2017, <i>bFGF</i> Polymorphism Is Associated with Disease Progression and Response to Chemotherapy in Multiple Myeloma Patients., Anticancer Res
    Esaki et al., 2002, Effects of omeprazole and famotidine on fibroblast growth factor-2 during artificial gastric ulcer healing in humans., Eur J Gastroenterol Hepatol
    Mehiri et al., 2005, Time-based gene expression programme following diaphragm injury in a rat model., Eur. Respir. J.
    Sehgal, 2003, Sirolimus: its discovery, biological properties, and mechanism of action., Transplant. Proc.
    Hoekstra et al., 2005, Phase I safety, pharmacokinetic, and pharmacodynamic study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced cancer., J. Clin. Oncol.
    Hull et al., 1997, Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration., Gut
    Traer et al., 2016, FGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia., Cancer Res.
    Hill et al., 1994, Basic fibroblast growth factor (basic FGF) in isolated ovine thyroid follicles: thyrotropin stimulation and effects of basic FGF on DNA synthesis, iodine uptake and organification, and the release of insulin-like growth factors (IGFs) and IGF-binding proteins., Thyroid
    Szabo et al., 1995, Growth factors: new 'endogenous drugs' for ulcer healing., Scand. J. Gastroenterol. Suppl.
    Szabo, 1991, The mode of action of sucralfate: the 1 x 1 x 1 mechanism of action., Scand. J. Gastroenterol. Suppl.
    Tarnawski et al., 1995, Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment?, Scand. J. Gastroenterol. Suppl.
    Korman et al., Sucralfate: the Bangkok review., J. Gastroenterol. Hepatol.
    Konturek, 1990, Role of growth factors in gastroduodenal protection and healing of peptic ulcers., Gastroenterol. Clin. North Am.
    Klauber et al., 1997, Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol., Cancer Res.
    Xiao et al., 2005, Effects of isoliensinine on proliferation of porcine coronary arterial smooth muscle cells induced by phenylephrine., Yao Xue Xue Bao
    Manetti et al., 1998, Synthesis and binding mode of heterocyclic analogues of suramin inhibiting the human basic fibroblast growth factor., Bioorg. Med. Chem.
  • SUCRALFATE   FGF2

    Interaction Score: 5.89

    Interaction Types & Directionality:
    agonist (activating)
    inducer (activating)

    Interaction Info:

    PMIDs:
    8578198 1957124 8578218 7948825 1970337


    Sources:
    TTD

  • REBAMIPIDE   FGF2

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8774986


    Sources:
    NCI

  • PYRAZOLE   FGF2

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9730230


    Sources:
    NCI

  • ABT-510   FGF2

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16051960


    Sources:
    NCI

  • FAMOTIDINE   FGF2

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11943947


    Sources:
    NCI

  • THYROTROPIN   FGF2

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7519916


    Sources:
    NCI

  • SQUALAMINE   FGF2

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • QUIZARTINIB   FGF2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27671675


    Sources:
    CIViC

  • FP-1039   FGF2

    Interaction Score: 0.59

    Interaction Types & Directionality:
    suppressor (inhibitory)

    Interaction Info:
    Notes Targets other FGF ligands as well

    PMIDs:
    None found


    Sources:
    TALC

  • PHENYLEPHRINE   FGF2

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15875663


    Sources:
    NCI

  • LENALIDOMIDE   FGF2

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28373444


    Sources:
    PharmGKB

  • MUPARFOSTAT   FGF2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Basic fibroblast growth factor inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRIAMCINOLONE   FGF2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15923512


    Sources:
    NCI

  • FLUVOXAMINE   FGF2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CAFFEINE   FGF2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15738284


    Sources:
    NCI

  • THALIDOMIDE   FGF2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28373444


    Sources:
    PharmGKB

  • INDOMETHACIN   FGF2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9071932


    Sources:
    NCI

  • SIROLIMUS   FGF2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:
    Trial Name LCP-Siro, sirolimus
    Novel drug target Established target

    PMIDs:
    12742462


    Sources:
    TdgClinicalTrial

  • VINCRISTINE   FGF2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8988045


    Sources:
    NCI

  • ATORVASTATIN   FGF2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12147302


    Sources:
    NCI

  • ASPIRIN   FGF2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9071932


    Sources:
    NCI

  • Ensembl: ENSG00000138685

    • Version: 101_38

    Alternate Names:
    FGF2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P09038

    • Version: 01-August-2011

    Alternate Names:
    FGF2 Gene Symbol
    P09038 Uniprot Accession
    FGF2_HUMAN Uniprot Id

    Gene Info:
    Target Subclass Growth factor
    Target Main Class Other
    Target Subclass Ligand

    Publications:

  • TdgClinicalTrial: P09038

    • Version: January-2014

    Alternate Names:
    FGF2 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Ligand
    Target Subclass Growth factor

    Publications:

  • PharmGKB: FGF2

    • Version: 18-August-2020

    Alternate Names:
    PA28115 PharmGKB ID

    Gene Info:

    Publications:
    Wróbel T et al., 2017, <i>bFGF</i> Polymorphism Is Associated with Disease Progression and Response to Chemotherapy in Multiple Myeloma Patients., Anticancer Res

  • CIViC: FGF2

    • Version: 14-September-2020

    Alternate Names:
    2247 Entrez Gene ID
    1872 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Traer et al., 2016, FGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia., Cancer Res.

  • NCI: FGF2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Nakamura et al., 1995, Increased immunoreactivity and concentration of basic fibroblast growth factor in lansoprazole-treated gastric mucosa., J. Clin. Gastroenterol.
    Spandau et al., 2005, Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo., Br J Ophthalmol
    Hull et al., 1997, Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration., Gut

  • ChemblInteractions: FGFB

    • Version: chembl_23

    Alternate Names:
    FGFB GENE_SYMBOL
    FGF2 GENE_SYMBOL
    Fibroblast growth factor 2 UNIPROT

    Gene Info:

    Publications:

  • TALC: FGF2

    • Version: 12-May-2016

    Alternate Names:
    FGF2 Gene Symbol

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000138685

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000138685 Gene Symbol
    FGF2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: FGF2

    • Version: 01-February-2022

    Alternate Names:
    FGFB GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR, GROWTH FACTOR

    Publications:

  • Tempus: FGF2

    • Version: 11-November-2018

    Alternate Names:
    FGF2 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Fibroblast growth factor-2

    • Version: 2020.06.01

    Alternate Names:
    FGF2 TTD Gene Abbreviation
    T31621 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21