2261 |
FIBROBLAST GROWTH FACTOR RECEPTOR 3 |
FGFR3 |
ACH |
CD333 |
CEK2 |
HSFGFR3EX |
JTK4 |
134934 |
3690 |
ENSG00000068078 |
OTTHUMG00000121148 |
CD_antigen=CD333 |
FGFR-3 |
P22607 |
FGFR3_HUMAN |
FIBROBLAST GROWTH FACTOR RECEPTOR 3 PRECURSOR (EC 2.7.1.112) (FGFR-3). [SOURCE:UNIPROT/SWISSPROT;ACC:P22607] |
FGFR1-3 |
23 |
PA28129 |
T91331 |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR001245 |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Uniprot Status | Swiss-Prot |
Interpro Type | Domain |
Human Readable Name | KINASE |
Human Readable Name | DRUGGABLE GENOME |
CancerCommons Reported Gene Name | FGFRs |
CancerCommons Reported Gene Name | FGFR3 and others (VEGFR) |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
Target Main Class | Receptors |
Target Subclass | Kinase |
Target Subclass | FGFR |
Transmembrane Helix Count | 1 |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
KINASE |
TYROSINE KINASE |
DRUG RESISTANCE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
inhibitor (inhibitory) |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Approval Status | Preclinical |
inhibitor (inhibitory) |
Notes | |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted – sensitive |
Approval Status | Preclinical - Cell line xenograft |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
Indication/Tumor Type | Advanced Solid Tumor |
inhibitor (inhibitory) |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | predicted – sensitive |
Approval Status | Phase I |
inhibitor (inhibitory) |
Response Type | resistant |
Indication/Tumor Type | urinary bladder cancer |
Evidence Type | Actionable |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | trafermin, fibro/ |
Novel drug target | Established target |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Fibroblast growth factor receptor 3 inhibitor |
n/a |
Trial Name | FP-1039 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Notes | |
Indication/Tumor Type | bladder urothelial carcinoma |
Approval Status | Preclinical - Cell culture |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor 3 inhibitor |
Direct Interaction | yes |
Notes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor 3 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
n/a |
combination therapy | BGJ398 + BYL719 |
Indication/Tumor Type | transitional cell carcinoma |
Response Type | predicted – sensitive |
FGFR3 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000068078 | Ensembl Gene Id |
FGFR3_HUMAN | Uniprot Id |
2261 | Entrez Gene Id |
Target Main Class | Receptors |
Target Subclass | Kinase |
Target Subclass | FGFR |
FGFR3 | Gene Symbol |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
FGFR3 | Display Id |
ENSG00000068078 | Ensembl Gene Id |
FIBROBLAST GROWTH FACTOR RECEPTOR 3 PRECURSOR (EC 2.7.1.112) (FGFR-3). [SOURCE:UNIPROT/SWISSPROT;ACC:P22607] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
FGFR3 | Uniprot Gene Name |
FGFR3_HUMAN | Uniprot Id |
P22607 | Uniprot Accession |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR001245 |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
KINASE, DRUGGABLE GENOME |
2261 | Entrez Gene ID |
CancerCommons Reported Gene Name | FGFRs |
CancerCommons Reported Gene Name | FGFR3 and others (VEGFR) |
2261 | CKB Entrez Id |
FGFR3 | CKB Gene Synonym |
ACH | CKB Gene Synonym |
PA28129 | PharmGKB ID |
2261 | Entrez Gene ID |
23 | CIViC Gene ID |
DRUG RESISTANCE, CLINICALLY ACTIONABLE |
ENSG00000068078 | Gene Symbol |
FGFR3 | Ensembl Id |
DRUGGABLE GENOME |
FGFR-3 | Gene Symbol |
JTK4 | GENE_SYMBOL |
FGFR3 | GENE_SYMBOL |
Fibroblast growth factor receptor 3 | UNIPROT |
2261 | Entrez Gene Id |
FGFR3 | MyCancerGenome Gene Symbol |
FGFR1-3 | MyCancerGenome Reported Gene Name |
FGFR3 | Gene Symbol |
2261 | OncoKB Entrez Id |
JTK4 | OncoKB Gene Synonym |
HSFGFR3EX | OncoKB Gene Synonym |
JTK4 | GO Gene Synonym |
CELL SURFACE, TYROSINE KINASE |
FGFR3 | Gene Symbol |
CLINICALLY ACTIONABLE |
2261 | Gene ID |
ACH | dGene Synonym |
CD333 | dGene Synonym |
KINASE, TYROSINE KINASE |
FGFR3 | TTD Gene Abbreviation |
T91331 | TTD Target ID |
Fibroblast growth factor receptor 3 | Gene Name |
P22607 | UniProt ID |
KINASE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |