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FKBP5 Gene Record

  • Summary
  • Interactions
  • Claims
  • FKBP5 2289 Druggable Genome

    Alternate Names:

    2289
    FK506 BINDING PROTEIN 5
    FKBP5
    AIG6
    FKBP51
    FKBP54
    P54
    PPIase
    Ptg-10
    602623
    3721
    ENSG00000096060
    OTTHUMG00000014576
    PA28162
    Q13451
    PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5
    FKBP5_HUMAN
    FK506-BINDING PROTEIN 5 (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (51 KDA FK506-BINDING PROTEIN) (FKBP- 51) (54 KDA PROGESTERONE RECEPTOR-ASSOCIATED IMMUNOPHILIN) (FKBP54) (P54) (FF1 ANTIGEN) (HSP90-BINDING IMMUNOPHILIN) (ANDR
    FKBP PROLYL ISOMERASE 5

    Gene Info:

    Interpro Short Name PPIase_FKBP_dom
    Interpro Name Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001179
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Ellsworth KA et al., 2013, Contribution of FKBP5 genetic variation to gemcitabine treatment and survival in pancreatic adenocarcinoma., PLoS One
    Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
    Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
    Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett
    Sarginson JE et al., 2010, FKBP5 polymorphisms and antidepressant response in geriatric depression., Am J Med Genet B Neuropsychiatr Genet
    Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics
    Papiol S et al., 2007, Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment., J Affect Disord
    Binder EB et al., 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment., Nat Genet
    Mitjans M et al., 2015, Hypothalamic-pituitary-adrenal system, neurotrophic factors and clozapine response: association with FKBP5 and NTRK2 genes., Pharmacogenet Genomics
    Tiwari AK et al., 2013, Analysis of 34 candidate genes in bupropion and placebo remission., Int J Neuropsychopharmacol
  • NEFAZODONE   FKBP5

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23733030 21449676 20709156 19676097 18597649 17467808 15565110


    Sources:
    PharmGKB

  • CLOMIPRAMINE   FKBP5

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23733030 21449676 20709156 19676097 18597649 17467808 15565110


    Sources:
    PharmGKB

  • VENLAFAXINE   FKBP5

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23733030 21449676 20709156 19676097 18597649 17467808 15565110


    Sources:
    PharmGKB

  • PAROXETINE   FKBP5

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23733030 21449676 20709156 19676097 18597649 17467808 15565110


    Sources:
    PharmGKB

  • CITALOPRAM   FKBP5

    Interaction Score: 1.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23733030 21449676 20709156 19676097 18597649 17467808 15565110


    Sources:
    PharmGKB

  • LITHIUM   FKBP5

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23733030 21449676 20709156 19676097 18597649 17467808 15565110


    Sources:
    PharmGKB

  • MIRTAZAPINE   FKBP5

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20709156 15565110


    Sources:
    PharmGKB

  • BUPROPION   FKBP5

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22947179


    Sources:
    PharmGKB

  • FLUOXETINE   FKBP5

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20709156 15565110


    Sources:
    PharmGKB

  • ESCITALOPRAM   FKBP5

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CLOZAPINE   FKBP5

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25751398


    Sources:
    PharmGKB

  • GEMCITABINE   FKBP5

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23936393


    Sources:
    PharmGKB

  • Ensembl: ENSG00000096060

    • Version: 101_38

    Alternate Names:
    FKBP5 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q13451

    • Version: 11-September-2012

    Alternate Names:
    FKBP5_HUMAN Uniprot Id
    Q13451 Uniprot Accession
    FKBP5 Uniprot Gene Name

    Gene Info:
    Interpro Short Name PPIase_FKBP_dom
    Interpro Name Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000096060

    • Version: 26-July-2011

    Alternate Names:
    FKBP5 Display Id
    FK506-BINDING PROTEIN 5 (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (51 KDA FK506-BINDING PROTEIN) (FKBP- 51) (54 KDA PROGESTERONE RECEPTOR-ASSOCIATED IMMUNOPHILIN) (FKBP54) (P54) (FF1 ANTIGEN) (HSP90-BINDING IMMUNOPHILIN) (ANDR Description
    ENSG00000096060 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: FKBP5

    • Version: 18-August-2020

    Alternate Names:
    PA28162 PharmGKB ID

    Gene Info:

    Publications:
    Ellsworth KA et al., 2013, Contribution of FKBP5 genetic variation to gemcitabine treatment and survival in pancreatic adenocarcinoma., PLoS One
    Mitjans M et al., 2015, Hypothalamic-pituitary-adrenal system, neurotrophic factors and clozapine response: association with FKBP5 and NTRK2 genes., Pharmacogenet Genomics
    Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett

  • HingoraniCasas: ENSG00000096060

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000096060 Gene Symbol
    FKBP5 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21