DGIdb - FKBP5 Gene Record

FKBP5 2289 Druggable Genome

Alternate Names:

2289
FK506 BINDING PROTEIN 5
FKBP5
AIG6
FKBP51
FKBP54
P54
PPIase
Ptg-10
602623
3721
ENSG00000096060
OTTHUMG00000014576
PA28162
Q13451
PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5
FKBP5_HUMAN
FK506-BINDING PROTEIN 5 (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (51 KDA FK506-BINDING PROTEIN) (FKBP- 51) (54 KDA PROGESTERONE RECEPTOR-ASSOCIATED IMMUNOPHILIN) (FKBP54) (P54) (FF1 ANTIGEN) (HSP90-BINDING IMMUNOPHILIN) (ANDR
FKBP PROLYL ISOMERASE 5

Gene Info:

Interpro Short Name	PPIase_FKBP_dom
Interpro Name	Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
Uniprot Status	Swiss-Prot
Interpro Acc	IPR001179
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Gene Biotype	PROTEIN_CODING

(1 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Ellsworth KA et al., 2013, Contribution of FKBP5 genetic variation to gemcitabine treatment and survival in pancreatic adenocarcinoma., PLoS One
Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett
Sarginson JE et al., 2010, FKBP5 polymorphisms and antidepressant response in geriatric depression., Am J Med Genet B Neuropsychiatr Genet
Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics
Papiol S et al., 2007, Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment., J Affect Disord
Binder EB et al., 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment., Nat Genet
Mitjans M et al., 2015, Hypothalamic-pituitary-adrenal system, neurotrophic factors and clozapine response: association with FKBP5 and NTRK2 genes., Pharmacogenet Genomics
Tiwari AK et al., 2013, Analysis of 34 candidate genes in bupropion and placebo remission., Int J Neuropsychopharmacol

NEFAZODONE FKBP5

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB
CLOMIPRAMINE FKBP5

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB
VENLAFAXINE FKBP5

Interaction Score: 2.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB
PAROXETINE FKBP5

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB
CITALOPRAM FKBP5

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB
LITHIUM FKBP5

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB
MIRTAZAPINE FKBP5

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20709156 15565110

Sources:
PharmGKB
BUPROPION FKBP5

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22947179

Sources:
PharmGKB
FLUOXETINE FKBP5

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20709156 15565110

Sources:
PharmGKB
ESCITALOPRAM FKBP5

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CLOZAPINE FKBP5

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25751398

Sources:
PharmGKB
GEMCITABINE FKBP5

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23936393

Sources:
PharmGKB

Ensembl: ENSG00000096060
- Version: 101_38
Alternate Names:

FKBP5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q13451
- Version: 11-September-2012
Alternate Names:

FKBP5_HUMAN Uniprot Id

Q13451 Uniprot Accession

FKBP5 Uniprot Gene Name

Gene Info:

Interpro Short Name PPIase_FKBP_dom

Interpro Name Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000096060

Version: 26-July-2011

Alternate Names:

FKBP5 Display Id

FK506-BINDING PROTEIN 5 (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (51 KDA FK506-BINDING PROTEIN) (FKBP- 51) (54 KDA PROGESTERONE RECEPTOR-ASSOCIATED IMMUNOPHILIN) (FKBP54) (P54) (FF1 ANTIGEN) (HSP90-BINDING IMMUNOPHILIN) (ANDR Description

ENSG00000096060 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: FKBP5

Version: 18-August-2020

Alternate Names:

PA28162 PharmGKB ID

Gene Info:

Publications:

Ellsworth KA et al., 2013, Contribution of FKBP5 genetic variation to gemcitabine treatment and survival in pancreatic adenocarcinoma., PLoS One

Mitjans M et al., 2015, Hypothalamic-pituitary-adrenal system, neurotrophic factors and clozapine response: association with FKBP5 and NTRK2 genes., Pharmacogenet Genomics

Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett

HingoraniCasas: ENSG00000096060
- Version: 31-May-2017
Alternate Names:

ENSG00000096060 Gene Symbol

FKBP5 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:

FKBP5_HUMAN	Uniprot Id
Q13451	Uniprot Accession
FKBP5	Uniprot Gene Name

FKBP5	Display Id
FK506-BINDING PROTEIN 5 (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (51 KDA FK506-BINDING PROTEIN) (FKBP- 51) (54 KDA PROGESTERONE RECEPTOR-ASSOCIATED IMMUNOPHILIN) (FKBP54) (P54) (FF1 ANTIGEN) (HSP90-BINDING IMMUNOPHILIN) (ANDR	Description
ENSG00000096060	Ensembl Gene Id

FKBP5 Gene Record

FKBP5 2289 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20709156 15565110

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22947179

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20709156 15565110

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25751398

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23936393

Sources: PharmGKB

Ensembl: ENSG00000096060

Alternate Names: FKBP5 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q13451

Alternate Names: FKBP5_HUMAN Uniprot Id Q13451 Uniprot Accession FKBP5 Uniprot Gene Name

Gene Info: Interpro Short Name PPIase_FKBP_dom Interpro Name Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain Uniprot Status Swiss-Prot

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000096060

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: FKBP5

Alternate Names: PA28162 PharmGKB ID

Gene Info:

HingoraniCasas: ENSG00000096060

Alternate Names: ENSG00000096060 Gene Symbol FKBP5 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20709156 15565110

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22947179

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20709156 15565110

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25751398

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23936393

Sources:
PharmGKB

Alternate Names:

FKBP5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

FKBP5_HUMAN Uniprot Id

Q13451 Uniprot Accession

FKBP5 Uniprot Gene Name

Gene Info:

Interpro Short Name PPIase_FKBP_dom

Interpro Name Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA28162 PharmGKB ID

Alternate Names:

ENSG00000096060 Gene Symbol

FKBP5 Ensembl Id

Gene Categories:

DRUGGABLE GENOME